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INDONESIA
CHEMPUBLISH JOURNAL
Published by Universitas Jambi
ISSN : -     EISSN : -     DOI : -
Core Subject : Science, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry
Arjuna Subject : -
Articles 144 Documents
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Characterization and In Vivo Evaluation of Durian Peel Extract Nanoliposome Transdermal Patch on Wound Healing Susanto, Nindita Clourisa Amaris; Putri, Milkazia Elda; Utami, Dayinta Tyas; Ermawati, Dian Eka; Sasongko , Heru; Rohmani , Sholichah; Artanti, Anif Nur; Utami, Dyah Tri; Zulpadly Mh, M. Fiqri; Darojati, Ulfa Afrinurfadhilah; Meitasari , Annisa Diyan; Untari, Meta Kartika; Izza, Alfina
Chempublish Journal Vol. 10 No. 1 (2026): Chempublish Journal (January - June)
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v10i1.48779

Abstract

Wounds are a form of continuity damage due to loss of tissue, structure and anatomical function of the skin caused by heat trauma or sharp object scratches. The prevalence of wound injury patients in Indonesia is 9.2%. One of the natural ingredients that is effective in inhibiting the growth of infectious organisms is durian, especially in its skin. In this study, durian peel was formulated in liposome dosage form and applied to patch preparations. The purpose of this study was to assess the effectiveness of durian skin extract liposomes (Durio zibethinus Murr.) on wound healing in white rats. The results of this study are that the patches produced can provide a therapeutic effect on the healing of incision wounds in wistar strain male white rats (Rattus norvegicus L.) with a healing percentage on day 7 of 72.5% which is characterized by the absence of edema, bleeding, growth of fur in mice, the appearance of scabs and wound closure.
In silico and In vitro Study of The Anticancer Potential of Essential Oil from Sembung (Blumea balsamifera) Leaves against HeLa Cervical Cancer Cells Ulia, Rahmi Vika; Raharto, Toto; Suryati; Santoni, Adlis; Herru, Yoan De Nanda
Chempublish Journal Vol. 10 No. 1 (2026): Chempublish Journal (January - June)
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v10i1.49160

Abstract

Blumea balsamifera (L.) DC. (sembung) is a medicinal plant widely recognized for its diverse pharmacological properties, including cytotoxic and anticancer activities. However, the anticancer potential of its leaf essential oil against cervical cancer remains poorly explored. This study aimed to evaluate the anticancer activity of B. balsamifera leaf essential oil against HeLa cervical cancer cells using integrated in silico and in vitro approaches. Molecular docking analysis against the anti-apoptotic Bcl-2 protein revealed favorable binding affinities for several major constituents, including camphor (-5.745 kcal/mol), caryophyllene (-7.077 kcal/mol), 7-epi-silphiperfol-5-ene (-7.311 kcal/mol), and γ-eudesmol (-7.083 kcal/mol), indicating potential interactions with apoptosis-related targets. Furthermore, cytotoxic activity assessed by the MTT assay demonstrated an IC₅₀ value of 32.90 µg/mL against HeLa cells, indicating moderate cytotoxic potency. These findings suggest that B. balsamifera leaf essential oil possesses promising anti-cervical cancer activity and may serve as a potential natural source for the development of apoptosis-targeting anticancer agents.
Synthesis and Characterization of Alginate/PVA/Fe3O4 as an Adsorbent for p-Nitrophenol Adsorption Vikandari, Sonya Nurizki; Fitriana, Fina Ahmad; Setiawati, Nia; Azizia, Negi Rahmah
Chempublish Journal Vol. 10 No. 1 (2026): Chempublish Journal (January - June)
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v10i1.50987

Abstract

p-nitrophenol (PNP) is one of the priority pollutants in the environment because PNP has toxic properties and is a persistent organic pollutant (POPs), so it requires more attention in waste treatment to maintain human health and aquatic ecosystems. Adsorption is one of the pollutant removal method that has the advantage of being simple and low-cost. The adsorption process involves an adsorbent that attracts and retains certain molecules, ions, and particles on its surface. Alginate is one of the biosorbents that can be used to adsorb liquid waste, but alginate has weak mechanical properties, so it can be modified with polyvinyl alcohol (PVA) to form a beads adsorbent. The addition of magnetic Fe3O4 to the adsorbent aims to provide magnetic properties to facilitate the separation of the adsorbent from the analyte. The adsorbent has been characterized using Fourier Transform Infra Red Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), X-Ray Diffraction (XRD), and Delsa™ Nano C Particle Analyzer. The adsorption of PNP using 0.1 gram of adsorbent using the batch method reached optimum conditions at pH 6 and a contact time of 120 minutes. The PNP adsorption process followed a pseudo-second-order adsorption kinetics model with a maximum adsorption capacity of 3.598 mg/g
Integrative Network Pharmacology and Molecular Docking Analysis of Tinospora crispa L. for Breast Cancer Therapy Dewi, Mirnawati; Ariefin, Mokhamat; Yolan Kalalinggi, Septaria; Andini, Novelia; Jipasca, Elon
Chempublish Journal Vol. 10 No. 1 (2026): Chempublish Journal (January - June)
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Breast cancer remains one of the leading mortality causes of disease related to cancer. Therefore, it is necessary to explore novel alternative therapeutic, particularly through the utilization of plant-derived natural product. Tinospora crispa L. contains diverse bioactive compounds with reported antioxidant and anticancer activities. This study integrates network pharmacology and molecular docking approaches to elucidate the molecular mechanisms of T. crispa against breast cancer. A total of 72 overlapping targets were identified between T. crispa compounds and breast cancer-related proteins, forming a highly interconnected PPI network consisting of 72 nodes and 340 edges. Clustering and enrichment analyses revealed that second cluster was significantly associated with cancer-related pathways, including AKT1, MAPK, and EGFR. The compound–protein–pathway network demonstrated two compound from T. crispa, apigenin and cycloeucalenone, possessed the highest degrees, suggesting their central regulatory roles. Molecular docking further confirmed these findings, showing that cycloeucalenone exhibited the strongest binding affinity toward EGFR and AKT1 through extensive hydrophobic interactions, whereas apigenin bound more stably to MAPK3 via multiple hydrogen bonds and hydrophobic interactions. These findings indicate that T. crispa compounds may exert anticancer effects by modulating multiple oncogenic pathways, supporting their potential development as multi-target agents in breast cancer therapy.

Page 15 of 15 | Total Record : 144

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