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INDONESIA
CHEMPUBLISH JOURNAL
Published by Universitas Jambi
ISSN : -     EISSN : -     DOI : -
Core Subject : Science, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry
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Articles 126 Documents
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PELAPISAN HIDROKSIAPATIT- POLYCAPROLACTONE PADA PERMUKAAN STAINLESS STEEL 316L DENGAN METODE DIP COATING Fadli, Ahmad; Hariz, Abdul; Helianty, Sri; Rifaldi, Muhammad
Chempublish Journal Vol. 8 No. 2 (2024): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v8i2.30842

Abstract

Stainless steel 316L is a metal that can be used for bone implants but exhibits low biocompatibility. The low biocompatibility can lead to inflammation, infection, or rejection within the body's tissue system. It is coated with hydroxyapatite-polycaprolactone to enhance the biocompatibility of stainless steel 316L. This study aims to examine the effects of stirring time, stirring speed, and the appropriate hydroxyapatite-polycaprolactone ratio on the shear strength of hydroxyapatite-polycaprolactone using the dip coating method and to determine the empirical model for the resulting shear strength of the hydroxyapatite-polycaprolactone layer. Hydroxyapatite and polycaprolactone were mixed using acetone and stirred at a speed of 150 rpm for 20 hours. Then, the stainless steel 316L substrate was immersed in the suspension and dried at 56°C for 1 hour. The process conditions optimization in this study employed a 2k modeling approach. The empirical shear strength model in this research is represented as y = -216.9 + 36.42A + 1.426B + 14.43C - 0.2345AB - 2.380AC - 0.08943BC + 0.01468AB*C, with an R2 value of 0.99. The variables with the most significant influence on shear strength, ranked from largest to smallest, are the HA-PCl ratio (A), followed by the two-way interaction between the HA-PCl ratio (A) and stirring speed (B), the three-way interaction between the HA-PCl ratio (A), stirring speed (B), and stirring time (C), followed by the two-way interaction between the HA-PCl ratio (A) and stirring time (C), stirring time (C), stirring speed (B), and the two-way interaction between stirring speed (B) and stirring time (C). The highest shear strength of the hydroxyapatite layer was achieved at a HA-PCl ratio of 5:1.5, stirring speed of 150 rpm, and stirring time of 20 hours, with a value of 5.71 MPa
In Silico Study of the Potential of Belimbing Wuluh (Averrhoa Bilimbi) for the Treatment of Type 2 Diabetes Mellitus Rachman Aziz, Dwinuari; Supriyanto, Sugeng; Kiromah, Naelaz Zukhruf Wakhidatul; Herniyatun; Saputra, Aditya Mahe; Pratama, Dimas Aji
Chempublish Journal Vol. 8 No. 2 (2024): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v8i2.36624

Abstract

PENGARUH METODE MASERASI DAN SOKHLASI TERHADAP KANDUNGAN SENYAWA ANTIOKSIDAN DAUN Pluchea indica L. DENGAN METODE LC-MS Afidatul Muadifah; Tilarso, Dara Pranidya; Sowe, Momodou Salieu; Tarigan, Indra Lasmana; Ngibad, Khoirul; Yuliantari, Sonia Devi
Chempublish Journal Vol. 8 No. 2 (2024): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v8i2.36869

Abstract

Pluchea indica L. is a plant have some secondary metabolite compounds namely flavonoids, alkaloids, tannins, saponins, terpenoids, and phenols that have antioxidants activity. The purpose of this study was to compare the content of antioxidant compounds analyzed using LC-MS and determine the relationship of antioxidant activity through the DPPH test on P. indica leaves extracted by maceration and soxhlation. The extracts from maceration and soxhlation of P. indica leaves were analyzed using LC-MS to determine the composition of the compounds contained therein then continued with the antioxidant activity test using the DPPH method. In the antioxidant activity test using DPPH, each extract was made 3 variations of concentration, namely 10 ppm, 50 ppm, and 100 ppm, and measured based on the absorbance of DPPH at a wavelength of 515 nm using a UV-vis spectrometer. The results of analysis using LC-MS on macerated extracts of P. indica leaves are 112 compounds consisting of flavonoids 72.4841%, phenols 9.00625%, terpenoids 6.11827%, alkaloids 6.99075%, tannins 2.2256%, and saponins 2.04458%. The Soxhlet extraction contained 116 compounds consisting of flavonoids 67.14345%, phenols 8.95854%, terpenoids 13.82165%, alkaloids 5.35637%, tannins 2.53305%, and saponins 0.2969%. The results of the antioxidant activity test using DPPH on maceration extracts have an IC50 value of 76.7576 and soxhlation 62.580 ppm. Both maceration and soxhlation extracts of P. indica leaves contain compounds that have high antioxidant potential and have good antioxidant activity, namely in the strong antioxidant category. However, the soxhlation extract has more compounds and a lower IC50 value. Thus, the more antioxidant compounds contained in an extract, the lower the IC50 value so that the better the antioxidant activity.
Modification of ZnO/Perlite for Methylene Blue Photodegradation Burhanudin; Setyaningtyas, Tien; Riyani, Kapti
Chempublish Journal Vol. 8 No. 2 (2024): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v8i2.37550

Abstract

Nanoparticles Formulated from Young Areca Nut Extract Utilizing Sodium Alginate as a Polymer and Calcium Chloride (CaCl2) Rohmahdana, Indis Hilwa; Maharini, Indri; Purba, Eka Novita Br; Salsabilah, Indah; Nugroho, Aulia Hafizhah; Virginia, Yulwilla
Chempublish Journal Vol. 8 No. 2 (2024): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v8i2.38128

Abstract

Nanoparticles are an innovative formulation designed to enhance the bioavailability of drugs with poor absorption while allowing for a more targeted release of active compounds to minimize the risk of side effects. This study aims to develop nanoparticle formulations of young areca nut extract. The ionic gelation method, utilizing 0.02% CaCl2 and 0.1% sodium alginate, was employed in the preparation process. The three formulas were developed with different concentrations and volumes of extract. The evaluation of nanoparticles included phytochemical screening, particle size analysis (PSA), zeta potential, % transmittance, and FTIR for functional group identification. The characterization results of the nanoparticles from young areca nut seed ethanol extract showed that formulas F1, F2, and F3 had particle sizes of 84.267±1.250 nm, 97.367±1.079 nm, and 82.333±0.723 nm, respectively. The polydispersity index values ranged from 0.254±0.046 to 0.325±0.02, suggesting good particle distribution. The zeta potential values, all below -30 mV, indicate the stability of the colloidal suspension system. FTIR analysis showed that the young areca nut seed extract nanoparticles in all formulas contained functional groups such as alcohol, alkene, and amide.
The Formulation of a Body Scrub Combining Sweet Orange Peel (Citrus x sinensis L.) and Coconut Dregs (Cocos nucifera L.) as an Antioxidant Riziek, Habieb; Arrahman, Ghery; Savitri, Anita; Zahara; Hanifah, Risa; Maharini, Indri; Efendi, M. Rifqi
Chempublish Journal Vol. 8 No. 2 (2024): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v8i2.38181

Abstract

The sweet orange peel (Citrus x sinensis L.) possesses antioxidant properties that can be harnessed for developing a pharmaceutical preparation based on natural ingredients, particularly in skin care products such as body scrubs. Meanwhile, coconut pulp (Cocos nucifera L.) has a textural quality that lends itself to use as a scrubbing agent, capable of removing dead skin cells. This study aimed to ascertain the antioxidant activity of body scrub formulations with varying concentrations of extract. The results of the phytochemical screening indicated the presence of alkaloids, flavonoids, tannins, and triterpenoids. Three formulations of body scrub were prepared, designated FI (1.25% extract), FII (2.5% extract), and FIII (5% extract). The results of the physical tests demonstrated that the organoleptic, pH, spreadability, and adhesion tests met the requisite standards. In the antioxidant activity test with the DPPH reagent, the IC50 value of each formula is as follows: The results demonstrated that the IC50 value of each formula was 7.28 ppm (very strong) for FI, 11.839 ppm (very strong) for FII, and 17.354 ppm (very strong) for FIII.
Antioxidant Activity of Bioactive Compounds in the Ethyl Acetate Extract of Putat Leaves (Planchonia valida) Nelson; Silaban, Desy Vania; Farid, Faizar; Puspitasari, Ratih Dyah; Tarigan, Indra Lasmana; Ramadhan, Ilham Ifandi; Latief, Madyawati
Chempublish Journal Vol. 6 No. 4 (2022): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v6i4.41632

Abstract

The Putat leaf (Planchonia valida) is a plant traditionally used by the community in the Tanjung Lanjut area, Jambi, both as a salad ingredient and as a traditional medicine to treat skin diseases and promote health. This identifies that the putat plant contains chemical compounds that potentially have antioxidant activity. In this study, putat leaf samples (Planchonia valida) that potentially have antioxidant activity. In this study, Planchonia valida (P. valida) leaf samples using n-hexane and ethyl acetate solvents through a multistep maceration process. Subsequently, phytochemical screening and antioxidant activity tests were conducted to obtain information about fractions that have the potential to be further isolated. The extraction percentage with a yield value of 1,28% was obtained in the maceration process. Further isolation was carried out using isolate liquid chromatography and FT-IR instruments. The obtained isolate was in the form of a wet solid, and through characterization, it was classified as a steroid compound suspected to be ergosterol. Free radicals or oxidants have reactive effects on the human body and can trigger various types of diseases. Antioxidants are known to have the ability to inhibit or neutralize free radicals in the human body. This study tested antioxidant activity using the DPPH (1,1-diphenyl-1,1-picrylhydrazyl) method on isolating F1. Isolate F1 was found to have antioxidant activity with a value of 714.637 ppm, falling into the range of weak antioxidant activity
Isolasi Proses Bioaktif Ekstrak Metanol Daun Putat (Planchonia valida) sebagai Antioksidan Farid, Faizar; Br Sembiring, Vera Lorensya; Nelson, Nelson; Saputra, Muhammad Furqon Novryan; Putri, Silvi Ayudiah; Tarigan, Indra Lasmana; Latief, Madyawati
Chempublish Journal Vol. 6 No. 4 (2022): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v6i4.41634

Abstract

Putat leaves (Planchonia valida) are a plant that is traditionally used by people in the Tanjung Lanjut areas, Jambi as fresh vegetables, and as a traditional medicine to treat skin diseases and restore health. This identifies that the putat plant contains chemical compounds that have the potential to have antioxidant activity. Extraction was carried out using n-hexane and ethyl acetate solvents using multistage maceration. Next, phytochemical screening and antioxidant activity tests are carried out to obtain information about fractions that can potentially proceed to the isolation stage. In the maceration process, an extract percentage was obtained with a yield value of 1.39%. Next, isolation was carried out using vacuum liquid chromatography. The isolates obtained were then characterized using UV-Vis and FT-IR spectrophotometer instruments. The isolate obtained was in the form of a wet solid, and if seen through characterization, it belonged to the class of steroid compounds; it was suspected to be an ergosterol compound. Antioxidants are known to have the ability to inhibit and reduce the presence of free radicals in the human body. In this study, antioxidant activity was tested using the DPPH (2,2-diphenyl-1-picrihidazil) method on F1 isolates. The F1 isolate obtained was proven to have antioxidant activity with a value of 99.2265 ppm, which is classified in the strong antioxidant activity range.
Flavonoid Compounds from Ethanol Extract of Sungkai Leaves (Peronema canescens. Jack) and Antibacterial Activity Test Against Staphylococcus epidermidis and Escherchia coli Susanto, Nindita Clourisa Amaris; Ardhica, Jammes; Nelson; Latief, Madyawati
Chempublish Journal Vol. 6 No. 4 (2022): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v6i4.41653

Abstract

The rise of antibiotic-resistant bacteria has intensified the global search for alternative antimicrobial agents, particularly from natural sources. Traditional medicinal plants have been widely recognized for their therapeutic potential, and Peronema canescens Jack is well-known to contain bioactive compounds. Among its pharmacological properties, its antibacterial potential has drawn scientific interest. Secondary metabolites such as flavonoids, tannins, and phenolics are believed to contribute to its antimicrobial activity. However, the specific antibacterial compounds in P. canescens remain largely unidentified. This study seeks to isolate and characterize antibacterial compounds from the ethanol extract of Sungkai leaves, aiming to discover new natural antibacterial agents. The research objectives include isolating antibacterial compounds using maceration extraction and fractionation, conducting phytochemical screening to identify metabolite classes, assessing antibacterial activity using the paper disc diffusion method, and characterizing bioactive isolates through UV-Vis spectrophotometry and FTIR analysis. The results indicate that the ethyl acetate fraction of the ethanol extract of P. canescens leaves exhibits significant antibacterial activity, particularly at concentrations of 500 and 1000 ppm. UV-Vis spectrophotometric analysis identified flavonoid compounds, including apigenin, flavones, and flavonols, based on characteristic absorption peaks. FTIR analysis confirmed the presence of functional groups associated with flavonoids, supporting their antibacterial potential. These findings highlight P. canescens as a promising source of natural antibacterial agents. Further studies focusing on compound purification and in vivo antibacterial testing are recommended to explore its pharmaceutical applications.
Cytotoxic Activity of Polymethoxyflavone Compounds Ethyl Acetate Extract of Sungkai Leaves (Peronema canescens Jack) as Anticancer Candidates Adriliana, Zairaini Adriliana; Susanto, Nindita Clourisa Amaris; Fikriansyah, Muhammad; Tarigan, Indra Lasmana; Sutrisno, Sutrisno
Chempublish Journal Vol. 6 No. 4 (2022): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v6i4.41660

Abstract

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