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INDONESIA
CHEMPUBLISH JOURNAL
Published by Universitas Jambi
ISSN : -     EISSN : -     DOI : -
Core Subject : Science, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry
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Articles 126 Documents
 9   10   11   12   13 
Comparative Study of Macerated and Soxhlet-Extracted Moringa Oleifera Leaf Extracts: LC-MS-Based Metabolomic Profiling, Antioxidant Activity, and In Silico Target Prediction Muadifah, Afidatul; Sulastri, Sulastri; Sowe, Momodou Salieu; Lintang, Anggun; Warni, Tri
Chempublish Journal Vol. 9 No. 1 (2025): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v9i1.36870

Abstract

Moringa leaves (Moringa oleifera L.) are rich in secondary metabolites such as flavonoids, alkaloids, tannins, saponins, and terpenoids, which function as natural antioxidants. This study aimed to analyze the metabolite profile of M. oleifera leaf extracts obtained through two extraction techniques using LC-MS, evaluate their antioxidant activity via the DPPH assay, and predict the interaction between NADPH oxidase (as a receptor) and key plant-derived compounds through molecular docking. LC-MS results indicated that the maceration method yielded 101 secondary metabolites, with flavonoid derivatives comprising 70.99% of the extract, dominated by five key compounds including Kaempferol 3-O-robinobioside and Luteolin-7-glucoside. In contrast, the Soxhlet method resulted in 83 identified compounds, with a higher proportion of flavonoids (75.61%), and prominent compounds including quercetin-3-O-glucoside and Kaempferol 3-(6G-malonylneohesperidoside). Antioxidant testing with DPPH at concentrations of 10, 50, and 100 ppm revealed the Soxhlet extract had a stronger activity (IC₅₀ = 14.328 ppm) compared to the macerated extract (IC₅₀ = 32.092 ppm), with statistically significant differences (p < 0.05). Molecular docking demonstrated that Kaempferol 3-(6G-malonylneohesperidoside) exhibited the strongest binding affinity to NADPH oxidase (-10.1 kcal/mol), followed by other flavonoid derivatives. These findings underscore the antioxidant potential of M. oleifera, particularly from Soxhlet extraction, and suggest its promising application in pharmaceutical development as a natural antioxidant source.
Secondary Metabolites of The Fabaceae Plant Family A Review of Extraction Methods, Molecules and Bioactivity Sowe, Momodou Salieu; Etonihu, Anayo Christian; Tarigan, Indra Lasmana; Muadifah, Afidatul
Chempublish Journal Vol. 9 No. 1 (2025): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v9i1.36964

Abstract

Traditional medicine helps manage and treat various illnesses worldwide, particularly in Africa and Asia. For example, Traditional Indonesian Medicine (Jamu), Traditional Indian Medicine (Ayurveda), and Traditional African Medicine use a range of indigenous herbs to treat health conditions like fevers, malaria, diarrhea, diabetes mellitus, Asthma, and hypertension. Alkaloids, flavonoids, saponins, terpenoids, and polyphenols are bioactive substances with anti-inflammatory, antibacterial, and antioxidant effects in plants. The Fabaceae family consists of flowering plants, peas, legumes, woody trees, and shrubs. Fabaceae plants are widely used across Africa and Asia for traditional medicinal purposes. In addition, Fabaceae plants have significant economic value as a source of wood for the timber industry. This review highlights extraction methods, isolated molecules, and antimicrobial and antioxidant activity of Fabaceae plants found in Africa and Asia. We also detailed secondary metabolite molecules extracted from Fabaceae plant body parts and their identified bioactivities. This review compiles scientific information on the phytochemicals and pharmacological properties of plants in the Fabaceae family that could be useful for future drug candidate investigations.
The Activity Test of Transdermal Patch Formulations From Ethanol Extract of Java Chili (Piper Retrofractum Vahl.) as an Analgesic in Male Mice Luthfiyyah, Annisa; Elisma; Lestari, Uce; Naufal Nabillah Putra; Istiazah Putri Sisva; Johan Hasyim Nugroho; Aulia Tria Yustika
Chempublish Journal Vol. 9 No. 1 (2025): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v9i1.38136

Abstract

Pain is an unpleasant sensory and emotional experience caused by actual or potential tissue damage. Java chili (Piper retrofractum Vahl.) is an Indonesian plant known for its secondary metabolites, including piperine, pipernonalin, guineensine, and essential oils. Among these, piperine is the primary compound with potential analgesic properties. This study evaluates the analgesic effects of transdermal patches containing ethanol extract of Java chili using the writhing test and macrophage count in acetic acid-induced mice. The patches were formulated with different concentrations of the active ingredient: F1 (1g extract), F2 (2g extract), and F3 (3g extract). The results show that increasing the ethanol extract concentration significantly alters the physical characteristics of the patches, including shape, thickness, color, and durability. In the analgesic test, the macrophage count in the negative control group was 29.33 ± 0.57. In contrast, the treatment groups showed a concentration-dependent reduction: F1 (20.00 ± 1.73), F2 (13.00 ± 3.00), and F3 (7.33 ± 1.15). The positive control group exhibited the lowest macrophage count (3.66 ± 1.15). These findings indicate that transdermal patches containing Java chili ethanol extract possess significant analgesic potential, with higher concentrations yielding stronger effects.
Review: Melastoma malabathricum Natural Compounds as Inhibitors of Resistant Bacterial Development Susanti, Febria Elvy; Efdi, Mai; Syafrizayanti; Septama, Abdi Wira
Chempublish Journal Vol. 9 No. 1 (2025): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v9i1.41114

Abstract

The abundance of natural medicines in nature is very capable of being used and developed in various lives both individually and in combination in the modern medical field. Various developments and treatments as well as the discovery of new concepts will be able to interact with human physiology. One plant that has the potential to be developed is Melastoma malabathricum, also known as senduduk. This plant from the Melastomataceae family is easily found in tropical Asia and has long been used as an herb in traditional Chinese medicine. Based on the data collected, various studies have shown the pharmacological bioactivity of Melastoma malabathricum which has antibacterial potential and is able to fight resistant bacteria. Chemicals in this plant, including flavonoids, terpenoids, alkaloids, and steroids have been detected and shown to be inhibitors of bacterial growth, including resistant bacteria.
The Role of Macrocyclic Compounds as Supramolecular Drug Delivery Systems: A-Review Saputra, Muhammad Furqon Novryan; Nursofia, Yesi; Tarigan, Indra Lasmana
Chempublish Journal Vol. 9 No. 1 (2025): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v9i1.41724

Abstract

In recent decades, significant advances in the development of drug delivery systems have unlocked new possibilities for enhancing therapeutic efficacy. Among the diverse range of innovative materials, macrocyclic-based supramolecular systems have emerged as promising platforms due to their unique physicochemical properties. Macrocyclic compounds such as cyclodextrins and cucurbiturils exhibit a remarkable ability to form stable inclusion complexes with various drug molecules, thereby improving their solubility, chemical stability, bioavailability, and pharmacokinetic profiles. This review highlights the design principles, synthetic strategies, and mechanisms of action underlying macrocyclic drug carriers, with particular emphasis on their responsiveness to environmental stimuli such as pH, temperature, and biomolecular triggers. Recent findings demonstrate that macrocyclic systems can significantly enhance drug loading efficiency, targeted delivery, and cellular uptake, while minimizing systemic toxicity. These advances underscore the potential of macrocyclic supramolecules as foundational elements for the development of next-generation drug delivery systems that are more precise, effective, and adaptable to personalized therapeutic needs.
Synergistic Effect of Cinnamon (Cinnamomum burmannii) Leaves Extract and Potassium Iodide on Mild Steel in HCl Rohil; Stiadi, Yeni; Emriadi
Chempublish Journal Vol. 9 No. 1 (2025): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v9i1.42334

Abstract

The synergistic impact of potassium iodide with cinnamon leaf extract (CLE) on hindering gentle steel corrosion in a HCl arrangement was examined utilizing weight loss measurement, UV-Vis spectroscopy, and X-ray diffraction (XRD) analysis. At an inhibitor concentration of 10 g/L CLE coupled with 0.04 g/L potassium iodide, the inhibition efficiency increased from 92.8% to 97.06% as the temperature and concentration increased. The Langmuir adsorption isotherm was followed by the inhibitor's adsorption on the mild steel surface. The synergistic interaction between CLE and potassium iodide was validated when the synergistic parameter (S) was greater than 1. The inhibitor components and the steel surface formed a coordination complex, according to UV-Vis analysis. When CLE was present, a defensive layer formed on the mild steel surface that prevented the corrosive medium from interacting with the metal, as confirmed by XRD analysis. These results imply that potassium iodide and CLE may be useful and sustainable corrosion inhibitors for mild steel in acidic environments
Formulation and Characterization of Microencapsules Containing Ethanol Extract of Sungkai Leaves (Peronema canescens Jack) Tarigan, Indra Lasmana; Farah, Farah; Puspitasari, Ratih Dyah; Saharin, Siti Munirah; Latief, Madyawati
Chempublish Journal Vol. 9 No. 1 (2025): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v9i1.43042

Abstract

The Sungkai plant (Peronema canescens Jack) is a widely recognized medicinal plant in Indonesia, with its leaves recently gaining attention for their potential health benefits. This study explores the microencapsulation of ethanol extract from Sungkai leaves using three different coating materials—maltodextrin, inulin, and Arabic gum—at varying concentrations. The aim of this study was to identify the optimal microencapsulation formulation using these materials. Microencapsulation was performed using the extrusion method, and the best formulation was characterized by evaluating its physicochemical properties, morphology, and infrared (IR) spectrum. Antioxidant activity was measured using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. The results showed that microencapsulant formulation A1 exhibited superior physicochemical properties compared to other formulations. Scanning electron microscopy (SEM) analysis of sample A1 revealed a smooth surface with a slightly rounded shape and minimal wall folds or cracks, suggesting good stability. Fourier-transform infrared (FTIR) analysis confirmed effective encapsulation of the ethanol extract. While the crude extract demonstrated the highest antioxidant activity, microencapsulation slightly reduced this activity. Among the microencapsulated samples, formulation A1 (using Arabic gum) retained the most antioxidant potential. In conclusion, formulation A1, utilizing Arabic gum as the coating material, was found to be the optimal microencapsulation formulation for the ethanol extract of Sungkai leaves.
Analgesic Effect of Ethanol Extract of Dillenia ochreata (Miq.) Teijsm. & Binn. Ex Martelli in Wistar Rats Yohandini, Heni; Ghaniya, Fahdelaa; Muharni, Muharni; Fitrya, Fitrya
Chempublish Journal Vol. 9 No. 1 (2025): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v9i1.43080

Abstract

Dillenia ochreata is a traditional medicine used to treat wounds and scabies. In wound healing, one of the treatments is to reduce pain (analgesic). Some compounds of triterpenoid groups have been known to be active as analgesic compounds. The leaf of D. ochrea was reported to contain secondary metabolites triterpenoid centulic acid and 3β-glucopyranosyl-lup-20(29)-en-28 oat. This study aimed to evaluate the analgesic activity and standardization of the ethanol extract of D. ochreata leaf and determine the mechanism of action. Analgesic activity was determined by a hot plate method and formalin test, and the mechanism of action was through muscarinic, dopamine, and opiate receptors, standardization of extract using the method issued by the Indonesian Ministry of Health.  The ethanol extract of D. ochreata leaf at a 400 mg/kg bw dose has higher analgesic activity (24.85%) than the positive control (18.32%).  Statistical analysis showed a significant difference in analgesic activity percentage between the positive group and those with a 400 mg/kg bw group dose. The 400 mg/kg bw dose also showed a significant difference (p<0.05) between neurogenic pain (46.92%) and inflammation (61.19%) in the formalin test caused by opioid receptors. The evaluation of the analgesic mechanism showed the ethanol extract of D. ochreata leaf works through opioid receptors. The extract meets the requirements of the standard parameters.  The leaf extract of D. ochreata can be developed as an anti-analgesic from natural medicine.
Effectiveness of Kepok Banana (Musa paradisiaca) Bread-Based Adsorbent for Fe(III) Removal Using HCl Activation: Freundlich and Langmuir Isotherm Models Silviyati, Idha; Supraptiah, Endang; Niati, Sri Murda; Hajar, Ibnu; Ningsih, Aisyah Suci; Amalda, Feby Nia
Chempublish Journal Vol. 9 No. 1 (2025): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v9i1.44926

Abstract

Activated carbon can be synthesized from lignocellulosic biomass, such as kepok banana (Musa paradisiaca) stems, which are an abundant agricultural waste rich in cellulose (~64%). In this study, kepok banana stems were utilized as a precursor to produce activated carbon using hydrochloric acid (HCl) as the chemical activating agent. The activation process employed HCl concentrations of 1.5, 2.0, 3.0, 5.0, and 7.0 N, with a carbonization temperature of 400 °C for 1 hour and an Fe adsorption contact time of 30 minutes. The resulting activated carbon was evaluated based on its physicochemical properties according to the Indonesian National Standard (SNI 06-3730-1995). The sample treated with 3.0 N HCl showed optimal characteristics, including moisture content of 2.34%, ash content of 0.28%, volatile matter content of 2.05%, and fixed carbon content of 95.33%. Its iodine number reached 1116.98 mg/g, and the Fe ion removal efficiency was 99.14%. FTIR spectroscopy confirmed the presence of functional groups typical of activated carbon—O–H, aromatic C=C, C–H, and C–O—suggesting good adsorption potential. Furthermore, adsorption behavior was analyzed using the Freundlich isotherm model, which describes multilayer adsorption on heterogeneous surfaces. The findings demonstrate that activated carbon derived from kepok banana stems is an effective, low-cost, and environmentally friendly adsorbent for iron removal, suitable for applications in water purification and wastewater treatment.
Antidiabetic activity of combined extracts of Hibiscus sabdariffa Linn. and Stevia rebaudiana Bert. on streptozotocin-induced diabetes Wistar rats Tjitraresmi, Ami; Febriyanti, Raden Maya; Anjabtsawa, Daffa; Susilawati, Yasmiwar; Muhaimin, Muhaimin
Chempublish Journal Vol. 9 No. 2 (2025): Chempublish Journal (July - December)
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v9i2.46449

Abstract

The increasing prevalence of diabetes mellitus and the limitation in its conventional therapies underscores the need for alternative treatments. Hibiscus sabdariffa Linn. and Stevia rebaudiana Bert. have demonstrated individual antidiabetic activities attributed to their secondary metabolites, including flavonoid and phenolic compounds. This study employed an experimental in vivo design using rats induced with STZ. Thirty rats were divided into five groups (n=6): normal control, negative control, positive control (Glibenclamide), and two treatment groups receiving the combined aqueous extracts of H.sabdariffa and S.rebaudiana (RSAE) at 500 and 1000 mg/kgBW. Diabetes was induced using STZ (50 mg/kgBW administered i.p). Blood glucose levels were measured fasting and 2 hr postprandial at days 0, 3, and 14 after administration of RSAE. Data were analyzed using One-Way ANOVA. RSAE exhibited dose‐dependent hypoglycaemic activity in STZ‐induced diabetic rats, significantly reducing (p < .005) fasting blood glucose by up to 50.7 % and two‐hour post‐prandial glucose by 44.97% at 1000 mg/kgBW.

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