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Made Krisna Adi Jaya
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Journal Pharmaceutical Science and Application (JPSA)
Published by Universitas Udayana
ISSN : 23017694     EISSN : 23017708     DOI : https://doi.org/10.24843/JPSA.2020.v02.i01
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health
Journal of Pharmaceutical Sciences and Applications (JPSA) is an online and print out Journal. This Journal publishes original research work that contributes significantly to further the scientific knowledge in pharmaceutical sciences and applications. Pharmaceutical Technology Pharmacognosy Natural Product Research Pharmaceutics Novel Drug Delivery Biopharmaceutics Pharmacokinetics Pharmaceutical/Medicinal Chemistry Computational Chemistry and Molecular Drug Design Pharmacology and Toxicology Pharmaceutical Analysis Pharmacy Practice Clinical and Hospital Pharmacy Community Pharmacy Cell Biology Genomics and Proteomics Pharmacogenomics Bioinformatics and Biotechnology The Journal publishes original research work either as a Full Research Paper or as a Short Communication. Review Articles on a current topic in the said fields are also considered for publication by the Journal. Journal of Pharmaceutical Scince and Application (JPSA), a half yearly publication, serves the need of different scientists and others involved in Pharmaceutical science research and application. All contribution to JPSA are reviewed by peer review process and copy editing process with the understanding that they have not been published previously and are not under consideration for publication elsewhere.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 63 Documents
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IDENTIFICATION OF THERAPY PROFILE AND FACTORS RELATED TO INCIDENCE OF PULMONARY TUBERCULOSIS IN DENPASAR-BALI Anisa Hanum; Made Krisna Adi Jaya; I Made Bakta
Journal Pharmaceutical Science and Application Vol 2 No 1 (2020): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (233.241 KB) | DOI: 10.24843/JPSA.2020.v02.i01.p01

Abstract

Background: Tuberculosis is a problem for millions of people around the world. Indonesia as the second biggest country with the highest number of Pulmonary Tuberculosis that treatment has improved gradually. Denpasar is a city with the highest sufferers in Bali. It’s caused by the high rate of population, dense human settlement, and other related factors. Objective: Profiling incident and pulmonary tuberculosis treatment in Denpasar City primary health care. Methods: Observational study with cross-sectional analytic approaches. Forty pulmonary tuberculosis patients and One hundred twenty non-tuberculosis patients were observed in this study. Those were taken by multistage random sampling. Data were collected from medical records and questionnaires. A Chi-Square test was used for analyzing data. Results: Pulmonary tuberculosis sufferers are in productive ages which 65% were men. The treatment profile was excellently seen from the final treatment results of 31 people recovered and 9 people with complete treatment. Factors that have a statistical relation with pulmonary tuberculosis were occupation (p=0,012), income (p=0.003), smoking behavior (p=0.001), and contact history (p=0.001). The other factors with no relationship were education (p=0.270) and occupancy density (p=0.540). Conclusion: Pay attention to the caused factors of tuberculosis infection; society is suggested to implement a healthy lifestyle, maintain home sanitation, and environment. Keywords: Factor Related, Pulmonary, Tuberculosis, Primary Health Care, Denpasar City
REVIEW OF SOME TRADITIONAL HERBALS INCLUDED IN USADA TENUNG TANYA LARA AS DIARRHEA THERAPY AGENTS I Kadek Suardiana; A.A Gede Rai Yadnya Putra
Journal Pharmaceutical Science and Application Vol 2 No 2 (2020): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2020.v02.i02.p01

Abstract

Background: Diarrhea is one of the most extraordinary diseases in the world, with a number of 2.195 children die every day, and 801.000 children die from diarrhea every year. Diarrhea therapy has actually been conducted by society, but the use of synthetic drugs is limited for diarrhea cases since it will trigger undesirable effects, such as abdominal pain and resistance to pathogenic bacteria. Bali, with its unique culture, has Usada Tenung Tanya Lara, which contains procedures for treating diarrhea using plants. Objective: This work aimed to review traditional medicine, which is written in Usada Tenung Tanya Lara, that has been intensified nowadays and can be an alternative in the treatment of diarrhea. Methods: This article review using a primary data source and secondary data sources. Result: Some of the plants that have been collected have anti-diarrheal activity in the usada Tenung Tanya Lara are turmeric (Curcuma longa), banana (Musa paradisiaca) and ancak (Ficus religiosa). These three plants mostly have anti-diarrheal activity by inhibiting and killing pathogenic bacteria that cause diarrhea, such as Shigella dysenteriae, Escherichia coli, and Vibrio cholerae. Aside from being antibacterial, all three plants also have several mechanisms to cure diarrhea. Conclusion: It was revealed that turmeric, banana, and ancak leaf could act as agents of diarrhea therapy with their respective mechanisms of actions. Keywords: Diarrhea, Usada Tenung Tanya Lara, Curcuma longa, Musa paradisiaca, Ficus religiosa.
PHARMACIST PROFESSION STUDENT PERCEPTION ABOUT PHARMACIST ROLE IN PHARMACY, COMMUNITY HEALTH CENTER AND HOSPITAL Luh Putu Febryana Larasanty; Kadek Nadia Marta Dewi; Made Ary Sarasmita
Journal Pharmaceutical Science and Application Vol 2 No 2 (2020): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2020.v02.i02.p06

Abstract

Background: Pharmacists play a role as a part of health services both at pharmacies, hospitals and community health centers. Pharmaceutical care was regulated in the Regulation of the Minister of Health of the Republic of Indonesia. In the internship, students of the Pharmacists program Faculty of Mathematics and Natural Sciences, Udayana University can see clearly how the implementation of the role of Pharmacists in the Pharmacy, Hospital and Community Health Center. Objective: This study aims to assess the perceptions (responses) of Pharmacist students on the role of Pharmacists in various pharmacy services. Methods: This study used a one-group posttest only design methods. The population of the study used all of the Pharmacist students who were internship at the Pharmacy, Community Health Center and Hospital. The research instrument used a closed-ended questionnaire about the perceptions of Pharmacist students on the role of Pharmacists in internship locations. Results: The results showed that the role of pharmacists in pharmacies and community health centers was greater in the field of clinical pharmacy services. While in hospitals, pharmacists have a greater role in the field of drug management. Conclusion: Students have a positive perception of the role of pharmacists. There were no significant differences in perceptions of Pharmacist students on the role of Pharmacists in the field of drug management and clinical pharmacy services (p> 0.05). Keywords: pharmacist, pharmaceutical care, perception, role, students
SIDE EFFECTS PROFILE OF ANTIPLATELET MEDICATION IN PATIENTS WITH CORONARY HEART DISEASE AT BHAYANGKARA HOSPITAL BALI-INDONESIA Anak Agung Indah Astrijayanti; Made Krisna Adi Jaya; Ida Ayu Manik Partha Sutema; Ni Putu Wulanda Evayanti; Ni Ketut Tria Purnamisari
Journal Pharmaceutical Science and Application Vol 2 No 2 (2020): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2020.v02.i02.p02

Abstract

Introduction: Coronary heart disease (CHD) is a disorder of heart function due to a lack of blood in the heart muscle due to narrowing of the coronary arteries. Antiplatelet in patients with CHD is a therapy that must be obtained by patients throughout their lives to prevent recurrent attacks and deaths from CHD. In the Province of Bali, especially in Denpasar, there is a lack of information about the type of side effects that occur on antiplatelet medication, so it is necessary to do a related study. Objective: The aim of this study is to identify the type of side effects that occur on antiplatelet medication in patients with CHD. Methods: A cross-sectional study involving 97 patients was done by observed the CHD patients treated with antiplatelet medication. Side effects were evaluate using Naranjo Algorithm. Patients were divided into three groups, including a low dose aspirin user group, clopidogrel user group, and aspirin-clopidogrel combination user group. Results: Antiplatelet side effects that occur in patients include headache (2.06%), diarrhea (1.03%), cyanosis (1.03%), gastrointestinal bleeding (8.25%), heartburn (11.34%), and nausea (6.19%). These side effects only occurred in 31.96% of the total subjects. The incidence of aspirin side effects was significantly greater than clopidogrel as well as aspirin-clopidogrel in combination (p <0.05). Conclusion: Patients with CHD who use antiplatelet agents in the long term to be more aware of the potential side effects that will occur, especially heartburn in chronic low-dose aspirin users. Keywords: Coronary Heart Disease, Side Effects, Antiplatelet, Aspirin, Clopidogrel
A NARRATIVE REVIEW OF APIACEAE FAMILY PLANTS IN USADA NETRA FOR EYE DISEASE TREATMENT Luh Pande Putu Tirta; A.A Gede Rai Yadnya Putra
Journal Pharmaceutical Science and Application Vol 2 No 2 (2020): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2020.v02.i02.p03

Abstract

Background: Eye health really needs to be maintained so as to avoid diseases such as red-eye (conjunctivitis) and stye (hordeolum). Conjunctivitis and hordeolum are caused by bacteria, and their treatment is generally using antibiotics. However, if antibiotics are used irrationally it can be dangerous to health, therefore at this time, people are more interested in traditional medicine. One of them is Balinese traditional medicine, Usada Netra. Usada Netra is a science that deals with the prevention, treatment and recovery of eye diseases. Objective: This review discusses conjunctivitis, hordeolum and its treatment, processing of herbs for eye diseases in Usada Netra, botanical aspects, phytochemical and pharmacological effects of three plant Apiaceae family based on the results of scientific research as well as the correlation with eye treatment in pharmaceutical sciences. Methods: Search data in this article review with the help of search engines namely Google Scholar, and online journal provider sites, including PubMed, Biomed, NCBI, and primary data obtained from international journals, national journals and usada Bali books that have been published. Result: Based on the pharmacological effects produced by the Apiaceae family plant can inhibit the growth of bacteria that cause conjunctivitis and hordeolum. Conclusion: The use of plant Apiaceae family can be recommended for treatment of the eye such as conjunctivitis and hordeolum, with due regard to the safety requirements for eye treatment preparations. Keywords: Antibacterial, Apiaceae Family, Conjunctivitis, Hordeolum
A NARRATIVE REVIEW OF ZINGIBERACEAE FAMILY AS ANTIBACTERIAL AGENT FOR TRADITIONAL MEDICATION BASED ON BALINESE LOCAL WISDOM Ayu Irayanti; A.A Gede Rai Yadnya Putra
Journal Pharmaceutical Science and Application Vol 2 No 2 (2020): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2020.v02.i02.p04

Abstract

Background: One of the native plants from Indonesia that have been widely used for traditional medication as an antibacterial comes from the Zingiberaceae family. Based on Usada Bali, the Zingiberaceae family used to treat digestive, respiratory, and skin diseases. Objective: This literature review aimed to discuss antibacterial activity from the Zingiberaceae family and see its validity as a traditional use as antibacterial based on Balinese local wisdom medication method (Usada) with its scientific evidence. Methods: The method of this literature review is the study of literature from several scientific publications in national and international journals about the antibacterial activity of the Zingiberaceae family. Results: Several studies showed that the Zingiberaceae family has an antibacterial activity with various inhibitions depended on the type of bacteria. Conclusion: The Zingiberaceae family mentioned in Usada Bali has been scientifically proved to have antibacterial activity, so it shows the validity as a traditional use as antibacterial based on Usada with its scientific evidence. Keywords: Zingiberaceae, antibacterial, Usada
EFFECT OF METHANOL CONCENTRATION AS A SOLVENT ON TOTAL PHENOLIC AND FLAVONOID CONTENT OF BELUNTAS LEAF EXTRACT (Pulchea indica L.) Ni Putu Sinta Mahasuari; N. L. P. Vidya Paramita; A.A Gede Rai Yadnya Putra
Journal Pharmaceutical Science and Application Vol 2 No 2 (2020): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2020.v02.i02.p05

Abstract

Background: Beluntas (Pluchea indica L.) is an Indonesian plant that grows wild and is used as traditional medicine. Beluntas leaves are reported to contain phenolic, and flavonoid is a part of phenolic compounds. Phenolic compounds other than flavonoids include 1,3,4,5-tetra-O-caffeoylquinic acid, 3,4,5-tri-O-caffeoylquinic acid, chlorogenic acid, and ferulic acid. Flavonoid compounds in beluntas leaves are quercetin, apigenin, luteolin and chrysoeriol. Methanol solvents are reported to be able to extract higher polyphenol and flavonoid contents than other solvents. Objective: The purpose of this study is to determine the effect of 20%, 50% and 75% solvent concentration of methanol on total phenol and total flavonoid levels of beluntas leaf extract. Methods: In this study, the extraction process was carried out by maceration, the determination of total phenol content was carried out by the Follin-Ciocalteu method. Determination of total flavonoid levels was carried out by the Colorimetric method. Data on phenol and flavonoid levels were analyzed statistically. Results: The yield of beluntas leaf extract in this study was respectively from the lowest methanol concentration of 24.094% w/w, 31.126% w/w, 24.838% w/w. The value of total phenol levels increased with increasing methanol concentration, namely 124.84 mg GAE/g, 138.3 mg GAE/g, and 147.91 mg GAE/g. The highest total flavonoid value in 75% methanol extract is 69.72 mg QE/g, followed by 20% methanol extract at 46.29 mg QE/g and the lowest is found in 50% methanol extract at 32.80 mg QE/g. The results of statistical analysis using the Kruskal-Wallis test showed that there were significant differences (p<0.05) in the value of total phenol levels and total flavonoids of the three extracts. Conclusion: The difference in the concentration of methanol solvents affects the value of total phenol levels and total flavonoids with the highest value produced by a 75% methanol solvent. Keywords: Beluntas Leaves (Pluchea indica L.), Total Phenol Content, Total Flavonoid Content, Gallic Acid, Quercetin.
A REVIEW OF PHYTOCHEMICAL AND PHARMACOLOGICAL STUDIES OF Piper retrofractum Vahl. Ni Putu Eka Leliqia; Ni Komang Sri Lumbung Artha Wardani
Journal Pharmaceutical Science and Application Vol 3 No 1 (2021): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2021.v03.i01.p05

Abstract

Background: Javanese long pepper (Piper retrofractum Vahl.) is a plant that commonly found in Southeast Asia and is empirically used to treat various diseases. It is known that the phytochemical content in plants is one factor responsible for its pharmacology activities. The study of the pharmacological effects of herbal ingredients both pre-clinically and clinically is an attempt to prove their empirical properties. Aims: This review article aims to provide information to academics and the public regarding phytochemical studies and pharmacological activity that have been carried out regarding the Javanese long pepper plant. Methods: Article preparation was carried out through literature studies from various national scientific journals, international journals, and online reference books. Javanese long pepper data search system was based on chemical content and pharmacological activity studies either in vitro, in vivo, or clinical trials. Results: Phytochemical studies have shown that the plant parts of Javanese long pepper contain compounds such as alkaloids, saponins, tannins, flavonoids, steroids, triterpenoid, and glycosides. Based on studies of its pharmacological activity, Javanese long pepper has been reported to have antimicrobial, antioxidant, cytotoxic, analgesic, androgenic, aphrodisiac, antihyperlipidemic, antihyperuricemic, lowering leukocyte count, antileishmanial and immunostimulant effects. Conclusion: The efficacy of Javanese long pepper has been scientifically proven to have pharmacological effects either through in vitro or clinical studies which can be taken into consideration for the development of traditional medicinal products. Keywords: Javanese Long Pepper, Piper retrofractum, Phytochemical, Pharmacology activity
REVIEW OF SOME EUPHORBIACEAE PLANTS IN USADA TARU PRAMANA AND ITS PHARMACOLOGICAL ACTIVITIES I Gede Bangkit Adi Sentosa; I Kadek Suardiana; A.A Gede Rai Yadnya-Putra
Journal Pharmaceutical Science and Application Vol 3 No 1 (2021): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2021.v03.i01.p01

Abstract

Background: World Health Organization (WHO) states that up to 65% of the world's population uses traditional medicines. Indonesia is one of the countries where most people still use traditional medicine, especially in Bali. The traditional Balinese plant-based medical system that has existed for a long time and is still inherited today is Usada Taru Pramana. One of the many plants found in Usada Taru Pramana is the Euphorbiaceae. Objective: This work aims to review some of the Euphorbiaceae plants written in Usada Taru Pramana, which have a variety of potential pharmacological activities. Method: This article review using a primary and secondary data sources. Results: Some parts of the Euphorbiaceae plants in Usada Taru Pramana contain important phytochemical constituents such as phenols, alkaloids, flavonoids, saponins, tannins and essential oils. Some of the potential pharmacological activities that have been tested are anti-inflammatory, analgesic, and antibacterial. Conclusion: The Euphorbiaceae plants in Usada Taru Pramana have a variety of phytochemical constituents and correlates with its pharmacological activities. Further research needs to be conducted to explore other Euphorbiaceae plants species in Usada Taru Pramana to find compounds and other pharmacological activities to deal with various diseases in the community. Keywords: Usada Taru Pramana, Euphorbiaceae, Phytochemical Constituents, Pharmacological Activities
PHARMACIST’S ROLE IN MEDICATION RECONCILIATION TO PREVENT THE RISK OF MEDICATION ERROR AT BALI MANDARA HOSPITAL Ida Ayu Manik Partha Sutema; IBN Maharjana
Journal Pharmaceutical Science and Application Vol 3 No 1 (2021): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2021.v03.i01.p06

Abstract

Background: Pharmacists have an important role in implementing drug reconciliation. The implementation of drug reconciliation allows the process of identifying drug administration errors due to information gaps, which we can avoid by optimizing information as early as possible at every shift in the process of providing health services through the reconciliation process. This process is crucial, especially for groups of patients with chronic diseases who have a high risk of changing health care delivery settings. Failure to identify results in errors in administering drugs that lead to worsening clinical conditions, resulting in increased service needs and health costs. Objective: Provides information about the tendency of pharmacists who work at the UPTD Bali Mandara General Hospital to reduce drug use errors through the drug reconciliation program. Methods: Thematic analysis of structured interview results. Results: Almost all participants (6 out of 8 pharmacists) tend to be willing to be involved in the drug reconciliation process. There are three main themes of consideration that underlie the tendency of pharmacists to be willing to be involved in the drug reconciliation process, namely, related to understanding the definition, purpose, and consistency of the implementation of reconciliation. In controlling the incidence of medication errors, the biggest preventable errors through medication reconciliation are drug duplication and drug discrepancy. Conclusion: The tendency for pharmacists to be involved is good, and the tendency to control the risk of medication errors is still lacking in terms of communication and consistency in filling out by all officers. Keywords: Pharmacist’s role, drug reconciliation, risk of medication errors

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