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Pharmascience
Published by Universitas Lambung Mangkurat
ISSN : 23555386     EISSN : 24609560     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Jurnal Pharmascience memuat naskah hasil penelitian dan artikel review bidang kefarmasian. Naskah dapat berasal dari mahasiswa, dosen, peneliti, dan lembaga riset. Setiap naskah yang diterima redaksi Jurnal Pharmascience akan ditelaah oleh Mitra Bebestari dan Anggota Redaksi. Jurnal Pharmascience terbit 2 (dua) kali dalam setahun yaitu Februari dan Oktober. Redaksi menerima pemesanan Jurnal Pharmascience untuk berlangganan atau pembelian setiap terbitan.
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Search results for , issue "Vol 8, No 2 (2021): Jurnal Pharmascience" : 15 Documents clear
Skrining Fitokimia dan Antibakteri Ekstrak Etanol Daun Binjai (Mangifera caesia) Terhadap Bakteri Escherichia coli Occa Roanisca; Robby Gus Mahardika
Jurnal Pharmascience Vol 8, No 2 (2021): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v8i2.9166

Abstract

 Escherichia coli merupakan bakteri Gram negatif yang dapat menimbulkan infeksi saluran kemih, saluran empedu,  penyakit serius lainnya di rongga perut, dan keracunan makanan yang ditandai dengan diare. Penyakitinfeksiyang disebabkan oleh bakteri dapat diobati dengan mengonsumsi antibiotik. Akan tetapi, resistensi bakteri terhadap antibiotik telah dilaporkan. Oleh karena itu perlunya pencarian obat dari bahan alami. Berdasarkan kajian literatur, Binjai (Mangifera caesia) telah dilaporkan memiliki aktivitas sebagai antibakteri. Tujuan penelitian ini adalah untuk mengetahui kandungan metabolit sekunder dan aktivitas antibakteri daun binjaiasal Bangka terhadap bakteri Eschericha coli.  Metode ekstraksi pada penelitian ini adalah maserasi dengan pelarut etanol 96% selama 3 x 24 jam. Skrining fitokimia dilakukan secara kualitatif dengan menggunakan pereaksi,dan pengujian antibakteri menggunakan metode difusi cakram. Berdasarkan hasil pengujian fitokimia didapatkan bahwa ekstrak etanol daun binjaididuga mengandung metabolit sekunder seperti alkaloid, flavonoid, tanin/fenol hidrokuinon, steroid, terpenoid dan saponin. Ekstrak etanol daun binjaimampu menghambat pertumbuhan bakteri E. colipada konsentrasi 20% dengan diameter zona beningsebesar 3.94 mm, konsentrasi 40% sebesar 5.38 mm, konsentrasi 60% sebesar 5,82 mm, serta pada konsentrasiekstrak 80% membentuk zona beningsebesar 6,90 mm.Berdasarkan data tersebut bioaktivitas antibakteri ekstrak daun binjai tergolong sedang. Kata Kunci: Mangiferacaesia, Escherichia coli, Antibakteri Escherichia coli is a Gram-negative bacteria that can cause urinary tract infections, bile ducts, other serious diseases in the abdominal cavity, and food poisoning characterized by diarrhea. Infectious diseases caused by bacteria can be treated by taking antibiotics. However, bacterial resistance to antibiotics has been reported. Therefore, it is necessary to search for drugs from natural ingredients. Based on literature review, Binjai (Mangifera caesia) has been reported to have antibacterial activity. The purpose of this study was to determine the content of secondary metabolites and antibacterial activity of Bangka binjai leaves against Eschericha coli bacteria. The extraction method in this study was maceration with ethanol for 3 x 24 hours. Phytochemical screening was carried out qualitatively using reagents, and antibacterial testing using the disc diffusion method. Based on the results of phytochemical testing, it was found that the ethanol extract of binjai leaves contained secondary metabolites such as alkaloids, flavonoids, tannins / phenol hydroquinones, steroids, terpenoids and saponins. Binjai leaf ethanol extract was able to inhibit the growth of E. coli bacteria at the concentration of 20% with a clear zone diameter of 3.94 mm, concentration of 40% of 5.38 mm, concentration of 60% of 5.82 mm, and concentration of 80% extractforming a clear zone of 6.90 mm. Based on these data, binjai leaves have the potential to be used as an antibacterial drug.
Review: Aktivitas Antihiperurisemia Beberapa Tanaman dari Arboretum Garut Puja Yanti; Anas Subarnas; Hesti Renggana
Jurnal Pharmascience Vol 8, No 2 (2021): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v8i2.9101

Abstract

Hiperurisemia merupakan suatu kondisi berlebihnya kadar asam urat dalam darah. Hal ini dapat terjadi karena adanya kelebihan produksi asam urat dan kekurangan ekskresi asam urat, yaitu ditandai dengan kadar asam urat yang tinggi (> 7 mg/ dL). Jika hal tersebut terjadi secara terus-menerus maka akan terjadi gout arthritis. Di Arboretum Garut Terdapat banyak tanaman yang dapat digunakan sebagai antihiperurisemia seperti sirsak (Annona muricata L.), kayu manis (Cinnamomum burmanii), temu putih (Curcuma zedoaria), jamblang (Syzigium cumini), kersen (Muntingia calabura L.), pucuk merah (Syzigium myrrtifolium), dan salam (Syzigium polyanthum). Review jurnal ini membahas aktivitas antihiperurisemia beberapa tanaman yang berada di Arboretum Garut. Metode yang digunakan yaitu studi literatur beberapa jurnal yang didapat melalui situs google scholar, sciencedirect, Elsevier, dan sebagainya. Hasil yang didapat dari beberapa tanaman tersebut memiliki aktivitas antihiperurisemia dan tanaman yang memiliki persentase penurunan asam urat terbesar yaitu daun S. polyanthum dengan nilai persentase penurunan asam urat sebanyak 79,35%. Daun S. polyanthum memiliki potensi antihiperurisemia paling baik, sehingga perlu dikembangkan lebih banyak di Arboretum Garut. Kata Kunci: Arboretum, Asam Urat, Gout, Hiperurisemia, Tanaman Obat Hyperuricemia is a condition of excessive levels of uric acid in the blood. This can occur due to an overproduction of uric acid and a lack of uric acid excretion, which is characterized by high uric acid levels (> 7 mg / dL). If it happens continuously, gout arthritis will occur. In Garut Arboretum, there are many plants that can be used as antihyperuricemia such as soursop (Annona muricata L.), cinnamon (Cinnamomum burmanii), white turmeric (Curcuma zedoaria), java plum (Syzigium cumini), cotton candy berry (Muntingia calabura L.), pucuk merah (Syzigium myrrtifolium), and indian baywatch (Syzigium polyanthum). This journal review discusses the antihyperuricemia activity of several plants in Garut Arboretum. The method used is a literature study of several journals obtained from the google scholar site, sciencedirect, Elsevier, etc. The results show that several plants have antihyperuricemia activity and among those plants the S. polyanthum) have the highest reducing effect on blood uric acid with the reducing percentage of 79.35%.  The leaves of S. polyanthum plant have the best potential for antihyperuricemia, so this plant is suggested to be developed in the Garut Arboretum.
Studi Observasional Pola Penggunaan dan Tingkat Pengetahuan Tentang Anti Inflamasi Non Steroid pada Masyarakat Kelurahan Sungai Besar Kecamatan Banjarbaru Selatan Muhammad Rizki Akbar; Difa Intannia; Herningtyas Nautika Lingga
Jurnal Pharmascience Vol 8, No 2 (2021): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v8i2.7772

Abstract

Anti Inflamasi Non Steroid (AINS) merupakan golongan obat untuk nyeri dan inflamasi yang banyak digunakan di masyarakat. Tujuan penelitian ini adalah mengidentifikasi karakteristik responden, pola penggunaan AINS, dan tingkat pengetahuan masyarakat di kelurahan Sungai Besar. Penelitian ini adalah penelitian noneksperimental dengan metode observasional deskriptif dengan teknik pengumpulan sampel menggunakan teknik quota sampling. Sampel penelitian yang memenuhi kriteria inklusi dan ekslusi berjumlah 96 responden. Instrumen penelitian berupa lembar kuesioner yang sudah dilakukan uji validitas dan reliabilitas. Hasil penelitian menunjukkan masyarakat kelurahan Sungai Besar yang menggunakan AINS adalah berjenis kelamin perempuan (56,25%), berumur 26–45 tahun (59,38%), berpendidikan SMA/SMK (43,75%), dan bekerja sebagai Ibu Rumah Tangga (36,64%). Pola penggunaan AINS meliputi jenis AINS yang digunakan adalah asam mefenamat (73,95%), waktu terakhir menggunakan obat 1 bulan terakhir (83,33%), cara memperoleh obat tanpa resep dokter (78,12%), tempat pembelian obat di apotek (83,33%). Tujuan pengobatan untuk mengurangi rasa nyeri (73,96%), bentuk sediaan obat yang digunakan sediaan tablet (100%), cara penggunaannya langsung diminum (100%), dan aturan pakai 3 x sehari (84,38%), responden tidak mengalami efek samping selama penggunaan AINS (83,33%), serta responden (96,87%) tidak memiliki kondisi penyakit lain/riwayat penyakit dalam penggunaan AINS. Tingkat pengetahuan responden terkait penggunaan AINS tinggi (77,08%). Kesimpulan dari penelitian ini responden memiliki tingkat pengetahuan tinggi tentang penggunaan obat AINS.Kata Kunci : AINS, Pola Penggunaan, Tingkat PengetahuanNon-Steroidal Anti-Inflammatory Drugs (NSAIDs) are a class of drugs for pain and inflammation that are widely used in the community. The aim of this study was to identify the characteristics of the respondents, the pattern of using NSAIDs, and the level of knowledge of the people in the Sungai Besar village who had used NSAIDs. This research is a non-experimental research with descriptive observational method with quota sampling technique. The research sample that met the inclusion and exclusion criteria was 96 respondents. The research instrument is a questionnaire that has been tested for validity and reliability. The results showed that the Sungai Besar community who used AINS were female (56.25%), aged 26–45 years (59.38%), had a high school education (43.75%), and worked as housewives ( 36.64%). The pattern of NSAID use includes the type of NSAID used is mefenamic acid (73.95%), the last time using the drug in the last 1 month (83.33%), get medicine without a doctor's prescription (78.12%), buy medicine at the pharmacy (83 ,33%). The purpose of treatment is to reduce pain (73.96%), the dosage form of the drug used is tablet (100%), how to use it directly to drink (100%), and the rule of use 3 times a day (84.37%), respondents do not experience side effects during the use of NSAIDs (83.33%), and respondents (96.87%) did not have other disease conditions/history of disease in the use of NSAIDs. The level of knowledge of respondents related to the use of NSAIDs is high (77.08%). The conclusion of this study is that respondents have a high level of knowledge about the use of NSAIDs.
Studi In Silico Senyawa Hylocereus polyrhizus dan Allium sativum terhadap Enzim HMG-CoA Reduktase Normaidah Normaidah; Dian Nurmansyah
Jurnal Pharmascience Vol 8, No 2 (2021): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v8i2.11639

Abstract

Ekstrak buah naga merah (Hylocereus polyrhizus) dan ekstrak bawang putih (Allium sativum) diketahui mampu menurunkan kadar kolesterol total darah dalam studi in vivo. Penambatan molekul dapat dilakukan dalam memprediksi senyawa yang bertanggung jawab berdasarkan nilai docking. Tujuan dari penelitian ini adalah mengetahui zat aktif potensial dari H. polyrhizus dan A. sativum yang berperan penting dalam penurunan kadar kolesterol darah melalui jalur inhibisi enzim HMG-CoA reduktase dalam uji in silico. Reseptor yang digunakan adalah enzim HMG-CoA reduktase (PDB ID: 1HW9) dengan ligan natif simvastatin yang dipreparasi menggunakan YASARA. Struktur senyawa aktif sebanyak 19 senyawa dari buah H. polyrhizus 17 dari A. sativum digambar menggunakan MarvinSketch pada pH 7,4 dengan 10 bentuk konformasi. Proses penambatan molekul dilakukan menggunakan program PLANTS dan divisualisasi dengan Discovery Studio Visualizer. Ligan natif menunjukkan nilai RMSD sebesar 1,5265 Å dengan nilai docking -79,1320. Senyawa 4, dan 17 pada buah H. polyrhizus serta senyawa 36 pada A. sativum menunjukkan kedekatan relative dengan ligan natif lebih dari 95%. Senyawa ini diprediksi mampu menurunkan kadar kolesterol total darah dengan penghambatan enzim HMG-CoA reduktase secara penambatan molekul. Kata Kunci: Buah Naga Merah, Bawang Putih, Vitamin E, Antilipidemia, Kolesterol Total  The red dragon fruit extract (Hylocereus polyrhizus) and garlic extract (Allium sativum) are able to decrease the total blood cholesterol levels in in vivo study. The molecular docking can predict the responsible compound based on the docking value. The purpose of this study is to determine the potential active substances of H. polyrhizus and A. sativum which play an important role in reducing blood cholesterol levels through the HMG-CoA reductase enzyme inhibition pathway in the in silico study. The receptor in this study was the enzyme HMG-CoA reductase (PDB ID: 1HW9) with the native ligand simvastatin and prepared using YASARA. The structure of the active compound (19 compounds from H. polyrhizus and 17 compouns from A. sativum) were drawn using MarvinSketch at pH 7.4 with 10 conformations. The molecular docking process was carried out using the PLANTS program and visualized with the Discovery Studio Visualizer. The native ligand showed RMSD value of 1.5265 Å with a docking value of -79.1320. The compounds 4 and 17 in H. polyrhizus fruit and compounds 36 in A. sativum showed relative closeness with native ligands of more than 95% of the docking score. Based on molecular docking, these compounds are to be able to decrease the total blood cholesterol levels by inhibiting the HMG-CoA reductase enzyme.
The Antibacterial Activity of Red Dragon Fruit Peel (Hylocereus polyrhizus Britton & Rose) Methanolic Fraction Against Staphylococcus epidermidis and Propionibacterium acnes Sri Wahdaningsih; Eka Kartika Untari
Jurnal Pharmascience Vol 8, No 2 (2021): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v8i2.10378

Abstract

Acnes can be caused by Propionibacterium acnes and Staphylococcus epidermidis. Red dragon (Hylocereus polyrhizus B & R) fruit peels is one of natural materials which is assumed to possess an antibacterial activity. The purpose of this study was to determine the antibacterial activity of red dragon fruit peels methanol fraction (RDFPMF) against S. epidermidis and P. acne by disc diffusion Kirby-Bauer method. Red dragon fruit peels were maceration in chloroform and fractionation in methanol. Clindamycin 4µg/disk was used as positive control and DMSO 10% was used as negative control. This research showed that the RDFPMF has antibacterial activity against P. acnes which the average of inhibition zones obtained from the concentrations from 100, 50, and 25 mg/mL respectively were 10.5 ± 0.50 mm, 10.0 ± 0.00 mm, and 8.5 ± 0.50 mm. The RDFPMF has no inhibition zone toward S. epidermidis. The red dragon fruit peels methanol fraction has antibacterial activity on P. acnes by disc diffusion method (Kirby-Bauer test).
Socio-Demografi Dalam Pengendalian HBA1C Pada Pasien Diabetes Mellitus Tipe 2 Di Sidoarjo Khurin In Wahyuni; Martina Kurnia Rohmah Rohmah; Herni Setyawati
Jurnal Pharmascience Vol 8, No 2 (2021): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v8i2.9506

Abstract

Diabetes Mellitus merupakan penyakit metabolit yang disebabkan oleh kurangnya insulin atau insulin yang resisten. Penurunan 1 persen HbA1c menurunkan 30-40% risiko komplikasi, Faktor-faktor ini mungkin berbeda dari satu populasi kepada orang lain berdasarkan Jenis kelamin, Lama menderita, Umur, Tingkat pendidikan, dan Riwayat DM, sehingga penelitian ini bertujuan untuk menilai hubungan socio demografi terhadap pengendalian HbA1c di Sidoarjo. Penelitian menggunakan metode analitik observasional dengan pendekatan cross sectional dengan instrument kuesioner dan HbA1c kit, hasil didapatkan bahwa Jenis Kelamin, lama menderita, umur, tingkat pendidikan dan riwayat DM tidak memiliki hubungan dengan pengendalian HbA1c (P>0,05) namun edukasi dan pengecekan HbA1c memiliki hasil signifikan terkait pengontrolan HbA1c (P<0.05).Kata Kunci: HbA1c, Socio Demografi, DM Tipe 2, Kontrol Glikemik, Pengendalian Gula DarahDiabetes Mrllitus is a metabolic disease caused by a lack of insulin or insulin resistance. Reduction of 1 % HbA1c could reduces 30-40% risk of complications. These factors may differ from one population to another based on gender, long-suffering, ages, level of education and historical of the disease, therefore this research aims to assess the relationship between the socio demographic and HBA1C control in Sidoarjo. The study used an observational analytic method with a cross sectional approach with a questionnaire instrument and HbA1c kit, the results showed that gender, long-suffering , ages, level of education and historical of the disease did not have a relationship with HbA1c control (P> 0.05) but education and HbA1c checking had significant results regarding HbA1c control (P <0.05).
Single Nucleotide Polymorphism rs1800497 in Risperidone and Aripiprazole Therapy for Schizophrenia Patients Benedictus Wicaksono Widodo; Mgs. M. Irsan Saleh; Theodorus Theodorus
Jurnal Pharmascience Vol 8, No 2 (2021): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v8i2.10514

Abstract

Schizophrenia is a variable of psychopathologic syndrome involving cognition, emotion, perception, and other behavioral aspects. Therapies on schizophrenia is solely based on history of mental illnesses and mental status. Schizophrenia affecting 1.1 million persons globally in 2017; 70.8% of them happened in 25-55 years old. This study was conducted in mental hospital in Palembang, Indonesia. Blood samples was taken from clinically diagnosed schizophrenia patients (20 patients taking aripiprazole and 60 patients taking risperidone) under therapy. DNA was extracted using Chelex 100 method and digested using Taq1 enzyme. DNA was electrophoresized and visualized. CC allele was found in 10% of patients taking aripiprazole and 11.67% patients taking risperidone. CT allele was found in 70% patients taking aripiprazole and 76.67% patients taking risperidone. TT allele was found in 20% patients taking aripiprazole and 11.67% patients taking risperidone. ANKK1 Taq1A polymorphism in schizophrenia patients shows different therapeutic response with worse therapeutic response compared to patients with normal allele.
Characteristics Study and Total Flavonoids Quantification of Kareho Leaves (Callicarpa longifolia Lam) Nashrul Wathan; Fadlilaturrahmah Fadlilaturrahmah; Saufy Arishandi; Akhmad Rezeki Firdaus
Jurnal Pharmascience Vol 8, No 2 (2021): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v8i2.10682

Abstract

The Callicarpa longifolia Lam. known as ‘kareho’ is one of the plants used by several Dayak tribes for traditional medicine such as antiacne, swelling, wounds, diarrhea, diabetes, and lowering cholesterol levels. This study has obtained scientific data on the characteristics of dried leaves and determined the flavonoids levels of methanol extract of C. longifolia leaves. Characterization includes both qualitative and quantitative examination on the dried leaves of C. longifolia leaves, while the determination of total flavonoid content was determined by the aluminium chloride method and calculated as quercetin equivalent (QE). The results of characteristics observations obtained organoleptic in the form of powder, dark green, bitter taste and have a distinctive smell. Microscopic test of leaves had an actinositic stomata type, ethanol soluble extract content of 17.50 ± 0.10% and water soluble extract content of 16.53 ± 0.37%. Drying loss 8.16 ± 0.25%, total ash content of 5.52 ± 0.06%, and acid insoluble ash content of 0.07 ± 0.01%. The results of phytochemical screening confirmed the presence of saponins, flavonoids, steroids, tannins, glycosides, and phenols. TLC observasions using 254 nm UV light obtained 6 spots and 7 spots appearance on sulphuric acid. It has total flavonoid levels obtained at 7.995 ± 0.050% w/w QE.
Aktivitas Sitotoksik dan Induksi Apoptosis dari Ekstrak Etanol Kulit Apel Hijau (Pyrus malus L.) terhadap Sel MCF-7 Syahrul Iqbal Setiawan; Erika Indah Safitri; Devi Nisa Hidayati; Laili Nailul Muna
Jurnal Pharmascience Vol 8, No 2 (2021): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v8i2.10729

Abstract

Ekstrak kulit apel hijau (Pyrus malus L.) mengandung senyawa Quercetin yang mampu menurunkan ekspresi Bcl-2. Penelitian ini bertujuan untuk mengetahui aktivitas sitotoksik dan induksi apoptosis ekstrak etanol kulit apel hijau (EEKAH) pada model sel kanker payudara MCF-7. Serbuk kulit apel hijau diekstraksi menggunakan pelarut etanol 70% dengan metode ultrasonik. Uji sitotoksik terhadap sel kanker payudara MCF-7 dengan metode MTT Assay pada konsentrasi EEKAH yaitu 31,25; 62,5; 125; 250; 500 dan 1000 µg/mL. Hasil uji sitotoksik dihitung nilai IC50menggunakan regresi linier. Pengamatan induksi apoptosis dengan konsentrasi ½ IC50(442,5 μg/ml) dan IC50 (885 μg/ml) menggunakan flowcytometry. Analisis data dianalisis menggunakan analisis statistik One Way Anova. Hasil penelitian menunjukan bahwa EEKAH memiliki aktivitas sitotoksik dengan nilai IC50 sebesar 885 µg/ml. Persentase rata-rata fase apoptosis total EEKAH pada konsentrasi ½ IC50sebesar 30,2% (p>0,05) dan IC50 sebesar 47,9% (p<0,05) dibandingkan kontrol sel sebesar 12,7%. EEKAH mampu menginduksi apoptosis terhadap sel MCF-7. Kata kunci: MCF-7, Pyrus malus L., Sitotoksisitas, Apoptosis  Green apple peel extract (Pyrus malus L.) contains Quercetin compound which decrease Bcl-2 expression. The aims of this study was to determined the cytotoxic activity and apoptosis induction of green apple peel ethanol extract (GASEE) on MCF-7 breast cancer cells. The green apple peel powder was extracted using 70% ethanol solvent by ultrasonic method. Cytotoxic test against MCF-7 breast cancer cells using the MTT Assay method at the GASEE concentration, namely 31.25; 62.5; 125; 250; 500 and 1000 µg/mL. The results of the cytotoxic test calculated the IC50 value using linear regression. Determination of apoptosis induction with a concentration of ½ IC50 (442.5 µg/mL) and IC50 (885 µg/mL) using flowcytometry. Data analysis was analyzed using statistical analysis One Way Anova. The results showed that GASEE has cytotoxic activity with an IC50 value of 885 µg/ml. Average percentage of total apoptosis phase are ½ IC50 concentration of 30.2% (p>0.05) and IC50 of 47.9% (p<0.05) than cell control of 12.6%. GASEE can apoptosis induced against MCF-7 cells.
Kajian Literatur: Tinjauan Remdesivir sebagai Pilihan Terapi pada COVID–19 Wien Maryati Awdisma; Ulfa Syafli Nosa; Didik Hasmono; Nurmainah Nurmainah
Jurnal Pharmascience Vol 8, No 2 (2021): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v8i2.11650

Abstract

Infeksi virus corona baru, pertama kali terdeteksi pada akhir Desember 2019, dengan jumlah kasus terkonfirmasi lebih dari 33 juta kasus dan lebih dari 900.000 kematian dilaporkan. Terdefinisi sebagai pandemi, dan belum ada “obat khusus” yang dianggap dapat mengatasinya. Salah satu pendekatan terapeutik yang sedang dievaluasi dalam berbagai uji klinis adalah saat ini adalah remdesivir,telah disetujui oleh Badan Pengawas Obat dan Makanan (BPOM sebagai obat Emergency Use Authorization (EUA) sebagai opsi  penggunaan darurat Tujuan penulisan ini untuk memberikan gambaran tentang penemuan remdesivir, mekanisme aksi, dan penelitian terkini yang mengeksplorasi efektivitas klinisnya. Metode penelitian dilakukan dengan pencarian sumber data PubMed, Google Scholar, Science Direct dan Cochrane hingga November 2020 dengan kata kombinasi kata kunci Convalescent Plasma”; “SARS-CoV-2”, Virus Corona dan dibatasi pada jurnal berbahasa Inggris. yang mengulas penemuan remdesivir, mekanisme kerja, farmakokinetik, farmakodinamik, dan efikasi uji klinis remdesivir dalam pengobatan pasien COVID-19. Kesimpulan dari penelitian ini bahwa remdesivir memiliki efek klinis yang baik setelah 10 hari pengobatan pada pasien COVID-19.Kata Kunci: COVID-19, EUA, Remdesivir, SARS-CoV-2 The new coronavirus infection identified at the end of December 2019 and is receiving a lot of attention around the world. Globally, the number of confirmed cases has increased to more than 33 million cases and more than 900,000 deaths have been reported. This condition is defined as a pandemic situation, and so far no "special drug" is believed to be able to overcome it. One therapeutic approach currently being evaluated in various clinical studies is remdesivir. This drug is approved by the Food and Drug Administration (BPOM) as Emergency Medicine (EUA). This emergency option for remdesivir is considered a promising option for treating patients with COVID19. The purpose of this paper is to provide an overview of recent studies investigating the discovery of remdesivir, its mechanism of action, and its clinical efficacy. The survey method was conducted by searching the data sources of PubMed, Google Scholar, Science Direct, and Cochrane until November 2020. Researchers limit literary studies to English journals. The results of 1000 articles searched that met the selection criteria were 10 articles examining the results of remdesivir, its mechanism of action, pharmacokinetics, pharmacodynamics, and the efficacy of clinical remdesivir in the treatment of patients with COVID 19. The conclusion of this study is that remdesivir has a good clinical effect 10 days after treatment of patients with COVID19.

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