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INDONESIA
Jurnal Farmasi Udayana
Published by Universitas Udayana
ISSN : 23017716     EISSN : 26224607     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Jurnal Farmasi Udayana merupakan jurnal elektronik yang dikelola oleh jurusan Farmasi FMIPA Udayana. Jurnal ini yang merupakan media publikasi penelitian dan review article pada semua aspek ilmu farmasi yang bersifat inovatif , kreatif, original dan didasarkan pada scientific. Artikel yang dimuat dalam jurnal ini meliputi penemuan obat, sistem penghantaran obat serta pengembangan obat. Jurnal ini memuat bidang khusus di farmasi seperti kimia medisinal, farmakologi, farmakokinetika, farmakodinamika, analisis farmasi, sistem penghantaran obat, teknologi farmasi, bioteknolofi farmasi, obat herbal dan komponen aktif tanaman serta evaluasi klinik obat
Arjuna Subject : -
Articles 322 Documents
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TINGKAT PENGETAHUAN, PERSEPSI DAN SIKAP APOTEKER DI APOTEK MENGENAI COVID-19 DI KOTA YOGYAKARTA susan Fitria Candradewi; Wiwin Nopita Putri; Jannatu Yasmin Adiningsih
Jurnal Farmasi Udayana Vol. 11, No. 2, Tahun 2022
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2022.v11.i02.p02

Abstract

The Corona virus found in Wuhan gives challenges for health workers such as pharmacists who are responsible for providing education to the public, especially regarding COVID 19. The aim of the study was to measure the level of knowledge, perceptions and attitudes of community pharmacists in Yogyakarta regarding COVID-19. The research design was analytic observational with a population of pharmacists who practiced in community pharmacies in Yogyakarta and the sample was a community pharmacists who practiced for at least 6 months. The results showed that community pharmacists in Yogyakarta had good knowledge about COVID-19 (60%) and 40% of them had sufficient knowledge. Pharmacists who have a positive perception was 66% and who have a negative perception was 34%. The attitude of pharmacists shows 68% positive and 32% negative. The relationship between education level and pharmacist's knowledge, perception and attitude obtained p-values ??of 0.241, 0.806 and 0.094, respectively, while the relationship between length of work experience and pharmacist's knowledge, perceptions and attitudes obtained p-values ??of 0.010, 0.352, and 0.022, respectively. The conclusion of this study is that pharmacists at the Yogyakarta City pharmacy have good knowledge, positive perceptions and attitudes about COVID-19 and there is a relationship between length of work experience and knowledge and attitudes (p<0.05).
PENGEMBANGAN OBAT ALAMI DI BALI SEBAGAI MODEL PENGEMBANGAN OBAT TRADISIONAL INDONESIA Ni Kadek Warditiani; I Made Agus Gelgel Wirasuta; I Ketut Adnyana
Jurnal Farmasi Udayana Vol. 11, No. 2, Tahun 2022
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2022.v11.i02.p06

Abstract

Kesehatan adalah bidang program prioritas Pemprov Bali (2018-2023) dengan salah satu Pelayanan Pengobatan Tradisional Integrasi, dengan usaha mengangkat pengobatan usadha dapan berjalan seiring saling bahu membahu, isi mengisi dalam mewujudkan manusia Bali dengan Jana Kertih. Tujuan penulisan artikel ini adalah Pemprov Bali mengembangkan obat alami Bali berdasarkan kearifan lokal leluhur Bali yang bersumber pada referensi Lontar Usadha menjadi salah satu kekuatan ekonomi Bali dengan memanfaatkan kekuatan ekonomi pariwisata. Caranya adalah dengan mencari, mentelaah dan merekap kebijakan yang sudah ada dan/atau yang sudah dijalankan oleh Kemenkes/Kementerian-kementerian dan pemerintah daerah Bali. Kegiatan yang dilakukan dalam pengembangan herbal di bali adalah Usadha referensi cara hidup sehat orang Bali, pengembangan industri obat herbal di bali, Percepatan Berjalannya Ekosistem, Standarisasi Obat Herbal, Kebijakan, Pengembangan Wisata Kebugaran Ala Bali “Balinesse Wellness“ Regulasi Pemprov Bali dalam pengembangan Obat Tradisional dan Pelayanan Kesehatan Tradisional Bali
SIFAT FISIKOKIMIA DAN LAJU DIFUSI PATCH TRANSDERMAL DISPERSI PADAT MELOKSIKAM YANG MENGGUNAKAN NATRIUM LAURIL SULFAT SEBAGAI PENINGKAT PENETRASI Anisa Amalia; Nining Nining; Jannatu Yasmin Adiningsih
Jurnal Farmasi Udayana Vol. 11, No. 2, Tahun 2022
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2022.v11.i02.p01

Abstract

Meloxicam is a non-steroidal anti-inflammatory medicine (NSAID) with gastrointestinal side effects, hence it's used in transdermal patch preparations as a substitute. Meloxicam was dispersed in PEG 6000 (1:8) and formed as a transdermal patch using sodium lauryl sulfate as a penetration enhancer in this study. The purpose of this study is to see how sodium lauryl sulfate, used as a penetration enhancer, affects the physicochemical characteristics and diffusion of meloxicam in solid dispersion transdermal patches. The patch comes in four different formulas, each with a different concentration of sodium lauryl sulfate: 0% (F0), 1% (F1), 3% (F2), and 5% (F3). The physicochemical parameters of each formula were evaluated, including organoleptic tests, pH, thickness, weight uniformity, moisture content, and folding resistance, as well as diffusion tests. Each formula's transdermal patch has physicochemical characteristics that fulfill the literature's standards. The percentage of meloxicam diffused in each formula was 80.6683 percent, 85.8091 percent, 90.7508 percent, and 93.3322 percent, respectively, with each formula's diffusion rate kinetics following Higuchi's kinetics. The physicochemical characteristics and diffusion rate of the meloxicam transdermal patch were altered by sodium lauryl sulfate (p < 0.05). The most promising patch as an alternative to meloxicam dosage form is meloxicam solid dispersion transdermal patch formulation with 5% sodium lauryl sulfate content.
Studi In Silico Senyawa Daun Sirsak (Annona muricata L.) Sebagai Inhibitor BRAF V600E Pada Kanker Melanoma Audry Rahma Dewayani; Salsabil Ghaliya; Natashya Parameswari; Alya Puteri Agustina Pribadi; Husna Muharram Ahadi; Diah Lia Aulifa; Angela Alysia Elaine; Bernap Dwi Putra Sitinjak
Jurnal Farmasi Udayana Vol. 11, No. 2, Tahun 2022
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2022.v11.i02.p07

Abstract

Melanoma is a cancer that develops in melanocytes and manifests itself on the skin as lumps and uneven skin pigmentation. A chemotherapeutic medication called Vemurafenib is one of the medicines used to treat this malignancy. Chemotherapeutic drugs, on the other hand, are known to induce a variety of adverse effects in the body, thus alternative substances with the same potential but fewer side effects must be sought. This study was conducted utilizing an in silico technique, which included molecular docking, as well as Lipinski rules and PreADMET to predict the pharmacokinetic profile. Compounds found in soursop leaves (Annona muricata L.) have been shown to inhibit cell division by interacting with the BRAF V600E receptor. Reticuline has a Gibbs energy of -8.78; a 395.39 nM inhibition constant; and binds to the amino acids GLN A:530, CYS A: 532, and ASP A: 594.
ANALISIS BIAYA DAN KUALITAS HIDUP PASIEN RAWAT JALAN DM TIPE 2 DENGAN TERAPI GLIQUIDONE DIBANDINGKAN GLIMEPIRIDE DI RSUD SURAKARTA TAHUN 2021 Inaratul Rizkhy Hanifah; Ela Dewi Puspita Sari; Samuel Budi Harsono
Jurnal Farmasi Udayana Vol. 11, No. 2, Tahun 2022
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2022.v11.i02.p03

Abstract

Diabetes Mellitus type 2 is a degenerative disease suffered by patients for life. WHO estimates that Indonesia's number of people with diabetes will be around 21.3 million in 2030. Poor blood sugar control in DM patients impacts the decreasing quality of life and increasing health costs. The aim of this study was to analyze the cost of gliquidone therapy compared to glimepiride and the quality of life of outpatients with type 2 DM at the Surakarta Hospital in 2021. The research was conducted using a cross-sectional study design. The sample in this study was obtained through the purposive sampling method with patients who met the inclusion criteria. Cost analysis was carried out by calculating direct medical and non-medical costs, followed by calculating the RUB value to determine which therapy had the most cost-utility. This study was conducted in August-September 2021. Cost data includes total medical costs from hospitals and transportation costs. Quality of life value in this study was measured using the D-QOL questionnaire. The results showed that the RUB value was Rp. 5,389,203; U = 0.749 while glimepiride was Rp. 4,117.949; U = 0.754. The sensitivity test results showed that the cost of non-ADO drugs had the longest range, so it became the most influential factor. More cost-utility compared to gliquidone. Keywords: Oral antidiabetic, CUA, Diabetes Mellitus, Quality of life
Potensi Terbentuk Interaksi molekuler pada Fitokimia alami sebagai inhibitor Sap 2 dari Candida albicans: Pendekatan In silico Gusnia Meilin Gholam; I Made Artika
Jurnal Farmasi Udayana Vol. 11, No. 2, Tahun 2022
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2022.v11.i02.p04

Abstract

Candida albicans (C. albicans) is a fungus that can live in the digestive tract, mouth, and vagina. C. albicans is the main cause of vulvovaginal candidiasis (VVC), with a percentage of about 80-90%. In addition, C. albicans also causes systemic candidiasis, one of the most common bloodstream infections in hospitalized patients worldwide and is associated with a 40-70% mortality rate. This study aimed to investigate natural phytochemicals potential in inhibiting Sap 2 C. albicans, thereby reducing its virulence factor. The methods used in this study were Sap 2 protein receptor preparation, test ligand preparation, validation and molecular docking of Sap 2, data analysis and visualization, and ADMET prediction using pkCSM. The results of this study are that Silibinin has the closest bond energy to the crystallographic ligands of 8.658 kcal/mol and Apigenin (7.608 kcal/mol), Catechin (7.469 kcal/mol), Resveratrol (6.329 kcal/mol), Gallic acid (5.245 kcal/mol) respectively. Receptors-ligands complex form van der Waals interaction and hydrogen bonds, including hydrogen bond distances. Each test ligand was predicted to bind with the catalytic residues and the S2 S3 and S4 substrate binding pockets from Sap 2. This study concludes that there are molecular interactions of the phytochemicals to inhibit Sap 2.
PENGARUH EKSTRAK ETANOL DAUN KARANDA (Carissa carandas L.) TERHADAP HISTOPATOLOGI GINJAL TIKUS PUTIH (rattus norvegicus) YANG DIINDUKSI ALOKSAN Ilhammudin Sirait; Husnarika Febriani; Syukriah -
Jurnal Farmasi Udayana Vol. 12, No 1, Tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i01.p05

Abstract

A metabolic condition called diabetes mellitus (DM) results from an inability to secrete insulin. The purpose of this study is to determine the impact of ethanol extract from karanda leaves (Carissa carandas L.) on diabetes mellitus mouse kidney morphology and renal histology. The study employed a complete random design (RAL) with the partition of variants into 6 groups, including normal control, negative control, glibenklamid group, and P1: karanda leaf extract doses of 500 mg/kg BB, 750 mg/kg BB, and 1000 mg/kg BB. hematoxylin-eosin (HE) staining and the paraffin method for producing mouse kidney histopathology preparations. Data analysis using the one-way Anova and the sophisticated tests of Duncan. The outcomes demonstrated that the kidneys of diabetic mice in the control and treatment groups had significantly different morphologies and histopathologies. The glomerulus was edematous in diabetic kidneys with melitus, and cell damage manifested as hydropic degeneration, necrosis of the proximal tubules, and variations in glomerular diameter. The administration of ethanol-extracted from karanda leaves can help with glomerular edema, shape, and cell healing in the proximal tubules. Conclusion: Caranda leaf ethanol extract improves the morphology, renal histology, and glomerular diameter of mice (Rattus norvegicus) with diabetic mellitus, with 1000 mg/kgbb of extract being the most efficacious dose. Keywords: Diabetes Mellitus, Karanda Leaf (Carissa carandas L.) and Kidneys
Review potensi Emblica officinalis (Amla) dalam mengatasi gangguan metabolisme dislipidemia dan antioksidan Ni Kadek Warditiani; Pande Made Nova Armita Sari; Ni Made Widi Astuti; I Made Agus Gelgel Wirasuta
Jurnal Farmasi Udayana Vol. 12, No 1, Tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i01.p10

Abstract

Emblica officinalis (Amla) is a plant that is not widely utilized in Bali, but it has tremendous potential. This study aims to investigate the antioxidant and anti-dyslipidemia potential of Amla. Literature search was conducted on Pubmed, Scopus, and Science Direct, followed by screening and review to match the inclusion and exclusion criteria. The search resulted in 346 articles, and after reviewing and screening the titles, keywords, and abstracts, 12 articles that met the criteria were obtained. The review findings indicate that Emblica officinalis (Amla) has a strong potential in preventing or addressing cardiovascular disorders such as atherosclerosis due to its abilities as a potential anti-dyslipidemia and antioxidant agent.
Aktivitas Anti-Wrinkle Gel Ekstrak Binahong (Anredera cordifolia) secara In Vivo Kintoko Kintoko; Hardi Astuti Witasari; Yuda Fajar Pratama
Jurnal Farmasi Udayana Vol. 12, No 1, Tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i01.p01

Abstract

Sinar ultraviolet memicu terbentuknya radikal bebas penyebab kerutan. Daun binahong (Anredera cordifolia) memiliki aktivitas antioksidan yang dapat menstabilkan radikal bebas. Penggunaan ekstrak daun binahong dalam bentuk gel lebih praktis dan nyaman dikulit. Penelitian ini bertujuan untuk mengetahui aktivitas anti-wrinkle pemberian gel ekstrak binahong pada mencit yang diinduksi sinar UV-B. Penelitian ini menggunakan 25 ekor mencit jantan, dibagi 5 kelompok. Kelompok normal (perlakuan apapun), kelompok UV-B (hanya paparan sinar UV-B), kelompok tretinoin (paparan sinar UV-B dan gel tretinoin), kelompok perlakuan 1 (paparan sinar UV-B dan gel ekstrak binahong satu kali sehari), kelompok perlakuan 2 (paparan sinar UV-B dan gel ekstrak binahong dua kali sehari. Paparan dilakukan dengan lampu UV-B Kernel KN-4003 selama 2 minggu. Pengamatan kerutan secara visual scoring dengan metode Bissett. Data yang diperoleh dianalisis menggunakan uji statistik SPSS. Skor kerutan pada kelompok normal adalah 0, kelompok UV-B 2,66±0,48, kelompok tretinoin 0,44±0,38, kelompok perlakuan 1 1,06±0,61, dan kelompok perlakuan 2 0,80±0,84. Kelompok UV-B memberikan perbedaan yang signifikan terhadap tretinoin, perlakuan 1, dan 2 (P<0,05). Kelompok tretinoin tidak berbeda signifikan terhadap skor kerutan pada perlakuan 1 dan 2 (P>0,05). Pemberian gel ekstrak binahong memiliki aktivitas sebagai anti-wrinkle dalam mencegah terjadinya kerutan pada mencit yang diinduksi sinar UV-B. Penambahan frekuensi memberikan perbedaan yang tidak signifikan. Kata kunci: anti-wrinkle, ekstrak daun binahong, gel
Formulasi dan Evaluasi Lip cream Halal Menggunakan Ekstrak Tomat (Lycopersicon esculentum Mill) Sebagai Pewarna Alami ABDUL QOSIM
Jurnal Farmasi Udayana Vol. 12, No 1, Tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i01.p06

Abstract

Abstract— Lip cream is a semi-solid to liquid textured preparation that functions as a lip dye. Tomato plants can be used as natural dyes because they contain lycopene compounds which can give a yellow to red color. This study aims to determine whether tomato fruit extract can be formulated as a dye, determine the effect of adding tomato extract concentration and determine the halal critical point in the preparation of tomato fruit extract lip cream as a natural dye. The tomato fruit extraction method was carried out using UAE with methanol solvent. The resulting extract was then added to each formula with concentrations of F0 (0%), F1 (5%), F2 (10%) and F3 (15%). The organoleptic test results showed that all formulas had a semi-solid texture, smelled of roses and F0 was white, F1 was light orange, F2 was orange and F3 was brick red. All formulas comply with the homogeneity and pH test standards as indicated by the pH value range of 6.47 - 5.17. All formulas had good smearing power, adhesion of ?60 seconds and spreadability test values ??ranging from 5.90 to 5.63. The results of the ANOVA analysis on the pH and spreadability tests showed that the preparations had significant differences between the formulas. Evaluation of halal critical points on preparations does not have halal critical points in terms of materials and processing.

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