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INDONESIA
Jurnal Farmasi Udayana
Published by Universitas Udayana
ISSN : 23017716     EISSN : 26224607     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Jurnal Farmasi Udayana merupakan jurnal elektronik yang dikelola oleh jurusan Farmasi FMIPA Udayana. Jurnal ini yang merupakan media publikasi penelitian dan review article pada semua aspek ilmu farmasi yang bersifat inovatif , kreatif, original dan didasarkan pada scientific. Artikel yang dimuat dalam jurnal ini meliputi penemuan obat, sistem penghantaran obat serta pengembangan obat. Jurnal ini memuat bidang khusus di farmasi seperti kimia medisinal, farmakologi, farmakokinetika, farmakodinamika, analisis farmasi, sistem penghantaran obat, teknologi farmasi, bioteknolofi farmasi, obat herbal dan komponen aktif tanaman serta evaluasi klinik obat
Arjuna Subject : -
Articles 322 Documents
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Uji Sifat Fisik dan Mikrobiologi Sediaan Lulur Krim yang Mengandung Serbuk Kopi serta Penentuan Aktivitas Antioksidannya Ni Kadek Warditiani
Jurnal Farmasi Udayana Vol. 12, No 1, Tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i01.p11

Abstract

In 2017 the Ministry of Industry noted Indonesia’s cosmetics industry in the country out numbered to 760 companies. Further,95% of the industry is dominated by small to medium industrial sector, for this reason, in order to comply with international standards and certification bodies, it is necessary to guarantee the product quality. One of the product tested was a cream scrub containing coffee. Coffee has various chemical compounds that have antioxidant activity which plays a very important role in preventing premature aging. The product quality testing carried out is physical testing, microbiology and also the determination of antioxidant activity. From the prior tests, it was found that the pH of the preparation was 5.73 for the type of oil-in-water emulsion, the spreadability was 5.34 and 6.29 cm. Adhesion 11.10 seconds. The preparation meets all microbiological requirements and has an IC50% of 69.09 ppm.
Kajian Literatur: Suplementasi Vitamin D Mengurangi Tingkat Keparahan serta Mencegah dan Mengobati COVID-19 Ayuningtyas Istiqomah; Wahyu Utami
Jurnal Farmasi Udayana Vol. 12, No 1, Tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i01.p02

Abstract

Supplementation can play a supporting role in COVID-19 patients, one of which is the provision of vitamin D supplementation. This study aims to discuss and examine the existing evidence regarding the effect of vitamin D supplementation in reducing severity and preventing/treating COVID-19. The method used is a literature study from various library sources that can be accessed using the PubMed and Google Scholar databases with the keywords [(“Vitamin D” OR “Vitamin D2” OR “Vitamin D3”) AND (“COVID-19” OR “Coronavirus Disease 2019” OR “SARS CoV 2”)]. Sixty-eight studies met the inclusion and exclusion criteria and are therefore included in this literature review. This study shows that the lower the level of vitamin D in the body, the higher the severity of COVID-19. In addition, the use of vitamin D supplementation has a positive effect on COVID-19 by reducing the risk of being infected with COVID-19, reducing the risk of death, and reducing the severity of COVID-19. This could be because vitamin D can enhance the innate immune system which is the body's first line of defense against pathogens and regulate the adaptive immune system to reduce cytokine storms, and has a potential protective role against acute respiratory distress syndrome by inhibiting the renin-angiotensin pathway. Therefore, vitamin D supplementation can be used as an additional treatment for COVID-19.
Analisis ABC Dalam Perencanaan Pengadaan Perbekalan Farmasi di Puskesmas Gamping 1 Yogyakarta Fiqri Zulpadly; Siti Nurhaliza Nadya Rahayu
Jurnal Farmasi Udayana Vol. 12, No 1, Tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i01.p07

Abstract

In carrying out the task of managing drugs and medical consumables, Primary Health Center has the responsibility to create a management that is done effectively and efficiently. One of them is managing a pharmaceutical inventory. In this study, ABC analysis on the planning of drugs and medical consumables procurement at Yogyakarta Gamping I Public Health Center was carried out with the aim of finding out the ABC grouping of its inventory based on its investment value and also the percentage proportion of each group. This research is a non-experimental study with descriptive analysis using quantitative data which was conducted retrospectively. Primary data was obtained through an interview with the pharmacist in charge at Yogyakarta Gamping I Primary Health Center. The source of the secondary data is the facility’s history of the procurement of drugs and medical consumables based on LPLPO from the period of Januari-Desember 2021. Results showed that among 137 items of drugs, only 0,73% of them were included in group A. Group B consists of 9 items and group C has 127 items. For medical consumables, 16,67% of the 54 items were categorized into group A. Group B has the percentage of 22,22% of items and group C with the remaining 61,11%. Keywords: abc analysis, procurement planning
Manfaat Terapi Tambahan Vitamin pada Pasien Nyeri Neuropati Diabetika Edenia Asisaratu; Rizaldy Taslim Pinzon; Esdras Ardi Pramudita
Jurnal Farmasi Udayana Vol. 12, No 1, Tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i01.p12

Abstract

Background: Painful Diabetic Neuropathy is one of the most common complications of Diabetes Mellitus, which becomes a burden that necessitates optimal treatment. Current treatment is symptomatic therapy with glycemic index control but it has yet to reach the best results. Supplementing with vitamins B and D has been shown to provide significant pain relief in previous studies. Methodology: This was a retrospective cohort study. A total of 107 subjects were sampled using consecutive sampling method and they were given either symptomatic therapy or symptomatic therapy plus vitamins for three months. The pain scale was measured using Neuropathic Pain Scale. Results: The subjects were compared in three comparison groups. Subjects who received symptomatic therapy plus vitamin had the greatest pain reduction (39,50±14,222) (p=0,000) in the first comparison group. Subjects who received symptomatic therapy plus vitamin B combination and vitamin D 1000 IU had the greatest pain reduction (53,00±6,749) (p=0,000) in the second comparison group. Subjects who received symptomatic therapy plus vitamin D 1000 IU had the greatest pain reduction (44,00±8,944) (p=0,088) in the third comparison group. Conclusions: Additional vitamin therapy resulted in a significantly greater pain reduction than symptomatic therapy alone. There was no significant difference in pain reduction between the vitamin D 400 IU addition and vitamin D 1000 IU addition. Keywords: painful diabetic neuropathy; pain intensity; vitamin B; vitamin D
Studi Potensi Ekstrak Etanol Biji Pepaya (Carica papaya L.) sebagai Pedikulisidal Semprot terhadap Kutu Pediculus humanus var. capitis Siti Jubaedah
Jurnal Farmasi Udayana Vol. 12, No 1, Tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i01.p03

Abstract

Pedikulosis kapitis merupakan infeksi kulit dan rambut kepala diakibatkan Pediculus humanus var. capitis yang saat ini masih sering terjadi. Pedikulisidal dari tumbuhan sudah banyak direkomendasikan sebagai pedikulisidal alternatif karena memiliki efek toksisitas pada manusia yang rendah. Penelitian ini bertujuan untuk mengetahui potensi ekstrak etanol biji pepaya terhadap kematian Pediculus humanus var. capitis. Penelitian menggunakan 5 ekor kutu kepala pada setiap kelompok perlakuan. Pengujian dilakukan dengan 5 perlakuan konsentrasi yaitu konsentrasi 5%, 10%, 15%, 20% dan 40%. Kontrol yang digunakan berupa kontrol positif yaitu permetrin 1% dan kontrol negatif yaitu aquabides. Dilakukan masing-masing tiga pengulangan. Hasil didapatkan konsentrasi 15%, 20%, 40%, dan kontrol positif memiliki presentase kematian yang tinggi yaitu 100%, konsentrasi 10% sebesar 80% kematian, kematian kutu terendah adalah konsentrasi 5% sebesar 60% dan kontrol negatif sebesar 0%. LC50 sebesar 9.685% sedangkan LC90 12.038%. Hasil uji fitokimia didapatkan bahwa esktrak etanol biji pepaya mengandung senyawa alkaloid, saponin, flavonoid dan tanin. Kesimpulan. Ekstrak biji pepaya memiliki efek pedikulisidal alami. Kata kunci : Carica papaya; Pedikulosis kapitis; Pedikulisidal
Narrative Review: Analisis Fitokimia Dan Manfaat Ekstrak Ketepeng Cina (Cassia alata L.) Sebagai Antijamur Baha Udin; Renditya Ismiyati; Eva Kholifah; Endah Endah
Jurnal Farmasi Udayana Vol. 12, No 1, Tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i01.p08

Abstract

Indonesia is known to have various types of plants that can be used in medicine, one of which is Cassia alata. Cassia alata is a plant that has many properties so it can be used as herbal medicine or traditional medicine. One of the properties of the Cassia alata plant that has been widely studied is as an antifungal. Every part of the Cassia alata plant has secondary metabolites. Cassia alata leaves contain secondary metabolites of alkaloids, steroids, phenols, glycosides, terpenoids and flavonoids. Cassia alata flowers contain flavonoids, tannins and phenolic compounds and saponins. Cassia alata level contains alkaloids, flavonoids, glycosides, phytosterols, quinones, tannins and terpenoids. Compounds that have a role or antifungal activity in Cassia alata are phenolics, tannins, flavonoids, saponins, triterpenoids, steroids, and alkaloids.
Potensi Senyawa Aktif Tanaman Herbal untuk Pengobatan Kanker Payudara dengan Metode Penambatan Molekuler: Review Artikel Alma Yunita Sari; Ellin Febrina
Jurnal Farmasi Udayana Vol. 12, No 1, Tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i01.p04

Abstract

Breast cancer is one of the leading causes of death in women worldwide. Breast cancer can be triggered due to physical, chemical, environmental factors and can be passed down from generation to generation through genetics. Therefore, recently, studies have been intensively conducted on the use of medicinal plants for the treatment of breast cancer as an alternative because they have minimal side effects compared to other chemotherapy. This review aims to describe medicinal plants and their active compounds that have the potential as anticancer therapy which has been carried out in silico studies with molecular anchoring methods. The method used in writing this article is a literature review both nationally and internationally over the last five years using the keywords breast cancer, molecular docking, herbal plants, anticancer, in databases such as PubMed, Cochrane, and Google Scholar. Herbal plants in in silico research that have high potential for further research as cancer therapy include 33 herbal plants with different active compounds and protein targets.
Senyawa penuntun antituberkulosis dari jamur yang berasal dari laut dan entomopatogen Ni Luh Putu Indah Suryani; I Putu Yogi Astara Putra; Nonye Treasure Ujam; Ni Putu Ariantari
Jurnal Farmasi Udayana Vol. 12, No 1, Tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i01.p09

Abstract

The occurrence of Mycobacterium tuberculosis resistance encourages the discovery of new antitubercular candidates. Microbes including fungi and bacteria are well known reservoir for isolating antibiotic compounds, among natural product resources. In this review, we report promising antitubercular compounds from marine-derived and entomopathogenic fungi, reported from 2000 to 2022. A comprehensive literature search was conducted through scientific websites, including Google Scholar, Springer, and Pubmed. Eighty-three antitubercular compounds were reported, where 57 of them derived from fungi associated with marine ecosystem. Those fungi belong to 10 fungal genera. The remaining active compounds were isolated from 7 genera of entomopathogenic fungi. Gliotoxin, 12,13-dihydroxy-fumitremorgin, and helvolic acid as well as hirsutellones A-D are among bioactive compounds reported for their remarkable antitubercular activity, which promising to be investigated further in the search of antitubercular leads. Deeper investigation on these compounds might be promising for the the discovery of antitubercular candidates in the future. Keywords: Antitubercular; entomopathogenic fungi; marine-derived fungi; Mycobaterium tuberculosis; secondary metabolites
Hubungan Kepatuhan Terapi Antihiperglikemia Terhadap Terkontrolnya HbA1c pada Pasien Terdiagnosa Diabetes Melitus Tipe 2 di RSU Prima Medika, Denpasar Ariyanti, Ni Kadek Nining; Virginia, Dita Maria; Hendra, Phebe
Jurnal Farmasi Udayana Vol. 13, No. 1, Tahun 2024
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Diabetes mellitus is a disease caused by chronic metabolic disorders accompanied by increased blood glucose levels. Adherence to treatment is very important to achieve therapeutic success in type 2 diabetes mellitus (T2DM) patients and prevent complications. HbA1c value is one of the parameters used to see the success of T2DM therapy. This study was conducted to determine the relationship between compliance with antihyperglycemic therapy for T2DM patients and the patient's HbA1c value. This study used a cross-sectional research design and data collection was carried out by non-random sampling with purposive sampling technique. The research subjects were 100 T2DM patients at RSU Prima Medika Denpasar, Bali with the age of 40-70 years. The level of patient compliance in taking medication was measured by the Medication Possession Ratio (MPR) method based on patient treatment records. The results showed 78% aged 40-59 years, 53% female, 86% T2DM with comorbidities 62% received combination therapy, 87% were compliant with taking medication. There was no significant relationship between the characteristics of T2DM patients and compliance (p-value > 0.05). There was a significant association between medication adherence and controlled HbA1c values in patients with T2DM (p-value < 0.05; OR (95%CI) : 4,902 (1,026 - 23,430)).
REVIEW : ETNOBOTANI, TOKSISITAS, FITOKIMIA, DAN AKTIVITAS BIOLOGI DARI TUMBUHAN RENDA (Carissa carandas L) Fadhli, Haiyul; Difa, Faradini Ramsanjami; Frimayanti, Neni; Aryani, Fina
Jurnal Farmasi Udayana Vol. 12, No. 2, tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i02.p04

Abstract

Renda (Carissa carandas L.) is a plant in the Apocynaceae family with dichotomous branches and milky sap. The plant bears small, oval-shaped fruits that are green at first and turn reddish-purple as they ripen. This review aims to integrate the secondary metabolites and biological activities of Carissa carandas L while also providing the scientific evidence required for future research. Online and offline literature were used to review this article. Online literature is sourced from local and international journal publications from journal providers on the internet and from online literature in books and e-books. This article covers the ethnobotany, toxicity, secondary metabolite compounds, and biological activities reported through search engines such as Google Scholar, NCBI, PubMed, ScienceDirect, Research Gate, and Springer. Based on existing literature, Carissa carandas can help treat diabetes, hypertension, hepatoprotection, anticonvulsants, antimalarials, antioxidants, anthelmintics, diarrhea, and hyperlipidemia.

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