cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
-
Contact Email
-
Phone
-
Journal Mail Official
-
Editorial Address
-
Location
Kota denpasar,
Bali
INDONESIA
Jurnal Farmasi Udayana
Published by Universitas Udayana
ISSN : 23017716     EISSN : 26224607     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Jurnal Farmasi Udayana merupakan jurnal elektronik yang dikelola oleh jurusan Farmasi FMIPA Udayana. Jurnal ini yang merupakan media publikasi penelitian dan review article pada semua aspek ilmu farmasi yang bersifat inovatif , kreatif, original dan didasarkan pada scientific. Artikel yang dimuat dalam jurnal ini meliputi penemuan obat, sistem penghantaran obat serta pengembangan obat. Jurnal ini memuat bidang khusus di farmasi seperti kimia medisinal, farmakologi, farmakokinetika, farmakodinamika, analisis farmasi, sistem penghantaran obat, teknologi farmasi, bioteknolofi farmasi, obat herbal dan komponen aktif tanaman serta evaluasi klinik obat
Arjuna Subject : -
Articles 322 Documents
 29   30   31   32   33 
Review Artikel Beyond Use Date Sediaan Steril Rekonstitusi wahyuni, LP eka; Warditiani, Ni Kadek; Suryani, N.P Febri; Sugiantara, I.W Eka; Rahayu, N.P Savitri; Dewi, N.P Apsari; Jayanti, N.K.P Aprilia; Adi P.S, I.K; Chantika P, N.K; Bayu J.K, I.M; Diah K, Shinta
Jurnal Farmasi Udayana Vol. 13, No. 1, Tahun 2024
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Beyond Use Date (BUD) is the last date on which a medicinal preparation is considered stable and safe for use after reconstitution or preparation. Determination Beyond Use Date (BUD) functions to keep injection preparations sterile, protected from contaminants, protected from physical and chemical degradation. The method used in preparing this article is based on pharmaceutical literature, especially related literature steril coumponding method and pharmaceutical libraries. The purpose of this review article is to find out the importance of information regarding the BUD of reconstituted sterile preparations and how to use the drug after reconstitution. Determination of BUD for sterile preparations based on literature review United states of Phamacophea, American Society of Health-System Pharmacists (ASHP), and national and international published journals. The results of the article preparation are that the BUD determination is based on factors such as the chemical, physical and microbiological stability of the diluted drug. Reconstitution injection is a process in which a drug in dry form, such as powder or crystals, is converted into an injectable solution by adding a certain solvent or liquid. Quality requirements for reconstituted preparations include criteria that must be met by medicinal preparations after the reconstitution process to ensure their quality, safety and effectiveness. There are obstacles in determining the BUD for sterile preparations because the BUD time available is shorter after reconstitution, so there are several solutions that can be applied to maintain the stability of the preparation.
Aktivitas Penangkapan Radikal 2,2-difenil-1-pikril hidrazil Fraksi Terhidrolisis Asam Daun Duwet (Syzigium cumini L.) dan Daun Nangka (Artocarpus heterophyllus) Irianti, Tatang; Yasmin, Intan Farida; Astuti, Ratih Dwi; Purnomo, Hari
Jurnal Farmasi Udayana Vol. 12, No. 2, tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i02.p05

Abstract

Plants contain secondary metabolites, including flavonoids, whose molecules are still bound to glycosides or are not free molecules. Hydrolysis treatment to form free molecules in this study is expected to increase antioxidant activity. The antioxidant activity test used the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenger test. The value of Inhibitory Concentration 50% (IC50) obtained will show the antioxidant activity of the acid hydrolyzed water fraction of duwet (Syzigium cumini L.) leaf and the insoluble hexane fraction of jackfruit (Artocarpus heterophyllus) leaf acid hydrolysis. The results of the hydrolysis of the water fraction of duwet leaves and the insoluble fraction of jackfruit leaf hexane were measured for their antioxidant activity by DPPH radical scavenging test using UV-Vis spectrophotometer. To identify compounds in the water fraction and insoluble hexane fraction that act as antioxidants, qualitative analysis was used TLC and determined total phenolic compounds and flavonoids. The highest antioxidant activity of duwet leaves was in the hydrolyzed water fraction for 3 hours, while in jackfruit leaves the insoluble hexane fraction was hydrolyzed for 3 hours. Thus, the hydrolysis carried out in this study was able to increase the antioxidant activity.
Review Artikel : Kandungan Fitokimia dan Potensi Urang Aring (Eclipta alba L.) Sebagai Bahan Baku Obat Untuk Mengatasi Kebotakan (Hair Loss) Angga Purnama, Dewa Julio; Dewi, Ni Luh Putu Putri
Jurnal Farmasi Udayana Vol. 12, No. 2, tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i02.p01

Abstract

Urang-Aring (Eclipta alba L.) belongs to the genus Eclipta from the Asteraceae family. This plant has been used for generations as traditional medicine and is known to have various pharmacological activities. In this review, we discuss the in vivo testing of several extracts from the urang-aring in mice, the phytochemical compounds contained and the pharmacological activity of the urang-aring extract. The results showed that the ethanol extract, petroleum ether and ethyl acetate fraction of the methanol extract from this plant were reported to have hair growth-promoting activity. Many research studies report that there are various types of phytochemical compounds such as triterpenes, saponins, flavonoids, thiophene, kumestan, coumarins and steroids in this plant. Among these compounds, wedelolactone and ?-sitosterol are considered to be responsible for their pharmacological activity in overcoming hair loss. Wedelolactone is known to have the activity of inhibiting the expression of TGF-?1 resulting in the elongation of hair follicles. Meanwhile, ?-sitosterol works as a 5?-reductase inhibitor so that it contributes to the treatment of androgenic alopecia.
Literatur Review: Gambaran Pengetahuan Masyarakat Mengenai Beyond Use Dates Obat Racikan Padat Non Steril Prascitasari, Ayu; Warditiani, Ni Kadek; Septiarini, Putu Ayudia; Permatasari, Ni Made Ayu Dinda; Ananda Putri, Ida Ayu Ngurah Trisna Noviani; Andika, Dewa Made Dwi; Candrayani, Komang Tri; Arkhania, Ni Putu Ayu Dhea; Sanjaya, Sadina Vania Tsany Dyah; Ariswari, Ni Kadek Putri; Nugrahaeni, Luh Gede Ratih Dewi Tri
Jurnal Farmasi Udayana Vol. 13, No. 1, Tahun 2024
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Kurangnya pemahaman masyarakat terkait Beyond Use Date (BUD) disebabkan oleh minimnya informasi yang diberikan oleh tenaga kesehatan mengenai hal tersebut. BUD merupakan batas waktu obat bisa dikonsumsi setelah kemasan primernya dibuka. Metode yang digunakan dalam penyusunan artikel ini didasarkan pada Literatur Review mengenai penerapan Beyond Use Date (BUD) pada obat campuran padat non-sterile. Artikel yang dipilih telah memenuhi kriteria inklusi yang telah ditetapkan yaitu artikel yang terpublikasi pada tahun 2014-2024. Hasil yang diperoleh yaitu peningkatan pengetahuan masyarakat setelah diberikan sosialisasi terkait BUD tentang pengertian BUD, perbedaan BUD dan ED pada tablet, kapsul, obat racikan, dan non racikan. Sediaan padat harus memiliki BUD paling lambat sama dengan sisa waktu sampai tanggal kadaluarsa zat aktif terawal dalam sediaan atau 180 hari, dipilih yang paling singkat.
Analisis Kadar Glukomanan dan Evaluasi Biopolimer Edible Film Umbi Porang Sebagai Pengemasan Pangan Fungsional Putra, I Gusti Ngurah Trisna Meyana; Kusuma, I Made Gede Ari; Kurniadinata, I Putu Bagus; Wulandari, Ni Made Widya; Dewi, Ni Komang Gita Listyari; Astuti, Ni Made Widi
Jurnal Farmasi Udayana Vol. 13, No. 1, Tahun 2024
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Kemasan mampu melindungi produk dari kontaminasi. Namun, disisi lain kemasan juga dapat sebagai sumber utama timbulnya limbah. Edible film adalah suatu bahan yang dapat diaplikasikan dalam pelapis dan pembungkus hidangan yang bisa dikonsumsi secara langsung bersama bahan makanan tersebut serta dapat menjaga sterilitas makanan dan mencegah hilangnya komponen gizi makanan. Produksi edible film dari glukomanan umbi porang ini melalui serangkaian tahapan produksi. Diawali dengan pembuatan tepung porang, penentuan kadar glukomanan, penentuan kadar kalsium oksalat, identifikasi dengan FTIR, pembuatan edible film, serta uji evaluasi atau karakterisasi edible film seperti uji organoleptis, ketebalan, kadar air, laju transmisi uap air, daya menahan air, dan daya menahan minyak. Kadar glukomanan dan kalsium oksalat yang didapatkan dari riset ini adalah sebesar 87,7% dan 59,1829 mg/100 g. Identifikasi dengan FTIR ditemukan adanya gugus -OH, -CH2, -CO dan -CH yang sesuai dengan pustaka. Hasil uji ketebalan edible film adalah 0,123 mm; 0,143 mm; 0,156 mm. Hasil uji kadar air adalah 6,331%; 6,728%; 7,6%. Hasil uji laju transmisi uap air adalah 10,147 g/jam.m2 ; 13,345 g/jam.m2 ; dan 24,108 g/jam.m2 . Hasil uji daya menahan air adalah 7,209 g/g; 7,266 g/g; dan 7,389 g/g. Hasil uji daya menahan minyak adalah 2,698 g/g; 2,495 g/g; dan 2,483 g/g.
KOMPARASI METODE PENINGKATAN LAJU DISOLUSI OBAT Rizqi, Syifa Maulidia; Chabib, Lutfi
Jurnal Farmasi Udayana Vol. 12, No. 2, tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i02.p02

Abstract

The speed of dissolution becomes an important part in the manufacture of drugs, because it is related to drug absorption and bioavailability. In order to achieve a good dissolution rate, various methods with certain criteria are needed. This review article aims to find out various methods that can be used to increase the speed of drug dissolution, and can be used as a reference for choosing the most appropriate dissolution method. The article review method used is a narrative review type in the form of a description or explanation of methods for increasing dissolution as a comparison in terms of method selection. Journals were obtained through chrome, google scholar and researchgate using 16 journals. The results obtained are that there are several methods that can increase dissolution including amorphous co, the use of surfactants and so on. The conclusion obtained from this review of the article is that there are various methods of increasing dissolution such as the use of surfactants, co-crystals, amorphous cos and so on. Keywords: dissolution; method; narrative review
AKTIVITAS ANTIBAKTERI FUNGI ENDOFIT DAUN SIRSAK (Annona Muricata Linn.) TERHADAP Vibrio Cholerae DAN Bacillus Subtilis Ratnah, St.; Andriani, Novita; Daswi, Dwi Rachmawaty; Pakadang, Sesilia Rante; Salasa, Alfrida Monica
Jurnal Farmasi Udayana Vol. 13, No. 1, Tahun 2024
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Sirsak plant is traditional plant that believed empirically as cough medicine, dysentery, rheumatism, lowering uric acid levels and diarrhea community. Vibrio cholerae and Bacillus subtilis types bacteria can cause diarrhea. This study aims to determine the number endophytic fungi found from Sirsak leaves, to determine antibacterial activity endophytic fungi isolates from Sirsak leaves against Vibrio cholerae, and Bacillus subtilis. Furthermore, inoculated repeatedly on SDA for 5-7 days until isolates were obtained. Each isolate was fermented with GDP for 2-3 weeks and then extracted with ethyl acetate. Ethyl acetate extract was used antibacterial with agar diffusion method MHA media. Test results showed that 5 isolates were obtained, namely White DS isolate, Toska DS isolate, Green DS isolate, Cream DS isolate, and Blackish Brown DS isolate. Where DS White isolate suspected of Cylindrocladium sp, DS Toska isolate suspected of Aspergillus fumigatus, DS Green, isolate suspected of Aspergillus flavus, DS Cream isolate suspected of Aspergillus terreus, DS Blackish Brown isolate suspected of Aspergillus niger. Sirsak leaf endophytic fungal isolates (White DS, Toska DS, Green DS, Cream DS and Blackish Brown DS) showed antibacterial activity against Vibrio cholerae and Bacillus subtilis.
Isolasi, Identifikasi dan Aktivitas Antibakteri Fungi Endofit dari Daun Jarak Pagar (Jatropha curcas L.) terhadap Escherichia coli dan Salmonella typhi Cantika, Andi Besse Intan; Pakadang, Sesilia Rante; Salasa, Alfrida Monica
Jurnal Farmasi Udayana Vol. 12, No. 2, tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i02.p07

Abstract

Jarak Pagar (Jatropha curcas L.) merupakan salah satu tanaman yang mana bagian daunnya banyak digunakan untuk mengobati berbagai macam penyakit serta memiliki daya antibakteri. Penelitian ini bertujuan untuk memperoleh isolat fungi endofit dari Daun Jarak Pagar yang berpotensi dalam menghasilkan senyawa antibakteri. Daun Jarak Pagar dicuci bersih dengan air mengalir yang bersih kemudian disterilkan permukaannya dengan alkohol 75% dan NaOCl 5 %. Lalu diinokulasi pada media PDA selama 3-7 hari. Fungi endofit yang tumbuh dimurnikan dan diperoleh 5 isolat murni. Dimana isolat 1 (hijau) diduga fungi Aspergillus fumigatus, isolat 2 (hitam) diduga fungi Gliocladium sp., isolat 3 (jingga) diduga fungi Fusarium sp., isolat 4 (krem) diduga fungi Chaetomium sp., isolat 5 (putih) diduga fungi Geotrichum sp. Selanjutnya dilakukan uji aktivitas antibakteri isolat fungi endofit dengan cara dilihat dari pembentukan zona hambat disekitar koloni menggunakan metode difusi agar. Bakteri uji yang digunakan Escherichia coli dan Salmonella typhi. Diperoleh hasil pengamatan bahwa isolat 1 (hijau) merupakan satu dari lima isolat yang ditemukan pada Daun Jarak Pagar tidak berpotensi dalam menghambat bakteri Escherichia coli dan dua isolat yaitu isolat 1 (hijau) dan isolat 3 (jingga) yang ditemukan pada Daun Jarak Pagar tidak berpotensi dalam menghambat bakteri Salmonella typhi.
Penumbuh Rambut Hair Tonic Aloe vera secara in vivo pada Kelinci Warditiani, Ni Kadek; Armita Sari, Pande Made Nova; Maha Dewi, Ni Kadek Santi; Natalia Kote, Jessica Christy
Jurnal Farmasi Udayana Vol. 13, No. 1, Tahun 2024
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Hair loss is an event of hair loss from the scalp that occurs regularly. However, hair loss becomes a problem if the amount of loose hair exceeds the normal limit. A hair tonic serves as a base for taking care of the hair and scalp. Aloe vera is often used as a hair care ingredient. In addition, this natural ingredient has the function of accelerating hair growth and reducing hair loss. Another natural ingredient used in making hair tonic is patchouli oil, which of course has a distinctive smell. The intention of this examine became to assess the effectiveness of a mixture of aloe vera and patchouli oil as a hair tonic for hair growth. In this study using a rabbit ridge which will be divided into 5 treatment groups with each different treatment. The treatment group that was given consisted of normal control, negative control (basic hair tonic), comparison control (hair tonic on the market), treatment control 1 (hair tonic given every 2 days) and treatment control 2 (hair tonic given 3 times). once a day). The test results were carried out by measuring the length of the rabbit's hair every 7 days for 21 days. One Way ANOVA and the LSD test were then used to statistically test the collected data. The study's findings demonstrated that a hair tonic consisting of aloe vera and patchouli oil, administered once every three days, significantly (p<0.05) accelerated the development of hair in rabbits.
Uji Aktivitas SOD (Superoxide Dismutase) Bakteri Limbah Cair Tahu dengan Metode WST-1 (Water Soluble Tetrazolium Salt-1) dan Identifikasi Molekuler Bakteri Menggunakan PCR 16S rDNA Pinesti, Arum; Indrayati, Ana; Cahyo, Lukito Mindi
Jurnal Farmasi Udayana Vol. 12, No. 2, tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i02.p03

Abstract

Abstrak-Superoksida dismutase (SOD) merupakan enzim antioksidan endogen yang dapat dihasilkan oleh beberapa mikroorganisme seperti bakteri yang digunakan untuk menetralisir radikal bebas. Tujuan penelitian ini adalah isolasi dan identifikasi bakteri penghasil SOD dari limbah cair tahu, menguji aktivitas SOD dan identifikasi molekuler dengan PCR 16S rDNA bakteri yang memiliki aktivitas SOD tertinggi. Tahapan penelitian meliputi: isolasi bakteri dari limbah cair tahu menggunakan media NA. Lima isolat bakteri dipilih dan diidentifikasi berdasarkan perbedaan morfologi. Tahap selanjutnya ekstraksi SOD, penetapan kadar protein dengan BCA Assay dan uji aktivitas menggunakan WST-1 Assay Kit. Bakteri dengan aktivitas SOD tertinggi didentifikasi molekuler menggunakan PCR 16S rDNA. Lima isolat bakteri berhasil diisolasi. LCT 1, 2 dan 3 termasuk Gram positif sedangkan LCT 4 dan 5 termasuk Gram negatif. Ekstraksi enzim dilakukan pada kelima isolat lalu dipresipitasi dengan amonium sulfat 80%. Isolat LCT 5 memiliki aktivitas SOD tertinggi yaitu 87,90%. Hasil identifikasi PCR 16S rDNA adalah Pseudomonas aeruginosa strain HSS-6.

Page 32 of 33 | Total Record : 322

 29   30   31   32   33 

Filter by Year

2012 2024


Reset
Filter By Issues
All Issue Vol. 13, No. 1, Tahun 2024 Vol. 12, No. 2, tahun 2023 Vol. 12, No 1, Tahun 2023 Vol. 11, No. 2, Tahun 2022 Vol. 11, No. 1, Tahun 2022 Vol. 10, No 2, Tahun 2021 Vol. 10, No 1, Tahun 2021 Vol. 9, No. 2, Tahun 2020 Vol. 9, No. 1, Tahun 2020 Spesial Issue, Desember 2020 Vol. 8, No. 2, Tahun 2019 Vol. 8, No. 1, Tahun 2019 Vol. 7 No. 2, Tahun 2018 Vol. 7, No. 1, Tahun 2018 Vol. 6 No. 2, Tahun 2017 Vol. 6 No. 1, Tahun 2017 Vol. 5 No. 2 Tahun 2016 Vol. 5, No. 1, Tahun 2016 Vol. 4, No. 2, Tahun 2015 Vol. 4, No. 1, Tahun 2015 Vol. 3, No. 2, Tahun 2014 Vol. 3, No. 1, Tahun 2014 Vol. 2, No. 4, Tahun 2013 Vol. 2, No. 3, Tahun 2013 Vol. 2, No. 2, Tahun 2013 Vol. 2, No. 1, Tahun 2013 Vol. 1, No. 1, Tahun 2012 More Issue