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INDONESIA
Jurnal Farmasi Udayana
Published by Universitas Udayana
ISSN : 23017716     EISSN : 26224607     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Jurnal Farmasi Udayana merupakan jurnal elektronik yang dikelola oleh jurusan Farmasi FMIPA Udayana. Jurnal ini yang merupakan media publikasi penelitian dan review article pada semua aspek ilmu farmasi yang bersifat inovatif , kreatif, original dan didasarkan pada scientific. Artikel yang dimuat dalam jurnal ini meliputi penemuan obat, sistem penghantaran obat serta pengembangan obat. Jurnal ini memuat bidang khusus di farmasi seperti kimia medisinal, farmakologi, farmakokinetika, farmakodinamika, analisis farmasi, sistem penghantaran obat, teknologi farmasi, bioteknolofi farmasi, obat herbal dan komponen aktif tanaman serta evaluasi klinik obat
Arjuna Subject : -
Articles 322 Documents
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Review : Potensi Aktivitas Anti Virus Dari Produk Alami Lebah Kelulut Muhammad Alib Batistuta; Annisa Aulia; Paula Mariana Kustiawan
Jurnal Farmasi Udayana Vol. 10, No 2, Tahun 2021
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2021.v10.i02.p06

Abstract

Up to present, many deadly diseases are caused by viral infections. Herbal therapy is a preventive effort made by the community to overcome diseases that come from viruses. Antiviral drug resistance is also the reason people consume herbs from natural ingredients. One of the natural products has the potential to come from kelulut bee products consisting of propolis, pollen, and honey. The kelulut bee or stingless bee is a type of bee that is commonly found in countries with tropical climates such as Indonesia, but there is still little scientific information that examines its potential as an antiviral. This study aims to analyze data on the potential antiviral activity of kelulut bee products through the collection of related articles. The research conducted is a literature review, so the research method is carried out by collecting related articles using search engines such as NCBI, Sciencedirect, and Google Schoolar. Kelulut bee products such as propolis, pollen and honey have potential pharmacological activity as antiviral. This anti-viral activity is due to the presence of compounds such as alkaloids, flavones, apigenin derivatives and other compounds which will be discussed further. Natural products from kelulut bees have potential as an alternative to antiviral therapy. It is also recommended to conduct more in-depth research on the potential of kelulut bee natural products to obtain these therapeutic products.
Review: Metabolit Sekunder dan Aktivitas Farmakologi Tanaman Mangrove Sonneratia alba Priskila Putri Mairing; Ni Putu Ariantari
Jurnal Farmasi Udayana Vol. 11, No. 1, Tahun 2022
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2022.v11.i01.p01

Abstract

Sonneratia alba is a mangrove species widely distributed in Indonesia and locally known as pidada putih or perepat. Various parts of this plant have been used in folk medicine for the treatment of bruises, sprains, malaria, appendicitis, liver, increased appetite, and stamina. This review summarizes the latest information regarding secondary metabolites and pharmacological activities of extracts and phytochemicals of the mangrove S. alba, potentially used for pharmaceutical and nutritional applications. In the last 10 years (2011-2021), a growing number of reports revealed pharmacological potential of S. alba as antibacterial and antioxidant. At least 17 secondary metabolites have been described from S. alba collected from various plant parts such as fruits, leaves, stems, and roots. In addition, various chemical classes of metabolites such as terpenoids/triterpenoids, alkaloids, flavonoids and phenolics, saponins, and steroids were reported from this plant. Keywords: Pharmacological activity, secondary metabolites, Sonneratia alba
Uji Aktivitas Ekstrak Etanol Kulit Durian (Durio zibethinus Murr.) Terhadap Bakteri Propionibacterium acnes dan Staphylococcus aureus Andi Tendriani Safitri; Ismail -; Nur Adiratna; Sakiah Drajat
Jurnal Farmasi Udayana Vol. 11, No. 1, Tahun 2022
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2022.v11.i01.p07

Abstract

Acne is a skin disease that teenagers often complain about at this time. The bacteria that are one of the causes of acne are Propionibacterium acne, Staphylococcus aureus, and Staphylococcus epidermidis. Durian skin (Durio zibethinus Murr) is used as a treatment. Durian contains secondary metabolites, namely flavonoids which have antibacterial activity. Extracts obtained by maceration using 70% ethanol. The phytochemical test shows that durian contains flavonoids as anti-bacterial compounds so that durian skin can be used as an alternative active ingredient in making anti-acne gel preparations. The ethanol extract of durian was then tested for activity by making 3 series concentrations of 10%, 15%, 25% which were then tested on Propionibacterium acne and Staphylococcus aureus bacteria. The results showed that with a concentration of 10%, 15%, 25% with Propionibacterium acne test bacteria had a inhibition zone with a diameter of 7.5 mm ± 0.4 mm (10%), 7.7 mm ± 0.3 mm (15%), 8.4 mm ± 0.2 mm (25 %) and using Stphylococcus aureus test bacteria has a inhibitory zone with a diameter of 8.11 mm ± 0.4 mm (10%), 8.11 mm ± 0.3 mm (15%), 8.8 mm ± 0.5mm(25%).
Aktivitas Antibakteri Krim Ekstrak Terpurifikasi Daun Beluntas (Plucea indica L.) terhadap Staphylococcus epidermidis Agitya Resti Erwiyani; Robiatul Adawiyah; Rendy Rahman; Niken Dyahariesti
Jurnal Farmasi Udayana Vol. 11, No. 1, Tahun 2022
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2022.v11.i01.p02

Abstract

Staphylococcus epidermidis merupakan bakteri flora normal kulit. Ketidaknormalan flora normal akan menyebabkan gangguan kulit diantaranya jerawat. Pengembangan kosmesetika sebagai antibakteri perlu terus dilakukan salah satunya menggunakan bahan alam daun beluntas. Beluntas merupakan tanaman yang memiliki aktivitas sebagai antibakteri dan anti inflamasi karena mengandung metabolit sekunder seperti tannin, polifenol, flavonoid dan minyak atsiri. Ekstrak dilakukan purifikasi untuk memperkecil massa ekstrak. Tujuan penelitian dilakukan untuk mengevaluasi ekstrak terpurifikasi daun beluntas dalam formulasi krim sebagai kandidat kosmesetika yang dapat menghambat pertumbahan bakteri S. epidermidis. Sediaan krim dilakukan pengamatan karakteristik fisik untuk melihat stabilitas krim dalam penyimpanan. Sediaan krim dilakukan uji antibakteri terhadap S. epidermidis menggunakan metode difusi. Krim yang mengandung ekstrak daun beluntas 5% b/v, 10% b/v dan 15% b/v memiliki aktivitas antibakteri terhadap S. epidermidis dengan diameter zona hambat berturut – turut sebesar 9,9±0,022 mm (sedang), 14,9±0,019 mm (kuat), dan 20,9±0,049 mm (sangat kuat). Krim daun beluntas tidak mengalami perubahan pada pengujian organoleptis. Pengujian nilai pH dan viskositas mengalami peningkatan tetapi masih memenuhi kriteria sediaan krim.
Profiling Senyawa Metabolit Sekunder Fraksi Aktif Antihiperkolesterolemia Dari Herba Ketumpang Air (Peperomia pellucida L) Tarso Rudiana; Dimas Danang Indriatmoko; Neneng Rohimah; Farhan Riza Afandi
Jurnal Farmasi Udayana Vol. 11, No. 1, Tahun 2022
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2022.v11.i01.p05

Abstract

Herba ketumpang air (Peperomia pellucida L) contains bioactive compounds such as alkaloids, saponins, flavonoids, and steroids which are thought to be efficacious as antihypercholesterolemia. The purpose of this study was to determine the effectiveness of herba P. pellucida extracts as antihypercholesterolemia in vitro and characterize the active fraction. Extraction using ultrasonication methods with stratified organic solvents, such us n-hexane, ethyl acetate, and methanol. The fraction of n-hexane, ethyl acetate, and methanol were tested for cholesterol reduction activity in vitro by photometry method, cholesterol was reacted with Lieberman-Burchard reagents then analyzed using a UV-Vis spectrophotometer. The fraction that has the best activity is characterized by using a Liquid Chromatographic Mass Spectrometer (LCMS). Ethyl acetate fraction had the best activity to reduce cholesterol with a value EC50 of 196.43 ppm. Based on phytochemical tests the active fraction of ethyl acetate contains alkaloids, flavonoids, saponins, and steroids. Results of LCMS analysis of ethyl acetate fraction at a retention time of 4.97; 7.82; and 10.80 are thought to contain active compounds of the flavonoid group namely velutin, casticin, and dihydrochalcone.
Aktivitas Antibakteri Hand Sanitizer Berbahan Dasar Asap Cair Hasil Torefaksi Cangkang Kelapa Sawit Terhadap Bakteri Escherichia coli Lilis Rosmainar; Karelius -; Angeline Novia Toemon; Idam Sulastri
Jurnal Farmasi Udayana Vol. 11, No. 1, Tahun 2022
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2022.v11.i01.p03

Abstract

Antibacterial activity of hand sanitizer based on liquid smoke from torrefaction of palm oil against Escherichia coli has been done. The liquid smoke produced from the oil palm shell torrefaction process has the potential to be used as an antiseptic base for hand sanitizer products. This is due to its high phenol and acetic acid content. Many other compounds must be separated from liquid smoke, one of the processes that can be separated with distillation. Compounds of liquid smoke from distillation are phenol, propanoic acid, 2-propanone, and acetic acid. This research was conducted by varying the concentration of liquid smoke in a hand sanitizer by 15%, 25%, and 35%. The results showed that the number of bacterial colonies at a concentration of 15% was 910,000 CFU/ml, 25% was 1,130,000 CFU/ml, and 35% was 1,140,000 CFU/ml. The effective concentration to kill bacteria is in hand sanitizer based on liquid smoke with a concentration of 15% was 57,59%. Keywords: palm kernel shells, liquid smoke, Escherichia coli
Cover JFU 2022-11-01 jfu jfu
Jurnal Farmasi Udayana Vol. 11, No. 1, Tahun 2022
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

cover JFU 2022-11-01
Formulasi Sediaan Lipstik Menggunakan Ekstrak Kulit Buah Naga Merah (Hylocereus Costaricensis) Dengan Kombinasi Beeswax dan Paraffin Wax Yahya Febrianto; Fifi Nur Apriliani
Jurnal Farmasi Udayana Vol. 11, No. 1, Tahun 2022
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2022.v11.i01.p04

Abstract

Limbah kulit buah naga merah (Hylocereus costaricensis) mengandung pigmen antosianin yang dapat dimanfaatkan sebagai pewarna lipstik alami dan dalam pembuatan lipstik dapat memberikan kelembaban pada bibir serta memiliki kesan warna pada bibir, terasa lembut dan tiddak kering dibibir. Penelitian ini bertujuan untuk mengetahui kombinasi basis paraffin wax dan beeswax yang memberikan formula dan mengetahui sifat fisiknya. Penelitian dilakukan secara experimental. Kulit buah naga merah (Hylocereus costaricensis) diformulasikan dengan membandingkan basis paraffin wax dengan formulasi masing-masing formula memiliki % konsentrasi yang berbeda yaitu 15%, 12.5%, 10%, 7.5%, 5% dan beeswax dengan formulasi masing-masing formula memiliki % konsentrasi 5%, 7.5%, 10%, 12.5%, 15% menjadi sediaan lipstik. Hasil uji bobot lipstik rata-rata 4,88-4,87g, dan uji pH diperoleh nilai rata-rata 5-6. Hasil analisis data pada bobot lipstik data normal dan homogen dilanjutkan dengan uji ANOVA pada bobot awal di peroleh nilai p ? 0,05 yang berarti ada perbedaan signifikan antar formula, dan pada bobot hari ke-7 diperoleh nilai p ? 0,05 yang berarti tidak ada perbedaan signifikan antar formula. Hasil analisis data pada ph data normal dan homogeny dilanjutkan dengan uji ANOVA di peroleh nilai p ? 0,05 yang berarti ada perbedaan signifikan antar formula.
Penetapan Kadar Astaxanthin Dalam Cincalok Yang Difermentasi Siti Nani Nurbaeti; Aulia Faradilla; Hadi Kurniawan; Inarah Fajriaty; Fajar Nugraha
Jurnal Farmasi Udayana Vol. 11, No. 1, Tahun 2022
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2022.v11.i01.p06

Abstract

Cincalok merupakan makanan tradisional khas Kalimantan Barat yang dibuat dari proses fermentasi dengan bahan dasar udang rebon. Udang rebon memiliki kandungan senyawa karotenoid, yaitu senyawa astaxanthin yang dikenal memiliki manfaat sebagai antioksidan. Pada penelitian ini dilakukan analisis kandungan senyawa astaxanthin dalam udang rebon yang telah difermentasi menjadi cincalok. Udang rebon diambil dari Desa Mendalok, Sungai Kunyit, Kalimantan Barat. Tujuan penelitian ini untuk mengetahui kadar senyawa astaxanthin dalam cincalok yang telah difermentasi selama 1 minggu dan 2 minggu. Ekstraksi cincalok 1 minggu dan 2 minggu masing-masing dibuat sebanyak 3 batch dengan metode maserasi menggunakan pelarut aseton selama 3 hari berturut-turut. Ekstrak yang diperoleh kemudian dilakukan pengukuran kadar senyawa astaxanthin dengan metode spektrofotometri UV-Vis pada panjang gelombang visibel (477 nm). Hasil kadar astaxanthin yang diperoleh tiap 100 g berat basah cincalok yaitu 3,292 mg (cincalok fermentasi 1 minggu) dan 0,920 mg (cincalok fermentasi 2 minggu).
INVENTARISASI TUMBUHAN OBAT TRADISIONAL SEBAGAI UPAYA SWAMEDIKASI OLEH MASYARAKAT SUKU TORAJA KABUPATEN TORAJA UTARA Hasria Alang; Ester Ayu; St. Rahmadani
Jurnal Farmasi Udayana Vol. 11, No. 2, Tahun 2022
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2022.v11.i02.p05

Abstract

The Toraja people have been using plants as medicine for their health since time immemorial, but the tribal medicinal plant inventory has never existed. The results of this study are expected to add references to plant species that can act as traditional medicines so that this knowledge can be known by future generations, and can also contribute knowledge, so that research related to traditional medicines for public health can continue to be developed. This study aims to determine the types of medicinal plants, the parts used, and how to process these medicinal plants. This research was conducted in six six villages namely Rura Village, Penanian Village, Singki' Village, Pasele Village, Karassik Village, and Saloso Village, in Rantepao District. The method used is a survey, data collection through interviews and observations. Data analysis was done descriptively. The results of the study found that there were 20 types of medicinal plants used by the Toraja people in Rantepao District as traditional medicines. Most types of medicinal plants come from the Zingiberaceae and Euphorbiaceae families. The most widely used medicinal plant part is the leaf, and the least part is the fruit flesh. The processing of medicinal plants is done by boiling, mashing and sticking them, and eating them directly. Conclusion: Toraja people in the study area use plants as traditional medicine

Page 29 of 33 | Total Record : 322

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