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MNJ (Malang Neurology Journal)
Published by Universitas Brawijaya
ISSN : 24076724     EISSN : 24425001     DOI : -
Core Subject : Science,
Neuroscience
Malang Neurology Journal is a peer-reviewed and open access journal that focuses on promoting neurological sciences generated from basic neurosciences and clinical neurology. This journal publishes original articles, reviews, and also interesting case reports. Brief communications containing short features of medicine, latest developments in diagnostic procedures of neurology disease, treatment, or other health issues related to neurology that is important also acceptable. Letters and commentaries of our published articles are welcome.
Arjuna Subject : -
Articles 278 Documents
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THE EFFECTIVENESS OF INTERFERON BETA-1A IN MANAGEMENT OF MULTIPLE SCLEROSIS: A CASE REPORT Puspitasari, Vivien; Sutanto, Anyeliria; Pangestu, Aristo Rinaldi
MNJ (Malang Neurology Journal) Vol. 6 No. 2 (2020): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

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Abstract

Multiple sclerosis is a chronic autoimmune disease that attacks myelin in the central nervous system. About 2.5 million people worldwide have been diagnosed with multiple sclerosis. Its clinical presentation could vary according to the location of the lesion. Interferon beta is the most commonly used as immunomodulation therapy. However, its effectiveness for long-term use is still questionable. We report a case of 24-year-old woman with complaints of ataxia and limb weakness which were diagnosed as multiple sclerosis relapsing remitting (MSRR) and treated with interferon beta 1a for five years. During routine interferon beta 1a treatment three times a week, patient has still experienced four episodes of relapse in spite of good compliance. Hence, the rare presence of neutralizing antibodies was suspected. It commonly occurs after a year of interferon therapy, which is consistent with the patient’s treatment history. Further biomarker testing of drug-specific antibodies might be valuable to find out the possibility of interferon resistance
LOW TOTAL CHOLESTEROL SERUM LEVELS AS A POOR OUTCOME PREDICTOR FOR INTRA-CEREBRAL HEMORRHAGE STROKE Ariswanda, I Gusti Agung Gede; Adnyana, I Made Oka; Widyadharma, I Putu Eka; Nuartha, A A B N; Laksmidwei, A A A Putri; Arimbawa, I Komang
MNJ (Malang Neurology Journal) Vol. 6 No. 2 (2020): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

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Abstract

Background: Stroke is affected by several factors, age, infection during treatment, obesity, and total cholesterol (TC) levels.  Objective: The study aimed to prove low TC serum levels as an unfortunate outcome predictor for intracerebral hemorrhage stroke. Methods: This study is a prospective cohort design. The research did in the Stroke Unit of Sanglah Hospital, Denpasar, from July 1st, 2018 to January 31th, 2019. The study involved patients with hemorrhage strokes with low TC serum levels and aged 40-95 years. Depending on variable divided into two groups with low TC serum levels (<180 mg/dL) and normal TC serum levels (>180mg/dL). Independent variable is The National Institutes of Health Stroke Scale (NIHSS) as an outcome. The processing of data analysis using Mac for SPSS version 23. Result: This study used 70 subjects. The age characteristics of the study subjects with a median value of 62 years in for low TC levels, and 57 years for normal TC levels, dominant in male (60% ), working (71.5%), not obese (58.6%), stroke-related infections (51.4%), and mean arterial blood pressure (MABP) £130mmHg (90%). Subjects with low TC had a risk of 64 times experiencing adverse outcomes (RR = 64: CI 95% = 14.06-291.32: p <0.001). Multivariate analysis showed a low TC serum level as an independent variable.Conclusion: Low TC serum levels as an independent predictor having a poor outcome in intracerebral hemorrhage stroke
ASTROCYTOMA OF THE BRAIN AND OPHTALMOLOGICAL SIGNS Yurievna, Safonenko Alexandra; Eduardovna, Ioyleva Elena
MNJ (Malang Neurology Journal) Vol. 6 No. 2 (2020): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

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Abstract

Background: The central nervous system neoplasms frequency is 1 per 1700 children aged from 0 up to 15 years old. The problem of the early diagnostics has not been solved yet. The recognition of the pathology, especially in childhood and adolescence is considerably difficult and affects the patient’s life prediction and quality.Objective: To reveal the value of ophthalmological signs in the diagnosis of astrocytoma of the brain.Methods: The young man with the only complaint of the binocular horizontal diplopia during the last year. One month prior to the visit, the patient lost his consciousness. Standard ophthalmic examination, optical coherence tomography (Cirrus HD-OCT), computer perimetry (Humphrey), MRI of the head on (Siemens symphony) with contrast were carried out.Results: Visual acuities were 20/20 for both eyes, an outward motions limitation of both eyes, the presence of paracentral and peripheral scotomas in computer perimetry, the reduction of the visual evoked potentials, pallor of the optic disk, thinning of the nerve fiber layer and ganglion cell on OCT. MRI with contrast revealed the existence of large tumor with a with clear, hilly contours compressing the brain stem. After confirming the presence of a large tumor size, signs of development of occlusal internal and external hydrocephalus, compression of brain stem with the development of life-threatening condition, the patient was referred for neurosurgical consultation. According to the urgent indications the surgical resection of the intracerebral tumor was performed. Biopsy result: pilocytic astrocytoma of the fourth ventricle region.Conclusion: Thus, in the absence of specific cerebral and focal neurological symptoms, the appearance of oculomotor disorders, defects in field of vision and fundus changes can be decisive factors in establishing an accurate diagnosis and timely referral of the patient to a neurosurgeon.
THE RELATIONSHIP BETWEEN WORKING PERIOD OF BATIK CRAFTSMEN AND INCIDENT OF CARPAL TUNNEL SYNDROME Subandi, Subandi; Mirawati, Diah Kurnia; Putra, Stefanus Erdana; Hafizhan, Muhammad; Susilo, Wahyu Agung; Danuaji, Rivan
MNJ (Malang Neurology Journal) Vol. 6 No. 2 (2020): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

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Abstract

Background: Carpal Tunnel Syndrome (CTS) is the most common mono-neuropathy caused by median nerve entrapment on the wrist. Major risk factor of the CTS is repetitive use of the hand, whether from occupational activities or hobbies. One of the most frequent occupation affected with CTS is the batik craftsmen.Objective: To investigate the relationship between working period of batik craftsmen with the incident of CTS at Kampung Batik Tulis Laweyan.Methods: Participants of this cross-sectional study were 30 batik craftsmen from Kampung Batik Tulis Laweyan who met the inclusion and exclusion criteria. They were classified into two groups based on working period (less or more than five years), clinically examined, and underwent the Nerve Conduction Velocity studies. Bland's classification was administered for grouping the nerve injury. Spearman correlation test was performed to investigate the correlation between working period and incident of CTS.Results: There was a significant medium positive correlation between working period and nerve injury based on Bland’s classification (r=0.559; p=0.013). While the chief complaints were also correlated with the working period, the association was not statistically significant (p=0.355).Conclusion: This research suggests an association between the incident of CTS and longer working period in batik craftsmen.
EXERCISE PREVENTS AGE-RELATED MEMORY DECLINE: THE ROLE OF NEUROTROPHIC FACTORS Rivarti, Arina Windri; Herawati, Lilik; Hidayati, Hanik Badriyah
MNJ (Malang Neurology Journal) Vol. 6 No. 2 (2020): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

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Abstract

Increasing aging population causes an increased prevalence of neurodegenerative diseases such as dementia that is associated with memory decline. Developing strategies for the prevention and therapy of age-related dementia is important to reduce the burden of treatment costs. Physical exercise is known to prevent cognitive decline and improve cognitive abilities. Physical exercise with moderate intensity for at least 150 minutes/week or 30 minutes/day for 5 days can reduce the incidence of degenerative diseases in the elderly. Thus, physical exercise appears as a simple, inexpensive, and affordable non-pharmacological therapy for most people. The processes of neurogenesis and neuronal survival involve the role of neurotrophic factors including BDNF, IGF-1 and VEGF, which are the three main neurotrophic factors that are known to increase after exercise. Many publications discuss about these neurotrophic factors, but their mechanism of signals and changes related to aging and exercise have not been completely studied. The purpose of this review is to discuss the mechanism of signals and changes of neurotrophic factors (focuses on BDNF, IGF-1, and VEGF) related to aging and exercise.
MUCOPOLYSACCHARIDOSES: PSYCHOSOCIAL VULNERABILITY OF FAMILY CAREGIVER Castañeda-Ibáñez, Nolly Nataly; Campos-Sánchez, Marcela
MNJ (Malang Neurology Journal) Vol. 6 No. 2 (2020): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

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Abstract

Background:  The majority of caregivers are family members and within the symptoms that the caregiver may present, there are manifestations of stress, psychological state of overload, stress or discomfort caused by the continuous provision of care for the family member, feelings and negative perceptions regarding their caring function.Objective: The purpose of this research is to study the psychosocial vulnerability of family caregivers of patients with Mucopolysaccharidoses (MPS).Methods: This study is based on a mixed method with a cross sectional and a descriptive approach. The first stage was quantitative and the second stage was qualitative, both of them to explore the psychosocial vulnerability of a group of family caregivers of patients (n=111) with MPS belonging to the Colombian association of patients with lysosomal storage diseases ACOPEL by its acronym in Spanish. This study collects quantitative data using the patient admission request format from ACOPEL, employed to obtain relevant sociodemographic variables: Gender, Age, Marital status, Education, Occupation, living area, type of housing, live with, socioeconomic stratum, monthly income and time spent as a caregiver. And this study collects qualitative data using a structured interview held to psychologists and healthcare professionals belonging to ACOPEL.Results: The results show that most of them are women, relatives in a relationship or married; most of them belonging to a low socioeconomic stratum and a low professional education. The categories of analysis revealed were the attitude is towards illness, taking account diagnosis and health staff, support networks and psychoeducation. Secondly, the impact of care work on the physical and psychological health of female caregivers. Third, coping resources and finally the double mother role-caregiver and her emotional bond with the patient.Conclusion: In conclusion, the attitude and knowledge towards the disease depend on the diagnosis and the prognosis according to the type of MPS. It is important more research the psychosocial aspects and vulnerability of family caregivers in patients with MPS to develop evidence-based knowledge, psychoeducation, and, appropriate interventions.
PATTERN OF ANTI EPILEPTIC DRUG ADVERSE EFFECT IN TERTIARY REFERRAL HOSPITAL Damayanti, Ria; Husna, Machlusil; Mondiani, Yeni Quinta; Kurniawan, Shahdevi Nandar
MNJ (Malang Neurology Journal) Vol. 6 No. 2 (2020): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

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Abstract

Background: Epilepsy is a major chronic neurological problem in the world. The goal of epilepsy therapy is seizure-free and without side effects. The emergence of side effects in patients with epilepsy will be its limitations that can cause the failure of epilepsy therapy. Therefore, it is necessary to do a simple descriptive study, which illustrates the pattern of side effects of anti-epileptic drugs that occur in people with epilepsy, so that later clinicians are more alert and can take preventative measures.Objective: Knowing the pattern of side effects of antiepileptic drugs at the Neurology Outpatient Clinic dr. Saiful Anwar hospital.Methods: This research is an observational descriptive study. Samples were taken by filling the questionnaire at the Neurology Outpatient Clinic dr. Saiful Anwar hospital. Demographic data in this study will be presented in the frequency distribution table. Chi Square test is used to determine the relationship of demographic data, also the pattern of therapy with the side effects that arise.Results: 93 epilepsy patients were involved in the study. More than 40% of patients experience side effects. The most common side effects appear in idiopathic epilepsy (30.1%). Based on the duration of epilepsy, the most side effects appear in epilepsy duration> 10 years (17.2%). However, from the results of the influence test using chi square, there was no significant difference between the duration of epilepsy with the appearance of side effects, even the type of epilepsy (p-value> 0.05). 28 patients who experience side effects, appear after the duration of use of AED 1 - 5 years. It was found that the duration of AED uses affected the emergence of side effects (p-value <0.05).Conclusion: Side effects occur in patients taking anti-epileptic drugs, and are related to the duration of drug use. This data can be used to increase the awareness of clinicians related to the emergence of side effects in patients who consume AED.
EFFECTIVITY OF NINTENDO WII AS REHABILITATION THERAPY IN POST STROKE PATIENTS: A SYSTEMATIC REVIEW Wardani, Rachmawati; Salsabila, Sirin; Rahman, Arizal Novrianto; Rakhmatiar, Rodhiyan
MNJ (Malang Neurology Journal) Vol. 7 No. 1 (2021): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2021.007.01.11

Abstract

Post stroke patients need medical rehabilitation to live an independent life. Nintendo Wii technology presents an alternative choice that is quite safe, feasible, and has a high potential in rehabilitating & restoring motor function in post stroke patients. Although it has been widely used as adjunct therapy in stroke rehabilitation facilities throughout the world, only a few acknowledge its effectivity in post-stroke patients. This study aims to conduct a systematic review in order to identify and assess the results used in evaluating Nintendo Wii technology as rehabilitation therapy for stroke patients. Thus, the study used for this research is systematic review. Materials included in this study are research/studies found in NCBI, PubMed, Cochrane and other relevant online databases. From this research, it is found that Virtual Reality (VR) such as Nintendo Wii considered as an additional rehabilitation therapy that provides a significant improvement in various aspects of exercise therapy, such as; balance; walking ability; statistical and dynamic strengths; motivation as well as socialization; and recovery of physical function in stroke patients. Nintendo Wii can also be used safely in stroke patients and there have been no reports of side effects from this therapy.
CRANIAL ULTRASOUND: EFFICIENT SCREENING TOOL FOR EARLY DETECTION OF BRAIN INJURY IN PRETERM INFANTS Erawati, Dini Rachma; Yueniwati, Yuyun
MNJ (Malang Neurology Journal) Vol. 7 No. 1 (2021): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2021.007.01.2

Abstract

Background: Cranial ultrasound becomes an important diagnostic tool to evaluate brain injury in infants. Brain injury is a major complication for preterm birth. The brain injury of preterm infants differs from that of a term infant. Brain injury has correlation with gestational age and mode of delivery.Objective: To analyze the correlation between cranial ultrasound findings with gestational age and mode of delivery and to reveal if cranial ultrasound can be used to detect brain injury in premature infants.Methods: An observational analytic study using cross-sectional design took place in Saiful Anwar Hospital Malang, Indonesia. 38 healthy preterm infants underwent cranial ultrasound examination within the first four day of life. Fisher Exact test was used to analyze the correlation between cranial ultrasound findings with gestational age and mode of delivery.Results:  Most of  the healthy preterm infants (89.5%) were  ≥ 32 weeks gestational age, and 52.6% of samples had caesarean section as their mode of delivery. There were three abnormal findings in cranial ultrasound; increased periventricular echogenic (5.3%), increased parenchym echogenic (5.3%), and indistinguishable of gray-white matter differentiation (5.3%). There was no significant correlation between abnormal cranial ultrasound findings with gestational age and mode of delivery (p= 0.202; p= 0.218).Conclusion: There were abnormal cranial ultrasound findings in some healthy preterm infants despite no significant correlation between ultrasound findings with gestational age and mode of delivery. Cranial ultrasound in preterm infants could become a screening tool for early detection of brain injury.
ALPHA-PINENE ATTENUATES MICROGLIAL NF-ΚB ACTIVATION AND INOS EXPRESSION IN GP120-INDUCED NEUROINFLAMMATION Rahayu, Masruroh; Widodo, M Aris; Lyrawati, Diana; Widjadjanto, Edi
MNJ (Malang Neurology Journal) Vol. 7 No. 1 (2021): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2021.007.01.16

Abstract

Background: Neuro-inflammation plays a role in the pathogenesis of HIV-associated dementia (HIV). Activation of microglia is essential for triggering inflammatory-mediated neurotoxicity. HIV-1 120 kDa envelope glycoprotein (gp120) induces microglial NF-κB signaling which in turn induce pro-inflammatory and iNOS gene transcription. Continuous or excessive activation of NF-κB signaling lead to persistent production of TNF-α and nitric oxide by microglia and induce neuronal apoptosis. Alpha-pinene is a natural substance found in pine tree and has efficacy on inhibiting NF-κB signaling.Objective: This study was designed as a true experimental study and aimed to investigate the effect of alpha-pinene administration toward inflammatory response represented by the percentage of microglia containing activated NF-κB and iNOS expression.Methods: Neuron-glia primary culture from brain tissue of rat fetus was divided into 5 groups as follows: negative control; positive control (gp120 1nM); treatment I, II, and III (gp120 1 nM + alpha-pinene 0.4 µg/mL, 2 µg/mL, and 10 µg/mL, respectively). Microglial NF-κB and iNOS expression were analyzed using immunohistochemistry method. Neuronal apoptosis was measured by TUNNEL method.Results: Result showed that alpha-pinene administration on gp120-treated neuron-glia at all dosages decrease NF-kB activation, iNOS expression, and apoptotic neuron significantly as compared to the gp120-only treated group (p<0.05). Furthermore, alpha-pinene did not affect NF-kB activation and neuronal apoptosis (p>0.05), but significantly elevate iNOS expression (p<0.05) mainly in dosage I and II.Conclusion: We concluded that alpha-pinene has neuroprotective effect on gp120-treated neuron-glia cells through modulation of NF-kB and iNOS expression thus inhibit neuronal apoptosis.

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