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MNJ (Malang Neurology Journal)
Published by Universitas Brawijaya
ISSN : 24076724     EISSN : 24425001     DOI : -
Core Subject : Science,
Neuroscience
Malang Neurology Journal is a peer-reviewed and open access journal that focuses on promoting neurological sciences generated from basic neurosciences and clinical neurology. This journal publishes original articles, reviews, and also interesting case reports. Brief communications containing short features of medicine, latest developments in diagnostic procedures of neurology disease, treatment, or other health issues related to neurology that is important also acceptable. Letters and commentaries of our published articles are welcome.
Arjuna Subject : -
Articles 278 Documents
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MEASUREMENT OF MIDSAGITTAL CORPUS CALLOSUM AREA WITH THE MODIFIED CAVALIERI METHOD IN HEALTHY RIGHT- AND LEFT-HANDED TURKISH ADULTS Ozdikici, Mete
Malang Neurology Journal Vol 6, No 1 (2020): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2020.006.01.5

Abstract

Background: Numerous studies have been published on the anatomy and physiology of the corpus callosum (CC). There are many contradictory studies in the literature about the changes in the size of the CC by handedness, sex, and age.Objective: This study was carried out to examine the morphometric influence of these factors (handedness, sex, and age) on the CC in healthy Turkish adultsMethods: Two hundred thirty-seven normal individuals, 101 males, and 136 females, divided into 5 age groups (20-29, 30-39, 40-49, 50-59, and 60-69) were subjected to magnetic resonance imaging (MRI) study of the brain. Of the 237 subjects, 27 males and 36 females were left-handed. Midsagittal corpus callosum area (CCA) was represented by the mean ± standard deviation of the age groups in square centimeters, and also comparisons of the right- and left-handed were also represented in Table 1. For statistical evaluation, the SPSS 15.0 was used. All statistical tests were set at a 95% confidence level (p<0.05).Results: The range of the reference values (mean values and standard deviation) for the performed measurements in the age groups and for men, women, and total are presented; and comparisons of the right- and left-handed were also represented in Table 1. In our study, CCA was found 6,46±1,05 cm2 in all men and 6,17±0,82 cm2 in all women. The values of CCA are 6,50±1,05 cm2 in right-handed men and 6,34±1,03 cm2 in left-handed men, 6,16±0,80 cm2 in right-handed women, and 6,19±0,91 cm2 in left-handed women. There is a statistically significant difference between males and females in CCA (p<0.05). There is no statistically significant difference between the age groups for CCA, and there is no difference between right- and left-handed for men and women (p>0.05) (Table 2).Conclusion: The results showed no statistical significance of the effect of age or handedness on the surface area of the CC. However, it was statistically significant that the size of men's CC was higher than that of women.Keywords:  Midsagittal corpus callosum area, modified Cavalieri method, handedness, Turkish adults, magnetic resonance imaging.
CLINICAL AND RADIOLOGIC APPROACH TO PROBABLE MIXED DEMENTIA (VASCULAR DEMENTIA AND PROGRESSIVE SUPRANUCLEAR PALSY) Lastri, Diatri Nari; Alwahdy, Ahmad Sulaiman
Malang Neurology Journal Vol 6, No 1 (2020): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2020.006.01.10

Abstract

Dementia as a global burden neurodegenerative disease need to be diagnosed as earlier as possible then treated accordingly. The varying aetiologies of dementia render specific diagnosis of dementia challenging. Other than clinical syndromes, cognitive function examination and neuroimaging are also important to determine the correct dementia diagnosis. This paper aims to provide a dementia case where the working diagnosis could not be decided at once and to show how cognitive function examination and neuroimaging are essential to determine the diagnosis. This paper reports an 80-year old male with dementia symptoms that was followed and regularly examined for one year. With time, additional neurological symptoms were observed thus the working diagnosis was established. The patient was diagnosed with mixed dementia that consisted of probable vascular cognitive impairment and probable progressive supranuclear palsy.
HISTOLOGICAL ANALYSIS OF WISTAR RATS SCIATIC NERVES SUBJECTED TO COMPRESSION AND TREATED WITH LOW LEVEL LASER THERAPY AND NEURAL MOBILIZATION Antunes, Juliana Sobral; Karvat, Jhenifer; Bernardino, Giovanni Ribeiro; Kakihata, Camila Mayumi Martin; Brancalhão, Rose Meire Costa; Ribeiro, Lucinéia de Fátima Chasko; Aragão, Fernando Amâncio; Bertolini, Gladson Ricardo Flor
Malang Neurology Journal Vol 5, No 2 (2019): July
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2019.005.02.1

Abstract

Background: The physical therapy resources, as Low-Level Laser Therapy (LLLT) and neural mobilization are usually used with regenerative purpose and for the relief of symptoms for peripheral nerve injury. However, there is a lack of consensus on its effects as well as its association. Objective: Evaluate the influence of low-level laser therapy (LLLT) associated with neural mobilization (NM) on nerve regeneration of female Wistar rats subjected to sciatic compression. Methods: Twenty four Wistar rats were divided into: G1 (Placebo), G2 (NM), G3 (LLLT) and G4 (NM+LLLT), all animals were subject to compression of the right sciatic nerve. The treatment occurred on the 3rd, 5th, 7th, 10th, 12th and 14th postoperative day (PO). On the 17th PO the animals were euthanized. Histological and morphometric analysis of the right (compression) and the left (control) sciatic nerve were performed.Results: In the morphometric analysis no significant differences between groups, but differences among sides were found. Histological analysis revealed the presence of inflammatory infiltrate and disruption of nerve fibers in the right sciatic nerves.Conclusion: Both techniques used (LLLT and neural mobilization), isolated and associated, on the parameters proposed, were not effective to accelerate the process of nerve regeneration.
PROFILE OF TYPE 2 DIABETES MELLITUS IN ACUTE THROMBOTIC STROKE Jordan, Danny Randy; Islamiyah, Wardah Rahmatul; Prayitno, Jongky Hendro
Malang Neurology Journal Vol 5, No 2 (2019): July
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2019.005.02.6

Abstract

Background: Stroke is a brain disorder in blood circulation that occur suddenly and last more than 24 hours, which is one leading cause of death in the world. One of the main risk factors of stroke is diabetes mellitus type 2. One complication is that when thrombosis occurs in the brain causing a stroke.Objective: This study aimed to determine the profile of type 2 diabetes mellitus in patients with acute thrombotic stroke who were treated in the Neurology Department at the Hospital Dr. Soetomo.Methods: Sampling was done with purposive sampling by observing the medical records of patients in the period of January 2014 to December 2015 based on inclusion and exclusion criterias that havebeen set.Results: Women with a history of type 2 diabetes are more exposed to acute thrombotic stroke; the age group which is most at risk for stroke is between age of 56-60 years; the average duration of DM until the occurence of stroke is 6,54 ± 4,85 years; more than two-thirds of patients come to the hospital when the acute thrombotic stroke occurs with a condition of hyperglycemia; the most common comorbid disease is hypertension; and insulin therapy is the most widely used therapy in acute thrombotic stroke patients with type 2 diabetes.Conclusion: Managing the risk factors of stroke should prolong or prevent the incident of acute thrombotic stroke since most of the patients with type 2 diabetes mellitus came to the hospital with a condition of hyperglycemia and hypertension.
FACTORS AFFECTING PROGNOSIS OF TUBERCULOUS MENINGITIS IN SAIFUL ANWAR GENERAL HOSPITAL MALANG Munir, Badrul; Prayudi, Firman; Setianto, Catur Ari; ., Siswanto
Malang Neurology Journal Vol 6, No 1 (2020): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2020.006.01.1

Abstract

Background. The mortality rate of tuberculous meningitis (TBM) is approximately 20-41%. The prognosis is influenced by clinical and radiologic features, laboratory findings, and therapy. Objective. To report factors affecting the prognosis of TBM patients in Saiful Anwar Hospital.Methods. The study design was a retrospective cohort with consecutive sampling. Data were taken from medical records of 47 patients from 2016-2017. The prognostic value used modified rankin scale showing good (0-2) and poor prognosis (3-6). The impact of clinical, radiological, and laboratory factors were investigated by univariate analysis and multiple logistic regression. Results. In this study, good (n=21) and bad (n=26) prognosis were compared. Patients with good prognosis experienced more episodes of seizure than poor prognosis (17% vs 4%; p = 0.011). Focal neurologic deficits was more prevalent in poor prognosis (4% vs. 23%, p = 0.012). Meningeal enhancement was more common in poor prognosis (21% vs 42%; p= 0.038). From multivariate analysis, we found that seizure and focal neurological deficit are independent prognostic factors (p=0.023 dan p 0.033).Conclusion. Clinical factors influencing prognosis of TBM in Saiful Anwar Hospital are seizure and focal neurological deficit. Focal neurological deficit is a poor prognostic factor. However, seizure is a good prognostic factor.  Keywords: prognostic factors, tuberculous meningitis
VITAMIN D LEVELS IN MULTIPLE SCLEROSIS Durmaz, Zeynep Hulya; Ayan, Durmuş; Demir, Aslıhan Dilara; Demir, Hatice Dörtok
Malang Neurology Journal Vol 6, No 1 (2020): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2020.006.01.6

Abstract

Background: Multiple Sclerosis is a  neurologic  disease that effect  Central Nervous System(CNS).  Vitamin D is a liposoluble prohormone. İt is thought that vitamin D deficiency is responsible for Lots of diseases which includes MS . In this study, we aimed to show the relationship between serum vitamin D level and MS.Objective: In our research  we wanted  to show the serum vitamin D levels in MS patients.Methods: We included 106 patients (76 female, 30 male)  to our study. Participants were divided into two groups as patient and control group. Serum vitamin D levels were evaluated.We excluded patients with known liver or renal disease. Liver enzymes and blood creatinine of the patients included in the study were normal.Results: There was a statistically significant difference when comparing two groups of serum vitamin D results. Serum vitamin D levels were lower in the control group. No correlation was found between vitamin D and age. There was no correlation between vitamin D and gender. According to the vitamin D level reference interval in the MS group, 28 patients had deficiency, 17 patients had failure, and 12 patients were normal. In the control group, according to the vitamin D level reference range, 35 patients had deficiency, 11 patients had failure and 3 patients were normal.Conclusion: In this study conducted with limited facilities, lower vitamin D levels in the control group suggested that vitamin D levels may be low when the population is examined in general. Vitamin D support throughout the population may reduce the prevalence of other diseases thought to be caused by vitamin D deficiency as well as MS.
HOXA GENE EXPRESSION IMPLICATED IN TREATMENT RESISTANCE AND POOR PROGNOSIS IN GLIOBLASTOMA Seidu, Naomi; Poluyi, Edward; Ikwuegbuenyi, Chibuikem; Morgan, Eghosa
MNJ (Malang Neurology Journal) Vol. 6 No. 2 (2020): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

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Abstract

This review brings into view the prognosis attributable to glioblastoma (GBM) and resistance to treatment, surgical interventions and chemotherapy seem ineffective at procuring a better prognosis for patients with the disease. Albeit there exist varying interventions for GBM, the median survival still comes to 12 to 15 months for afflicted patients, this has aroused the need for improvement in treatment success The principal goal is to create a better prognosis and have a decline in treatment resistance invariably leading to better survival rates via adequate treatment for GBM. A relationship exists between HOX genes (homeobox genes) and glioblastoma as is evident from literature. Treatment resistance has been observed in overexpression of HOX genes, the effectiveness of treatment could result from silencing these genes A series of studies have highlighted the role that HOX genes play in glioblastoma prognosis. Promotion of human glioblastoma initiation, aggressiveness, and resistance to Temozolomide has been associated with HOXA9 as shown by Pojo et al. The role of HOX gene expression in cancer stem cells should be studied as it could provide a means of designing CSC-targeted therapies, as CSCs play a part in initiation and progression of solid tumors.
NEUROLOGICAL MANIFESTATION ON HOSPITALIZED PATIENT WITH PROBABLE COVID-19 IN SAIFUL ANWAR HOSPITAL INDONESIA (SERIAL CASES) Munir, Badrul; Rianawati, Sri Budhi; Kurniawan, Shahdevi Nandar; Santoso, Widodo Mardi; Arisetijono, Eko; Candradikusuma, Didi; Heri, Sutanto; Chozin, Iin Noor; Dwi, Pratiwi Suryanti; Astuti, Tri Wahju; Asmiragani, Syaifullah
MNJ (Malang Neurology Journal) Vol. 6 No. 2 (2020): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

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Abstract

Background: Coronavirus disease 2019 (Covid-19) caused by SARS-Cov-2 had been spreading worldwide including Indonesia, but In Indonesia, it was difficult to diagnose confirmation Covid-19 by Polymerase Change Reaction (PCR). and in clinical practice to treat covid-19,  Indonesia Health Ministry use term probable covid-19 for patients under observation Covid-19, but study for neurological manifestation on  probable Covid-19 is very lacking.Objective: Knowing the neurological manifestation of patient probable Covid-19.Methods: Observational study from Covid-19 medical record and neuro-Covid-19 medical record of all probable Covid-19 hospitalized in the isolation ward of Saiful Anwar Hospital (RSSA) Malang since March-May, 2020 (3 months). Probable Covid-19 criteria were given by Covid-19 task force team based on Health Minister Indonesia criteria. This criterion was based on clinical manifestation (severe upper respiratory symptoms, or mild-severe pneumonia), radiologic examination (lung infiltrate and or chest CT scan), and laboratory examination. Neurological manifestation is based on clinical symptom appeared while patient hospitalized, supported with radiologic and laboratory data which was supervised by neurologist or neurologist resident. All data was inputted to neuro-Covid-19 e-registry on the smartphone application, sent periodically to the data center in Neurology Department RSSA Malang.Results: A hundred and fourteen probable Covid-19 was registered with mean age 34,5 year old and mostly at the young age of 20-50 years (38%). The neurological manifestation was observed in 4 patients (3,4% from all possible Covid-19 patients) with thrombotic stroke as the most common manifestation (50%), followed by myelum tumor (25%) and hypoxia encephalopathy (25%). Stroke patients in probable Covid-19 had old age (72 and 82 years) accompanied by several comorbid such as hypertension, DM and CVA history and Covid symptoms of cough, shortness of breath and fever. Hemiparesis was found improved with aspirin and neurotropic therapy. Patient with myelum tumor had a covid symptom of shortness of breath, cough, and fever with UMN tetraparesis. Previous MRI examination results suspected meningioma. The patient died while hospitalized. Patients with hypoxia encephalopathy admitted with decreased consciousness due to shortness of breath with acidosis respiratory symptoms (pH 7,22 ). This condition improved after oxygenation without focal neurologic deficit.Conclusion: Neurological manifestation in probable Covid-19 was 3,4% of all patients. The most common diagnosis was a thrombotic stroke, followed by myelum tumor, hypoxia encephalopathy, and mortality rate is 25%.
SUBJECTIVE WELL-BEING AND HEALTHY BEHAVIOR OF ELDERLY WITH DEMENTIA ALZHEIMER’S (A PHENOMENOLOGICAL STUDY) Pariama, Aprillia Mauren; Ranimpi, Yulius Yusak; Setiawan, Adi
MNJ (Malang Neurology Journal) Vol. 6 No. 2 (2020): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

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Abstract

Background: Dementia is a syndrome caused by decreased cognitive function due to aging, genetics, vascular disease and low physical and cognitive activities. Alzheimer's is the most common cause of dementia. Despite experiencing holistic changes in their lives, elderly with dementia Alzheimer's are entitled to well-being. Measurement of Subjective Well-being (SWB) is used to determine the well-being state of elderlies.Objective: The purpose of this study is to analyze the expression of Subjective well-being (SWB) and the healthy behavior of elderlies with dementia Alzheimer's.Methods: This study uses a qualitative phenomenological approach with a descriptive hermeneutics type. The data collection was done by in-depth interview techniques with the type of auto-anamnesis, observed, and family statements. The data analysis process was carried out in 3 stages (Verbatim, initial and focused coding, determination of categories were made in the form of themes). Data validity test used data triangulation techniques.Results: Participants in this study are 3 elderlies age 75 and 76 years who had mild dementia Alzheimer's. This condition affects participants ability in expressing their SWB and health behavior that are described in physical disorders, life satisfaction, satisfaction with important domains, positive influence, behavior change, treatment-seeking, and cognitive failure.Conclusion: Reported high subjective well-being is closely related to the low level of unpleasant emotions during their life journey. Healthy behavior is strongly influenced by knowledge, demographic factors, personal goals and values, social influence, and access to health services. Two participants managed to express SWB and healthy behaviors better than one participant.
PERCEPTION OF SEVERITY LEVEL AND DECISION MAKING OF FAMILY CORRELATION TOWARD DEPARTING INTERVAL OF ISCHEMIC STROKE PATIENT Rahmawan, Fajri Andi; Yueniwati, Yuyun; Suharsono, Tony
MNJ (Malang Neurology Journal) Vol. 6 No. 2 (2020): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

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Abstract

Background: Ischemic stroke is an emergency state condition of brain which needs immediate rescue so the sufferer will not get any injury or risk of death. Interval of departing period still becomes problem. Level of severity perception and process of decision making of family are factors correlated to interval of departing time of the patient to Emergency Department.Objective: The purpose of this research is to find out correlation of severity level perception and process of decision making of family to interval of departing time of patient suffering stroke to Emergency Department of Public Regional Hospital Blambangan Banyuwangi.Methods: The method of this research is quantitative with cross sectional approach by involving 113 respondents. The technique of sampling is purposive sampling. The instruments are interview and observation sheet. The data analysis is done by spearman test to find out the correlation between variables namely level of severity and process of decision making of family’s patient to interval of departing time.Results: Findings show that p value between perceptions of severity level to the interval is 0.000 and process of decision making of the family to the interval with p value = 0.000 < α 0.05 meaning that variable of severity level and process of decision making are correlated to interval of departing time.Conclusion: Nurses need to improve standard of stroke severity by determining half-body weakening symptom into severity of ischemic stroke then it is socialized to society and to let them know the importance of immediate transport to emergency department when ischemic stroke symptom is found

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