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INDONESIA
MNJ (Malang Neurology Journal)
Published by Universitas Brawijaya
ISSN : 24076724     EISSN : 24425001     DOI : -
Core Subject : Science,
Neuroscience
Malang Neurology Journal is a peer-reviewed and open access journal that focuses on promoting neurological sciences generated from basic neurosciences and clinical neurology. This journal publishes original articles, reviews, and also interesting case reports. Brief communications containing short features of medicine, latest developments in diagnostic procedures of neurology disease, treatment, or other health issues related to neurology that is important also acceptable. Letters and commentaries of our published articles are welcome.
Arjuna Subject : -
Articles 278 Documents
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EFFICACY OF SHORT TERM VIDEO EEG IN DETECTING PSYCHOGENIC NON-EPILEPTIC SEIZURES Parameswaran, Sajeesh; Vijayamma, Anil Kumar Thankappakurup; Pillai, Ananthanarayana Marthanda
Malang Neurology Journal Vol 5, No 2 (2019): July
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2019.005.02.3

Abstract

Background: Short term video Electroencephalography (SVEEG) is a non-invasive diagnostic procedure typically last for about 1-5 hours. SVEEG can be utilize to differentiate epileptic from Psychogenic Non-epileptic Seizures (PNES).
 Objective: To assess the yield of short term video EEG in detecting PNES.Methods: Retrospective analysis of short term video EEG in a tertiary level hospital. Patient history, provisional diagnosis, previous EEG and imaging reports were tabulated. Various short term video EEG findings like epileptiform abnormalities, PNES and other non-epileptic events were analyzed in detail. According to the provisional diagnosis formed two groups; Suspecting NEE and suspecting seizure disorders. Change in the provisional diagnosis after SVEEGs were also studied.Results: A total of 417 SVEEGs analyzed: 34(8.2%) patients developed events to suggest PNES, 16(3.8%) patients had other non-epileptic events; 96(23%) showed interictal epileptiform discharges,15 (3.6%) showed seizures and 90(21.6%) patients showed non specific EEG abnormalities. Around 60% SVEEGs were conclusive.Conclusion: A diagnostic event was recorded during SVEEG in majority of patients in the PNES group. SVEEG is a cost effective and useful diagnostic procedure; especially to identify non-epileptic events.
NEUROCYSTICERCOSIS IN SOLID ORGAN TRANSPLANTATION PATIENTS Wiwanitkit, Viroj
Malang Neurology Journal Vol 5, No 2 (2019): July
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2019.005.02.8

Abstract

The neurocysticercosis is an important neurological infection. It can be seen in several tropical countries. The neurocysticercosis can affect both healthy people and patients. The organ transplant patient can also get neurocysticercosis. Similar to general case, the neurocysticercosis in organ transplant patients might present with neurological presentation. The practitioner should include neurocysticercosis in differential diagnosis of unexplained neurological episode in any patients with solid organ transplantation.
COMPARISON OF THE EFFECTIVENESS OF THERAPY IN HYDRODISSECTION INJECTION USING ULTRASONOGRAPHY GUIDENCE BETWEEN NORMAL SALINE AND TRIAMCINOLONE IN CARPAL TUNNEL SYNDROME PATIENTS Santoso, Widodo Mardi; Rakhmatiar, Rodhiyan; Rakhmani, Alidha Nur; Sahidu, Muhammad Ghalvan
Malang Neurology Journal Vol 6, No 1 (2020): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2020.006.01.2

Abstract

Background: Carpal tunnel syndrome (CTS) is a peripheral nerve lesion because of the nontraumatic mechanism or a pressure or entrapment of the median nerve under the transverse ligament (flexor retinaculum). Hydrodisection is used for adhesiolysis to eliminate adhesion and release the median nerve from the retinaculum and connective tissue around it and avoid injury to the nerves. Objective: Compare the effectiveness of hydrodisection injection therapy using an ultrasound guide between normal saline and triamcinolone in patients with carpal tunnel syndrome.Methods: Experimental study was carried out in the outpatient clinic of the hospital Dr. Saiful Anwar Malang from August 2018 to October 2018. A total of 30 patients. All study subjects were subjected to NPS, FSS, SSS scoring compared to before and 4 weeks after injection of hydrodisection and compared the effectiveness of injection agents.Results: NPS before and after triamcinolone injection (sig 0.000; p <0.05), FSS (sig 0.020; p <0.05), and SSS (sig 0.001; p <0.05). NPS before and after injection of normal saline 0.9% NaCl  (sig 0.001; p <0.05), FSS (sig 0.005; p <0.05), and SSS (sig 0,000; p <0.05). NPS between triamcinolone injection results and normal saline 0,9% NaCl  (sig 0.341; p <0.05), FSS (sig 0.425; p <0.05), SSS (sig 0.350; p <0.05).Conclusion: There no significant difference between injection of hydrodisection USG guiding with triamcinolone and normal saline 0,9% NaCl to reduce symptom CTS. Both of injection hydrodisection USG guiding has more or less the same effectiveness in treatment of carpal tunnel syndrome.Keywords: CTS, Hydrodisection, NPS, FSS, SSS
PHYSICAL ACTIVITY AND SPORTS IN PATIENTS WITH EPILEPSY Odintsova, G.V.; Koloteva, A.V.; Lovyagina, A.E.
Malang Neurology Journal Vol 6, No 1 (2020): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2020.006.01.8

Abstract

Background: For many years, patients with epilepsy have been strongly advised to avoid sports and exercise, as it was believed that sporting activities can trigger seizures.Objective: To study the level of physical and sporting activity on the example of the patients of the Russian Epilepsy Center.Methods: The study includes 50 patients with a verified diagnosis of epilepsy. The survey has been conducted according to a specially developed questionnaire "Peculiarities of physical activity in patients with epilepsy", clinical and demographic study.Results: The average age is 29.6 years +/- 8.3. 57.2% of patients had restrictions on physical activity at school due to epilepsy. Motor activity was assessed as low by 12% of patients, as average — by 60%, as high — by 28%.Conclusion: Physical activity of patients with epilepsy remains insufficient due to medical and social restrictions. In most cases, physical activity and sports do not trigger seizures and worsening of the disease. Expansion of sports opportunities will improve social adaptation and reduce stigmatization with epilepsy. A differentiated approach to the definition of indications for sports and the engagement of a neurologist to determine contraindications are necessary.
EVALUATION OF THE CANADIAN CT HEAD RULE FOR ANALYZING DIAGNOSTIC ACCURACY IN PATIENTS WITH MINOR HEAD TRAUMA Kızılgöz, Volkan; Avcı, Sema; Sivrioğlu, Ali Kemal; Aydın, Hasan; Çetin, Türkhun; Kızılgöz, Berihat
Malang Neurology Journal Vol 5, No 2 (2019): July
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2019.005.02.4

Abstract

Background: Head computed tomography (CT) scans, which provide reliable information to assessor rule out neurological abnormalities and injuries, should be used judiciously to minimize radiation exposure and cost. Objective: The aim of this study was to evaluate the widely used Canadian CT Head Rule (CCHR) to determine the necessity of head CT scans in patients with minor head trauma.Methods: This retrospective study included 913 patients with head trauma who were admitted to Harakani State Hospital between June 2014 and December 2017. The patient data were reevaluated according to CCHR and compared with the radiological findings. Results: There were a total of 556 patients fulfilling the inclusion criteria with a male/female ratio of 2.95 and a mean age of 37 ± 4.24 years. The most common injury mechanism of head trauma wasmotor vehicle accidents. Chi square tests were applied for statistical calculations. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of the CCHR were 93%, 88%, 88%, 94%, and 90%, respectively.Conclusion: CCHR was highly useful for patients with minor head trauma who could benefit from head CT evaluation with high sensitivity and specificity.
THE SIDE EFFECTS OF CHEMOTHERAPY IN GLIOMA Raisa, Neila; Marhaendraputro, Eko Arisetijono
Malang Neurology Journal Vol 5, No 2 (2019): July
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2019.005.02.9

Abstract

The increasing number of people who survive in the long term because of the advanced of glioma therapy with chemotherapy causes more slowly emerging neurologic side effects. Currently, there were three medical treatments are approved by the FDA for the management of glioblastoma namely temozolomide, carmustine wafer, and bevacizumab. However, most of the traditional chemotherapy drugs have a target in cell proliferation and cause toxicity of healthy cells. The side effects of chemotherapy on central nervous systems are chemobrain, acute encephalopathy, leukoencephalopathy, cerebellar dysfunction, and spinal cord toxicity. In addition, severe chemotherapy side effects may also occur in the peripheral nervous system called Chemotherapyinduced peripheral neuropathic pain (CIPNP). The clinician should recognize the symptoms of those side effect in glioma patients who received chemotherapy.
COGNITIVE IMPAIRMENT AND DEPRESSION ARE THE MOST IMPORTANT RISK FACTORS FOR FRAILTY Hariyanti, Tita; Sunarti, Sri; Vistiandini, Seravina Ayu
Malang Neurology Journal Vol 6, No 1 (2020): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2020.006.01.4

Abstract

Background: Frailty is a condition that causes a decline or failure in homeostasis mechanism on older people resulting in increased susceptibility to stressor. The risk factors of frailty include: cognitive impairment and depression.Objective: To prove the relation between cognitive impairment and depression with frailty.Methods: This study is using cross-sectional approach. Samples are collected from 222 citizens from the elderly population of Malang using accidental sampling method. Variables measured in this study are frailty that is determined by Fried Criteria, cognitive impairment that is determined by MMSE score and depression status that is determined by GDS score.Results: The analysis result of relation between cognitive impairment and depression and frailty using the Spearman correlation test produces the value of p = 0,000 and the correlation coefficients for rare 0,500 and 0,508 respectively. Different levels of cognitive impairment and depression in the frail group compared to pre-frail and robust groups resulted in p = 0,000, whereas the level of cognitive impairment and depression in the pre-frail group compared to robust group yielding p values of 0.735 and 0.944 respectively.Conclusion: There is a relation between cognitive impairment and depression on frailty. There was a significant difference in the levels of cognitive impairment and depression in the frail group compared to the pre-frail and robust groups, whereas in the pre-frail group compared to robust group the levels of cognitive impairment and depression did not have a significant difference.
THE EFFECTS NEUROPROTECTION OF TELMISARTAN ON STROKE WITH HYPERTENSION Ernawati, Iin; Hidayati, Hanik Badriyah; ., Sumarno
Malang Neurology Journal Vol 6, No 1 (2020): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2020.006.01.9

Abstract

Stroke is the second deadly disease in the world after ischemic heart disease. According to data of RISKESDAS (Riset Kesehatan Dasar), stroke was the highest cause of death in Indonesia in 2013. Hypertension is the one of the most important risk factors for stroke. Hypertension therapy is done by modification and the use of antihypertensives. The antihypertensives used is Telmisartan which is a class of Angiotensin Receptor Blocker (ARB) that works by inhibiting bind to angiotensin II type receptors that is angiotensin II type 1 receptors (AT-1R) which directly make angiotensin II bind to AT-2R (angiotensin receptor type 2 receptors). Telmisartan has a neuroprotectant effect that works by inhibiting the appearance of inflammatory cytokines, production of ROS (Reactive Oxygen Species), PGE2 (prostaglandin E2) and NMDA (N-Methyl-D-Aspartate) activity. Telmisartan activates PPAR-gamma (PPAR-γ), which is very useful in carbohydrate and lipid metabolism which directly protect blood vessels. Telmisartan has the advantage of structure and pharmacokinetics that support the effects of nerve protection. Based on lipophilicity and chemical structure, Telmisartan easily penetrates the brain barrier and high affinity to PPAR-γ, supporting the effects of Telmisartan neuroprotection. Based on pharmacokinetic aspects, telmisartan has the advantage of having a rapid onset that ranges from 30-60 minutes, with T ½ (half life) elimination is 24 hours. T 1/2 elimination for up to 24 hours from Telmisartan is clinically beneficial to improve medication adherence.
THE PREDISPOSING FACTORS OF PIRIFORMIS SYNDROME: STUDY IN A REFERRAL HOSPITAL Siahaan, Yusak Mangara Tua; Ketaren, Retno Jayantri; Hartoyo, Vinson; Tiffani, Pamela
Malang Neurology Journal Vol 5, No 2 (2019): July
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2019.005.02.5

Abstract

Background: Piriformis syndrome is a neuromuscular condition characterized by hip and gluteal pain caused by abnormality of piriformis muscle. In clinical practice, this syndrome is usually misdiagnosed with other spinal disorders. There is no specific test in diagnosing piriformis syndrome, therefore by understanding the characteristics and predisposing factors, clinicians may be more aware in diagnosing this syndrome.
Objective: To investigate the characteristics and predisposing factors of piriformis syndrome.Methods: A descriptive study was conducted on patients with gluteal pain in a referral hospital. Diagnosis was established by block injection on piriformis muscle and showed clinical improvement afterwards. Demographic characteristics, predisposing factors, and physical examination were analyzed. The data is collected and processed by SPSS 20.0.Results: The total of 65 patients were evaluated, with a male to female ratio 1:3. As much as 47.7% of patients were > 60 years old. Average weight was 60 kg and BMI (Body Mass Index) was within normal range (58.9%). Most subjects were housewives (55.4%) and the majority of subjects had history of microtrauma such as sitting on rigid surfaces (36.9%), walking or running long distances (18.5%), and cross-legged sitting (10.8%). Average sitting per day was approximately 5 hours. In 56.9% of subjects, exercises were conducted. There was no history of back pain in 81.5% of subjects.Conclusion: Our study showed age and housewives characteristics differ with other studies. The most predisposing factors were history of microtrauma, female, age, and normal BMI.
CLINICAL APPROACH AND GUIDELINES FOR MANAGEMENT OF SEPSIS ASSOCIATED ENCEPHALOPATHY Trisnawati, Ayu; Munir, Badrul
Malang Neurology Journal Vol 5, No 2 (2019): July
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2019.005.02.10

Abstract

Septic associated encephalopathy (SAE) is simply define as an encephalopathy incidence that occurs in sepsis patients. Ironically this entity can increases the mortality rate. Importantly, the clinical presentations of this entity is vary ranging from malaise to coma condition. The central nervous system is susceptible to damage that caused by systemic inflammation including sepsis with complex pathophysiologies such as endothelial dysfunction, neurotransmitter imbalance, oxidative stress, mitochondrial dysfunction and apoptosis. In general, current management of SAE is similar with the management of sepsis incidence which includes infections management, maintaining tissue perfusion and symptomatic therapy to treat delirium and convulsions that may occur. Also, several studies continue to be developed including the use of corticosteroids, magnesium, antioxidants, and immunoglobulin. Early identification and appropriate initial handling significantly affect the output of the SAE patients.

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