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MNJ (Malang Neurology Journal)
Published by Universitas Brawijaya
ISSN : 24076724     EISSN : 24425001     DOI : -
Core Subject : Science,
Malang Neurology Journal is a peer-reviewed and open access journal that focuses on promoting neurological sciences generated from basic neurosciences and clinical neurology. This journal publishes original articles, reviews, and also interesting case reports. Brief communications containing short features of medicine, latest developments in diagnostic procedures of neurology disease, treatment, or other health issues related to neurology that is important also acceptable. Letters and commentaries of our published articles are welcome.
Arjuna Subject : -
Articles 278 Documents
DEPRESSION AND INTERNET GAMING DISORDER AMONG MEDICAL STUDENT IN MALANG, INDONESIA Kurnianingsih, Nia; Cahayani, Wike Astrid; Yudhantara, Dearisa Surya; Ratnawati, Retty
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.08

Abstract

Background: Medical education is widely regarded as a highly demanding curriculum that causes significant stress among students. Chronis stress generates depression and increase of internet gaming activity. Previous research examined the relationship between the length of time spent for internet gaming activity as well as grade point average (GPA) towards internet gaming disorder (IGD) among medical student in Malang Indonesia. The limited data on the frequency of depression and the association between depression with IGD among medical students calls for more research. Objectives: This study was purposed to analyse the prevalence of depression as well as its association with IGD among medical students in Malang, Indonesia. Methods: This descriptive and cross-sectional study involved 437 medical students who completed a set of self-report questionnaires. The questionnaires included sociodemographic data, Beck Depression Inventory (BDI) scale and Personal Internet Gaming Disorder-9 (PIE-). Descriptive and bivariate analyses were employed for statistical analysis. Results: Depression was identified among 37.99% students, with female being more likely to suffer from it. There were 59.64%, 34.94% and 5.42% correspondingly of students with mild, moderate, and severe depression. The rate of depression was highest among 1st year students. Poor GPA achievement was observed in 50.98% of students with depression. Students without internal motivation were more likely to have depression (57.14%). Surprisingly, depression was not linked associated with IGD (p=0.06). Conclusion: This study concluded a high prevalence of depression among medical students with various sociodemographic characteristics. Despite depression had no association with IGD, future research is necessary for evaluate the potential risk factor of depression among medical students.
EFFICACY OF REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION AS UPPER EXTREMITY MOTOR REHABILITATION THERAPY AFTER STROKE: A SYSTEMATIC REVIEW Purwandhono, Azham; Adji, Novan Krisno; Abrori, Cholis; Fatmawati, Heni; Habibi, Ali
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.12

Abstract

Background: The most frequent impairment following a stroke is the hemiparesis of the opposite-side upper extremity. Repetitive Transcranial Magnetic Stimulation (rTMS) is popular in research studies on upper extremity motor rehabilitation after stroke. Information regarding the onset of therapy, duration of therapy, and the type of rTMS in post-stroke upper extremity motor rehabilitation therapy is still spread in various journals, therefore researchers are interested in making this systematic review. Objective: This study aimed to assess the efficacy of rTMS for upper extremity motor rehabilitation after stroke, and had specific aims to compare different treatment timings and durations, as well as evaluating the effectiveness of high-frequency versus low-frequency rTMS. Methods: Literature search was conducted with multiple electronic databases, such as PubMed, ScienceDirect, Cochrane Library, and LinkSpringer. The boolean operator method will be used for the keywords and the synonyms were searched using the Medical Subject Heading (MeSH) database. Critical appraisal and Risk of biases were assessed for each study using The Joanna Briggs Institute (JBI) Critical Appraisal Tools. Data analysis in this systematic review are using descriptive analysis. Results: The included studies consisted of two types of rTMS with varying onset and duration of the therapy. The duration of rTMS therapy consists of 5-18 sessions. In the Upper Extremity Fugl-Meyer Assessment (UE-FMA) based study, High-Frequency (HF) rTMS had significant overall results when compared to sham, whereas Low-Frequency (LF) rTMS therapy still showed contradictory results. HF-rTMS therapy can be performed in acute, subacute, and chronic stroke phases. The duration of HF-rTMS therapy can be done with 5 or 10 sessions, but it still needs further research in order to determine the number of sessions that have the best efficacy. Conclusion: This study show HF-rTMS has better efficacy compared to LF-rTMS for upper extremity motor rehabilitation therapy after stroke.
COMPARISON OF EFFICACY BETWEEN EDARAVONE AND RILUZOLE COMBINATION THERAPY FOR PATIENT WITH AMYOTROPHIC LATERAL SCLEROSIS: A SYSTEMATIC REVIEW AND META-ANALYSIS Budianto, Pepi; Mirawati, Diah Kurnia; B, Benedictus; Tan, Kenneth; Hafizhan, Muhammad; Putra, Stefanus Erdana
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.13

Abstract

Background: Amyotrophic Lateral Sclerosis (ALS) is a fatal neuromuscular disease with a survival period of less than 5 years. Although the past decade has shown a major growth of interest in Edaravone research due to its superior efficacy, a growing number of research done on Riluzole combinations for ALS therapy. Objective: A systematic review is needed to compare the patient outcomes as shown in the ALS functional rating scale (ALSFRS-R) of Edaravone and Riluzole combinations. Methods: This research is a systematic review from PubMed, ProQuest, and Science Direct. The studies included were randomized controlled trials (RCT) and post-hoc analysis of RCT published from 2012 to 2023. This research included 16 studies (11 RCT studies and 5 post-hoc studies of RCT). The studies discussed the patient population, side effects, and ALSFRS-R scores. Results: Edaravone showed better efficacy than Riluzole combination in maintaining ALSFRS-R score with mean difference between Edaravone (MD=2.19, 95% CI: 0.42-3.96, p=0.02) and Riluzole (MD=1.67, 95% CI: -0.19-3.52, p=0.08). The meta-analysis showed heterogeneity in both Edaravone (I2=90%, p<0.00001) and Riluzole (I2=77%, p=0.004) studies. Conclusion: The results conclusively showed that Edaravone was more efficacious than the explored Riluzole combinations so far. Nevertheless, Riluzole-Masitinib showed promising results to be further explored.
COMPARISON OF FLAIR AND DWI MRI IMAGES IN ACUTE CEREBRAL ISCHEMIC STROKES Atalu, Abolfazl; Abbasi, Vahid; Sadeghieh-Ahari, Saeed; Mohammadi, Farnaz
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.06

Abstract

Background: Given the significance of the topic in the early identification of stroke symptoms through Magnetic Resonance Imaging (MRI) techniques. Objective: This study aimed to compare the result of fluid-attenuated inversion recovery (FLAIR) and diffusion-weighted imaging (DWI) MRI in the early detection of acute ischemic stroke in patients. Methods: This cross-sectional study was done n 100 patients with stroke who referred to Alavi hospital in Ardabil city during 2019. Demographic information including age, gender, place of residence, level of education was extracted from patient’s file. Finally, MRI of these patients who were imaged through DWI and FLAIR methods was included in the checklist and then analyzed by using independent t-test and chi-2 in SPSS version 21. Results: Among the patients studied, 70% were male, with an average age of 64.38 years. Additionally, 64% of the patients had a history of hypertension, while 39% were diagnosed with diabetes. The comparison of DWI and FLAIR results showed significant differences within the first 24 hours following the stroke event. Conclusion: The results showed that DWI method is better than FLAIR for early detection of stroke.
CLINICAL ASPECT OF NORMAL PRESSURE HYDROCEPHALUS: WHAT TO DO? A LITERATURE REVIEW Nazwar, Tommy; Bal’afif, Farhad; Wardhana, Donny; Riskiyana, Riskiyana; Agustina, Kartika; Panjaitan, Christin
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.14

Abstract

Normal pressure hydrocephalus (NPH) is a medical condition characterized by the enlargement of brain ventricles and associated clinical manifestations, including gait disturbance, cognitive impairment, and urinary incontinence. In many cases, NPH is often misdiagnosed or diagnosed late due to its symptoms closely resembling those seen in other neurological conditions. Therefore, a comprehensive understanding of the clinical characteristics of NPH is crucial. This article aims to present an in-depth literature review on the clinical aspects of NPH and offer valuable insights to clinicians regarding the appropriate approach to diagnosing and managing patients with NPH. Gait apraxia is usually the first symptom, followed by incontinence and cognitive impairment, particularly in attention and memory. The diagnosis of NPH follows specific criteria, classifying patients as "possible" or "probable." Imaging examinations, such as computed tomography (CT) scans and magnetic resonance imaging (MRI), are essential to assess ventricular size and identify radiological findings such as ventriculomegaly, disproportionately enlarged subarachnoid space hydrocephalus (DESH), callosal angle, temporal cornu enlargement, and white matter changes. NPH can be managed through conservative care, ventriculoperitoneal (VP) shunt surgery, and, in select cases, endoscopic third ventriculostomy (ETV). VP shunt surgery is the main surgical option, offering different valve choices such as fixed-pressure, programmable-pressure, and overdrainage prevention mechanisms. VP shunts have been shown to effectively relieve NPH symptoms, with lumbo-peritoneal (LP) shunts considered less favorable due to higher complications. ETV is a possibility for specific patients.
THE ROLE OF ETHANOL CONSUMPTION IN ALTERING VISUAL OUTCOMES IN METHANOL-INDUCED TOXIC OPTIC NEUROPATHY: A CASE COMPARISON I Nyoman Surya Ari Wahyudi; Vierlia, Wino Vrieda; Prayitnaningsih, Seskoati
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.17

Abstract

Methanol toxicity can cause a rapid onset of severe bilateral vision loss with prominent optic nerve head edema. This case report provides clinical manifestation of two similar acute cases of methanol induced toxic optic neuropathy with different visual outcome. The patients admitted to emergency room with weakness, headache, nausea, abdominal pain and blurred vision. Both patients drank the same bootleg alcohol 3 days before admission. The first case present worse clinical condition than the second case. Further history taking revealed the patient in second case had ingested ethanol 3 hours prior to the bootleg alcohol. Both patients were treated with hemodialysis, high dose of intravenous steroid and folic acid along with supportive therapies. Funduscopy examination and optic nerve head Ocular Coherence Tomography revealed worse edema in the first patient. On the first month follow-up, the visual acuity (VA) of the first case showed no significant improvement, while the second case revealed normal VA on both eyes. The better visual outcome in second case may caused by history of ethanol consumption which prevented more severe methanol toxicity, but further investigation may still be needed.
THE CORRELATION BETWEEN SLEEP QUALITY AND MEMORY FUNCTION IN MEDICAL STUDENTS Setyo Pambudi , Arif; Sahidu, Muhammad Ghalvan; Hunaifi, Ilsa
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.10

Abstract

Background: sleep is a physiological need for every human, including medical students. Studies have shown that poor sleep quality can lead to a decline in learning and memory abilities in medical students. The dual process theory explains that certain types of memory depend on common sleep conditions. This study aims to determine the association between sleep quality and short-term memory function, as measured by the digit span test, among medical students at the University of Mataram Objective: To determine the association between sleep quality and short-term memory function as measured by the digit span test among Medical Students at the University of Mataram. Methods: Observational analytic study with a cross-sectional design. The primary data included sociodemographic characteristics, Pittsburgh Sleep Quality Index, and the Digit Span Test. Data were analyzed using chi-square test and Fisher's exact test. Results: 62 participants were observed. Participants ranged from 18 to 23 years, with 42 students (67.7%) identified as female. 71% of the participants experienced poor sleep quality, while 29% reported good sleep quality. All 62 students showed normal performance in the forward digit span test. In the backward digit span test, 79% obtained normal results, while 21% performed abnormally. There is no relationship between sleep quality and short-term memory (p=0,739). Conclusion: sleep quality doesn’t influence memory function among medical students at the University of Mataram.
DIFFERENCES IN THE AMPLITUDE OF ACCOMMODATION BETWEEN CHILDREN WITHOUT DEVELOPMENTAL DISABILITIES AND CHILDREN WITH DEVELOPMENTAL DISABILITIES Karim, Muhammad Rico Abdul; Wulandari, Lely Retno; Dewi, Nadia Artha; Anandita, Nanda Wahyu
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.11

Abstract

Background: Accommodation is the eye's ability to change the refractive power of the lens, allowing objects to focus on the retina at different distances. The Amplitude of Accommodation (AoA) is the closest point at which the eye can focus and the distance between the far point and near point on the diopter scale. Children with developmental disabilities (CDD) are at a higher risk of encountering vision problems, including accommodation issues. Objective: This study aims to ascertain the disparity in Amplitude of Accommodation (AoA) results between children with developmental disabilities (CDD) and those without developmental disabilities (CWDD) Methods: This research constitutes an observational study with cross-sectional data, involving 44 subjects with developmental disabilities (CDD) and 44 subjects without developmental disabilities (CWDD). The participants were further categorized into 33 deaf children (DC) and 11 children with intellectual disabilities (CID). The data were obtained from eye examinations conducted at several special schools and orphanages in the city of Malang. The examinations covered the right eye (OD), left eye (OS), and binocular vision (ODS). Results: Significant differences were identified among groups in OD (P<0.001), OS (P<0.001), and ODS (P<0.001). To assess the specific variations between groups, a Bonferroni post-hoc test was conducted. The results indicated significant differences between CWDD and DC in both OD (P<0.001), OS (P<0.001), and ODS (P<0.001). Additionally, significant differences were observed between CWDD and CID in OD (P=0.002), OS (P=0.005), and ODS (P<0.001). Conclusion: It can be concluded that there is a significant difference in the average AoA value between CWDD and CDD, both CWDD-DC and CWDD-CID.
BENEFICIAL EFFECTS OF ANTHOCYANINS ON NEUROCOGNITIVE FUNCTIONS: A SYSTEMATIC REVIEW Suryantari, Sang Ayu Arta; Masnathasari, NM Ayu; Sugiritama, I Wayan; Linawati, NM; Widianti, IGA
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.15

Abstract

Background: Increased research interest in natural compounds from plant has been reported to show possible protective effects on neurocognitive function. Anthocyanins, a polyphenol widely present in many red-blue fruits or plants, has received the most attention in this regard. Objective: This study was conducted to reviews published literature of anthocyanins effect on cognitive outcomes according to PRISMA guideline. Methods: We systematically searched relevant data in PubMed, ScienceDirect, and Medline database published in January 2014 to December 2023. Results: Thirteen studies were reviewed consisting of animal studies (n=7) and human studies (n=6). In animal studies, the effects are particularly important for critical signaling pathways involved in the development of Parkinson's and Alzheimer’s disease. Six human studies found that consuming anthocyanins-rich foods improved either one or more cognitive outcomes with the most significant improvement across all tests associated with memory. Conclusion: The impact of anthocyanins on cognitive aspects in both animal and human studies shows substantial potential. Due to the methodological restrictions and variations among the studies, future study is needed to explore the underlying mechanism and validate these discoveries.
RELATIONSHIP BETWEEN HYPOTHALAMUS AND SEXUAL ORIENTATION Checa, Alejandro; Alvear, Mercedes; Navas, Eliana; Córdova, Nathaly; Martínez, Briggitte; Tapia, William; Yánez-Ortiz, Érika
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.05

Abstract

Background: Research on biological sexual differences in brain function, structure, and sexual orientation suggests links to prenatal androgen exposure, gender traits, and brain patterns, but findings remain inconclusive due to methodological challenges, inconsistent definitions, and societal or sampling biases. Objective: Determine if there is a relationship between the size of the hypothalamus and sexual orientation. Methods: This was a cross-sectional cohort study conducted between January 2022 and January 2023 at the Eugenio Espejo Specialties Hospital in Quito, Ecuador. Male subjects aged between 20 and 40 years participated. They were asked to reveal their sexual orientation and in the case of homosexual men, specify their sexual role as “active” or “passive”, the “versatile” did not participate in the study. The size of the hypothalamus was identified using simple MRI of the brain. Results: A total of 51 subjects were recruited, of which 40 self-identified as homosexual, of which 25 were passive and 15 active, the remaining 11 were defined as heterosexual. It was found that there is a statistically significant relationship between the size of the hypothalamus and sexual orientation with a p = <0.001. Conclusion: In our study, there is a statistically significant relationship between the size of the hypothalamus and sexual orientation. Keywords: Hypothalamus, sexual orientation, MRI, heterosexual, homosexual