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JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA

JFIKI
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Published by Universitas Airlangga

ISSN : 24069388 EISSN : 25808303 DOI : -

Core Subject : Health, Science, Education,

Chemistry Education Health Professions Medicine & Pharmacology Other

Jurnal ini adalah jurnal peer-review nasional, yang diterbitkan dua kali dalam membahas tentang topik-topik hasil penelitian di bidang pelayanan dan praktik kefarmasian, konsultasi masyarakat, teknologi kefarmasian serta disiplin ilmu kesehatan yang terkait dengan erat. Jurnal ini memfokuskan pada area-area berikut: 1. Farmasi Klinis 2. Farmasi Komunitas 3. Farmasetika 4. Kimia Farmasi 5. Farmakognosi 6. Fitokimia

Arjuna Subject : -

Articles 259 Documents

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Profil Pelepasan Andrografolid Granul Kombinasi Ekstrak Terpurifikasi Herba Pegagan (Centeella Asiatica) Dan Sambiloto (Andrographis Paniculata) Lina Widyastuti; Akhmad Kharis Nugroho
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 3 No. 2 (2016): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Pendahuluan: Andrografolid merupakan senyawa yang sukar larut dalam air, penentuan jumlah dan profil pelepasan andrografolid dari bentuk sediaan perlu dilakukan. Tujuan: Penelitian ini dilakukan untuk menentukan jumlah dan profil andrografolid yang dilepaskan dari formula granul kombinasi ekstrak terpurifikasi herba pegagan dan herba sambiloto. Hal tersebut untuk memastikan eksipien tidak mengikat zat aktif. Metode: Uji pelepasan dilakukan dengan melakukan uji disolusi menggunakan media dapar asetat pH 4,5. Hasil disolusi granul kombinasi ekstrak terpurifikasi herba pegagan dan herba sambiloto ditentukan menggunakan KLT-densitometri. Hasil: Hasil perhitungan efisiensi disolusi (ED60) sebesar 75,00% ± 1,33. Profil disolusi ditentukan dengan regresi nonlinear dengan pendekatan orde nol, orde 1, Higuchi, Hixon Crowell dan Korsmeyer Peppas. Mekanisme penentuan profil disolusi dari pelepasanan andrografolid dilihat secara visual dari kesesuaian hasil prediksi solver (QPrediksi) dan hasil percobaan (Qobservasi) dengan melihat garis identitas. Kurva dari suatu model yang mendekati garis identitas merupakan gambaran mekanisme pelepasan andrografolid yang dibentuk dengan pendekatan tersebut. Kurva dengan pendekatan Korsmeyer Peppas terlihat lebih dekat dengan garis identitas bila dibandingkan dengan 4 model pendekatan yang lain. Berdasarkan perhitungan regresi nonlinear, pelepasan andrografolid dikontrol dengan mekanisme difusi matriks, yang berarti pelepasan andrografolid dari granul terjadi karena adanya pengikisan lapisan terluar karena Avicel PH 101 terhidrasi dengan cepat. Dengan menggunakan persamaan Korsmeyer-Peppas mekanisme pelepasan andrografolid mengikuti hukum difusi Fick dengan nilai n = 0,320 (< 0,45). Kesimpulan: Jumlah dan profil pelepasan andrografolid dari granul adalah hasil penelitian yang dapat dijadikan suatu referensi untuk menentukan jumlah ekstrak yang dipakai dalam formulasi.

Gambaran Histopatologi Organ Hati dan Ginjal Mencit Balb/c setelah Pemberian Krim Ekstrak Teh Hijau (Camellia sinensis L.) Nining Sugihartini; M Alif Fajri
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 3 No. 1 (2016): Jurnal Farmasi dan Ilmu Kefarmasian Indonesia
Publisher : Universitas Airlangga

Background:Development of green tea extract formulation with the addition of enhancers to increase the ability of epigallocatechin gallate to penetrate the skin layers has been done. Objective: The purpose of this study was to determine the effect of green tea extract cream that containing enhancers on the profile of kidney and liver histopathology. Methods: The study used 4 groups which each group was treated with different concentrations of extract (2,0%; 2,5%; 3,0%; 3,5%) and 1 control group. After 24 hours and 14 days of application of the cream, the mice were sacrificed. The liver and kidneys were weighed and made preparations histopathology. Results: The results of the study showed that there similar (p>0,05) of the weight ratio of the liver and kidneys of Balb/c mice after 24 hours and 14 days. As well the histopathological test indicated that there similar (p>0,05) of the liver and kidneys after 24 hours and 14 days of administration of green tea extract cream. Conclusions: The levels concentration of green tea extract in cream (2,0%; 2,5%; 3,0%; 3,5%) that contain enhancers do not affect the liver and kidney histopathological of Balb/c mice.

Injektabel Komposit Hydroksiapatit-Gelatin sebagai Sistem Penghantaran Alendronat Aniek Setiya Budiatin; Junaidi Khotib; Didik Hasmono; Samirah Samirah
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 3 No. 1 (2016): Jurnal Farmasi dan Ilmu Kefarmasian Indonesia
Publisher : Universitas Airlangga

Background: Bisphosphonates, such as alendronate (ALE), have been known to be effective in the treatment of bone cancer and osteoporosis. However, it has been reported that the systemic administration of ALE causes a considerable side effect. Thus, the formulation injectable bone substitute (IBS) for local administration of ALE, which functions as drug delivery system (DDS) as well as filling agent in osteoporosis-induced bone fracture, is needed. Objective: To establish the biodegradable and biocompatible formulation for ALE in injectable form which supports the drug delivery system and acts as filling agent in bone fracture. Methods: Hydroxyapatite (HA) was added to the mixture of gelatin and hydroxypropyl methyl cellulose (GEL-HPMC). ALE was added to the mixture and semisolid form was prepared for granulation. The dried granule, as injectable matrix, was grinded and mixed with appropriate amount of Na2HPO4. Results: Porosity of injectable form was higher than those of granule form. Injectable semisolid form was produced by adding 0.8 mL Na2HPO4 on each gram of granule with 10-12 min setting time. MTT assay showed that matrix was biocompatible showed by more than 100% viability. In vitro dissolution study showed that ALE was slowly released in more than 20 days. Conclusions: The formula of IBS using HA-GEL-HPMC may act as an effective drug delivery system for local administration of ALE in bone fracture.

Design and Molecular Docking Studies of Quinazoline Derivatives as Antiproliferation Anita Puspa Widiyana; Galih Satrio Putra; Luthfi Ahmad Muchlashi; Mellany Ika Sulistyowaty; Tutuk Budiati
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 3 No. 2 (2016): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Background: Nowadays, a lot of new active substances as anticancer agents have been developed. One of the protein targets of anticancer is selective cyclooxygenase-2 (COX-2). Selective COX-2 is the regulator of cell proliferation. Objective: In this research, quinazoline derivatives were used to design the anticancer agent through a selective COX-2 inhibition. The potential activity of quinazoline derivatives could be increased by substitution in position 2 and 3 of quinazolinone. Molecular docking of selective COX-2 inhibition was required to predict their antiproliferation activity. Methods: The molecular docking of quinazoline derivatives was carried out using Molegro Virtual Docker (MVD) Ver.5.5. Twenty-one of quinazoline derivatives were docked into selective COX-2 with PDB code 3LN1. The interaction was evaluated based on the re-ranked score comparison between quinazoline derivatives with co-crystallized ligand CEL_682. Celecoxib was used as the reference to this research. Results: The result indicated that 18 of 21 quinazoline derivatives showed the approximately re-ranked score -131.508 to -108.418 kcal/mol. Eight of these 18 new quinazoline derivatives have re-ranked score better than Celecoxib. Conclusions: In conclusion, 8 of the new quinazoline derivatives are feasible to be synthesize and performed their in vitro evaluation.

Kadar Polifenol Total Ekstrak Etanol Kulit Buah Manggis (Garcinia mangostana) Pada Variasi Asal Daerah Any Guntarti
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 3 No. 1 (2016): Jurnal Farmasi dan Ilmu Kefarmasian Indonesia
Publisher : Universitas Airlangga

Background:Mangosteen peel is one of the waste of mangosteen, that nowadays have already utilized much to manage health problems. One of the ingredients in the mangosteen fruit skin is a polyphenols. Objective: to determine the polyphenols content of the ethanol extract of mangosteen peel variations based on different regions. Methods: Powder of dried mangosteen peel that come from 3 difference areas, Sumatera (Pekanbaru), Jawa (Yogyakarta) and Kalimantan (Martapura) extracted with ethanol 70% by multilevel maceration. Extract that obtained than tested specific parameter form of qualitative test of polyphenols compounds with FeCl3, AlCl3, ammonia vapor, Folin Ciucalteau and tannin test. Determination level of polyphenols (Gallic acid) with visible spectrophotometri after reacted with Folin Ciucalteau reagent. Results: The result of this research was quality test of extract etanol 70% Specific parameter test total phenol content (mg GAE/g ekstrak) from Sumatera, Jawa and Kalimantan are :824.13 (mg GAE/g ekstrak); 155,86 (mg GAE/g ekstrak); 688,9 (mg GAE/g ekstrak). Conclusions: There were difference in contents of polyphenol of mangosteen peel origin among Sumatera, Jawa and Kalimantan.

Skrining Aktivitas Antimalaria Beberapa Tanaman Indonesia Hasil Eksplorasi Dari Hutan Raya Cangar, Batu-Malang, Jawa Timur Achmad Fuad Hafid; Nike Puliansari; Nur Suci Lestari; Lidya Tumewu; Abdul Rahman; Aty Widyawaruyanti
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 3 No. 1 (2016): Jurnal Farmasi dan Ilmu Kefarmasian Indonesia
Publisher : Universitas Airlangga

Background: Malaria is the most important parasitic disease. Malaria control which depends on specific chemotherapy now complicated by resistance of Plasmodium falciparum to most commonly available antimalarial drug. Such situation has heralded the need for alternative antimalarial therapy. Objective: This research aim was to find new antimalarial candidates from some Indonesia plants collected from Cangar National Forest, Batu-Malang, East Java. Methods: Eleven samples of leaves and stem extracts were screened against Plasmodium falciparum 3D7 culture which maintained in RPMI-1640 Medium. Samples tested in concentration of 0.01, 0.1, 1, 10 and 100 µg/ml. Probit analysis was used to determine IC50. Results: In vitro antimalarial activity revealed that only three crude extracts samples from Fraxinus griffithi stem extract, Piper sulcatum leaves extract and Eucalyptus globulus stem extract had good antimalarial activity with IC50 value of 0.33, 0.20 and 0.55 µg/ml, respectively. Conclusions: Fraxinus griffithi stem extract, Piper sulcatum leaves extract and Eucalyptus globulus stem extract might be a good candidate for antimalarial natural product resources.

Anti-Inflammatory And Anti-Oxidant Activities Of Glochidion Daltonii Branch Extract Jintana Junlatat; Bungorn Sripanidkulchai
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 3 No. 2 (2016): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Background: Glochidion daltonii (Míœll. Arg.) Kurz, Euphorbiaceae family, is a native medicinal plant in tropical regions of Asia. In Thailand, it has traditionally been used for treating pain and mouth inflammation. Objective: This study aims to investigate the anti-inflammatory and anti-oxidant effects of G. daltonii ethanolic extract (GDE) both in vitro and in vivo. Method: The anti-inflammatory mechanism was examined in E.coli LPS-stimulated RAW264.7 cells by using semi-quantitative-reverse transcription-polymerase chain reaction and the potential anti-inflammatory effect of GDE was evaluated in Sprague-Dawley rat using carrageenan-induced rat paw edema method. In addition, DPPH assay was used for anti-oxidant evaluation. Result: The results showed that GDE at 0.063 - 0.250 mg/mL concentrations inhibited the expressions of tumor necrosis factor-α and interleukin-1β. Moreover, an intraperitoneal administration of GDE significantly reduced paw edema in rats. Furthermore, GDE showed high anti-oxidant property with IC50 values at 6.35 ± 0.28 µg/mL. Conclusion: The results support the traditionally use of GDE for treating inflammation.

Evaluasi Kandungan Glukosa Dan Indeks Glikemik Beberapa Sumber Karbohidrat Dalam Upaya Penggalian Pangan Ber-Indeks Glikemik Rendah Nuzul Wahyuning Diyah; Aprilia Ambarwati; Gita M. Warsito; Greta Niken; Eriza T. Heriwiyanti; Rany Windysari; Deka Prismawan; Robi'atul F. Hartasari; Purwanto Purwanto
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 3 No. 2 (2016): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Pendahuluan: Berbagai penelitian menunjukkan bahwa diet makanan ber-Indeks Glikemik (IG) rendah mampu menurunkan resistensi insulin pada penderita Diabetes Mellitus. Masalah utama dalam diet pangan IG rendah adalah ketersediaan bahan pangan dengan IG rendah sementara makanan pokok sebagian besar penduduk Indonesia adalah nasi, yang tergolong pangan dengan IG tinggi.Tujuan: menentukan kandungan glukosa dan indeks glikemik beberapa bahan pangan sumber karbohidrat dari kelompok biji-bijian (beras merah, jagung, sorgum), umbi-umbian (singkong, bentul), buah-buahan (pisang kapok, pisang ambon, sukun), serta kacang-kacangan (kacang hijau, kacang merah), untuk memperoleh bahan pangan sumber karbohidrat ber-IG rendah sebagai pangan alternatif pengganti nasi dalam diet penderita Diabetes Mellitus. Metode: Kadar glukosa ditentukan dengan metode Luff-Schoorl dan penentuan indeks glikemik dilakukan menggunakan hewan coba kelinci terhadap pangan standar, glukosa 0.47 g/Kg berat badan. Sampel pangan uji diberikan dalam jumlah yang setara dengan kandungan glukosa dalam setiap pangan uji. Hasil: Kandungan glukosa yang ditetapkan sebagai gula pereduksi total dalam pangan uji bervariasi, bergantung pada karakter pati dalam pangan sumber karbohidrat. Semua pangan uji memiliki indeks glikemik yang lebih rendah dibanding nasi putih, tetapi singkong kukus dan bentul kukus masih tergolong pangan IG tinggi. Kesimpulan: Kecuali singkong dan bentul, semua pangan yang diuji adalah pangan sumber karbohidrat yang direkomendasikan untuk penderita diabetes.

Optimasi Waktu Maserasi untuk Manggis (Garcinia mangostana L.) Rind Menggunakan Pelarut Etil Asetat Ni Putu Ayu Dewi Wijayanti; Dewi LPMK; Astuti KW; Fitri NPE
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 3 No. 1 (2016): Jurnal Farmasi dan Ilmu Kefarmasian Indonesia
Publisher : Universitas Airlangga

Background: Maceration is a non-heating extraction method the result of which is affected by the type of solvent and the maceration time. Objective: To get the higher alpha-mangostin concentration (Garcinia mangostana L.) rind that was macerated using ethyl acetate solvent and to determine the optimum maceration time needed to produce high concentration of alpha-mangostin. Methods: the mangosteen rind was macerated using ethyl acetate with the variation of the maceration time of 6, 12, 24 and 48 hours. The extract was then dried using the freeze drying method. The optimum maceration time was determined by looking at the highest concentration of alpha-mangostin from each extraction time using TLC-densitometry method with a silica gel stationary phase of GF254 and a mobile phase of chloroform”methanol (10:0.1, v/v). Results: The results showed that the difference in the maceration time can affect the concentration of alpha-mangostin compound contained in the extract. Conclusions: It was found out that the 24-hour maceration time produced the highest concentration of alpha-mangostin that is 3031.34 ng.

Pengaruh Lioprotektant Terhadap Karakteristik Nanopartikel Artesunat-Kitosan Yang Dibuat Dengan Gelasi Ionik-Pengeringan Beku Abhimata Paramanandana; Retno Sari; Pawahid Pawahid; Eryka A. Novarinandha; Widji Soeratri
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 3 No. 2 (2016): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Latar belakang: Nanopartikel merupakan partikel dengan rentang ukuran diameter antara 1 - 1000 nm. Nanopartikel Artesunat-Khitosan diformulasikan menjadi nanopartikel menggunakan metode gelasi ionik-pengering beku ditujukan untuk melindungi bahan obat dari peruraian selama proses pembuatan. Untuk memperoleh produk dari pengeringan beku yang baik, optimasi lioprotektan sangat diperlukan. Tujuan: Tujuan dari penelitian ini adalah untuk mempelajari karakteristik fisik nanopartikel Artesunat-Khitosan yang diformulasikan dengan tiga lioprotektan yang berbeda: sukrosa, trihalosa dan maltodekstrin menggunakan metode pengeringan beku. Metode: Pembuatan nanopartikel dilakukan menggunakan gelasi ionik dengan tripolifosfat sebagai crosslinker. Evaluasi nanopartikel kering meliputi: morfologi, sifat fisik, spektrum inframerah dan redispersabilitas. Hasil: Data deferential thermal analysis (DTA) menunjukkan, penambahan lioprotektan menjebak artesunat dalam sistem nanopartikel chitosan, dimana formula tanpa penambahan lioprotektan tidak ditemukan artesunat di dalam matriks chitosan. Pemeriksaan morfologi menggunakan scanning electron microscopy (SEM) menunjukkan nanopartikel dengan 2,5% maltodextrin memiliki permukaan yang halus dan bentuk yang speris. Selain itu, maltodextrin menunjukkan efek perlindungan selama pengeringan beku, laju pengendapan yang lebih lambat dan kemampuan untuk redipersi yang lebih baik dibandingkan dengan sukrosa dan trehalosa. Lioprotektan dengan konsentrasi tinggi menunjukkan redispersibilitas nanopartikel artesunat-chitosan yang lebih baik. Kesimpulan: Berdasarkan hasil penelitian ini, dapat disimpulkan bahwa dengan penambahan lyoprotectant mempengaruhi karakterisitik nanopartikel artesunat-chitosan.

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Elida Zairina

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