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INDONESIA
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Published by Universitas Airlangga
ISSN : 24069388     EISSN : 25808303     DOI : -
Core Subject : Health, Science, Education,
Chemistry Education Health Professions Medicine & Pharmacology Other
Jurnal ini adalah jurnal peer-review nasional, yang diterbitkan dua kali dalam membahas tentang topik-topik hasil penelitian di bidang pelayanan dan praktik kefarmasian, konsultasi masyarakat, teknologi kefarmasian serta disiplin ilmu kesehatan yang terkait dengan erat. Jurnal ini memfokuskan pada area-area berikut: 1. Farmasi Klinis 2. Farmasi Komunitas 3. Farmasetika 4. Kimia Farmasi 5. Farmakognosi 6. Fitokimia
Arjuna Subject : -
Articles 299 Documents
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Use of Analgesics in Digestive Surgery Patients: A Retrospective Observational Study Budi Suprapti; Sania Rifatul Azizah; Arina Dery Puspitasari; Ismu Nugroho; Zam Zami Jauhari; Mas Agus Milawati Baay
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 13 No. 2 (2026): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v13i22026.160-172

Abstract

Background: Digestive surgery can cause acute postoperative pain of varying intensity, which, if not treated adequately, can increase morbidity, length of stay, and decrease the quality of life. This study aimed to analyze the analgesic use (type, route, dose, frequency, and duration) in patients who underwent digestive surgery. Methods: A retrospective observational study was conducted at Universitas Airlangga Hospital Surabaya from October 2024 to March 2025. The inclusion criteria were as follows: inpatients aged ≥ 18 years who underwent digestive surgery with one of the five most common diagnoses (cholelithiasis, colorectal cancer, appendicitis, hernias, or hemorrhoids) and received analgesic therapy.  Data were collected from the patients’ medical records, and a descriptive analysis was performed. Results: A total of 142 patients met the inclusion criteria, comprising 48.6% men and 51.4% women, with the majority aged 18-59 years (75.4%). The most common diagnosis was cholelithiasis (45.8% of patients). The analgesic drugs used included opioids (fentanyl, morphine, pethidine, and tramadol), NSAIDs (ketorolac, diclofenac, mefenamic acid, and ibuprofen), non-opioids (metamizole and paracetamol), and adjuvants (diazepam, gabapentin, and amitriptyline). The most commonly used intraoperative analgesic was intravenous fentanyl at a dose of 25-100mcg (83.1%). The most commonly used postoperative analgesic was metamizole 1–3 × 1 g intravenously for 1-8 days (66.2%), and in combination therapy, the most commonly used was paracetamol and ketorolac (18,3%). All patients received postoperative analgesics intravenously, whereas 34.5% received them orally as follow-up therapy. Conclusion: Fentanyl is the preferred option for intraoperative pain relief, and metamizole is commonly used for postoperative pain relief. Another multimodal therapy option is a combination of paracetamol and ketorolac.
A Comprehensive Evaluation of Antibiotic Use Appropriateness in General Surgical Ward and Its Associated Factors Samirah; Firstia Rif’atul Chumaidah; Amaliyah Rusmanto Zubaidi; Bambang Arianto; Dewi Ramdani
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 13 No. 2 (2026): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v13i22026.202-214

Abstract

Background: Antibiotic use in general surgical wards is essential for preventing surgical site infections (SSI), although irrational prescribing remains common and increases the risk of antimicrobial resistance. Objective: This study aimed to examine antibiotic use patterns, assess the appropriateness of antibiotic use, and analyze factors associated with antibiotic use in a surgical ward. Methods: A cross-sectional study was conducted using medical records from the general surgical ward of Hajj Regional General Hospital, East Java, Indonesia, from May to June 2023. Antibiotic use patterns were measured using the ATC/DDD methodology and the WHO AWaRe classification. The appropriateness of antibiotic use was assessed using the Gyssens classification. Descriptive analysis was used to characterize the demographic profiles, bacterial isolates, and antibiotic use. The chi-square test was used to assess the association between patient characteristics and the appropriateness of antibiotic use. Results: A total of 180 patients participated in this study, most of whom were female (56.67%) and aged 46-59 years (34.44%). The results indicated that the most commonly isolated bacteria were ESBL-producing Escherichia coli (14.29%) and Staphylococcus aureus (14.29% each). Cefazolin was the predominant prophylactic agent, accounting for 87.34% of the total, with a DDD per 100 procedures value of 32.85. In comparison, ceftriaxone and metronidazole were the most prescribed therapeutic antibiotics, accounting for 39.94% and 27.93% of the DDD values of 36.50 and 26.19 per 100 patient-days, respectively. Antibiotics classified in the Watch group predominated among therapeutic prescriptions (56.33%), whereas the Access group accounted for only 42.87%. The appropriateness of antibiotic use was documented in 68.89% of the cases, with the most common causes of inappropriate antibiotic use being inappropriate timing (9.84%) and duration (9.21%). Age, diabetes comorbidity, and LOS were significantly associated with the appropriateness of antibiotic use. Conclusion: Although the appropriateness of antibiotic use in the general surgical ward was relatively high, substantial improvements are recommended through monitoring and strengthening adherence to clinical guidelines.
Innovation of Lipophilic Vitamin C Derivative (Tetrahexyldecyl Ascorbate) Using Nanocarrier Technologies For Skin Matrix Restructuring: A Scoping Review Salsabila Bara Putri; Andang Miatmoko; Noorma Rosita; Firmansyah Ardian Ramadhani
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 13 No. 2 (2026): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v13i22026.231-239

Abstract

Background: L-ascorbic acid is a potent antioxidant and critical cofactor for collagen synthesis; however, its clinical application is heavily constrained by its high hydrophilicity, poor passive stratum corneum penetration, and rapid chemical instability. Tetrahexyldecyl Ascorbate (THDC), a stable lipophilic ester derivative, has emerged as a promising alternative capable of enhancing dermal bioavailability at near-neutral pH. Objective: This scoping review systematically maps the research landscape regarding the molecular mechanisms, clinical efficacy, patent innovations, and lipid-based nanocarrier delivery systems (specifically, Nanostructured Lipid Carriers [NLCs] and liposomes) of THDC for skin matrix restructuring. Methods: Following the JBI methodology and PRISMA-ScR guidelines, a systematic literature and patent search was performed across the United States Patent and Trademark Office (USPTO), World Intellectual Property Organization (WIPO), PubMed, Scopus, ScienceDirect, and Google Scholar. Studies evaluating topical THDC formulations, synergistic antioxidant combinations, patent claims, and nanocarrier systems were extracted and analyzed. Results: Clinical evidence demonstrates that topical applications of THDC (5%–30%), especially when combined with co-antioxidants such as Acetyl Zingerone (AZ) or retinoids, significantly reduced fine lines, wrinkles, and hyperpigmentation while improving skin elasticity and epidermal barrier function within 8–12 weeks. Mechanistically, THDC stimulates dermal collagen synthesis, upregulates Nrf2 pathways, and downregulates matrix metalloproteinases (MMP-1, MMP-3, and MMP-9). Furthermore, encapsulation into NLCs and biomimetic liposomes overcomes the degradation and expulsion of active ingredients, enabling sustained release and deeper dermal penetration. Conclusion: The integration of THDC into lipid nanocarrier systems represents a highly effective, low-irritation approach that shifts topical anti-aging interventions from superficial protection to comprehensive skin matrix repair.
Antiretroviral Adherence and Treatment Outcomes Among People Living with HIV Receiving Monthly and Multi-Month Dispensing: A Cross-Sectional Study Zamrotul Izzah; Mirzario Aryananda Verrian; Madona Dwi Fitriani; Tri Pudy Asmarawati; Din Amalia Widyaningrum
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 13 No. 2 (2026): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v13i22026.184-193

Abstract

Background: Human immunodeficiency virus (HIV) requires lifelong antiretroviral therapy (ART), and sustained adherence is essential for achieving viral suppression and preventing disease progression. Multi-month dispensing (MMD) was introduced to reduce clinic visits and improve treatment continuity; however, comparative evidence between MMD and monthly dispensing remains limited in Indonesia. Objective: This study aimed to assess treatment adherence and therapeutic outcomes among people living with HIV who received ART through MMD and monthly dispensing systems. Methods: A cross-sectional study was conducted at the HIV clinic of Universitas Airlangga Hospital, Indonesia, involving 160 people living with HIV, consisting of 80 patients in the MMD group and 80 in the monthly care group. MMD was operationally defined as ART dispensation for two or more months in the study setting. Adherence was assessed using the Self-Reported Adherence (SERAD) questionnaire and pill count method, while therapeutic outcomes were evaluated based on viral load (VL) results. Data were analyzed using appropriate statistical tests to determine the differences between the groups. Results: Significant differences were found in adherence based on the pill count (p = 0.03) and SERAD drug use (p = 0.00). Viral suppression rates were significantly higher in the MMD group (p < 0.001), with all patients achieving undetectable VL levels. Conclusion: MMD was associated with better adherence and improved virological outcomes than monthly dispensing, suggesting an association that warrants further evaluation with a longitudinal design to optimize HIV treatment outcomes.
The Role of Medicinal Plants as Hepatoprotectors: A Scoping Review Noor Hanifah; Malinda Najwah Sifa Athallah; Retno Sari; Zainul Amiruddin zakaria; Tutik Sri Wahyuni
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 13 No. 2 (2026): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v13i22026.215-230

Abstract

Background: The liver is a central organ in metabolism, detoxification and protein biosynthesis. However it is very susceptible to injury by toxins, drugs and infections. Medicinal plants have gained interest as a potential source of hepatoprotective agents in recent years due to their wide range of bioactive compounds and superior safety profiles than conventional synthetic therapies. Objective: This scoping review aims to identify and summarize medicinal plants with hepatoprotective potential, their bioactive compounds, and the pharmacological mechanisms underlying their protective effects against hepatotoxicity. Methods: The study materials consisted of peer-reviewed scientific publications retrieved from Web of Science, SpringerLink, ScienceDirect, Google Scholar, PubMed, and Scopus. The selected articles focused on medicinal plants with hepatoprotective activity, their bioactive constituents, hepatoprotective mechanisms, and hepatotoxicity induction models. Results: A total of 19 medicinal plant species were identified, predominantly evaluated in in vivo models of chemically induced liver injury, including CCl₄, paracetamol, methotrexate, alcohol, and diclofenac induced hepatotoxicity. Various of metabolite, including, alkaloids, saponins, terpenoids, and glycosides. Most studies demonstrated significant reductions in serum ALT, AST, bilirubin, and oxidative stress markers, accompanied by improved antioxidant status and liver histopathology. These effects were associated with modulation of the NF-κB, STAT3, and PI3K/AKT signalling pathways. Conclusion: This review highlights medicinal plants as promising candidates for the development of hepatoprotective agents for the management of liver diseases.
Pattern and Timing of Parenteral Nutrition in Critically Ill Patients: Adherence to Updated Nutritional Protocols Mirza Junando; Muhammad Iqbal; Ramadhan Triyandi; Hesti Yuningrum; Nurma Suri
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 13 No. 2 (2026): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Nutrition is fundamental in supporting patient care in the intensive unit. New guidelines advocate starting Enteral Nutrition (EN) and Parenteral Nutrition (PN) gradually within 48 h; nevertheless, they are still frequently initiated early and aggressively. Objective: This study aimed to assess the timing, utilization, and financial implications associated with PN therapy. Methods: One of the referral hospitals in Lampung Province was selected as the setting for this prospective cohort study, which was conducted from December 2023 to April 2024. Nutritional risk was evaluated using the mNUTRIC score, and the cost of PN was collected from secondary data. The cost analysis was limited to the cost of PN. The prices used in this study were hospital-established selling prices. Furthermore, data analysis was performed using univariate and bivariate analyses. Results: In this study, 61 patients in the intensive care unit who received nutritional support were included. Among these patients, 96.7% received PN concurrently with EN and 3.3% received PN without EN.  PN was administered aggressively and remained stable within 24 h of admission for seven days. The total cost of PN amounted to IDR 299,478,581, with a mean cost of IDR 4,909,485 per patient and a median cost of IDR 2,755,309 (IQR IDR 4.580.653). The bivariate analysis found a significant association between PN cost and extended hospitalization (p < 0.001), patient mortality (p = 0.003), and elevated nutritional (p = 0.004). However, this study had a limitation in that it did not identify specific diagnoses or clinical conditions that warranted the concurrent use of PN and EN. Conclusion: In this study, we observed that accurate assessment of caloric needs, regular monitoring of nutritional intake, and judicious use of nutritional support may improve patient outcomes by reducing the duration of hospitalization and increasing the efficiency of nutritional management in patients with stroke.
Evaluation of Acute Toxicity, Analgesic and Anti-Inflammatory Effect of Mahogany Seed (Swietenia mahagoni (L.) Jacq.) Infusion: An In Vivo Study in Wistar rats Emelda; Nurul Kusumawardani; Arga Bima Pramudya; Chaedar Ahmad Qoedowie; Rizal Fauzi; Mochammad Saiful Bachri; Danang Prasetyaning Amukti
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 13 No. 2 (2026): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v13i22026.290-303

Abstract

Background: A traditional Javanese ethnomedicine is a mahogany seed (Swietenia mahagoni (L.) Jacq.) infusion (MSI). It is frequently used to reduce inflammation and alleviate pain. However, its safety profile and pharmacological effectiveness remain underexplored. However, its pharmacological efficacy and safety profiles remain unexplored. It is frequently used to reduce inflammation and pain. Its safety profile and pharmacological effectiveness. However, its pharmacological efficacy and safety profile remain underexplored. Objective: This study evaluated MSI’s acute toxicity, analgesic, and anti-inflammatory effects of MSI.  Methods: Wistar rats (200-300 g) were used in a completely randomized, single-factor experimental design. For pharmacological activity, the mice were divided into five groups (n=6 per group). The group included a negative control (1% CMC-Na), a positive control, and three treatment groups receiving MSI orally at 5,10, and 20 mg/kgBW. Analgesic activity was assessed using the acetic acid-induced writhing test, while anti-inflammatory activity was evaluated using the carrageenan-induced paw edema model. Acute toxicity was tested at a maximum oral dose of 2000 mg/kg. Results: MSI at 20 mg/kgBW significantly reduced the writhing frequency, comparable to mefenamic acid 65 mg/kg (p>0.05), and all MSI doses showed significantly lower writhing than the controls (p<0.05). Furthermore, 20 mg/kg MSI showed greater inhibition of carrageenan-induced edema, similar to that of the diclofenac group (50 mg/kg; p<0.05). No mortality or significant behavioral changes were observed at the highest dose, indicating a favorable safety profile of the drug. Conclusion: These results confirm MSI’s traditional use of MSI and its potential as a safe, natural medicinal drug, indicating that it possesses strong peripheral analgesic and anti-inflammatory properties with low acute toxicity. It is advisable to conduct a thorough toxicological analysis to determine safety and effectiveness, as well as to separate and describe the bioactive components.
Association Between Beliefs About Antiretroviral Therapy and Medication Adherence Among People Living with HIV: A Cross-Sectional Study Zamrotul Izzah; Wiweka Santikrama; Toti Cahyaningsih; Indira Dhany Kharismawati; Erika Marfiani
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 13 No. 2 (2026): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Adherence to antiretroviral therapy (ART) is a key factor in managing HIV/AIDS. Positive beliefs about ART among people living with HIV (PLHIV) are crucial for maintaining good treatment adherence, whereas negative beliefs about ART result in low treatment adherence. Objective: This study aimed to analyze the association between beliefs regarding treatment and ART adherence among PLHIV receiving outpatient care. Methods: A cross-sectional study was conducted on 157 PLHIV at the HIV clinic of Universitas Airlangga Hospital between April and June 2025. Adherence was measured using the Self-Reported Adherence (SERAD) questionnaire and pill count, with a cutoff of ≥80%. The relationship was analyzed using binary logistic regression analysis. Results: Most respondents held positive beliefs regarding the necessity of ART (87.9%) and were classified as adherent (86%). However, no statistically significant associations were observed between ART adherence and the BMQ domain scores for necessity, concerns, overuse, or harm. The odds ratios were 1.00 (95% CI: 0.88–1.12) for necessity, 0.99 (95% CI: 0.89–1.12) for concerns, 0.97 (95% CI: 0.82–1.16) for overuse, and 0.97 (95% CI: 0.82–1.15) for harm. Psychological factors such as depression and low motivation, as well as practical reasons such as forgetfulness, were identified as causes of non-adherence despite a strong belief in the medication. Conclusion: Although most PLHIV had strong beliefs and adherence, no statistically significant association was observed between beliefs about treatment and ART adherence. These findings suggest that ART adherence may be influenced by multiple factors beyond treatment beliefs, underscoring the need for holistic and comprehensive interventions that address the diverse barriers to sustaining ART adherence.
Medication Adherence and Health-Related Quality of Life Among Hospital-Based Outpatients with Drug-Susceptible Tuberculosis Intani Kusuma Wardani; Zamrotul Izzah; Amitasari Damayanti; Edijono; Budi Suprapti; Sumarno
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 13 No. 2 (2026): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v13i22026.277-289

Abstract

Background: Tuberculosis (TB) remains a significant public health issue in Indonesia, despite the availability of effective anti-TB treatments. Sustained medication adherence is essential for treatment success and may contribute to improved Health-Related Quality of Life (HRQoL), which is also influenced by clinical and sociodemographic factors. However, evidence regarding the association between medication adherence and HRQoL among outpatients with drug-susceptible tuberculosis in Indonesia remains limited. Methods: A cross-sectional analytical study was performed on 133 outpatients with drug-susceptible tuberculosis at Rumah Sakit Pusat Angkatan Laut dr. Ramelan Surabaya. Medication adherence was assessed using the Comprehensive Medication Adherence Assessment Scale-12 (CMAAS-12), and HRQoL was assessed using the World Health Organization Quality of Life-BREF (WHOQOL-BREF). The Indonesian CMAAS-12 showed nine valid items (r=0.376–0.616; critical r=0.361) and a reliability coefficient of 0.50. Data were analyzed using chi-square tests and multivariable logistic regression in IBM SPSS Statistics 29.0, with a 95% confidence level and p<0.05 considered statistically significant. Results: Good medication adherence was observed in 58.6% of participants and was significantly associated with better HRQoL in the physical health (p<0.00), psychological (p<0.00), social relationships (p=0.04), and environmental (p<0.00) domains, but not overall QoL (p=0.08). Age, distance to hospital, and medication adherence were significant determinants of domain-specific HRQoL. Conclusion: Medication adherence is an important determinant of HRQoL in outpatients with drug-susceptible tuberculosis. Strengthening adherence-focused interventions may improve patient-centered outcomes and optimize tuberculosis management.

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