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JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Published by Universitas Airlangga
ISSN : 24069388     EISSN : 25808303     DOI : -
Core Subject : Health, Science, Education,
Chemistry Education Health Professions Medicine & Pharmacology Other
Jurnal ini adalah jurnal peer-review nasional, yang diterbitkan dua kali dalam membahas tentang topik-topik hasil penelitian di bidang pelayanan dan praktik kefarmasian, konsultasi masyarakat, teknologi kefarmasian serta disiplin ilmu kesehatan yang terkait dengan erat. Jurnal ini memfokuskan pada area-area berikut: 1. Farmasi Klinis 2. Farmasi Komunitas 3. Farmasetika 4. Kimia Farmasi 5. Farmakognosi 6. Fitokimia
Arjuna Subject : -
Articles 285 Documents
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In Silico Study of Beluntas Leaves (Pluchea indica) on DPP-4, α-Glucosidase, SGLT-2, and PPAR-γ as Antidiabetic Targets Andri Prasetiyo; Simanjuntak, Triviana; Kendok, Edelburga Suryati; Dalo, Matilde Tiwery; Mumpuni, Esti; Esti Mulatsari
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 13 No. 1 (2026): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v13i12026.122-140

Abstract

Background: Diabetes mellitus (DM) is a chronic metabolic disease with a steadily increasing prevalence globally. Long-term use of synthetic antidiabetic drugs is often associated with side effects, making exploration of alternative therapies from natural ingredients important. Pluchea indica L. leaves have been reported as a traditional Indonesian plant empirically used to lower blood sugar levels. Objective: This study aims to explore the potential of active compounds from Pluchea indica L. leaves as candidate multi-target antidiabetic agents through an in silico approach. Methods: An in silico study was conducted using molecular docking with Molegro Virtual Docker (MVD) to evaluate the interaction of four active compounds from beluntas leaves [(+)-Lirioresinol B, β Stigmasterol, (+)-Pinoresinol, and Plucheoside A against diabetes target proteins DPP-4 (PDB: 4FFW), α-glucosidase (PDB: 3L4W), SGLT-2 (PDB: 7VSI), and PPAR-γ (PDB: 5UGM)]. Method validation was performed by re-docking the original ligands (RMSD < 2.0 Å). Lipinski's 5 Rule analysis and ADMET prediction were performed to evaluate the drug-likeness and pharmacokinetic profiles of the compounds. Results: Method validation showed RMSD of 0.31-1.71 Å for all target proteins. Docking results showed that (+)-Pinoresinol had the best affinity as a DPP-4 inhibitor (Rerank score -103.452), (+)-Lirioresinol B as an α-glucosidase inhibitor (-100.173), Plucheoside A as an SGLT-2 inhibitor (-126.555), and β Stigmasterol as a PPAR-γ agonist (-131.023). Lipinski's 5 Rules analysis showed that all compounds most often violated 1 criterion (PSA). ADMET predictions showed an acceptable pharmacokinetic profile with low toxicity. Conclusion: The active compounds from beluntas leaves show potential as multi-target antidiabetic agents with good binding affinity to diabetes target proteins. These findings are still predictive and require further validation through in vitro and in vivo studies to confirm their biological activity, selectivity, safety, and pharmacological relevance as effective antidiabetic candidates in the future.
The Impact of Clinical Pharmacists on Improving Outcomes for Cancer Patients – A Systematic Review Agnes Evonella Pangaribuan; Syafhan, Nadia Farhanah; Titiesari, Yovita Diane
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 13 No. 1 (2026): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v13i12026.92-111

Abstract

Background: Clinical pharmacists play a crucial role in the management and care of patients with cancer. Objective: This systematic review evaluated the effectiveness of clinical pharmacist-led interventions on clinical outcomes in patients with cancer undergoing chemotherapy. Methods: A comprehensive literature review was performed using PubMed, Scopus, and ScienceDirect, focusing on randomized controlled trials (RCTs) published between January 2010 and May 2025. The search included relevant keywords and MeSH terms such as “Antineoplastic Agents,” “Pharmaceutical Services,” and “Clinical pharmacists.” This study focused on English-language journals reporting on studies of patients with cancer undergoing chemotherapy, evaluating clinical pharmacist-led interventions. The initial search yielded 3,803 articles screened. After a thorough evaluation of the titles, abstracts, and full texts, along with an assessment of quality and risk of bias, 10 trials were included in the analysis.  Results: Clinical pharmacists help patients take their medications more effectively, improving patient adherence by up to 30%. They also reduce problems with side effects, adverse effects, and medication incompatibilities, with one study showing a 77.3% success rate in reducing problems with medications. Patient satisfaction was high at 93%, and quality of life improved. One study found cost savings of USD 269,420 over eight months of use. The intervention included messaging and vaccination programs for older adults, conducted in-person and online. Conclusion: Clinical pharmacist-led interventions are crucial for improving medication adherence, ensuring patient safety, and enhancing clinical outcomes in patients undergoing chemotherapy. Incorporating clinical pharmacists as integral members of the oncology care team is a valuable strategy.
Bioactivity Screening of Endophytic Fungi Isolated from Nypa fruticans Leaves: Antioxidant, Antibacterial, and Cytotoxic Evaluations Dwinatrana, Khiky; Gefi Dwi Hermanto; Intan Lestari; Ananda Ogesta; Helmice Afriyeni; Rustini
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 13 No. 1 (2026): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v13i12026.150-159

Abstract

Background: Nypa fruticans is a mangrove palm known to harbor diverse endophytic microorganisms with potential bioactivity. However, studies on the biological properties of endophytic fungi are scarce. Objective: This study aimed to evaluate the antioxidant, antibacterial, and cytotoxic activities of endophytic fungi isolated from N. fruticans leaves and to characterize their secondary metabolite profiles. Methods: Eight fungal isolates (NF1–NF8) were obtained and screened for antioxidant activity using the DPPH radical-scavenging method, antibacterial activity against Staphylococcus aureus and Escherichia coli using the disc diffusion method, and cytotoxicity using the Artemia salina lethality test. The most active isolates were further analyzed using thin-layer chromatography (TLC) and phytochemical tests. Results: The isolates exhibited varying bioactivities, with NF5 showing antioxidant potential (IC₅₀ = 152.6 µg/mL) and NF7 showing the strongest antibacterial (19.1 ± 0.25 mm inhibition zone) and cytotoxic activities (LC₅₀ = 198.81 µg/mL). TLC and reagent detection confirmed the presence of phenolic compounds in NF5 and terpenoid compounds in NF7, corresponding to their biological profiles. Conclusion: The endophytic fungi from N. fruticans leaves exhibited significant antioxidant, antibacterial, and cytotoxic activities, indicating their potential as novel sources of natural bioactive metabolites, particularly in palm-associated fungal communities.
Cost of Illness of Diabetic Foot Ulcer in Lower Middle-Income Countries: A Systematic Review Wulandari, Sinta; Allizaputri, Alfadea Irbah; Libriansyah; Nita, Yunita
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 13 No. 1 (2026): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v13i12026.72-83

Abstract

Background: Diabetic foot ulcers (DFU) are a consequence of diabetes mellitus (DM) that cause a significant financial burden on the healthcare system, society, and individuals. The average prevalence of DFU was 6.3%. The cost of diabetic foot care is 50% to 200% higher than that of primary diabetes care. Objective: This systematic review aimed to provide an overview of the variations in the economic burden of DFU in lower middle-income countries (LMICs). Methods: This systematic review examined studies published in English that investigated the costs associated with evaluating diabetic foot disease in LMICs. COCHRANE, CINAHL, DOAJ, EMBASE, GOOGLE SCHOLAR, Ovid MEDLINE, PUBMED, SCIENCE DIRECT, and SCOPUS were used as literature sources without publication date restrictions. Results: A systematic search identified six eligible studies conducted across multiple countries. The studies were published between 2000 and 2024, with study durations ranging from 6 to 12 months. These studies showed large variations in cost components, estimating both direct and indirect costs of the disease. The total costs incurred for DFU vary among LMICs, ranging from USD 379.39 to USD 60,014.81 per year. Conclusion: DFU impose a significant economic burden in LMICs, with substantial variations in cost estimates owing to differences in methodology and data availability. Future studies on the cost burden of DFU should be conducted on a larger scale to obtain more accurate cost estimates.
Formulation and Optimization Spanlastic Gel Loaded Epigallocatechin Gallate for Transdermal Delivery Munthe, Mhd. Yogi; Diyah , Nuzul Wahyuning; Hendradi, Esti
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 13 No. 1 (2026): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v13i12026.60-71

Abstract

Background: Epigallocatechin gallate (EGCG) is an antioxidant that has been shown to have various pharmacological activities in both in vivo and in vitro studies. However, EGCG has low oral bioavailability. Alternative routes of administration, such as transdermal, can be used to overcome the stratum corneum of the skin, which provides a barrier that inhibits drugs from entering the dermal microcirculation to prove systemic availability. This limitation can be overcome by applying an elastic nanosized delivery system such as Spanlastic. Objective: To develop a spanlastic gel as an EGCG delivery system for transdermal application. Methods: Sp-EGCG was prepared by injecting ethanol with Tween 60 as the EA and Span 60 as the VB. Design Expert Software was then used to determine the optimum formula to be added to the gel base and tested for ex vivo permeation and in vitro release. Results: Optimization of 13 Sp-EGCG formulas resulted in entrapment efficiencies (79.2925–86.1921) %, zeta potentials (23.86-38.06) -mV, and vesicle sizes (129.933–225.233) nm. The optimal formulation consisted of Span 60 and Tween 80 in a 6:4 ratio and a rotation speed of 1000rpm. The pH value of the Sp-EGCG gel was 5.057 ± 0.016, with a viscosity of 795.43 ± 4.224 cPs and a spreadability of 5.833 ± 0.024 cm. In vitro release results showed that Sp-EGCG provided controlled release following the Higuchi model, while ex vivo permeability test results showed that Sp-EGCG gel increased the amount of EGCG penetration by up to 2.51 times. Conclusion: EGCG was successfully formulated into Sp-EGCG, and F3 was identified as the optimum formula, with a VS of 129.33 nm, ZP of-38.06 mV, and EE of 86.19%. The Sp-EGCG gel increased EGCG permeability in the skin.

Page 29 of 29 | Total Record : 285

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