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INDONESIA
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Published by Universitas Airlangga
ISSN : 24069388     EISSN : 25808303     DOI : -
Core Subject : Health, Science, Education,
Chemistry Education Health Professions Medicine & Pharmacology Other
Jurnal ini adalah jurnal peer-review nasional, yang diterbitkan dua kali dalam membahas tentang topik-topik hasil penelitian di bidang pelayanan dan praktik kefarmasian, konsultasi masyarakat, teknologi kefarmasian serta disiplin ilmu kesehatan yang terkait dengan erat. Jurnal ini memfokuskan pada area-area berikut: 1. Farmasi Klinis 2. Farmasi Komunitas 3. Farmasetika 4. Kimia Farmasi 5. Farmakognosi 6. Fitokimia
Arjuna Subject : -
Articles 272 Documents
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The The Impact of Antidiabetic Dose Appropriateness Based on Renal Function on Therapeutic Outcomes among Geriatric at Bali, Indonesia Sugiastana, Bagus N.; Hendra, Phebe; Virginia, Dita Maria
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 3 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i32025.330-341

Abstract

Background: Diabetes mellitus is a significant global health issue, especially in the older population. Appropriate drug dosing is crucial in geriatric patients because renal function generally declines with age. A decline in renal function is directly associated with the adverse effects of antidiabetic drugs, particularly hypoglycemia, rather than their therapeutic efficacy. Objective: The objective of the present study was to assess the effect of antidiabetic dose appropriateness according to renal function on therapeutic outcomes among geriatric patients at three hospitals in Bali Province. Methods: The research was designed as an observational analytic study with a cross-sectional design. The study involved patients with diabetes aged ≥ 60 years, with or without renal function impairment. Medical records from January to December 2024 were also reviewed for this study. The suitability of antidiabetic drug dosing was evaluated using the estimated glomerular filtration rate (eGFR) calculated using the Cockcroft–Gault equation. The prescribed doses were compared with the dosage guidelines based on the renal function. A Chi-square analysis was performed to assess the relationship between the appropriateness of the antidiabetic dose and the therapeutic outcomes. Moreover, multivariate analysis was performed using logistic regression after adjusting for other factors. Results: Among the included patients, 27.6% were diagnosed with CKD and 28.4% had renal function classified as stage G2. A total of 51.5% of patients received appropriately adjusted antidiabetic doses. Dose appropriateness was significantly associated with primary clinical outcomes (p<0.05) but not with secondary clinical outcomes. Conclusion: In conclusion, appropriate dose adjustment is essential for enhancing diabetes treatment strategies for geriatric patients with diverse stages of kidney dysfunction.
Feasibility Prediction of Quercetin and Ascorbic Acid Combination for Skin Lightening through Tyrosinase Inhibition Mechanism by Molecular Docking Nugroho, Nadia Paramitha; Rosita, Noorma; Widji Soeratri
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 3 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i32025.364-371

Abstract

Background: Hyperpigmentation is an aesthetic problem that can affect people psychologically and emotionally. Quercetin and ascorbic acid are topical ingredients commonly used as skin lightening active ingredients by their role as tyrosinase inhibitors. Objective: This research is to determine quercetin’s feasibility to be combined with ascorbic acid or one of its more stable and commercially most used derivatives in cosmetics, 3-O-ethyl ascorbic acid in inhibiting tyrosinase. Methods: The research was conducted in an in silico manner by molecular docking, supplemented by literature research on in vitro experiments. The ligands and receptor preparation were undertaken prior to performing molecular docking with AutoDockTools 1.5.6. Molecular docking was carried out after the validation step with the RMSD value of 0.91 Å. Results: Quercetin has greater binding affinity to tyrosinase (ΔG = -5.01 kcal/mol) than ascorbic acid (ΔG = -4.20 kcal/mol), as well as owning the most similar type of interaction and comparable affinity to L-tyrosine (ΔG = -5.87 kcal/mol) as the native ligand. Quercetin shares several same amino acid residues with ascorbic acid which indicates similar mechanisms of inhibition. Meanwhile, ascorbic acid possesses virtually equal binding affinity to 3-O-ethyl ascorbic acid (ΔG = -4.63 kcal/mol), though has considerably more potent tyrosinase inhibition activity in in vitro studies. Conclusion: Ascorbic acid is postulated to be feasible to combine with quercetin for inhibiting tyrosinase activity to eventually yield more optimized depigmenting effect.

Page 28 of 28 | Total Record : 272

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