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INDONESIA
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Published by Universitas Airlangga
ISSN : 24069388     EISSN : 25808303     DOI : -
Core Subject : Health, Science, Education,
Chemistry Education Health Professions Medicine & Pharmacology Other
Jurnal ini adalah jurnal peer-review nasional, yang diterbitkan dua kali dalam membahas tentang topik-topik hasil penelitian di bidang pelayanan dan praktik kefarmasian, konsultasi masyarakat, teknologi kefarmasian serta disiplin ilmu kesehatan yang terkait dengan erat. Jurnal ini memfokuskan pada area-area berikut: 1. Farmasi Klinis 2. Farmasi Komunitas 3. Farmasetika 4. Kimia Farmasi 5. Farmakognosi 6. Fitokimia
Arjuna Subject : -
Articles 285 Documents
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The The Impact of Antidiabetic Dose Appropriateness Based on Renal Function on Therapeutic Outcomes among Geriatric at Bali, Indonesia Sugiastana, Bagus N.; Hendra, Phebe; Virginia, Dita Maria
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 3 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i32025.330-341

Abstract

Background: Diabetes mellitus is a significant global health issue, especially in the older population. Appropriate drug dosing is crucial in geriatric patients because renal function generally declines with age. A decline in renal function is directly associated with the adverse effects of antidiabetic drugs, particularly hypoglycemia, rather than their therapeutic efficacy. Objective: The objective of the present study was to assess the effect of antidiabetic dose appropriateness according to renal function on therapeutic outcomes among geriatric patients at three hospitals in Bali Province. Methods: The research was designed as an observational analytic study with a cross-sectional design. The study involved patients with diabetes aged ≥ 60 years, with or without renal function impairment. Medical records from January to December 2024 were also reviewed for this study. The suitability of antidiabetic drug dosing was evaluated using the estimated glomerular filtration rate (eGFR) calculated using the Cockcroft–Gault equation. The prescribed doses were compared with the dosage guidelines based on the renal function. A Chi-square analysis was performed to assess the relationship between the appropriateness of the antidiabetic dose and the therapeutic outcomes. Moreover, multivariate analysis was performed using logistic regression after adjusting for other factors. Results: Among the included patients, 27.6% were diagnosed with CKD and 28.4% had renal function classified as stage G2. A total of 51.5% of patients received appropriately adjusted antidiabetic doses. Dose appropriateness was significantly associated with primary clinical outcomes (p<0.05) but not with secondary clinical outcomes. Conclusion: In conclusion, appropriate dose adjustment is essential for enhancing diabetes treatment strategies for geriatric patients with diverse stages of kidney dysfunction.
Feasibility Prediction of Quercetin and Ascorbic Acid Combination for Skin Lightening through Tyrosinase Inhibition Mechanism by Molecular Docking Nugroho, Nadia Paramitha; Rosita, Noorma; Widji Soeratri
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 3 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i32025.364-371

Abstract

Background: Hyperpigmentation is an aesthetic problem that can affect people psychologically and emotionally. Quercetin and ascorbic acid are topical ingredients commonly used as skin lightening active ingredients by their role as tyrosinase inhibitors. Objective: This research is to determine quercetin’s feasibility to be combined with ascorbic acid or one of its more stable and commercially most used derivatives in cosmetics, 3-O-ethyl ascorbic acid in inhibiting tyrosinase. Methods: The research was conducted in an in silico manner by molecular docking, supplemented by literature research on in vitro experiments. The ligands and receptor preparation were undertaken prior to performing molecular docking with AutoDockTools 1.5.6. Molecular docking was carried out after the validation step with the RMSD value of 0.91 Å. Results: Quercetin has greater binding affinity to tyrosinase (ΔG = -5.01 kcal/mol) than ascorbic acid (ΔG = -4.20 kcal/mol), as well as owning the most similar type of interaction and comparable affinity to L-tyrosine (ΔG = -5.87 kcal/mol) as the native ligand. Quercetin shares several same amino acid residues with ascorbic acid which indicates similar mechanisms of inhibition. Meanwhile, ascorbic acid possesses virtually equal binding affinity to 3-O-ethyl ascorbic acid (ΔG = -4.63 kcal/mol), though has considerably more potent tyrosinase inhibition activity in in vitro studies. Conclusion: Ascorbic acid is postulated to be feasible to combine with quercetin for inhibiting tyrosinase activity to eventually yield more optimized depigmenting effect.
Microwave-assisted Synthesis of Bis(4-hydroxy-3-methoxybenzylidene)cyclopentanone using Ba(OH)2.8H2O as a Base Catalyst Gunawan, Maggie Anastasya; Budiati, Tutuk; Soewandi, Ami
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 13 No. 1 (2026): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v13i12026.12-19

Abstract

Background: Synthetic curcumin analogs have been widely studied due to their pharmacological activity. One of the curcumin analog compounds, namely 2,5-bis(4-hydroxy-3-methoxybenzylidene)cyclopentanone (HM-BCP), which has more potent anti-inflammatory activity than curcumin.. In the synthesis process, the presence of the OH-phenolic group is still a problem to maximize the reaction condition. The use of strong base catalysts may cause unwanted side reactions with the phenolic OH group present in the substrate. Therefore, barium hydroxide was used as the catalyst because it has lower basicity than NaOH, which is commonly used in this reaction. Objective: This study aims to synthesize HM-BCP using Ba(OH)2.8H2O as a catalyst in several concentrations. The reaction was assisted by microwave irradiation. Methods: Synthesis of HM-BCP from cyclopentanone and vanillin via Claisen-Schmidt condensation in alkalis condition. Cyclopentanone, vanillin, and Ba(OH)₂·8H₂O were mixed for 15 min, followed by microwave irradiation (480 W, 10 min). The reaction mixture was stirred for 5 min after each minute of irradiation. The reaction product was analyzed by TLC to determine the area percent ratio of the starting material (vanillin), and HM-BCP. The purity of the synthesized products were tested using TLC and melting point determination, while structure identification by IR and H-NMR spectroscopic methods. Results: The use of 2–4 molEq of Ba(OH)₂ as the catalyst in the synthesis of HM-BCP produced relative percentage areas of 11.4%, 15.8%, and 20.9%, respectively. Conclusion: Barium hydroxide has been shown to act as a catalyst in the synthesis of HM-BCP via Claisen-Schmidt condensation but optimization of reaction conditions is needed.
Adherence and Predictors of Endocrine Therapy Use Among Breast Cancer Patients in a Private Hospital: A Cross-Sectional Study Setiawardani, Maria Fitri; Cholisoh, Zakky; Hapsari, Pramudita Mila
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 13 No. 1 (2026): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v13i12026.20-30

Abstract

Background: Breast cancer has a high incidence rate. One of the treatments involves long-term endocrine therapy, which can cause boredom in patients with cancer, leading to non-compliance with therapy. Objective: This study aimed to evaluate adherence and identify the variables that affect the level of adherence in patients with breast cancer receiving endocrine adjuvant therapy at a private hospital in Central Java. Methods: This cross-sectional study used purposive sampling. Data were collected from 87 respondents in total. Data were collected using questionnaires and patient medical records. Results: We categorised the patient adherence level as adherent (65.5 %) and non-adherent (34.5 %). The logistic regression test revealed a relationship between adherence and education level (p-value=0.001; OR=0.056; 95% CI 0.012-0.281), stage (p-value=0,002; OR 0.096; 95% CI 0.022-0.424), and other medication use (p-value=0,020; OR=0.061; 95% CI 0.006-0.650). This indicates that education level, cancer stage, and other medication use significantly influenced the adherence rate of patients receiving endocrine adjuvant therapy. These findings emphasise the need for targeted educational support and optimised medication management to improve adherence among patients undergoing long-term endocrine therapy.
Population Pharmacokinetic-Based Model-Informed Precision Dosing: Current Implementation Status and Global Equity Gaps – A Structured Narrative Review Aisyah, Novia Dani; Nugroho, Akhmad Kharis; Andayani, Tri Murti
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 13 No. 1 (2026): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v13i12026.31-50

Abstract

Background: Model-Informed Precision Dosing (MIPD) leverages population pharmacokinetics (PopPK) and Bayesian forecasting to optimise drug therapy in heterogeneous populations. Despite its theoretical promise, real-world implementation remains limited, particularly in low- and middle-income countries (LMICs). Objective: This review synthesises evidence on the clinical integration, outcomes, enablers, and barriers of population pharmacokinetic (PopPK)-based MIPD. Methods: A structured narrative review was conducted across five databases to identify studies reporting real-world PopPK implementation (2014-2025) in clinical settings. Results: Twenty-seven studies were included, predominantly from high-income countries (HICs). Antibiotics were the most studied drug class, particularly vancomycin, which dominated the therapeutic areas studied; however, routine clinical implementation remained minimal. MIPD improved pharmacokinetic target attainment, reduced ICU stay by 2.13 days, and generated cost savings of up to $12,324 per patient. Key enablers included clinician-pharmacist collaboration and user-friendly software, whereas barriers included inadequate therapeutic drug monitoring (TDM) infrastructure and digital disparities in LMICs. Conclusion: PopPK-based MIPD demonstrates clinical and economic benefits but faces significant global implementation challenges. Accessible software development, TDM infrastructure enhancement, and validation studies in underrepresented populations are essential.
Development of Gingerol-Loaded Nanostructured Lipid Carriers Using a Two-Step Method Sagala, Reynelda Juliani; Iswandana, Raditya; Louisa, Melva; Surini, Silvia
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 13 No. 1 (2026): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v13i12026.51-59

Abstract

Ginger (Zingiber officinale) is well known for its beneficial effects on health, and it use as a culinary spice, mainly due to the presence of bioactive compounds such as 6-,8-, and 10-gingerol. Although 6-gingerol exhibits remarkable therapeutic potential, its clinical application is constrained by poor bioavailability and rapid metabolic degradation. Nanotechnology-based drug delivery systems have been widely explored to overcome these limitations by improving the stability, solubility, and bioavailability of bioactive compounds. Among these systems, nanostructured lipid carriers (NLCs) have attracted considerable to facilitate high drug-loading, enhanced stability, and controlled drug release. To address these issues, this study focused on formulating and characterizing gingerol using nanostructured lipid carriers. Gingerol-loaded NLCs were produced using a two-step process of high-shear homogenization followed by ultrasonication. Different total lipid contents were tested, specifically 5%, 8%, 10%, and 15%. Characterization of the resulting NLCs included particle size, polydispersity index (PDI), zeta potential, entrapment efficiency, in vitro release of gingerol, and stability over 30 days. The findings revealed that the NLC formulation with a total lipid content of 5% yielded the smallest average particle size of 208.32 ± 3.20 nm, alongside the lowest PDI of 0.231 ± 0.014, and the zeta potential measured at -25.90 ± 1.38 mV. The entrapment efficiency for this optimal total lipid was noted to be 70.65 ± 0.75%. Furthermore, stability testing conducted over a designated period demonstrated that the gingerol-loaded NLC formulation with a 5% lipid content maintained its integrity, exhibiting no significant degradation or alteration in properties. The results of this study highlight the critical role of the total lipid content in influencing the characteristics of NLC formulations achieved at 5% total lipid content, which not only improved the properties of gingerol delivery but also presented a potential approach for improving the delivery of compounds with low water solubility such as gingerol.
Response Surface Method-driven Design of Experiments for The Sublingual Immunotherapy Tablets of Indonesian House Dust Mites Allergenic Extract Pratama, Yusuf Alif; Marhaeny, Honey Dzikri; Prasetya, I Made Slamet Putra; Pramesthi, Anak Agung Istri Evinia; Winarto, Sulistyanengci; Miatmoko, Andang; Ardianto, Chrismawan; Rahmadi, Mahardian; Taher, Muhammad; Khotib, Junaidi
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 13 No. 1 (2026): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v13i12026.1-11

Abstract

Background: Allergic diseases represent a significant global health burden, and current pharmacological treatments primarily offer symptomatic relief without addressing the underlying immune dysregulation. Allergen-specific immunotherapy (AIT) is the only disease-modifying approach capable of inducing long-term remission by targeting the immunological mechanisms that drive the allergic response. Sublingual immunotherapy (SLIT) is a noninvasive alternative to subcutaneous immunotherapy, leveraging the rich vascularisation and antigen-presenting cell population of the oral mucosa. Objective: SLIT tablets were formulated using Indonesian house dust mite (IHDM) allergenic extracts, with the aim of optimising tablet properties by modulating the disintegrant concentration and croscarmellose-to-crospovidone ratios. Methods: Six formulations, each with three batches, were prepared via direct compression, varying the total disintegrant content (5.25 and 10.5% w/w) and excipient ratios. The tablets were evaluated for hardness, disintegration time, friability, and dissolution, and specific allergenic protein release (Der p 1 as a marker) was quantified using ELISA. A 2 × 3 factorial experimental design was used in the DoE approach, with data analysed using GraphPad Prism and Minitab, and response surface methodology (RSM) applied via Stat-Ease 360. Results: Higher disintegrant concentrations reduced tablet hardness but increased friability and disintegration rates. Pareto analysis revealed that both the total disintegrant content and disintegrant ratio significantly influenced tablet performance. All formulations demonstrated favourable dissolution profiles. The optimised formulation (F2), containing 5.25% (w/w) total disintegrants with a croscarmellose-to-crospovidone ratio of 1.5:2, achieved a disintegration time of 4.33 ± 0.88 s, hardness of 89.20 ± 6.12 N, and friability of 0.00 ± 0.01 %. Conclusion: These findings support the potential of IHDM-based SLIT tablets as an effective and mechanistically rational platform for allergen immunotherapy, contributing not only to symptoms but also to long-term modification of allergic diseases
Activity Test of Water Hyacinth (Eichhornia crassipes) Leaf Extract Against Streptozotocin-Nicotinamide-Induced Diabetic Nephropathy in Rats Afandi, Mukhamad; Herdwiani, Wiwin; Wijayanti, Tri
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 13 No. 1 (2026): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v13i12026.112-121

Abstract

Background: Diabetes mellitus is a metabolic disorder characterized by hyperglycemia. Chronic hyperglycemia in diabetes causes microvascular complications such as diabetic nephropathy (DN) which can affect kidney function. The parameters of kidney damage due to diabetes are increased levels of albumin and creatinine. Objective: The aim of this study was to determine the effect and effective dose of water hyacinth (Eichhornia crassipes) leaf extract on reducing blood glucose levels, microalbumin, serum creatinine, and improving kidney histopathology in STZ-NA-induced diabetic nephropathy rats. Method: The water hyacinth leaves were dried and made into a fine powder, then extracted using the maceration method using 70% ethanol. The initial testing process prepared 25 rats which were divided into 5 treatment groups, namely the negative group, positive control (Pioglitazone), water hyacinth leaf extract 61.25 mg/kg BW, 122.5 mg/kg BW and 245 mg/kg BW. The test animals were conditioned to be diabetic by being induced by STZ-Na intraperitoneally. Data analysis using One Way Anova and continued testing post hoc test. Results: The results showed that water hyacinth leaf extract at a dose of 245 mg/kg BW was the most effective in reducing microalbumin levels by 19.23% and improving kidney function, and had the potential to reduce blood glucose levels by 11.76% and serum creatinine by 15.04%, although it had not achieved the same effectiveness as the positive control. Conclusion: Water hyacinth leaf extract at a dose of 245 mg/kg BW can reduce blood glucose and microalbumin levels, as well as improve kidney function in diabetic nephropathy rats induced by STZ-Na.
Online Health and Antibiotic Information-Seeking Behavior Among University Students Awaludin, Adila; Nurhidayah, Dewi; Fadilah, Nitya Nurul; Rizki Amalia, Tania; Alvi Syahrina, Nadira
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 13 No. 1 (2026): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v13i12026.141-149

Abstract

Background: The Internet plays an important role in providing health information, particularly among university students. However, limited guidance from healthcare professionals may contribute to misinformation and inappropriate antibiotic use in the community. Understanding online health-seeking behaviors, especially regarding antibiotics, is important for effective public health promotion strategies; however, related research remains limited. Objective: This study aimed to investigate the patterns and motivations of Internet use related to seeking health and antibiotic information, including online purchasing behavior and self-medication practices, among university students in Tasikmalaya. Methods: This cross-sectional study used stratified sampling of 132 non-health students at Universitas Perjuangan Tasikmalaya. Data were collected using a questionnaire on internet use related to health information seeking and antibiotic self-medication. Results: Most students (94.7%) used the Internet to search for health-related information, while 65.2% searched specifically for antibiotic information. More than half of the respondents (58.3%) reported self-medicating with antibiotics, and 57.6% purchased pharmaceutical products online. Female students were significantly more likely than male students to seek health information (OR= 7.0; P = 0.021), seek antibiotic information (OR= 4.0; P = 0.001), and purchase pharmaceutical products online (OR= 2.8; P = 0.013). Convenience and lower prices were the main reasons for making online purchases. Additionally, 75.3% of students reported limited time to consult healthcare professionals as a reason for self-medicating with antibiotics. Conclusion: University students frequently use the Internet to seek health- and antibiotic-related information. Strengthening digital health promotion and oversight of online pharmaceutical sales is important to support rational antibiotic use.
Effect of Atorvastatin on Lipoprotein Lipase and Lipid Profile in Children with Refractory Nephrotic Syndrome and Hyperlipidemia Damayanti, Nurul; Yulistiani; Ninik Asmaningsih Soemyarso; Mariyatul Qibtiyah
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 13 No. 1 (2026): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v13i12026.84-91

Abstract

Background: Statin are Food and Drug Administration (FDA)-approved for hyperlipidemia but remain controversial in children. This study provides novel evidence of the molecular effects of atorvastatin on lipoprotein lipase (LPL) in children with refractory nephrotic syndrome, a population in which such data are limited. Objectives: This study aims to evaluate the effects of atorvastatin on serum lipoprotein lipase (LPL) levels and lipid profile parameters in children with refractory nephrotic syndrome. Methods: Randomized controlled trial (RCT) double-blind study of 31 children with hyperlipidemia and refractory nephrotic syndrome, included pre- and post-test groups. A placebo was given to the first group (n = 18 patients), while atorvastatin was administered to the treatment group (n = 13 patients). Results: Total cholesterol and Low-Density Lipoprotein (LDL) levels decreased significantly after treatment in both groups (p<0.05). In the atorvastatin group, LDL reduction was more pronounced compared to baseline. High-Density Lipoprotein (HDL) and Triglyceride (TG) levels showed no significant changes in either group (p>0.05). Lipoprotein Lipase (LPL) levels increased in the atorvastatin group and decreased in the control group; however, these changes were not statistically significant. No significant differences were observed between the atorvastatin and control groups in terms of changes in lipid profile parameters and LPL levels (p>0.05). Conclusions: Atorvastatin reduced cholesterol and LDL levels within the treatment group, although no significant differences were observed compared to the control group.

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