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INDONESIA
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Published by Universitas Airlangga
ISSN : 24069388     EISSN : 25808303     DOI : -
Core Subject : Health, Science, Education,
Chemistry Education Health Professions Medicine & Pharmacology Other
Jurnal ini adalah jurnal peer-review nasional, yang diterbitkan dua kali dalam membahas tentang topik-topik hasil penelitian di bidang pelayanan dan praktik kefarmasian, konsultasi masyarakat, teknologi kefarmasian serta disiplin ilmu kesehatan yang terkait dengan erat. Jurnal ini memfokuskan pada area-area berikut: 1. Farmasi Klinis 2. Farmasi Komunitas 3. Farmasetika 4. Kimia Farmasi 5. Farmakognosi 6. Fitokimia
Arjuna Subject : -
Articles 272 Documents
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In Silico Study of Green Tea (Camellia sinensis) Compound as Potential Anxiolytic Drug Material Targeting Estrogen Alpha Receptor Harfiah Nur Aini; Susanti; Richa Mardianingrum
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 1 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i12025.93-103

Abstract

Background: The prevalence of anxiety disorders has significantly increased each year but has not been matched by the availability of adequate treatments. Estrogen receptor alpha (ERα) is known to induce anxiety through the activation of a complex system in the body, and drugs that inhibit ERα activity are predicted to have anxiolytic potential. Objective: This study aims to evaluate 50 compounds derived from green tea leaves to discover potential anxiolytic candidates that act by inhibiting ERα. Methods: The research methods used include toxicity screening, pharmacokinetic screening, drug scan, molecular docking, and molecular dynamics. Results: Based on the screening results, quercetin was identified as non-carcinogenic, non-hepatotoxic, easily absorbed, evenly distributed, non-interfering with CYP2D6 enzyme metabolism, and potentially effective as an oral drug. In molecular docking results, quercetin showed a ΔG value of -7.54 kcal/mol and Ki of 2.97 µM, which are better than the reference drug with a ΔG value of -7.20 kcal/mol and Ki of 5.24 µM. Quercetin also shown more stable interactions with the Erα binding site, indicated by amino acids Glu353 and Arg394 in RMSD and RMSF analysis during molecular dynamics simulation. Conclusion: From the study result it can be concluded that quercetin has potential as a good candidate for anxiolytic drug material by inhibiting ERα activity.
In Vitro Evaluation of Antidiabetic and Anti-Inflammatory Activities of Five Selected Syzygium Leaves Ethanolic Extract as Alpha-Glucosidase Inhibitors and Anti-denaturation of Bovine Serum Albumin (BSA) Meiliza Ekayanti; Feri Setiadi; Siti Aminah; Alam Almaaz Afandi
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 1 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i12025.83-92

Abstract

Background: Diabetes mellitus (DM) has become a major health problem worldwide, with a continuous increase in mortality due to complications caused by hyperglycemia. Chronic hyperglycemia is often associated with inflammation due to increased production of free radicals. Objective: This study’s main objective is to assess antidiabetic and anti-inflammatory properties in vitro of five particular Syzygium leaves extract (S. cumini, S.aqueum, S. malaccense, S. polyanthum, and S. aromaticum) using alpha-glucosidase and Bovine Serum Albumin (BSA).  Methods: The five of selected Szygium leaves were macerated by using ethanol 96%, each extract was assessed in vitro for antidiabetic activity by analyzing the inhibitory of alpha-glucosidase using acarbose as strandard, and anti-inflammatory activity by analyzing the inhibitory denaturation of BSA Heat-induced and BSA induced by 2,2-diphenyl-1-picrylhydrazine (DPPH) with Sodium diclofenac as standard. Results: The IC50 of α-glucosidase inhibition was 76.235 µg/mL (strong) for S. malaccense and 0.241 µg/mL (very strong) for the acarbose standard. The greater IC50 of antidenaturation of BSA with heat-induced was S. polyanthum (95.7 µg/mL) and sodium diclofenac standard (59.25 µg/mL) both were strong inhibitor. Along with greater anti-denaturation of BSA, DPPH-induced S. malaccense (90.320 µg/mL) and sodium diclofenac standard (43.301 µg/mL), both of which are strong inhibitors. Conclusion: The ethanol extract of Syzygium leaves has the potential to be developed as an antidiabetic and anti-inflammatory herbal medicine, particularly S. malaccense and S. polyanthum leaf extracts, which provided greater activity in this study.
Formulation, Characterization, and In Vitro Evaluation of Sunscreen Cream Containing Kenikir (Cosmos caudatus Kunth.) Extract and Chicken Bone Collagen Hydrolysate Zukhruf, Annisa; Afifah, Ika Qurrotul
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 1 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i12025.114-125

Abstract

Background: Sunlight is a major contributor to skin damage, including erythema, pigmentation, premature aging, and other related conditions. Kenikir extract contains flavonoid derivatives, which have the potential to act as sunscreen due to the presence of chromophore groups that can reduce the intensity of sun exposure on the skin. In this study, sunscreen was made from kenikir extract with the addition of collagen hydrolysate. Objective: This study aims to assess the effectiveness and characteristics of various sunscreen cream formulations produced. Methods: Kenikir extract was obtained through ethanol-based maceration, while collagen hydrolysate was prepared by isolating chicken bone collagen using acetic acid solvent, followed by enzymatic hydrolysis with bromelain. Four sunscreen cream formulations were developed using various concentrations of kenikir extract and collagen hydrolysate. The creams were characterized by evaluating sun protection factor (SPF), percent erythema, percent pigmentation, organoleptic properties, acceptance testing, homogeneity, pH, viscosity, centrifugation, and spreadability. Results: The cream containing kenikir extract was effective as sunscreen with an SPF of 45.59, erythema of 1.96%, and pigmentation of 1.27%. It also exhibited homogeneity, with a pH of 7.83 and a viscosity of 46,700 cps, which met the permissible range for sunscreen use. The stability test indicated that it was stable, with no separation observed. Conclusion: Sunscreen cream containing kenikir extract has the potential to protect the skin from excessive sun exposure due to the effectiveness and good characteristics according to the Indonesian National Standard (SNI).
Formulation of Lip Balm Extract of Temu Mangga Rhizome (Curcuma mangga Val) as Moisturizer Andriani, Rina; Mus Ifaya; Rismayanti Fauziah; Dian Rahmaniar Trisnaputri; Wa Ode Ida Fitriah; Qur’ani
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 1 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i12025.126-141

Abstract

Background: Lip balm moisturizes the lips and can be made from natural ingredients such as mango rhizome extract (Curcuma mangga Val), which is rich in antioxidants. Objective: This study aims to evaluate the formulation of lip balm with varying concentrations of mango rhizome extract and determine its optimal concentration. Methods: The research employs a qualitative and quantitative approach using 1 Kg of mango rhizome simplisia from Southeast Sulawesi. The lip balm formulations include extract concentrations of 0%, 5%, 10%, and 15%, involving ingredients such as mango rhizome extract, cera alba, olive oil, glycerin, BHT, nipasol, strawberry essence, D & C Red 6, and vaseline album. Evaluation was conducted through organoleptic tests, pH, homogeneity, adhesion, spreadability, melting point, cycling test, moisture, irritation, and panelist preference. All formulations demonstrated stability in color, texture, and aroma at room temperature and during the cycling test. Consistency, homogeneity, and pH of all formulas remained stable. Results: Spreadability and adhesion improved with the concentration of the extract, with Formula F3 (15% extract) showing the best results, including an increased melting point indicating thermal stability. All formulas were safe and did not cause irritation. Preference tests indicated that F3 was preferred for moisture, while F1 and F2 were favored for aroma and color. Conclusion: The mango rhizome extract lip balm is stable, safe, and effective as a lip moisturizer, with Formula F3 being the most effective. Future research is expected to develop other formulations from mango rhizome to enhance moisturizing effects while maintaining the stability of the preparation.
Influence of Hesperetin Concentration in Poloxamer P84 and TPGS Mixed Micelles on Physical Characteristics and Cytotoxicity in T47D Cell Line Aulia, Nanda Intan; Rijal, Muh. Agus Syamsur; Yusuf, Helmy
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 1 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i12025.104-113

Abstract

Background: Hesperetin is a natural compound that has several properties including anticancer, but has limitation on low solubility in water. In this case, the development of a hesperetin delivery system using the micellar system is carried out. Objective: The current study aims to determine the effect of drug concentration on the physical characteristics and cytotoxicity of the mixed micelle. Methods: In this study, mixed micelles were formulated with D-a-tocopheryl polyethylene glycol 1000 succinate (TPGS) and poloxamer P84 as polymers through the thin film method, with hesperetin loaded at four different concentrations, i.e., 5 mg (F1), 10 mg (F2), 20 mg (F3), and 40 mg (F4). The mixed micelles were formulated using thin film hydration method. The evaluation of micelle’s physical characteristics was the measurement of particle size, Critical Micelle Concentration (CMC) value, drug loading, and drug entrapment efficiency. The evaluation of cytotoxicity used the T47D cell line and Micro Tetrazolium (MTT) method. Results: The CMC value of the mixed micelle was 0.0029% w/v, which was lower than the CMC of TPGS and poloxamer P84 only. The particle size of the micelles produced was between 17.07–20.37 nm. Among the various formulations, F3 showed relatively small particle size and has homogeneous particle size, high drug loading and encapsulation efficiency, and low IC50. Based on the study, particle size of F3 was 17.93  0.32 nm with polydispersity index (PDI) of 0.256 0.034. The drug loading percentage of F3 was 4.0092  0.0048% with an encapsulation efficiency of 94.5492 0.0013%. Based on cytotoxicity test using MTT method, F3 has low IC50, there was 4.036 ppm. Conclusion: Hesperetin-loaded mixed micelles offer potential as anticancer drugs that improve hesperetin efficacy. The results showed that F3 was the most potent anticancer formulation based on the physical characteristics and cytotoxicity tests.
Formulation and Physical Evaluation of Kratom (Mitragyna speciosa Korth.) Leaf Extract Emulgel as Analgesic in Mice (Mus musculus) Zulhakim, Iqmal; Kathina Deswiaqsa; Jane Arantika
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 1 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i12025.75-82

Abstract

Background: Kratom leaves contain major alkaloid compounds, particularly mitragynine and 7-hydroxymitragynine which have demonstrated anti-pain or analgesic properties. Objective: This study aims to evaluate the effectiveness of kratom leaf extract emulgel in reducing pain when applied topically in mice. Methods: This study was conducted on male mice that had been induced with acetan acid intraperitoneally. Following induction, emulgel formulations were applied topically and pain responses were recorded every five minutes over 30 minutes period. Group 1 (emulgel base without active ingredient), Group 2 (voltaren emulgel), Group 3 (emulgel with 5.6% extract concentration), Group 4 (emulgel with 11.6% extract concentration) and Group 5 (emulgel with 17.6% extract concentration).  Results: The results of physical evaluations of emulgel formulations met the applicable standards. Observations of pain responses indicated optimal analgesic effect in the emulgels containing 11.6% and 17.6% extract concentration with analgesic values of 51.52% and 63.06% respectively. An active substance is considered to have analgesic activity whent it demonstrates ≥50% effectiveness. Conclusion: This study concluded that emulgels formulated with kratom leaf extract exhibited analgesic activity as evidenced by the decreased in the writhing response of mice every five minutes.
Antihypertensive Activity of Black Garlic Extract in Rats and Its Phytochemical Analysis using GC-MS Estiningsih, Daru; Saiful Bachri, Moch; Hayu Nurani, Laela; Ma’ruf, Muhammad; Yuliani, Sapto; Sofia, Vivi; Prasasti, Dian
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 1 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i12025.67-74

Abstract

Background: Hypertension is defined as a medical condition where blood pressure rises above 140/90 mmHg. Black garlic is recognized as a natural remedy that may help lower high blood pressure, primarily due to its abundant antioxidant properties, which are believed to inhibit the function of the angiotensin-converting enzyme (ACE) that is essential for regulating blood pressure. Objective: This study aimed to identify the chemical composition of black garlic using GC-MS and assess its antihypertensive effects in rat models. Methods: This study characterized the chemical composition of black garlic using GC-MS (Agilent 7890A) and evaluated its antihypertensive effects in rats. Hypertension was induced by oral administration of NaCl at a dose of 3.75 g/20 g body weight (BW) from day 0 to day 14. Blood pressure measurements were taken on days 0, 14, and 21. Black garlic extract was administered at three dose levels 4.2 mg/20 g BW, 8.4 mg/20 g BW, and 12.4 mg/20 g BW to evaluate dose dependent antihypertensive responses. Statistical analysis included the Kolmogorov-Smirnov test for normality, homogeneity testing, One-Way ANOVA Results: The GC-MS analysis identified 9-octadecenoic acid as the dominant compound in black garlic, accounting for 34.53% of its total composition. The antihypertensive activity test showed that administering black garlic at a dose of 12.4 mg/20 g BW significantly lowered systolic, diastolic, and mean arterial blood pressure while enhancing nitric oxide levels in hypertensive rats. Conclusion: Black garlic has the potential as an effective herbal treatment to lower blood pressure.
Effect of Glycerin on Stability and Antioxidant Activity of Ethyl Acetate Fraction of Secang Wood Face Mist Nur Halisa Rahmawati; Nastiti Utami; Dian Puspitasari
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 2 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i22025.218-228

Abstract

Background: Secang wood (Caesalpinia sappan L.) is a plant that contains brazilin, a natural antioxidant. A potential problem in the brazilin formulation process is that brazilin becomes unstable due to environmental influences. Face mist is one of the formulations that contains glycerin to maintain the stability. Glycerin can stabilize brazilin by forming hydrogen bonds between glycerin and brazilin. Objective: The main objective of this research was to evaluate the effect of glycerin on the physical stability and antioxidant activity in ethyl acetate fraction of secang wood face mist. Methods: Face mist formulation was prepared using different glycerin concentrations, such as F1 (10%), F2 (15%), and F3 (20%). Face mist was formulated using ethyl acetate fraction of secang wood, glycerin, phenoxyethanol, and aquadest. Physical evaluation stages included organoleptic, homogeneity, pH, specific gravity, viscosity, spray spreadability, skin moisture, cycling tests, and hedonic tests. 2,2-Diphenyl-1-picrylhydrazyl (DPPH) method was used to examine antioxidant activity. Results: The physical evaluation showed that face mist produced good results and complied with the requirements of face mist. The antioxidant activity test showed that face mist with the IC50 value for F1 was 22.114±0.046 µg/mL, F2 was 21.828±0.033 µg/mL, and F3 was 21.378±0.025 µg/mL. Conclusion: Based on these observations, the best formula was F3 because the antioxidant activity was classified as very strong, and the physical evaluations were considered more stable than others. In addition, F3 had the highest average score on the hedonic test.
Exploring Side Effects of Warfarin in Outpatients at Tertiary Hospital in Indonesia Zahra Oviary Satryo, Fatimatuz; Wahyuni, Dewi; Suprapti, Budi; Putri Nilamsari, Wenny; Yusuf Alsagaff, Mochamad; Makmuroh Nurul Qomar Purnamawati, Dewi; Subakti Zulkarnain, Bambang
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 2 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i22025.142-150

Abstract

Background: Patients with atrial fibrillation, venous thromboembolism, valvular disease, cardioembolic stroke, and acute myocardial infarction are prescribed the oral anticoagulant warfarin to treat thrombi. To guarantee its efficacy and safety, anticoagulants must be closely monitored. Furthermore, warfarin has a narrow therapeutic index, which increases the risk of side effects, particularly in the early stages of treatment. Objective: This study aimed to analyze the incidence of warfarin side effects in outpatients at Dr. Soetomo General Hospital. Methods: A retrospective cross-sectional design was adopted for outpatients at the Cardiology Department of Dr. Soetomo General Hospital from March to May 2023. Data were collected on the incidence of side effects in outpatients who received warfarin for a minimum of one month through an interview process. Other data, including age, sex, duration of warfarin therapy, comorbidities, and INR at the last scan, were extracted from medical records. The Chi-Square test was used to examine the data. Results: The results showed that 88 patients (42.7%) had side effects of bleeding (126 events). These included gum bleeding (22.3%), hematoma (20.4%), melena (7.7%), menometrorrhagia (2.4%), epistaxis (1.9%), hematuria (1.5%), hematemesis (1.0%), hemoptysis (1.0%), spontaneous venous bleeding  (1.0%), hematochezia (0.5%), hemostasis during blood sampling  (0.5%), tongue bleeding  (0.5%), and subconjunctival bleeding  (0.5%). Conclusion: The incidence of side effects during warfarin treatment was high, accounting for approximately 42.7% of cases. Furthermore, one patient experienced more than one side effect.
Efficacy of Ticagrelor Monotherapy in Patients at High Bleeding Risk Undergoing Percutaneous Coronary Intervention: a Systematic Review Nur Arifana, Erlita; Subakti Zulkarnain, Bambang
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 2 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i22025.174-194

Abstract

Background: Dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) prevents ischemic events. However, prolonged therapy increases the risk of bleeding. In this context, an antithrombotic strategy is applied to post-PCI patients by discontinuing aspirin and maintaining P2Y12 receptor monotherapy. Currently, patients with ACS treated with the single antiplatelet agent ticagrelor prefer to apply DAPT for 1 to a few months to open blocked arteries. Objectives: This systematic review aimed to evaluate the clinical efficacy of transitioning high-bleeding-risk patients to ticagrelor monotherapy following a three-month course of DAPT. Methods: A systematic literature review based on the PRISMA statement was conducted to review articles on DAPT, PCI, ticagrelor monotherapy, and high bleeding risk (HBR). The article search was conducted using Internet search databases, including PubMed and ScienceDirect, published between January 2014 and December 2024. Results: Six studies met the inclusion criteria and were included in the analysis. Clinical outcomes were assessed over a follow-up period of up to one year, including endpoints such as all-cause mortality, myocardial infarction, stent thrombosis, stroke, and target vessel revascularization. The secondary endpoints included major adverse cardiovascular and cerebrovascular events (MACCE), significant bleeding defined by Bleeding Academic Research Consortium (BARC) types 2, 3, or 5, and net adverse clinical events (NACE). Conclusion: the use of ticagrelor monotherapy after 3 months of dual antiplatelet therapy is expected to assist healthcare professionals in considering the risk-benefit of single therapy for patients after percutaneous coronary intervention.

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