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INDONESIA
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Published by Universitas Airlangga
ISSN : 24069388     EISSN : 25808303     DOI : -
Core Subject : Health, Science, Education,
Chemistry Education Health Professions Medicine & Pharmacology Other
Jurnal ini adalah jurnal peer-review nasional, yang diterbitkan dua kali dalam membahas tentang topik-topik hasil penelitian di bidang pelayanan dan praktik kefarmasian, konsultasi masyarakat, teknologi kefarmasian serta disiplin ilmu kesehatan yang terkait dengan erat. Jurnal ini memfokuskan pada area-area berikut: 1. Farmasi Klinis 2. Farmasi Komunitas 3. Farmasetika 4. Kimia Farmasi 5. Farmakognosi 6. Fitokimia
Arjuna Subject : -
Articles 272 Documents
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Cost Effectiveness Analysis of Antibiotics Use Prophylactic in Caesarean Surgery Patients at Dirgahayu Hospital Samarinda Maulida, Baidha' Rahma; Hanifa, Deasy Nur Chairin
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 3 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i32025.414-422

Abstract

Background: Caesarean delivery carries the risk of complications, such as surgical wound infection. Surgical wound infections can be prevented by administering prophylactic antibiotics, which have been proven to reduce the risk of surgical wound infections. Various types of prophylactic antibiotic use affect the costs incurred during treatment; therefore, it is necessary to carry out a cost-effectiveness analysis to determine treatment options with the best effectiveness and low cost. Objective: This study aimed to determine the cost-effectiveness of using prophylactic antibiotics in patients undergoing caesarean sections at Samarinda City Hospital. Methods: This research used an observational approach with retrospective data collection using medical record data from January 2023 to September 2024, with sampling using total sampling. In this study, 75 samples were obtained that met the inclusion and exclusion criteria of the study. Results: The results of the study showed that the prophylactic antibiotics used in caesarean section patients were cefotaxime, ceftriaxone, and cefazolin. Based on the cost-effectiveness analysis, cefazolin was more cost-effective than cefotaxime and ceftriaxone in patients undergoing caesarean section, with an ACER value of IDR 123,998, and was included in quadrant II. Conclusion: Cefazolin IV (1 g) is a cost-effective prophylactic antibiotic for caesarean section patients at Dirgahayu Hospital Samarinda, with 100% therapeutic effectiveness and low costs based on the average total cost, ICER calculation, cost-effectiveness grid analysis, and cost-effectiveness plane.
The Rationality of Drug Therapy in Pulmonary Anti-Tuberculosis Patients at Puskesmas Cimahi Tengah Purnamawati Suherman, Linda; Abdul Rozzaaq, Muhammad; Ramdani, Robby; Amelia, Riza; Hermanto, Faizal; Septiani, Vina; Nurul Islamiyah, Alfi
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 3 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i32025.382-390

Abstract

Background: Tuberculosis (TB) is a significant global health challenge in Indonesia. The rational use of anti-TB drugs is essential for treatment success and for preventing drug resistance in patients with TB. Objectives: This study aimed to evaluate the rationality of anti-TB drug use in patients with pulmonary TB at the Cimahi Tengah Public Health Center (Puskemas Cimahi Tengah). Methods: This research employed a descriptive method with a retrospective approach based on observational data from the Tuberculosis Information System (SITB) between January and December 2023. Samples were selected using purposive sampling based on the predefined inclusion and exclusion criteria. Results: The results showed that All patients (100%) received treatment according to the national guidelines and WHO recommendations, including the HRZE regimen (rifampicin, isoniazid, pyrazinamide, and ethambutol). The accuracy of indication, drug selection, dosage, and administration intervals also reached 100%, demonstrating adherence to the clinical standards. Conclusion: Anti-TB drug use at the Cimahi Tengah Public Health Center complies with established treatment standards, ensuring treatment effectiveness and contributing to optimal patient outcomes.
Molecular Docking of Flavan-3-Ol Compounds from Cocoa Beans Againts Matrix Metalloproteinases (MMPs) as Anti-Photoaging Agents Cindi Dia Annisa; Tristiana Erawati; Widji Soeratri; A'liyatur Rosyidah, M.Si., Ph.D
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 3 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i32025.312-320

Abstract

Background: Premature aging of the skin is an abnormal aging process that is primarily triggered by UV exposure, which leads to increased production of matrix metalloproteinases (MMPs). These enzymes degrade skin collagen. The abundant flavan-3-ol content of cocoa beans has been demonstrated to possess antioxidant properties, thereby serving as a potential agent to impede premature aging. A molecular docking approach can facilitate the prediction of cocoa bean flavan-3-ols' capacity to impede MMP enzyme activity. Objective: This study aims to predict the interaction between cocoa bean flavan-3-ol compounds and MMP enzymes as potential photoaging inhibitors. Methods: Flavan-3-ol compounds from cocoa beans, including (-)-epicatechin, (+)-catechin, procyanidin B1, B2, and C1 were obtained from PubChem and modeled in 3D using ChemDraw 3D software. These compounds were docked into the collagenase (MMP-1), stromelysin (MMP-3), and gelatinase (MMP-9). The docking results were compared to native ligands of the proteins. AutoDock was used for docking, and the results were visualized using Biovia Discovery Studio. Results: Method validation confirmed that all proteins were suitable for docking. The docking results showed negative docking scores for all compounds, with each compound binding at least one amino acid residue similar to native ligands. Procyanidin B2 exhibited the best docking score and the smallest inhibition constant for collagenase and gelatinase 9. Conclusion: Cocoa bean flavan-3-ol compounds can inhibit collagenase, stromelysin, and gelatinase activity. Procyanidin B2 is the most effective compound among those tested. Consequently, further testing may be undertaken to generate supporting evidence for potential utilization of cocoa beans as an active compound in cosmetic formulations.
Optimization of Self-Nanoemulsifying Drug Delivery System Combining Red Ginger and Aromatic Ginger Extracts to Improve Solubilization and Stability Hindiana, Linda; Widyowati, Retno; Sukardiman
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 3 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i32025.355-363

Abstract

Background: Red ginger (Zingiber officinale var. rubrum) and aromatic ginger (Kaempferia galanga L.) are traditional Indonesian medicinal plants with proven pharmacological activity, but their poor aqueous solubility requires formulation strategies to enhance solubilization and physical stability. Objective: This study aimed to optimize and evaluate a Self-Nanoemulsifying Drug Delivery System (SNEDDS) combining red ginger and aromatic ginger. Methods: The optimization was conducted by varying the oil-to-Smix ratio and extract concentration, while the internal Smix composition (Tween 80: PEG 400 = 1:2.8 w/w) remained constant to isolate the effect of oil–surfactant proportion. Virgin coconut oil (VCO), Tween 80, and PEG 400 were used as the oil phase, surfactant, and co-surfactant, respectively. Three formulas were prepared based on oil-to-Smix (w/w): Formula A (1:4.68, 500 mg extract), Formula B (1:10.6, 500 mg extract), and Formula C (1:10.6, 460 mg extract). Physical characterization included visual observation, centrifugation, particle size, polydispersity index (PDI), and transmittance before and after thermodynamic stability tests. Results: Formula A was unstable and exhibited precipitation. Before stability testing, Formula C showed improved dispersion, with a 41.5% reduction in droplet size and a 79.9% decrease in PDI relative to Formula B. After stability testing, Formula C demonstrated markedly better performance, including an 85.5% smaller droplet size, 81.4% lower PDI, and a 2.4% increase in transmittance compared with Formula B. These quantitative improvements indicated that Formula C exhibited more optimal solubilization capacity and physical stability. Conclusion: This study concludes that extract concentration and the oil-to-Smix ratio significantly influence SNEDDS characteristics, and Formula C represents the most favorable formulation for further development.
Hypoxia-inducible Factor-2α Probably Mediated the Toxicities of Intravenous Beta-Cyclodextrin in Normal and Diabetic Rats’ Kidneys Anita Purnamayanti; Suharjono; Mahardian Rahmadi
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 3 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i32025.372-381

Abstract

Background: Intravenous β-cyclodextrin administration poses an increased risk of toxicity. Objective: This study aimed to determine the nephrotoxicity of intravenous beta-cyclodextrin (BCD) and its underlying molecular mechanism. Methods: Sixteen Wistar rats were randomly assigned to the healthy or diabetic test group, which received a daily intravenous injection of water for injection or a 6% beta-cyclodextrin solution, respectively, for 28 days. Histopathology was analyzed semi-quantitatively on a 0-5 score basis, and RT-PCR was used to quantify the mRNA expression of HIF-1, HIF-2, IL-1, IL-6, IL-18, and eNOS. Results: There were no deaths in any of the groups, and renal function declined in the test groups. Histopathological findings revealed abnormalities in vascular integrity, cellular infiltration/damage, and necrosis in the kidney, while the relative expression of mRNA for hypoxia-inducible factors (HIFs), a marker of regional renal hypoxia, was upregulated. Conclusion:  Intravenous administration of beta-cyclodextrin increases the risk of nephrotoxicity, and the molecular mechanisms underlying kidney injury are probably mediated by hypoxia inducible factors-2α (HIF-2α). We strongly suggest that future research should be conducted with an adequate sample size.
Copper Contamination Levels and Storage-Related Migration in Commercial Canned Fruit Cocktail Products Using AAS and Dithizone Screening Adrianto, Muhammad Faris; Sudjarwo; Angelie, Khanaya; Putri, Luvena Navelyn Anggi
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 3 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i32025.391-398

Abstract

Background: Heavy metal contamination in food has become a growing health concern due to its toxic and accumulative effects, particularly from metals such as copper (Cu). Canned fruit products, especially those containing acidic components, are vulnerable to metal leaching from packaging. Objective: This study aimed to determine the levels of copper contamination in commercially available canned fruit cocktail products and evaluated temporal changes in Cu levels during 12 weeks of room-temperature storage. Additional qualitative screening using dithizone-impregnated strips was assessed for detecting Cu presence. Methods: A total of 12 samples from four different brands were analyzed using Atomic Absorption Spectrophotometry (AAS) to quantify copper concentrations at two-week intervals. Results: Initial copper concentrations ranged from 0.09 to 1.47 ppm, all of which were below the FAO/WHO permissible limit of 2 ppm for processed foods, although several samples approached the upper threshold. After 12 weeks, Cu levels increased progressively during storage, confirmed statistically by repeated-measures ANOVA (p < 0.05). The dithizone strip test confirmed copper presence through visible color changes. Conclusion: The study confirmed that copper contamination in canned fruit cocktail products increased with storage time, potentially exceeding safety limits.
Evolving Patterns of Anxiety and Depression Among Pharmacy Students: A One-Year Observational Study Dewi Susanti Atmaja; Yuwindry, Iwan
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 3 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i32025.321-329

Abstract

Background: Mental health issues, particularly anxiety and depression, are increasingly concerning for university students. Pharmacy students are especially vulnerable to stress owing to high academic demands. This study is one of the first longitudinal analyses exploring the evolution of anxiety and depression symptoms among Indonesian pharmacy students. Objective: To observe the longitudinal patterns of depression and anxiety symptoms among pharmacy students using the Patient Health Questionnaire 9 (PHQ-9) and Generalized Anxiety Disorder 7 (GAD-7) over an academic year. Methods: This prospective cohort study involved 106 first-year pharmacy students (undergraduate and professional programs). Depression and anxiety symptoms were measured using the PHQ-9 and GAD-7 instruments at two time points: the beginning and the end of the academic year. Data were analyzed using descriptive statistics and the Wilcoxon Signed-Rank test. Results: The mean GAD-7 score slightly increased from 9.15 (SD=3.29) to 9.45 (SD=3.47), while the PHQ-9 score increased from 10.81 (SD=4.37) to 11.47 (SD=4.56). Wilcoxon tests showed that the increase in anxiety was not statistically significant (p=0.036), whereas the paired t-test indicated that the increase in depression was not statistically significant (p=0.079). However, a higher severity category was observed for depressive symptoms. Conclusion: Although changes in anxiety and depression scores were not statistically significant, a trend toward worsening depressive symptoms was observed during the academic year. These findings highlight the importance of continuous mental health monitoring and early supportive intervention among pharmacy students.
Formulation, Physical Characterization, and Stability Study of Nanoemulgel Containing Jatropha curcas Leaves Extract Aly, M. Ainun Najib; Pratama, Edo; Shobahah, Jauharotus; Munandar, Tristiana Erawati; Sukardiman
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 3 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i32025.407-413

Abstract

Background: Jatropha curcas extract has been identified as a promising herbal remedy for various skin disorders. However, its application is limited by its low water solubility and poor skin permeability. Nanotechnology-based strategies provide a way to overcome these limitations. Objective: This study aimed to develop a new drug delivery system for J. curcas extract as a topical treatment for skin conditions. Methods: J. curcas extract was obtained through maceration. The system included a Carbopol 940-based gel and a J. curcas extract (JCE 10% w/w) nanoemulsion (NE) created using a high-energy method with an ultrasonic homogenizer. The appearance, pH, viscosity, spreadability, particle size, polydispersity index, and zeta potential of the nanoemulgel were assessed to verify its physical properties. Results: The optimal formulation produced a dark green nanoemulgel with a distinctive leafy smell and a semi-solid texture. Physical characterization of the JCE-NE-gel included a pH of 6.3, particle size of 142.67 nm, polydispersity index of 0.248, zeta potential of -23.23 mV, viscosity of 87.881 cP, and spreadability of 6.13 cm. Stability testing showed no significant differences after accelerated stability testing and thermal cycling. Conclusion: The study demonstrated that J. curcas extract (JCE-NE-gel) was successfully incorporated into a nanoemulgel formulation (F4), showing excellent physical properties and stability.
Effect of Integrated TOGA-Nutrition Education on Stunting Prevention Knowledge among Health Volunteers and Adolescents in Lamongan, Indonesia: A Pre-Post Intervention Study Kusumawati, Idha; Puspitasari, Hanni Prihhastuti; Soesilawati, Pratiwi; Izzah, Zamrotul; Fitria, Anisa Lailatul; Ramadhani, Firmansyah Ardian; Rullyansyah, Subhan; Pratama, Yusuf Alif; Pattymahu, Charlyna Veronika Puspitasari; Gamar, Fahmi Haitsami Ibnu; Ruzainah Ali
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 3 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i32025.342-354

Abstract

Background: Lamongan, Indonesia, is facing a significant public health issue, with high rates of stunting (27.5% in 2022) and adolescent anemia (60.0% in Babat district). A significant knowledge gap exists in the community, particularly regarding the effective use of Family Medicinal Plants (TOGA) for prevention, highlighting the need for structured intervention programs to address these public health issues. This study evaluated an integrated education program designed to improve knowledge and shift perceptions regarding TOGA, assessing differential knowledge gains between health volunteers and adolescents. Methods: This pre-post intervention study involved 54 female participants (27 health volunteers and 27 adolescents) from Kebalanpelang Village, Babat District, Lamongan. All participants received the same 120-minute integrated TOGA-nutrition education based on Social Cognitive Theory, covering stunting prevention, complementary feeding, breastfeeding optimization, and TOGA applications using evidence-based traditional medicinal plants. Knowledge was assessed using the same validated 10-item questionnaire (Cronbach's α=0.81) for both groups, covering three domains: complementary feeding guidelines (3 items), breastfeeding optimization (3 items), and TOGA applications for stunting prevention (4 items), administered before and immediately after the intervention. Results: The intervention was highly effective, yielding a statistically significant 25.4% mean knowledge gain across all participants (3.6±2.1-point gain, p<0.001). Adolescents showed the most dramatic improvement, achieving a 39.7% knowledge increase (a 4.8-point gain). While health volunteers had a more modest gain of 14.7% (a 2.4-point increase), the intervention successfully narrowed the initial knowledge disparity between the two groups by 57% (reducing the gap from Δ4.2 to Δ1.8 points). Domain-specific analysis revealed significant gains across all areas: complementary feeding (+26.8%), breastfeeding (+26.7%), and TOGA applications (+23.9%, all p<0.001). A strong inverse correlation between age and knowledge gain (r=-0.72, p<0.001) indicated that younger participants, particularly those aged 15-17 years, demonstrated superior learning capacity. Conclusions: The implementation of integrated TOGA-nutrition education significantly enhanced stunting prevention knowledge. This intervention is particularly effective for adolescents, which employs role-specific content, successfully mitigates cultural barriers and leads to a measurable reduction in knowledge equity gaps. Strong evidence of participant confirms the program's cultural fit and operational readiness, making a compelling case for its integration and scaling within Indonesia’s broader stunting prevention efforts.
Measurement Quality of Life in People with Diabetes Mellitus using EQ-5D-5L, SF-6D, and QWB-SA Nugraha, Akbar; Endarti, Dwi; Andayani, Tri Murti
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 3 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i32025.304-311

Abstract

Background: Quality of life is considered a humanistic outcome that can be used as a utility value in cost-utility analysis to compare therapeutic interventions. Diabetes mellitus can affect quality of life Objective: This study aimed to assess the utility values among patients diagnosed with diabetes mellitus and examine their correlation with patient characteristics. This study provides the first comparison of utility values derived from the EQ-5D-5L, SF-6D, and QWB-SA among Indonesian patients with diabetes mellitus in a primary care setting, offering locally relevant evidence for cost-utility analyses and highlighting the sociodemographic and clinical factors influencing QoL. Methods: Utility values were measured using the EuroQol Five-Dimension Five-Level (EQ-5D-5L), Short Form Six-Dimension (SF-6D), and Quality of Well-Being Self-Administered Scale (QWB-SA). The research design was cross-sectional, with a sample of Prolanis program members from community health centers in Gunung Kidul, Surakarta, Surabaya, and Madiun. Patient responses were converted to utility scores. Correlations between utility values and patient characteristics were analyzed using the Mann–Whitney or independent t-tests. Results: Utility scores obtained from EQ-5D-5L, SF-6D, and QWB-SA showed significant differences across instruments, with mean values of 0.89 ± 0.1575, 0.92 ± 0.0932, and 0.66 ± 0.1229, respectively. Conclusion: The utility scores of patients with diabetes mellitus measured using the EQ-5D-5L, SF-6D, and QWB-SA questionnaires showed significant differences. Patient characteristics that significantly influenced utility values included education level, employment status, income level, blood glucose control, and the presence of comorbidities.

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