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INDONESIA
Majalah Kedokteran Sriwijaya
Published by Universitas Sriwijaya
ISSN : 08523835     EISSN : 26850486     DOI : https://doi.org/10.36706/mks.v52i4
Core Subject : Health,
Health Professions Medicine & Pharmacology Nursing Public Health
Majalah Kedokteran Sriwijaya (MKS) is published by Fakultas Kedokteran Universitas Sriwijaya since 1962. MKS is a peer-reviewed, multidisciplinary and scientific journal which publishes all areas regarding medical sciences. The covered research areas as follows : Microbiology Pathology Surgery Ophthalmology Gynecology and Obstetrics Psychiatry Anesthesia Pediatrics Orthopedics Anatomy Physiology Biochemistry Pharmacology Biophysics Endocrine and Metabolism Mental Health Forensic Medicine Medical Education Research Methodology Medical Ethics Nursing Community Medicine Public Health
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 229 Documents
 19   20   21   22   23 
ASSOCIATION BETWEEN METABOLIC SYNDROME AND CORONARY HEART DISEASE IN WOMEN PATIENTS AT DR. MOHAMMAD HOESIN HOSPITAL PALEMBANG Desi Oktariana
Majalah Kedokteran Sriwijaya Vol 54, No 2 (2022): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/mks.v54i2.13809

Abstract

Metabolic syndrome is still a risk factor for coronary heart disease. This study aims to analyze the association between metabolic syndrome and coronary heart disease in women. This study is an observational analytic study using a cross-sectional design on 138 samples selected using consecutive sampling method and data were collected through observation of the medical records of patients at dr. Mohammad Hoesin Palembang. The results showed that the highest proportion of metabolic syndrome components in the sample of this study was hypertension (54.3%), while the lowest was hyperglycemia (26.8%). This study found a significant relationship between metabolic syndrome and coronary heart disease in female patients (p = 0.047). Female patients with metabolic syndrome had a 2.218 times greater risk of developing coronary heart disease (PR 2.218 95% CI = 1.072 - 4.587).
ACUTE RESPONSE OF LEUCOCYTE TOTAL OF WHITE RAT (RATTUS NORVEGICUS) WITH VARIATIONS VEGETARIAN DIETARY IN STRENUOUS EXERCISE Arwan Bin Laeto; Septi Purnamasari; Rara Inggarsih; Masayu Farah Diba
Majalah Kedokteran Sriwijaya Vol 54, No 1 (2022): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/mks.v54i1.16139

Abstract

Gaya hidup sehat menjadi hal penting yang perlu diperhatikan dan dijadikan prinsip dalam menjaga derajat kesehatan. Namun, kesibukan harian dalam memenuhi membuat masyarakat kurang memperhatikan diet dan pola aktivitas fisik yang baik dan benar, sehingga berpotensi menimbulkan penyakit yang dapat dinilai salah satunya melalui total leukosit. Penelitian ini bertujuan untuk menganalisis respon akut total leukosit tikus putih (Rattus norvegicus) pada variasi diet vegetarian pada olahraga berat. Metode penelitian berupa eksperimental in vitro melalui pendekatan eksploratif analitik dengan menggunakan desian pre-posttest design with nonequivalent groups. Penelitian ini menggunakan hewan coba tikus putih (Rattus norvegicus) sebagai sampel dengan pemberian tiga tipe diet vegetarian dan diet standar. Pengukuran total leukosit dilakukan sebelum dan sesudah perlakuan olahraga berat berupa berenang hingga lelah. Data setiap kelompok dianalisis secara statistik menggunakan uji-t. Hasil menunjukkan bahwa terdapat perubahan signifikan total leukosit pasca olahraga berat pada kelompok diet vegetarian tipe quasi p=0,028 (p<0,05), lacto-ovo p=0,007 (p<0,05) dan diet standar p=0,045 (p<0,05), sedangkan diet vegetraian tipe vegan tidak menunjukkan perubahan total leukosit yang signifikan pasca olahraga berat p=0,752 (p<0,05). Kesimpulannya, perubahan respon akut total leukosit tikus putih pasca olahraga berat terjadi pada diet vegetarian tipe quasi dan lacto-ovo.
THE BIOMOLECULAR CHARACTERISTICS OF ANGIOTENSIN II TYPE 1 RECEPTORS AS PARAMETERS IN KIDNEY FIBROSIS: A BIOINFORMATICS ANALYSIS Evi Lusiana; Irfannuddin Irfannuddin
Majalah Kedokteran Sriwijaya Vol 54, No 2 (2022): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/mks.v54i2.17535

Abstract

AGTR1 is a modulator of angiotensin II-induced signal transduction. This article aims to examine the biomolecular characteristics of AGTR1 and the role of AGTR1 in the renal fibrosis pathway in Rattus norvegicus rats. The gene ID NC 051352.1 and protein ID NP 112271.2 for AGTR1 were retrieved from the National Center for Biotechnology Information's website. The 'NCBI' website has details on AGTR1's structure, location, and expression. Protease prediction using 'PEPTIDE CUTTER'; glycosylation index prediction using NETNGLYC; and target protein location evaluated on the 'TARGETP' homepage. AGTR1 in Rattus norvegicus is located on chromosome 17p12, This protein has a stability score of 34.48. The aliphatic index was 114.62. AGTR1 is found inside, outside, and on the transmembrane, as determined by the THMM. Only 21 enzymes were predicted to be capable of cleaving the AGTR1 protein, out of a total of 37 protease. AGTR1 protein has four glycosylated amino acid sequences. AGTR1 protein is primarily at other location 0.850, secretory pathway (0.590), and a little amount in mitochondria (0.018AGTR1/AT1R is a marker for renal fibrosis in the renin angiotensin system, which can lead in vasoconstriction, inflammation, fibrosis, sodium retention, and water retention. The AGTR1 protein's molecular feature is a determinant in the progression of renal fibrosis, revealed to a bioinformatics study.
PfCRT GENE POLYMORPHISMS IN PLASMODIUM FALCIPARUM ISOLATES FROM MALARIA PATIENTS IN MALARIA ENDEMIC AREAS USING ACT AS STANDARD THERAPY Jhons Fatriyadi Suwandi; Betta Kurniawan; Hanna Mutiara; Aila Karyus
Majalah Kedokteran Sriwijaya Vol 54, No 1 (2022): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/mks.v54i1.15137

Abstract

The pfcrt gene is a biomarker to determine the resistance of Plasmodium falciparum to chloroquine and amodiaquine. When chloroquine was switched to ACT, it is very likely that there will be an increase in wild type strains (pfcrt K76) due to the absence of exposure to chloroquine. Currently chloroquine has not used for malaria treatment. The aims of this study were to identify polymorphisms in the pfcrt gene and phylogenetic analysis of Plasmodium falciparum isolates from malaria patients in Pesawaran Regency, Lampung Province. This research is a laboratory research by analyzing blood samples which are stored biological materials (BBT). DNA isolation was carried out using a DNA isolation kit QIAmp DNA Mini kit from Qiagen, followed by amplification using an appropriate primer. The amplification results were followed by sequencing and then analyzed using Mega 10. The results showed that all samples had mutations in codons 76 (K76T) and 72 (C72S) of the pfcrt gene. Pesawaran isolates were closely related to other isolates. The conclusion of this study is that polymorphisms were found in codons 72 and 76 of the PfCRT gene, although chloroquine has long been abandoned as an antimalarial. The sequenced pesawaran isolates were also related to other isolates. 
RISK FACTOR OF IMPAIRED FASTING GLUCOSE IN PRODUCTIVE AGE GROUP Abdussalam Abdussalam; Iche Andriyani Liberty; Pariyana Pariyana; Ardesy Melizah Kurniati
Majalah Kedokteran Sriwijaya Vol 54, No 4 (2022): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/mks.v54i4.19657

Abstract

Impaired fasting blood glucose is a condition that we can still try to turn back to normal. However, this has not been a concern. We aimed to analyze the contribution of risk factors (age, occupation, gender, systolic blood pressure, diastolic blood pressure, body mass index, physical activity, diet quality, and abdominal circumference) to the incidence of impaired fasting blood glucose in people of productive age in Palembang. This research was an observational analytic study with a cross sectional design. The results of the analysis using logistic regression showed that the most dominant risk factor associated with impaired fasting glucose was the diastolic blood pressure with OR=4.56, 95% CI=1.956-10,632, and p-value <0.001. Diastolic blood pressure was a significant and dominant risk factor for impaired fasting glucose in productive age communities. It is recommended that people who are more than 15 years old are expected to maintain blood pressure within the normal range, especially diastolic blood pressure in order to reduce the risk of disrupted fasting blood glucose by continuing to do physical activity
CHARACTER BUILDING OF INTEGRATED SERVICES POST ELEMENTS WITH AN ENTREPRENEURSHIP APPROACH AS AN EFFORT TO REVITALIZE INTEGRATED SERVICES POST AFTER PANDEMIC Elly Dwi Masita; Lailatul Khusnul Rizky; Firly Irhamni; Chaliestha Ayu Anggelliae; Risma Pramudhita
Majalah Kedokteran Sriwijaya Vol 54, No 3 (2022): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/mks.v54i3.18522

Abstract

Sebagian besar posyandu pada pasca pandemi tealh aktif melaksanakan programnya, namun terkendala kinerja kader yang kurang optimal. Hasil survey pasca pandemi didapatkan data bahwa sebagian besar program posyandu belum terlaksana secara optimal (73%), kinerja  kader posyandu mengalami penurununan sebesar 56% dan kunjungan posyandu sebesar 35% dari target 98%. Metode yang digunakan pada kegiatan pengabdian masyarakat ini adalah dengan menggunakan program studi independent melalui booth camp kader kesehatan pada kader kesehatan yang berjumlah 22 kader dengan pendekatan entrepreneurship. Variabel yang diukur pada kegiatan ini adalah kinerja kader posyandu meliputi keaktifan kader, kemampuan problem solving, ketepatan dalam pengisian laporan, kecepatan dalam menyelesaikan program, kerjasama antar tim, kemampuan komunikasi dengan masyarakat. Instrument menggunakan kuesioner dan cek list pre dan post. Analisis menggunakan independent t test (paired t test ) dengan melihat perbedaan mean dan sig < 0.05.  Hasil analisis didapatkan ada perbedaan masing- masing varibel indikator pre dan pos test. Pada keaktifan kader diperoleh perbedaan mean sebesar 21.77, problem solving sebesar 21.36, ketepatan pelaksanaan program sebesar 22.09, kecepatan dalam menyelesaikan program sebesar 21.05, kerjasama tim sebesar 23.53 dan kemampuan komunikasi sebesar 23.64 dengan nilai sig < 0.05. Metode studi independent booth camp melalui in person, online dan self perced mampu mengembalikan dan revitalisasi peran dan fungsi keseluruhan element posyandu
SEVERITY DETERMINANT OF COVID-19 WITH COMORBID HYPERTENSION IN PALEMBANG Mariana Mariana; Eddy Roflin; Emma Novita
Majalah Kedokteran Sriwijaya Vol 54, No 4 (2022): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/mks.v54i4.19663

Abstract

Hypertension is a risk factor for disease severity in COVID-19 patients. Data collected from the COVID-19 Handling Task Force as of October 13, 2020, as many as 13.2% of patients who died had comorbid hypertension. This research is an analytic observational study with a cross sectional design. This study uses primary data obtained through observation and questionnaires distributed to COVID-19 patients in Palembang. Most respondents aged 18-25 years (43.5%), female (56.5%), tertiary education level (79.6%), work as civil servants (30.6%) , and domiciled in Ilir Barat I District (14.8%), there are 24 subjects who have comorbid hypertension (22.2%) There are 26 subjects infected with COVID-19 without symptoms (24.1%), 55 subjects with a mild degree ( 50.9%), 23 subjects with moderate (21.3%), and 4 subjects with severe (3.7%) There is a significant relationship between comorbid hypertension and the severity of COVID-19 with a p value = 0.033. Hypertension is 2.8 times more at risk of contracting severe COVID-19 compared to mild and asymptomatic degrees.
FACTOR ASSOCIATED TO DAIRY MILK STORAGE BY WORKING MOTHER’S IN SOSIAL PUBLIC HEALTH CENTER Amelia Putri Habsari; Chairil Zaman; Helen Evelina
Majalah Kedokteran Sriwijaya Vol 54, No 2 (2022): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/mks.v54i2.19652

Abstract

Mothers can prepare “Dairy Milk Mother’s Savings”. An understanding of the importance of Dairy Mother's Milk saving must be supported by her husband and the surrounding environment because mothers can prepare themselves in prioritizing the health of babies with breast milk that has been dairy. This study aims to determine the factors associated with dairy breastmilk storage by worked mothers in work area at the Sosial Health Center Social in Palembang. This study uses a quantitative analytic survey research design with a cross sectional approach. The population of this study were babies who received exclusive breastfeeding totaling 475 babies. The minimum research sample in this Sukajaya village is 343 babies from 17 posyandu. The sampling technique uses accidental sampling. Interview data collection method using a questionnaire. Data analysis was done by Chi square test of 95% confidence level (? = 0.05). The results of this study indicated there were an associated between knowledge (? = 0.011), occupation (? = 0.003), education (? = 0.030), husband's support (? = 0.043) and health promotion (? = 0.024), there were no between relationship attitude (? = 0.341) and age (? = 0.246) with dairy milk storage by the mother of the worker. It was recommended to the Health Center can be taken into consideration made decision carrying counseling.
DETERMINANTS OF FITNESS AFFECTING MORBIDITY FOR HAJJ PILGRIMS IN PALEMBANG Emma Novita; Mariana Mariana; Achmad Ridwan
Majalah Kedokteran Sriwijaya Vol 54, No 3 (2022): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/mks.v54i3.19658

Abstract

Indonesia's largest pilgrim in the world where every year more than 220,000 pilgrims and followed by more than 5 million pilgrims in the world. Hajj is a physical worship, namely the congregation must adapt to a crowded environment, extreme hot temperatures, tiring pilgrimages can cause physical fatigue and illness. This study aims to evaluate at the morbidity of the Palembang pilgrims in 2019 so that it can be used to look at the risk factors for outpatient pilgrims and prevent diseases of the pilgrims in the Holy Land. This study was observational Retrospective Cohort design with 2053 outpatient Hajj pilgrims in Mecca and Medina. The results of the analysis of the 5 most outpatient diseases based on ICD X were acute nasopharyngitis (common cold),cough, primary hypertension, ARI, and acute pharyngitis. There was a significant relationship between age and morbidity of primary hypertension, physical fitness with nasopharyngitis, with cough, with hypertension, with acute pharyngitis, with ARI. There was no significant association between gender and disease in pilgrims. The results of the study were that pilgrims were required to maintain fitness with physical exercise and balanced food intake, especially those with comorbid diseases or those who were over 60 years of age.
HEADACHE PROFILE OF BRAIN TUMOR PATIENTS IN MOHAMMAD HOESIN HOSPITAL PALEMBANG Yunni Diansari; Henry Sugiharto; Sheila Stephanie Chandra
Majalah Kedokteran Sriwijaya Vol 54, No 3 (2022): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/mks.v54i3.16329

Abstract

Background: Headache is one of the most common complaint in population while a serious causative of underlying disease is very rare. Although headaches are rarely the result of a brain tumor, brain tumors are frequently associated with headaches. The challenges to the physician are to determine the specific feature of headache related to brain tumor.Methods: This is cross sectional study involved primary and metastatic brain tumor patient admitted in neurology ward of Mohammad Hoesin hospital from April 2018 to June 2019. The inclusion criteria including age > 18 years old and there was symptom of headache based on anamnesis. All were interviewed about their personal details (age, gender). The characteristic of headache was obtained based on questionnaire designed in our department. Various neurological symptoms related to the tumor were also recorded. Information of the tumor was obtained from the patient’s chart (histopathology of the tumor) and from characteristic of neuroradiological finding (magnetic resonance imaging or computed tomography). Headache and tumor characteristics were compared between primary and metastatic tumor by contrasting frequencies. We also analysed the correlation between tumor characteristics (location, hidrocephalus, vasogenic edema and tumor type) with headache intensity.Results: A total of 95 of 199 patients (48%) with headache symptom were studied in this series. Most patients were complained of chronic headache. Headache was mostly throbbing in both primary and metastatic brain tumors.  Progressively headache was dominant in this study and more than half patients report the quality of headache as moderate at the onset. In 35,8% patients, headache was the patient’s first complaint.  Headache as the isolated symptom of brain tumor was found in only 3,2% and only 28,4% of patients ful?lled the three ‘classic criteria’ of the brain tumor headache. A great localizing value of the headache was found in 63 cases of 95 patients. Of the 61 patients with single tumor and unilateral side, the unilateral headache was on 48 cases (78,8%). Of the 26 patients with strictly bilateral headache, 10 cases (38,5%) had bilateral sided tumors. Conclusion: The incidence of brain tumor headache in this study is similar to previous reports although the classic brain tumor headache features was found in a small portion of the patients. 

Page 21 of 23 | Total Record : 229

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