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INDONESIA
Biomedical Journal of Indonesia
Published by Universitas Sriwijaya
ISSN : 24077097     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
Biomedical Journal of Indonesia is an open access, peer-reviewed journal that focus on basic medical sciences, emphasizing on providing the molecular studies of biomedical problems and molecular mechanisms to integrate researches in all aspects of human health. BJI is dedicated to publishing original research and review articles covering all aspects of biomedical sciences.
Arjuna Subject : Kedokteran - Anatomi
Articles 392 Documents
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Coagulase-Negative Staphylococcus (CoNS) Susceptibility Pattern Towards Antibiotics in Infection Patients at RSUP Dr. Mohammad Hoesin Palembang Silvia Putri Sudirman; Tia Sabrina; Rizki Andini Nawawi; Rima Zanaria; Masayu Farah Diba
Biomedical Journal of Indonesia Vol. 10 No. 2 (2024): Vol 10, No 2, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v10i2.189

Abstract

Introduction. Coagulase Negative Staphylococcus (CoNS) is a bacterial species commonly causing infection in humans upon entrance into bloodstream. Antibiotics remain the therapeutic modality of choice in eradicating CoNS bacteria. Increasing incidence of antimicrobial resistance has made it difficult to administer the right treatment. In addition, CoNS susceptibility patterns differ between regions and with time. This study aimed to determine the susceptibility pattern of CoNS towards various antibiotics in infection patients at RSUP Dr. Mohammad Hoesin Palembang.  Methods. This study was a descriptive, observational study using the data from blood cultures of CoNS bacteria undergoing antimicrobial susceptibility test (AST) in the Clinical Microbiology Laboratory, and utilizing demographic and clinical data from the Medical Records Installation from July 1, 2021 to December 31, 2021. Results. There were 123 isolates from patient blood cultures which underwent AST. The most frequently identified bacterial species were Staphylococcus hominis ssp hominis, Staphylococcus epidermidis, Staphylococcus haemolyticus, and Staphylococcus saprophyticus. AST results showed that on average, CoNS were susceptible to tigecycline (100%), nitrofurantoin (98.4−100%), linezolid (86.1−100%), and vancomycin (80.6−100%). CoNS were most resistant to benzylpenicillin (100%), oxacillin (85.5−97.2%), and erythromycin (75−97.2%). Conclusion. CoNS were resistant towards several available antibiotics in RSUP Dr. Mohammad Hoesin Palembang.
The Impact of Sambiloto Extract (Andrographis paniculata) as a Potential Antidiabetic Treatment Clara Alverina; Nita Parisa; Rio Dwi Arliansyah; Nia Savitri Tamzil
Biomedical Journal of Indonesia Vol. 10 No. 2 (2024): Vol 10, No 2, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v10i2.190

Abstract

Diabetes mellitus (DM) is a metabolic disease caused by an inappropriate increase in blood glucose levels. The development of traditional medicines, including extracts, fractions, and isolates from plants, remains highly intriguing and challenging. Andrographis paniculata is a one of medicinal plants with a long history of use in Asia for the treatment of various ailments. Andrographolide, a bioactive compound found in A. paniculata, has been extensively studied for its medicinal benefits, specifically its antidiabetic effects. This study employs a literature review approach to investigate the effect of Sambiloto extract (Andrographis paniculata) as an antidiabetic medication using Google Scholar, Science Direct, and PubMed databases. The publication year range for the literature data sources is from 2020 to 2024. Based on the conducted searches, three reference journals are included in this study. Andrographolide, the active compound contained in Sambiloto, may act as an antidiabetic medication through various mechanisms, thus representing a potential treatment for diabetes mellitus.
Single-Nucleotide Polymorphisms of Interleukin-17 and Susceptibility to Tuberculosis Rizki Nawawi; Zefianto; Ella Amalia
Biomedical Journal of Indonesia Vol. 10 No. 2 (2024): Vol 10, No 2, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v10i2.191

Abstract

Interleukin-17 (IL-17) is involved in the immune response to various infectious diseases. Two isoforms, IL-17A and IL-17F, are well studied and may play an important role in host defence towards tuberculosis. Genetic polymorphisms involving genes coding for these IL-17 isoforms may influence the function of this cytokine, hence affecting an individual’s susceptibility to tuberculosis infection. This narrative review discusses the role of several single-nucleotide polymorphisms involving IL-17A and IL-17F in tuberculosis susceptibility. Several SNPs, including rs2275913 and rs8193036 of the IL-17A gene and rs763780 of the IL-17F gene influence the immune response mediated by IL-17 to tuberculosis through different ways. The rs2275913 and rs8193036 SNPs are located in the promoter of the IL-17A gene, altering the expression of the gene by regulating the binding of transcription factors. Meanwhile, the rs763780 SNP is located in the coding region of the IL-17F gene, resulting in an amino acid substitution that affects the function of expressed IL-17. Future studies may elaborate the interactions of these SNPs with related polymorphisms in a haplotype-based approach, as well as their roles against infection of different Mycobacterium tuberculosis lineages.
Incidence and Risk Factors for Acute Kidney Injury in PICU of Dr. Mohammad Hoesin Hospital Palembang Desti Handayani; Rio Dwi Arliansyah; Indra Saputra; Msy Farah Diba; Hertanti Indah Lestari
Biomedical Journal of Indonesia Vol. 10 No. 2 (2024): Vol 10, No 2, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v10i2.192

Abstract

Introduction. Acute kidney injury (AKI) is a heterogeneous group of conditions characterized by a sudden decrease in the glomerular filtration rate, manifested by an increase in serum creatinine or oliguria. In the Pediatric Intensive Care Unit (PICU), AKI is one of the most common conditions found. Several factors, including age, infection, sepsis, shock, heart disease, mechanical ventilation, and multiple organ failure cause the increase in the incidence of AKI in children. This study aimed to determine the incidence and risk factors for AKI in critically ill children in the PICU of Dr. Mohammad Hoesin Hospital Palembang. Methods. This study was an observational analytic with a cross-sectional design. This study used secondary data based on the medical records of patients treated at the PICU. Critically ill children aged 1-18 years who were treated at the PICU of Dr. Mohammad Hoesin Hospital Palembang in the period of 1 January 2020 to 31 December 2021 were included while existing kidney dysfunction before being admitted to PICU and not fulfilled medical records were excluded to the study. Results. AKI incidence in PICU was 46.7%. There were significant risk factors for AKI which are age (p 0.025), sepsis (p 0.019), shock (p 0.002), mechanical ventilation used (p 0.043), nephrotoxic drugs (p 0.039), and fluid overload (p 0.039). Conclusion. This study found that age, sepsis, shock, mechanical ventilation, nephrotoxic drugs, and fluid overload, were significant risk factors for the incidence of AKI in critically ill children in PICU.
The Effect of Gargling Young Coconut Water (Cocos Nucifera L.) On Changes In Salivary pH In Children At SMP Negeri 1 Muara Pinang, Empat Lawang Shafira Ari Yuni; Abu Hamid
Biomedical Journal of Indonesia Vol. 10 No. 2 (2024): Vol 10, No 2, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v10i2.197

Abstract

Introduction. Dental caries is one of the various dental health cases that has a high prevalence in Indonesia. One of the variables that influences the development of dental caries is saliva. The way to control the acidity (pH) of saliva is to gargle with antibacterial fluid. Young coconut water (Cocos Nucifera L.) contains tannins or antidote (anti-toxic). The aim is to determine the effect of gargling young coconut water (Cocos Nucifera L.) on changes in the pH of saliva. Methods. This research uses a quasi-experimental research type with a pre-test post-test design and a control group (comparison group) using a purposive sampling technique. Results. Proves that there is a significant impact on the pH of saliva before and after gargling with young coconut water, namely before gargling the pH is 7.645 and after gargling the pH is 7.325 or it can be concluded that there is an effect of consuming coconut water on changes in saliva pH. Conclusion. There is a significant effect of gargling young coconut water (Cocos Nucifera L.) on saliva pH.
Quintet Educational Cards on Breast Cancer Patients’ Knowledge Regarding Nutrition Mutia Nadra Maulida; Hikayati; Devin Alfira
Biomedical Journal of Indonesia Vol. 10 No. 3 (2024): Vol 10, No 3, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v10i3.194

Abstract

Introduction. Nutrition is important in undergoing treatment and healing process in breast cancer patients. The incidence of malnutrition and nutritional disorders in breast cancer patients reaches 35-70% of 72 breast cancer patients. One of the factors that can influence patients' attitudes toward managing nutrition in breast cancer patients is increasing knowledge through health education. This study aims to determine the effect of quintet card educational media on breast cancer patients' level of nutrition knowledge. Methods. This type of research is a quantitative pre-experimental study with a one-group pretest-posttest design. The population in this study was breast cancer patients in the Association for Supporting Women with Breast Cancer (ASWBC). The sample in this study consisted of 27 respondents. Sampling using a purposive sampling method. The statistical analysis used in this study is the marginal homogeneity test. Results. The analysis showed a p-value of 0.000 (α ≤ 0.05),  which showed a significant difference in knowledge about nutrition in breast cancer patients before and after health education was carried out through the quintet card educational media. Nutrition knowledge is urgently needed by breast cancer patients and the quintet card educational media can be used as information material about nutrition in breast cancer patients and can be used in activities in the ASWBC. Conclusion. This educational media can be used by breast cancer patients following SOP as a play guide and as a media for health education.
Spinal Instability in Myogenic Low Back Pain : Stabilization Exercise Approach Awab Zakie Habibie; M Lutfi Dharmawan; Tertianto Prabowo; Marina A. Moeliono; Lia Amalia Suparyadi
Biomedical Journal of Indonesia Vol. 10 No. 3 (2024): Vol 10, No 3, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v10i3.195

Abstract

Spinal instability can be caused by various conditions including an illness, trauma, and degenerative processes affecting one or more of the three spinal subsystems. These three subsystems are the spine and ligaments, back muscles, and the nervous system work synergistically to maintain spinal stability. Until now it is still difficult to identify spinal instability. Low back pain (LBP) affects 60-80% of the world's population and in the United States causes losses of around $15-50 billion each year. For several decades, a muscle training program has been the main program that recommended to solve LBP, based on the premise that the muscle subsystem is a subsystem that can be repaired and improved, a muscle training program is developed and applied in the management of NPB. This literature review focuses on aspects of stabilization exercises in the management of low back pain with and without spinal instability.
The Relationship Between Personal Hygiene And The Incidence Of Pediculosis Capitis Among Students Of Sungai Beringin 02 Public Elementary School, District 50 Kota Letvi Mona; Madhuri Dixit; Nadia Purnama Dewi
Biomedical Journal of Indonesia Vol. 10 No. 3 (2024): Vol 10, No 3, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v10i3.196

Abstract

Introduction. Pediculosis capitis or commonly known as head lice is a skin infection that attacks the human head. It is caused by the ectoparasite Pediculus Humanus Capitis, which lives by sucking blood on the scalp of infected people. One of the factors that can be related to pediculosis capitis is personal hygiene. The general objective of this research is to determine the relationship between personal hygiene and the incidence of pediculosis capitis in students at Sungai Beringin 02 Public Elementary School, Kabupaten 50 Kota. Methods. This research uses an analytical observational method with a cross-sectional approach, namely a study conducted to study the dynamics of the correlation between two variables. The accessible population in this research is all students of Sungai Beringin 02 Public Elementary School, Kabupaten 50 Kota in 2023. Results. This study shows 63.6% of students are not infested with pediculosis capitis. The highest class infested with pediculosis capitis is class 3-4, there are 50%, 95% of students who are infested with pediculosis capitis are female, and 65.5% of students have good personal hygiene. The results of the research show that there is a relationship between personal hygiene and the incidence of pediculosis capitis in students because  68.4% of students who are infested with pediculosis capitis do not have good personal hygiene. Conclusion. The results of bivariate analysis show that there is a significant relationship between the level of personal hygiene and the incidence of Pediculosis Capitis in students at Sungai Beringin 02 Public Elementary School with a p-value of 0.001.
The Relationship of Fat Intake and Body Fat Percentage in Medical Students Nurul Yuli Permata Sari; Ardesy Melizah Kurniati; Julius Anzar; Liniyanti D. Oswari; Sri Nita; Syarinta Adenina
Biomedical Journal of Indonesia Vol. 10 No. 3 (2024): Vol 10, No 3, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v10i3.201

Abstract

Introduction. Obesity is an excessive fat accumulation in the body, now the prevalence is increasing in the group aged>18 years based on Body Mass Index (BMI). Nowadays body fat percentage has been declared to assess the risk factor of disease-related body weight better than BMI, people with proportioned weight had excessive body fat percentage evenly. Excessive fat intake is one of the important factors for obesity. The objective of this study was to analyze the association between fat intake with body fat percentage. Methods. This study was conducted with a cross-sectional design on 275 medical faculty students of Sriwijaya University, starting from August until December 2017 by collecting primary data through completing forms, food records, questionnaires, and physical examinations. Results. The results were analyzed statistically using chi-square. 67.3% of subjects had excessive body fat percentage and 50.2% with excessive fat intake. Results by the chi-square test indicate a negative association between fat intake with body fat percentage (p value=0.184). Conclusion. Fat intake with body fat percentage was negatively associated.
Knowledge And Perceptions of Nutrition and Weight Among First-Year Medical Students at Sriwijaya University Mitha Ramadea; Ardesy Melizah Kurniati; Joko Marwoto; Syarif Husin; Wardiansyah Wardiansyah; Syarinta Adenina
Biomedical Journal of Indonesia Vol. 10 No. 3 (2024): Vol 10, No 3, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v10i3.202

Abstract

Introduction. Medical students of Sriwijaya University batch 2019 are new students who don’t have much knowledge about nutrition. In addition, new students also don’t know how to calculate Body Mass Index (BMI) through body height and weight. This study aimed to know the level of nutritional knowledge and the suitability of weight perception among the medical students of Sriwijaya University batch 2019. Methods. Descriptive research with a cross-sectional research design was conducted in Health Clinic UPT of Sriwijaya University and the Faculty of Medicine of Sriwijaya University in September 2019. The sample of this study was all medical students from Sriwijaya University batch 2019 who met the inclusion and exclusion criteria. The data was obtained through direct measurement and filling M-GNKQ questionnaire and weight perception questionnaire online. Results. In this study, 222 students met the inclusion and exclusion criteria, with 74 male students and 148 female students. As many as 70.7% of students have normal nutritional status. The average value of nutrition knowledge is 18.21 (45.5%) with the lowest value 0 and the highest value 32. Of all of the students, only 52.3% can perceive body weight correctly. The rest, as much as 33.3% is exaggerating perception and 14.4% is reducing perception. Conclusion. The knowledge of nutrition among the medical students of Sriwijaya University batch 2019 is still quite low and there are still many students who mistakenly perceive their weight.

Page 36 of 40 | Total Record : 392

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