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Biomedical Journal of Indonesia
Published by Universitas Sriwijaya
ISSN : 24077097     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
Biomedical Journal of Indonesia is an open access, peer-reviewed journal that focus on basic medical sciences, emphasizing on providing the molecular studies of biomedical problems and molecular mechanisms to integrate researches in all aspects of human health. BJI is dedicated to publishing original research and review articles covering all aspects of biomedical sciences.
Arjuna Subject : Kedokteran - Anatomi
Articles 392 Documents
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Identifying Gene Variants That Are Pathogenic In Osteoporosis Using An Omics Data And Bioinformatics Approach Danang Prasetyaning Amukti; Lalu Muhammad Irham; Ria Indah Pratami; Wirawan Adikusuma
Biomedical Journal of Indonesia Vol. 10 No. 3 (2024): Vol 10, No 3, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v10i3.199

Abstract

Introduction. The biological cause of osteoporosis, a metabolic bone disease, is osteoclastic bone resorption that is not offset by osteoblastic bone synthesis. Fractures become more likely as a result of the bones being brittle and weak. Common genetic variants that indicate hereditary susceptibility factors to osteoporosis in the general population, as well as mutations affecting specific genes that cause uncommon monogenic causes of osteoporosis, are the two main types of osteoporosis. Bone defects can now be caused by numerous additional genes. In this study, we aimed to identify variants of this pathogen across continents using genome-based and bioinformatics methodologies. Methods. We integrated osteoporosis-associated variants into this study using various bioinformatics-based techniques by using GWAS data from the National Human Genome Research Institute (NHGRI). Results. We found that the variant rs3742909 is likely to cause osteoporosis. SMOC1 gene expression in whole blood tissue also appears to be affected by this variant. We found that this genomic variant requires additional research to validate functional and clinical studies in patients with osteoporosis. Conclusions. We suggest that better understanding of disease susceptibility, including osteoporosis, can be achieved through the merging of genome-based databases and bioinformatics. Our goal is to validate the findings of this study both in vitro and in vivo during the preclinical stage.
Comparative Evaluation of Electrochemiluminescence and Chemiluminescence Microparticle Immunoassays for Anti-Hepatitis C Virus (HCV) Detection Phey Liana; Mita Al Maida; Gita Dwi Prasasty; Desi Oktariana; Tungki Pratama Umar
Biomedical Journal of Indonesia Vol. 10 No. 3 (2024): Vol 10, No 3, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v10i3.208

Abstract

Introduction. Anti-hepatitis C virus (HCV) testing is an immunological analysis designed to identify the presence of antibodies against the HCV antigen. This investigation is typically conducted using the chemiluminescence immunoassay (CLIA) technique, which yields precise results. Current research attempts to evaluate the outcomes of the anti-HCV test utilizing the Chemiluminescence Microparticle Immunoassay (CMIA) and the Electrochemiluminescence Immunoassay (ECLIA) approaches. Methods. This cross-sectional study comprised 63 serum samples collected via consecutive sampling. The acquired data were subjected to statistical analysis utilizing Cohen's Kappa agreement test. Results. Both immunoassay methods yielded identical results, indicating four reactive samples out of 63, equating to 6.35%. The agreement test result for the anti-HCV test was κ=1.000, signifying an almost perfect level of agreement. Conclusion. The anti-HCV assessment utilizing CMIA and ECLIA methodologies demonstrated near-perfect agreement. This signifies that these two procedures can be employed in clinical laboratories concurrently or interchangeably for the test.
Anti-Inflammatory and Anti-Hyperuricemic Effects of Chrysin in a Rat Model of High Fructose Corn Syrup Induced Hyperuricemia Tahany, Hanifah; Parisa, Nita; Nugraha, M Daffa; Harahap, Debby Handayati; Theodorus, Theodorus
Biomedical Journal of Indonesia Vol. 11 No. 1 (2025): Vol 11, No 1, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v11i1.200

Abstract

An increase in the blood level of uric acid, or hyperuricemia, is a disorder that can cause damage to the kidneys and gout among other health problems. Worldwide, the incidence of hyperuricemia has been rising, in part because of dietary factors such the use of HFCS, a prevalent sweetener found in processed foods. Thus, research into natural substances with anti-inflammatory and anti-hyperuricemia attributes, such as chrysin, is critical to the fields of therapeutic and preventive medicine. This study investigates the anti-inflammatory and anti-hyperuricemic effects of chrysin in a rat model of hyperuricemia induced by high-fructose corn syrup. The research reveals that chrysin exerts its therapeutic effects through antioxidant activity and the inhibition of inflammatory signaling pathways, resulting in a decrease in oxidative stress and the expression of the pro-inflammatory cytokine IL-1β. Treatment with chrysin leads to a significant increase in tissue weight, tissue index, and kidney histology, indicating its potential in mitigating kidney damage associated with hyperuricemia. The study demonstrates a dose-dependent reduction in IL-1β levels and inflammation activation with chrysin treatment, surpassing the anti-inflammatory effects of the comparison group. Furthermore, chrysin treatment reduces malondialdehyde concentration and mitigates the activation of inflammasome-related protein induced by high-fructose corn syrup. These findings highlight the promising therapeutic potential of chrysin in managing hyperuricemia and related metabolic disorders.
Supplement Consumption and Facial Care Products on Acne Vulgaris: A Cross-Sectional Study Among Medical Students Aras, Dara Ugi; Wahyuni, St. Nurul Rezki; Adam, Adriyanti; Arif, Sitti Musafirah; Viviani L.
Biomedical Journal of Indonesia Vol. 11 No. 1 (2025): Vol 11, No 1, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v11i1.205

Abstract

Introduction. Signs of acne vulgaris, a condition of widespread inflammation in pilosebaceous units, include blackheads, papules, pustules, and nodules. Acne vulgaris affects 85% of teenagers and young adults between the ages of 12 and 15. Acne vulgaris is primarily caused by hyperkeratinization of the pilosebaceous ducts, inflammation, mycobacterial infection, and excessive sebum production. The term dysseborrhea refers to the changes in sebum levels that happen during puberty, both in terms of quantity and quality. Apart from exogenous factors such as cosmetics and comedogenic medications, endogenous elements such as hormones and genetics can also contribute to the issue. The aim of this study is to investigate the relationship between the use of face care products and supplementation and the incidence of acne vulgaris in medical students at the University of Muhammadiyah Makassar (Unismuh). Methods. For the study, a cross-sectional technique was used. The sample method used is simple random sampling. A sixteen-item questionnaire was used to gather data, which the Chi-Square test was then used to analyze. Results. The analysis yielded two significant results, a value of p=0.552 (p>0.05) showed no significant correlation between the incidence of acne vulgaris and the use of face products, and a value of p=0.132 (p>0.05) showed no significant correlation between the incidence of acne vulgaris and consumption of supplements. Conclusion. There is no correlation between consuming vitamins and using face care products to stop pupils from getting acne vulgaris.
Comparative Analysis of Molecular Diagnostic Techniques for Pulmonary Tuberculosis: A Literature Review Rachmatunisa, Anita; Oktariana, Desi
Biomedical Journal of Indonesia Vol. 11 No. 1 (2025): Vol 11, No 1, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v11i1.207

Abstract

Pulmonary tuberculosis is a global health problem that requires early and precise diagnosis for effective control. In this literature review, we compare several molecular diagnostic techniques used in the detection of pulmonary tuberculosis, such as Polymerase Chain Reaction (PCR), Whole Genome Sequencing (WGS), and Next Generation Sequencing (NGS), as well as Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-based Diagnostic Techniques. Polymerase Chain Reaction stands out for its high sensitivity, although time-consuming and high operational costs. Meanwhile, whole genome sequencing and next generation sequencing have detailed tuberculosis (TB) strain identification capabilities but have high costs and limited availability. On the other hand, CRISPR-based diagnostic techniques offer speed and low cost but are still in the advanced stages of development. Challenges in implementing new techniques include technical barriers, logistics, and improving sensitivity and specificity. Suggestions for future research include the development of more effective, faster, and affordable techniques, especially in developing portable diagnostic tests for accessibility of pulmonary tuberculosis diagnosis in various regions.
The Relationship Between Personal Hair Hygiene and The Incidence of Pityriasis Capitis in Students at Faculty of Medicine, Baiturrahmah University Marsa Qalbina Abdi; Irma Primawati; Dessy Abdullah
Biomedical Journal of Indonesia Vol. 11 No. 1 (2025): Vol 11, No 1, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v11i1.209

Abstract

Introduction. Pityriasis capitis or commonly known as dandruff, pityriasis sicca, pityriasis simplex is a disorder resulting from mild inflammation caused by excessive exfoliation of the stratum corneum which is characterized by the presence of white-gray flakes on the scalp and hair shaft. Personal hygiene, including self-care carried out by a person to protect and maintain their health. Aim the research to the relationship between personal hair hygiene and the incidence of pityriasis capitis in students at Faculty of Medicine, Baiturrahmah University. Methods. This study is quantitative research that applies an analytical approach by design cross-sectional. The research participants came from students at the Faculty of Medicine, Baiturrahmah University and total of 108 samples were selected using techniques consecutive sampling. The data in this study is primary data obtained from the results of questionnaires and scalp observations. Data analysis used SPSS version 25 and the test used was chi-square test. Results. Students who experience pityriasis capitis are 66 people (61.1%) with the largest gender experience it being women, namely 46 people (42.6%). Personal hair hygiene of students are in the medium category, namely 76 students (70.4%). There is a relationship between personal hair hygiene and the incidence of pityriasis capitis with a p-value of 0.029 (p<0.05). Conclusion. There is a relationship between personal hair hygiene and the incidence of pityriasis capitis in students at the Faculty of Medicine, Baiturrahmah University.
A Review of the Therapeutic Effects of Garlic in Lowering Blood Pressure: A Comprehensive Analysis of Recent Mechanisms and Existing Clinical Data Hamdi, Ibnati Amira; Panggabean, Ridha Inayah; Theresa, Cindy Calista; Nainggolan, Bahagia Willibrordus Maria; Balatif, Ridwan
Biomedical Journal of Indonesia Vol. 11 No. 1 (2025): Vol 11, No 1, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v11i1.211

Abstract

Hypertension is a medical condition characterized by an elevation in systolic blood pressure equal to or greater than 140 mmHg and/or diastolic blood pressure equal to or greater than 90 mmHg. Hypertension elevates the likelihood of developing cerebrovascular disease and mortality. The administration of conventional antihypertensive drugs frequently leads to the occurrence of adverse effects. Moreover, a significant proportion of the population in developing nations, approximately 70%, currently favors the utilization of herbal remedies as opposed to conventional pharmaceuticals. Garlic is a herbal plant known for its antihypertensive properties. This review specifically examines the current mechanisms by which garlic acts as an antihypertensive, and presents the clinical evidence available to date regarding garlic's effectiveness in lowering blood pressure. The present mechanism by which garlic acts as an antihypertensive agent involves its anti-inflammatory, vasorelaxant, antioxidant, anti-apoptotic effects, enhancement of microbiota activities, and improvement of heart function. The antihypertensive effect of garlic is derived from its organosulfur content. Based on multiple clinical trials, the majority of studies have found that administering interventions in the form of capsules containing garlic or aged black garlic extract leads to a decrease in blood pressure. Garlic has anti-hypertensive effects, especially in the form of aged black garlic extract.
Gummy Mandjah (Honey, Tamarind, Red Ginger) on Emesis in Pregnant Women Huzaima, Huzaima; Sari, Diani Mega; Razak , Rifka Atika
Biomedical Journal of Indonesia Vol. 11 No. 1 (2025): Vol 11, No 1, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v11i1.221

Abstract

Introduction. One of the discomforts that mothers frequently experience during the start of pregnancy is emesis gravidarum, which is characterized by nausea and vomiting. The welfare of the mother and child will be impacted if emesis episodes are not handled right away. Herbal remedies like red ginger, tamarind, and honey can help people stay healthy. The purpose of this study is to examine how “Gummy Mandjah” can help pregnant women experience less nausea. Methods. This study used a pre-experimental research design, one group pretest posttest. Giving gummy made from honey, tamarind, and red ginger to 20 pregnant women who met the inclusion criteria, sampling technique using simple random sampling, Gummy was given for 14 days with a dose of 2 times a day and then assessed using the PUQE score. Results. The results obtained showed that there was a decrease in the frequency of emesis after consuming gummy with an average difference of 0.60. Data analysis used a paired sample t-test and showed that there was an effect of giving gummy on reducing emesis with a p-value of 0.001 < 0.05. Conclusion. Honey, tamarind, and ginger can be an option to overcome nausea and vomiting in pregnant women. These ingredients are easy to obtain, practical to process, and have minimal side effects. With gummy innovations or other forms, it can make it easier for pregnant women to consume them and reduce the dominant smell and taste of each ingredient that can trigger mothers not to want to consume them.
Analysis of Menstrual Periods, Menstrual Cycle, Menstrual Pain and Body Mass Index with the Incidence of Anemia in Adolescent Girls Karinda, Merlin; Lellyawaty, Lellyawaty; Vaira, Rizky
Biomedical Journal of Indonesia Vol. 11 No. 1 (2025): Vol 11, No 1, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v11i1.222

Abstract

Introduction. Periodic blood loss due to menstruation makes adolescent girls more susceptible to anemia. Menstrual periods such as prolonged menstruation, irregular monthly cycles, volume of blood loss, and health problems that accompany menstruation such as menstrual pain coupled with nutritional status can affect the occurrence of anemia in adolescents. The purpose of the study was to determine the relationship between menstrual periods, menstrual cycle, menstrual pain, and BMI with the incidence of anemia. Methods. This study was a cross-sectional study with a sample size of 53 respondents of adolescent girls of the Mambaul Ulum Islamic Boarding School in Banjarmasin City using an accidental sampling technique and analyzed using chi-square. The study was conducted in July 2024. The respondent’s height was measured using a microtoise and weight using a scale. Furthermore, they filled out a questionnaire about the menstrual periods, menstrual cycle, and menstrual pain, and the hemoglobin levels were checked using the Easytouch tool. Results. There was a relationship between BMI and anemia with a p-value of 0.026. Conclusion. It is important to provide education about understanding good and sufficient eating patterns and nutrition, as well as education about the importance of taking iron tablets and education about the side effects of iron tablets in an effort to prevent anemia.
The Effectiveness of a Menstrual Hygiene Pocketbook in Improving Knowledge and Hygiene Behavior Among Students at SDN 2 Petuk Katimpun Sari, Uswatun Hasanah Purnama; Ahmad, Farah Fauziyah Radhiyatulqalbi; Rahmawati, Laila; Siskaevia, Siskaevia
Biomedical Journal of Indonesia Vol. 11 No. 1 (2025): Vol 11, No 1, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v11i1.228

Abstract

Introduction. Menstruation is a natural biological phenomenon experienced by every woman. However, limited knowledge and misconceptions about menstruation can affect reproductive health. This study aims to assess the effectiveness of the Menstrual Hygiene Pocketbook in improving the knowledge and menstrual hygiene behavior of female students in grades 4, 5, and 6 at SDN 2 Petuk Katimpun. Methods. The research method used a quantitative method with a quasi-experiment design; the approach used in this study was a pre-test and post-test design without a control group.  Results. The results show that the average knowledge score of the students increased from 10.09 in the pre-test to 14.53 in the post-test. Students' behavior also showed a significant improvement, with the average pre-test score increasing from 9.59 to 13.26 after receiving education using the pocketbook. Conclusion. The Menstrual Hygiene Pocketbook proves to be an effective tool for enhancing awareness and menstrual hygiene practices among adolescent girls. However, without a control group, conclusions about causality should be drawn with caution, and external factors such as information from parents or the media may influence the study's results.

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