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INDONESIA
Biomedical Journal of Indonesia
Published by Universitas Sriwijaya
ISSN : 24077097     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
Biomedical Journal of Indonesia is an open access, peer-reviewed journal that focus on basic medical sciences, emphasizing on providing the molecular studies of biomedical problems and molecular mechanisms to integrate researches in all aspects of human health. BJI is dedicated to publishing original research and review articles covering all aspects of biomedical sciences.
Arjuna Subject : Kedokteran - Anatomi
Articles 392 Documents
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The Relationship between Family Support and Breast Self-Examination (BSE) in Breast Tumor Patients Azza Nabila, Amira; Indriyani, Indriyani; Pratiwi, Ratih; Mitayani, Mitayani
Biomedical Journal of Indonesia Vol. 11 No. 1 (2025): Vol 11, No 1, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v11i1.237

Abstract

Introduction. In the management of both benign and malignant breast tumors, early detection via breast self-examination (BSE) is essential. It is thought that family support is crucial in promoting BSE behavior. Finding out how family support and breast self-examination (BSE) in patients with breast tumors relate to one another is the goal of this study. Methods. Cross-sectional is a study used in this study with an analytic observational method. The research sample was taken using a total sampling technique, which included all breast tumor patients who met the inclusion criteria at the surgical clinic of Muhammadiyah Hospital Palembang, totaling 32 respondents. Results. It was found that the majority of respondents suffered from malignant breast tumors (breast cancer), with 23 individuals (28.13%). Meanwhile, 9 other individuals had benign breast tumors (71.87%). Most of the respondents received family support categorized as adequate or insufficient, with their Breast Self-Examination (BSE) behavior also categorized as adequate or insufficient. The analysis revealed a p-value of 0.000 and an odds ratio (OR) of 27.00. Conclusion. It can be concluded that there is a significant relationship between breast tumor patients' behavior and family support, with those who received family support having a 27-fold higher likelihood of engaging in breast self-examination than those who did not.
The Potential of Rosella (Hibiscus sabdariffa L.) for Diabetes Mellitus Model Rats: Histopathological Focus on Pancreatic Organ Putria, Sinta Julia Liona; Rohani, Siti; Suarni, Ertati; Astri, Yesi; Mundijo, Trisnawati
Biomedical Journal of Indonesia Vol. 11 No. 1 (2025): Vol 11, No 1, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v11i1.236

Abstract

Introduction. Ethanolic extract of rosella flowers (Hibiscus sabdariffa L.) contains secondary metabolite compounds: flavonoids, alkaloids, saponins, and tannins. This study aims to determine whether the ethanol extract of rosella flowers has the potential to regenerate pancreatic β cells in white rats (Rattus norvegicus) with alloxan-induced diabetes mellitus models.  Methods. The type of research used was an in vivo laboratory experimental study with a true experimental design. The experimental animals used as test objects in this study were male rats (Rattus norvegicus L.), weighing 100-110 grams. The test objects were 30 rats, divided into 6 groups randomly, each containing 5 rats, the groups consisted of K (N), K (-), K (+), P (1), P (2), and P (3). The level of histopathological damage to the pancreas was observed with HE staining at 400x magnification, using binocular light microscope type CX23 and BX51. Results. The study showed that the ethanol preparation of rosella flower extract at a dose of 1500 mg/kgBW and 3000 mg/kgBW BB was effective in regenerating pancreatic β cells with a damage value of 0 and at a dose of 750 mg/kgBW with a damage value of 2 did not provide a maximum regeneration effect on pancreatic β cells in male white rats induced by alloxan. Conclusion. The results of this research show that the ethanol extract of rosella flowers has an influence on the regeneration of pancreatic β cells so that it can be used for supportive treatment in the management of diabetes mellitus.
Help-seeking Behavior of Disorders of Sex Development Patients in Palembang, Indonesia Khairunnisa, Tyas Citra; Maritska, Ziske; Purnamasari, Septi; Zulissetiana, Eka Febri; Inggarsih, Rara
Biomedical Journal of Indonesia Vol. 11 No. 2 (2025): Vol 11, No 2, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v11i2.220

Abstract

Introduction. Disorders of Sex Development (DSD) is a congenital disorder in which there is atypical chromosomal, gonadal, or anatomical sex development. Children with DSD are often brought to the hospital too late for care due to limited knowledge about this condition among medical practitioners. Early diagnosis is important to improve prognosis and minimize complications and comorbidities of DSD patients. Methods. This study is a descriptive observational study with a cross-sectional approach through interviews and data collection from medical records of Dr. Mohammad Hoesin Palembang Hospital in 2020 - 2023. Results. In this study, it was found that the infancy age group (28 days - 1 year) was the most common age of arrival of patients to the hospital (29%) and the most common main complaint was clitoral enlargement (19.4%). Conclusion. This study found a wide variation in patients’ chief complaints, which makes the age of arrival of DSD patients to the hospital still quite late.
Prevalence and Characteristics of Pregnant Women With Urinary Incontinence at Rika Amalia Hospital Palembang Juenli, Angelica; Fauzi, Amir; Putra, Hadrians Kesuma; Krisna, Ratih; Nurwany, Raissa
Biomedical Journal of Indonesia Vol. 11 No. 2 (2025): Vol 11, No 2, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v11i2.224

Abstract

Introduction. Urinary incontinence (UI) is the involuntary discharge of urine. UI is often not reported due to social stigma and public relief. In addition, UI is a non-life-threatening condition so people consider UI as a nuisance and not a health problem. This shows the need for promotive and preventive efforts so that patients can immediately seek medical treatment and prevent UI. This study aims to identify the prevalence and characteristics of pregnant women with UI at Rika Amalia Hospital Palembang. Methods. This study is an observational descriptive research with a cross-sectional research design using primary data by filling out questionnaires and direct interviews with pregnant women at Rika Amalia Hospital Palembang. Results. This study involved 73 pregnant women. Most UI cases were at the age of <35 years (88%), education level ≤12 years (68%), no smoking behavior (100%), no caffeinated beverage consumption behavior (96%), third trimester (60%), multipara (40%), vaginal delivery (56%), BMI ≥ 25 kg/m2 (56%), no history of constipation (60%), no history of UI before pregnancy (92%), and had no family history of UI (88%). Conclusion. The prevalence of pregnant women with UI at Rika Amalia Hospital Palembang from August to October 2024 is 34.2%. Most UI cases happened in pregnant women with the age of <35 years, education level ≤12 years, no smoking behavior, no caffeinated beverage consumption behavior, third trimester, multipara, vaginal delivery, BMI ≥ 25 kg/m2, no history of constipation, no history of UI before pregnancy, and no family history of UI.
Total Phenol, Flavonoid Content, and Antioxidant Activity of the Ethanol Fraction of Arcangelisia Flava Stem Fatmawati, Fatmawati; Oktharina, Eka Handayani; Mulawarman, Hisham; Sinulingga, Sadakata; Safyudin, Safyudin
Biomedical Journal of Indonesia Vol. 11 No. 2 (2025): Vol 11, No 2, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v11i2.225

Abstract

Introduction. Oxidative stress caused by an imbalance between reactive oxygen species (ROS) production and antioxidant defenses leads to various diseases. Arcangelisia flava, a medicinal plant, contains antioxidant-active phenols and flavonoids. This study evaluates the total phenol and flavonoid content and the antioxidant activity of the ethanol fraction of A. flava stem. Methods. An experimental study was conducted using 750 grams of A. flava stem. The sample underwent fractionation and was analyzed using Folin-Ciocalteu and AlCl3 methods to determine total phenol and flavonoid content. Antioxidant activity was assessed using the DPPH method. Data were analyzed using regression equations and IC50 values. Results. The ethanol fraction contained 57.81 ± 3.28 mg GAE/g of total phenol and 114.6 ± 1.02 mg QE/g of total flavonoid. The IC50 value for the ethanol fraction was 72.88 ppm, indicating strong antioxidant activity, albeit less potent than ascorbic acid (IC50 7.37 ppm). Conclusion. The ethanol fraction of A. flava stem is a potential natural antioxidant source.
Young Adults' Mental Health Status: Investigating GERD's Relationship with Anxiety and Depression Annabih, Muhammad Fikri; Putri, Mustika Anggiane
Biomedical Journal of Indonesia Vol. 11 No. 2 (2025): Vol 11, No 2, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v11i2.243

Abstract

Introduction. Gastroesophageal Reflux Disease (GERD) is a chronic digestive disorder that occurs when stomach acid or, occasionally, stomach contents flow back (reflux) into the esophagus. This backwash (acid reflux) can irritate the lining of the esophagus, causing uncomfortable symptoms and potential complications. studies suggest that smoking, obesity, anxiety/depression, and older age are some of the contributing factors to GERD development. Young adults in Jakarta showed a 7.5% GERD prevalence rate during 2017. This research explores the potential correlation between anxiety and depression with GERD development in young adult populations. Methods. This study utilized a cross-sectional method to assess the symptoms of anxiety, depression, and GERD using the Hospital Anxiety and Depression Scale (HADS) questionnaire and GERD Questionnaire (GERDQ). The research involved 115 participants aged 18-40 from Pondokkaso Urban Village. The study analyzed gender, anxiety, depression, and Gerd using Fisher Exact tests (p<0.05). Results. Analysis of 115 respondents revealed GERD prevalence in 26 subjects (22.6%), anxiety in 5 subjects (4.3%), and depression in 6 subjects (5.2%). Statistical analysis demonstrated no significant correlation between anxiety (p=1.000), depression (P=0.128), or gender and GERD incidence (P=0.756) among young adult subjects. Conclusions. Statistical analysis revealed no significant correlation between GERD incidence and the variables of anxiety, depression, and gender among young adults in Pondokkaso Urban Village.
Effect of Vitamin D Supplementation During Pregnancy on Birth Weight: An Experimental Study in Rats Sari, Widia; Khudri, Ghaniyyatul; Zeffira, Laura; Handayani, Kurnia Maidarmi
Biomedical Journal of Indonesia Vol. 11 No. 2 (2025): Vol 11, No 2, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v11i2.247

Abstract

Introduction. Vitamin D deficiency, commonly observed during pregnancy, can affect fetal growth, which can be evaluated by birth weight. Vitamin D supplementation during pregnancy is anticipated to beneficially affect birth weight, a crucial factor for neonatal health and long-term health outcomes. Methods. This research was conducted using an in vivo experimental design on Rattus norvegicus rats as animal models. This study involved 24 rat pups from four groups of pregnant rats, each provided with standard feed and varying doses of vitamin D supplementation: Group A received 62 IU/kgBW, Group B received 415 IU/kgBW, Group C received 663 IU/kgBW, and Group D received no vitamin D supplementation. Vitamin D supplementation was provided through oral gavage from the first day of gestation until parturition. At the time of delivery, six pups from each group were randomly chosen to measure their birth weights. Results. The finding from this research indicated that vitamin D supplementation during pregnancy positively influenced birth weight (p<0.001). The birth weights of pups in Group C were significantly higher compared to those in group D (p<0.001) and Group A (p<0.001). Pups in Group B also had significantly higher birth weights compared to Group D (p=0.002) and Group A (p=0.006). Conclusion. Based on these findings it can be concluded that vitamin D supplementation at doses 415 IU/kgBW and 663 IU/kgBW can increase birth weight.
Dermatological Infectious Diseases Prevalence at Dermatology-Venereology Outpatient Clinics of Hospitals in Medan Yosi, Ariyati; Fujiati, Isti Ilmi; Yulfi, Hemma; Nasution, Irina Kemala
Biomedical Journal of Indonesia Vol. 11 No. 2 (2025): Vol 11, No 2, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v11i2.248

Abstract

Introduction. Skin infections are common in developing countries but are often not considered a significant health problem. One cause of this condition is a lack of epidemiological information about the prevalence and/or severity of the disease. This study aims to determine the prevalence and proportion of infectious skin diseases based on gender and age in the teaching hospitals at the Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia. Methods. A descriptive-retrospective method was used in this study and the data were obtained from the medical records of patients at the dermatology and venereology polyclinic at Adam Malik Hospital and Prof. Dr. Chairuddin P. Lubis Universitas Sumatera Utara Hospitaletween 2017 and 2019. Results. A total of 12,686 patients were enrolled in this study, 26% were diagnosed with infectious skin disease with a total of 3,297 cases. Based on gender, patients were more dominated by men (55%) than women (45%). Most patients with infectious skin diseases were in the late adolescent age group or 17–25 years (20.4%) and the least were in the 0–4 years age group (3.2%). Furthermore, fungi were the dominant causative agent, which accounts for 51.5% of all cases. Conclusion. Infectious skin disease is a skin disease that is often found, especially in men and the age group of 17–25 years.
Side Stream Cigarette Smoke and Its Role in Inducing Oxidative Stress in Rat Cerebral Tissue Farindra, Irmawan; Rakhmawati, Annisa; Rusdi, Warda Elmaida; Benge, Wilhemus Dionysius Mario Randy; Farmananda, Irsandi Rizki; Rusdi, Muhammad Salsabeela
Biomedical Journal of Indonesia Vol. 11 No. 2 (2025): Vol 11, No 2, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v11i2.253

Abstract

Introduction. Smoking behavior can affect not only the individual smoker but also those around them. Individuals exposed to secondhand smoke are at risk of developing similar health problems as those faced by individuals who actively smoke. Secondhand smoke causes an imbalance of systemic oxidants and antioxidants characterized by the presence of a lipid peroxidation product, namely Malondialdehyde (MDA). The main objective of this study was to assess how exposure to sidestream cigarette smoke affects MDA levels in rat cerebral tissue Methods. A true experimental study was conducted using 30 male Wistar rats with a post-test only control group design. All rats were randomly divided into 5 groups, namely 1 control group and 4 treatment groups. A total of 270 cigarettes were used as exposure sources. A spectrophotometer at a wavelength (λmax) of 533 nm was used to measure MDA levels. The MDA level data were then analyzed. ANOVA and Kruskall Wallis tests were performed after evaluating the results of the Normality and Homogeneity tests. A p value <0.05 indicates significant data. Results. The results indicate that the group exposed to cigarette smoke using 4 cigarettes for 30 days (P4) exhibited elevated MDA levels compared to the control group. Statistical analysis showed a significant correlation between secondhand smoke and increased MDA levels (p < 0.05). Conclusion. This study results suggest that exposure to SSCS contributes to increased MDA levels in the brain tissue of Wistar rats, which indicates oxidative stress.
The Correlation Between Weight Gain and Diet With Gestational Hypertension at Montong Health Center, Tuban, East Java Hurin'in, Nur Maziyah; Keswati, Wiwik Duwi
Biomedical Journal of Indonesia Vol. 11 No. 2 (2025): Vol 11, No 2, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v11i2.255

Abstract

Introduction. Hypertension in pregnant women can cause blood vessels to narrow so that the blood supply to the body's tissues decreases resulting in organs not functioning as they should. The consequences that can appear in the mother are respiratory disorders, HELLP syndrome, cardiovascular disorders, liver disorders, which can eventually result in maternal death. In the fetus, it can cause Intra Uterine Growth Retardation (IUGR), premature fetus, low birth weight and death.  Methods. This was a correlational research with a cross sectional time approach. The population in this research was all TM II pregnant women at the Montong Health Center, which totals 40 respondents. The sample in this case was 36 respondents who met the inclusion criteria and exclusion criteria. The sampling technique used was simple random sampling. The bivariate analysis of the statistical test used was Spearman Test, then the data was analyzed using the SPSS program with an error level of 0.05. Results. There was a statistically significant moderate correlation between weight gain and gestational hypertension (Spearman's ρ = 0.448, p = 0.006) and a very strong and statistically significant correlation was found between dietary patterns and gestational hypertension (Spearman's ρ = 0.673, p = 0.000). Conclusion. Weight gain and diet are significant risk factors for gestational hypertension, and implementing daily digital lifestyle monitoring could be an innovative approach to prevent its occurrence during pregnancy

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