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Pengaruh Kombinasi Ekstrak Etanol Daun Beluntas (Pluchea indica Less.) dan Daun Sukun (Artocarpus altilis (Park.) Fosberg) terhadap Bakteri Staphylococcus aureus ATCC 25923 Setyowati, Rini; Indrayati, Ana; Sari, Ghani Nurfiana Fadma
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 5, No 1 (2024): Januari
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v5i1.17285

Abstract

Indonesians are frequently afflicted with infectious diseases caused by the Staphylococcus aureus bacteria. Beluntas and breadfruit leaves contain flavonoids, saponins, alkaloids, and tannins which have potential as antibacterials. This research seeks to the impact of mixing ethanol extracts of breadfruit and beluntas leaves on S. aureus ATCC 25923. Powder were macerated using 96% ethanol followed by identification of the compound class. Single extracts were examined for dilution to acquire effective concentrations before being mixed with concentration ratios of 1:1, 1:2, and 2:1. The extracts combination was tested using the disc diffusion method, and the combination effect was tested using the paper tape method. The results demonstrated that the beluntas and breadfruit leaf extracts had MBC value of 12.5% and 6.25%. The most effective extract combination was at a concentration ratio of 2:1, with an average diameter of the inhibition zone of 20.72 mm, while the ratios of 1:1 and 1:2 were only 17.78 and 18.15 mm, respectively. The combination effect of extracts is synergistic
ANTIOXIDANT ACTIVITY PROFILING OF RED BAJAKAH TAMPALA (Spatholobus littoralis Hassk) FRACTIONS USING THE DPPH RADICAL SCAVENGING METHOD Amanda, Nathasya Gracya; Sari, Ghani Nurfiana Fadma; Novita, Mega; Marlina, Dian
Berita Biologi Vol 24 No 3 (2025): Berita Biologi
Publisher : BRIN Publishing (Penerbit BRIN)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/berita_biologi.2025.11322

Abstract

Indonesia’s rich biodiversity harbors numerous plants with medicinal properties, including Red Bajakah Tampala (Spatholobus littoralis Hassk.), which has long been used in traditional medicine for its therapeutic benefits. Despite its promising ethnomedicinal reputation, scientific validation of its antioxidant potential remains limited. This study aims to evaluate the antioxidant properties of Red Bajakah Tampala and identify key bioactive compounds responsible for its bioactivity. The plant's antioxidant capacity was assessed using the DPPH assay, and the chemical composition was analyzed through phytochemical screening and thin-layer chromatography (TLC). The ethyl acetate fraction exhibited the strongest antioxidant activity, with an IC₅₀ value of 12.87 ppm, followed by the n-hexane fraction (24.08 ppm) and the water fraction (57.23 ppm). Phytochemical screening revealed the presence of flavonoids, tannins, triterpenoids, phenols, and saponins, which contribute to the plant's antioxidant effects. These findings provide scientific evidence supporting the traditional use of Red Bajakah Tampala as a natural antioxidant, with implications for its potential use in therapeutic and cosmetic applications. Further research into the molecular mechanisms and practical applications of Bajakah-based formulations is recommended.