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All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) WARTA Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Journal of Dedicators Community Jurnal Farmasi Indonesia Jurnal Biomedika Cendekia Journal of Pharmacy Lumbung Farmasi : Jurnal Ilmu Kefarmasian Bengawan :Jurnal Pengabdian Masyarakat Organisms: Journal of Biosciences CERATA Prosiding Seminar Nasional Unimus Jurnal Sains dan Kesehatan Berita Biologi
Ghani Nurfiana Fadma Sari
Program Studi Farmasi, Fakultas Farmasi, Universitas Setia Budi Surakarta, Indonesia
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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ANTIOXIDANT ACTIVITY PROFILING OF RED BAJAKAH TAMPALA (Spatholobus littoralis Hassk) FRACTIONS USING THE DPPH RADICAL SCAVENGING METHOD Amanda, Nathasya Gracya; Sari, Ghani Nurfiana Fadma; Novita, Mega; Marlina, Dian
Berita Biologi Vol 24 No 3 (2025): Berita Biologi
Publisher : BRIN Publishing (Penerbit BRIN)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/berita_biologi.2025.11322

Abstract

Indonesia’s rich biodiversity harbors numerous plants with medicinal properties, including Red Bajakah Tampala (Spatholobus littoralis Hassk.), which has long been used in traditional medicine for its therapeutic benefits. Despite its promising ethnomedicinal reputation, scientific validation of its antioxidant potential remains limited. This study aims to evaluate the antioxidant properties of Red Bajakah Tampala and identify key bioactive compounds responsible for its bioactivity. The plant's antioxidant capacity was assessed using the DPPH assay, and the chemical composition was analyzed through phytochemical screening and thin-layer chromatography (TLC). The ethyl acetate fraction exhibited the strongest antioxidant activity, with an IC₅₀ value of 12.87 ppm, followed by the n-hexane fraction (24.08 ppm) and the water fraction (57.23 ppm). Phytochemical screening revealed the presence of flavonoids, tannins, triterpenoids, phenols, and saponins, which contribute to the plant's antioxidant effects. These findings provide scientific evidence supporting the traditional use of Red Bajakah Tampala as a natural antioxidant, with implications for its potential use in therapeutic and cosmetic applications. Further research into the molecular mechanisms and practical applications of Bajakah-based formulations is recommended.
Pengaruh Durasi dan Konsentrasi Pelarut Ekstrak Etanol Daun Teh (Camellia sinensis) Menggunakan Metode Ultrasonik Terhadap Aktivitas Antibakteri Escherichia coli Thessarah Lia; Ismi rahmawati; Ghani Nurfiana Fadma Sari
CERATA Jurnal Ilmu Farmasi Vol 17 No 1 (2026): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v17i1.1766

Abstract

Tea leaves (Camellia sinensis) are one of the plants that contain flavonoids, tannins, alkaloids, and secondary metabolites of catechins that have the potential as antibacterials. Extraction using the Ultrasonic Assisted Extraction (UAE) method is influenced by the duration and concentration of the solvent. The purpose of this study was to determine the effect of different durations and solvent concentrations on the antibacterial activity of Escherichia coli tea extract using the UAE method. Tea leaves were extracted using the UAE method with sonication waves using 50%, 70%, and 96% ethanol solvents with a duration of 15, 30, and 45 minutes, as much as 25 grams in 250 ml. The extract was dissolved in 10% DMSO and an antibacterial activity test was carried out with a concentration of 75% as much as 50 µL per well. The negative control in the bacterial activity test used 10% DMSO, and used ciprofloxacin as a positive control. The antibacterial activity test was determined using the well diffusion method to determine the diameter of the inhibition zone. The test results data were analyzed statistically using SPSS. The results showed that tea leaves have antibacterial activity against Escherichia coli bacteria, the resulting yield related to variations in solvent concentration and extraction duration did not differ significantly, however the results of the inhibition test against Escherichia coli bacteria showed significant differences. Tea leaf extract extracted with UAE with 70% ethanol for 30 minutes had the highest inhibition diameter resulting in antibacterial activity with an average value of 13.475mm ± 0,38.
Pengaruh Kombinasi Ekstrak Etanol Daun Beluntas (Pluchea indica Less.) dan Daun Sukun (Artocarpus altilis (Park.) Fosberg) terhadap Bakteri Staphylococcus aureus ATCC 25923 Rini Setyowati; Ana Indrayati; Ghani Nurfiana Fadma Sari
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 5, No 1 (2024): Januari
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v5i1.17285

Abstract

Indonesians are frequently afflicted with infectious diseases caused by the Staphylococcus aureus bacteria. Beluntas and breadfruit leaves contain flavonoids, saponins, alkaloids, and tannins which have potential as antibacterials. This research seeks to the impact of mixing ethanol extracts of breadfruit and beluntas leaves on S. aureus ATCC 25923. Powder were macerated using 96% ethanol followed by identification of the compound class. Single extracts were examined for dilution to acquire effective concentrations before being mixed with concentration ratios of 1:1, 1:2, and 2:1. The extracts combination was tested using the disc diffusion method, and the combination effect was tested using the paper tape method. The results demonstrated that the beluntas and breadfruit leaf extracts had MBC value of 12.5% and 6.25%. The most effective extract combination was at a concentration ratio of 2:1, with an average diameter of the inhibition zone of 20.72 mm, while the ratios of 1:1 and 1:2 were only 17.78 and 18.15 mm, respectively. The combination effect of extracts is synergistic
OPTIMASI KONSENTRASI PELARUT ETANOL DAN SUHU EKSTRAK DAUN TURI PUTIH (Sesbania grandiflora L.) DENGAN METODE UAE TERHADAP AKTIVITAS ANTIOKSIDAN SECARA FACTORIAL DESIGN Ghani Nurfiana Fadma Sari; Shella Juana Putri; Nuraini Harmastuti
Jurnal Farmasi Indonesia Vol 22 No 2 (2025): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v22i2.2947

Abstract

White Turi leaves (Sesbania grandiflora L.) are widely recognized as ornamental plants and vegetables and are known for their antioxidant properties due to their content of various secondary metabolites, such as alkaloids, saponins, tannins, flavonoids, and terpenoids. This study aimed to optimize solvent concentration and extraction temperature using the ultrasound-assisted extraction (UAE) method and to investigate the antioxidant activity of white turi leaf extracts using a factorial design approach. The UAE method was employed for the extraction process with ethanol concentrations of 70% and 96% and extraction temperatures of 45°C and 50°C as experimental factors. The responses observed included the extraction yield of white turi leaf extract and antioxidant activity expressed as IC₅₀ values. The results revealed that an ethanol concentration of 96% at an extraction temperature of 50°C produced the highest extraction yield of 18.66%. The highest antioxidant activity was observed using 70% ethanol at 45°C, with an IC₅₀ value of 18.86 µg/mL. Based on the factorial design analysis, an ethanol concentration of 70% combined with an ultrasonic extraction temperature of 45°C was selected as the optimal extraction condition for achieving a favorable balance between extraction yield and antioxidant activity.
FORMULASI SLEEPING MASK EKTRAK AIR TEH HIJAU (Camellia Sinesis L) DENGAN VARIAN CARBOPOL 940 DAN AKTIVITAS SEBAGAI ANTIBAKTERI TERHADAP propinibacterium acne Taufik Turahman; Ghani Nurfiana Fadma Sari

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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31596/cjp.v10i2.425

Abstract

Sleeping mask merupakan salah satu produk perawatan kulit yang diaplikasikan pada malam hari dengan penggunaan yang mudah dan praktis. Daun teh hijau (Camellia sinensis L.) berpotensi dimanfaatkan sebagai bahan aktif dalam pembuatan sleeping mask karena mengandung senyawa seperti flavonoid, alkaloid, dan tanin yang memiliki sifat antibakteri. Penelitian ini dilakukan untuk menilai aktivitas antibakteri ekstrak daun teh hijau terhadap Propionibacterium acnes serta mengkaji pengaruh variasi konsentrasi bahan pembentuk gel, yaitu Carbopol 940, terhadap kualitas fisik sediaan. Ekstrak daun teh hijau diperoleh dengan teknik maserasi menggunakan pelarut etanol 96%. Sediaan sleeping mask diformulasikan dalam tiga variasi kadar Carbopol 940 (0,5%; 1%; dan 1,5%) serta satu formula kontrol negatif dengan konsentrasi Carbopol sebesar 1%. Pengujian yang dilakukan meliputi organoleptik, homogenitas, pH, daya sebar, daya lekat, viskositas, stabilitas, serta aktivitas antibakteri terhadap P. acnes menggunakan metode difusi cakram. Data hasil penelitian kemudian dianalisis menggunakan uji One Way ANOVA. Hasil penelitian menunjukkan bahwa ekstrak daun teh hijau dapat diformulasikan menjadi sediaan sleeping mask pada berbagai konsentrasi, yang ditunjukkan oleh stabilitas sediaan yang secara umum tidak mengalami perubahan. Pada konsentrasi 5%, ekstrak menunjukkan aktivitas antibakteri dengan diameter zona hambat sebesar 59,25 mm. Perbedaan konsentrasi Carbopol berpengaruh terhadap karakteristik fisik sediaan, seperti viskositas, pH, daya sebar, dan daya lekat. Aktivitas antibakteri dari sleeping mask ditunjukkan melalui diameter zona hambat pada masing-masing formula, yaitu FI sebesar 9,07 mm, FII sebesar 7,30 mm, dan FIII sebesar 6,37 mm.
Efek Kombinasi Ekstrak Etanol Daun Anting-Anting (Staphylococcus aureus ) dan Kulit Jeruk Manis (Citrus sinensis) terhadap Bakteri Staphylococcus aureus ATCC 25923 dengan Metode Pita Kertas Ghani Nurfiana Fadma Sari; Isnaini Nurendra Hidayati; Ana Indrayati; Destik Wulandari; Ismi Puspitasari
Jurnal Farmasi Indonesia Vol 23 No 01 (2026): JURNAL FARMASI INDONESIA
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v23i01.2993

Abstract

Infections caused by Staphylococcus aureus ATCC 25923 continue to increase due to antibiotic resistance, making natural product-based antibacterials a promising alternative. This study aimed to evaluate the antibacterial activity and combination effect of ethanol extracts of anting-anting leaves (Staphylococcus aureus) and sweet orange peel (Citrus sinensis) against Staphylococcus aureus ATCC 25923. Extraction was performed by maceration using 96% ethanol. Antibacterial activity was assessed by disc diffusion, MIC and MBC by dilution method, and combination effects by the paper strip method at ratios of 1:1, 1:2, and 2:1. Data were analyzed using One-Way ANOVA and Tukey's HSD test. Results showed that MIC and MBC of both single extracts were at 12.5%. Average inhibition zones of anting-anting leaves and sweet orange peel single extracts were 15.80 mm and 9.33 mm, respectively. The 1:1 combination produced the largest inhibition zone (18.57 mm). The paper strip method revealed a synergistic effect for the 1:1
Co-Authors Amanda, Nathasya Gracya Ana Indrayati Ana Indrayati Bila, Nabila Salsa Desi Ratna Destik Wulandari Endang Sri Rejeki Endang Sri Rejeki Hilda Khairunnisa Ilham Kuncahyo, Ilham Isma Rosida Ismi Puspitasari Isnaini Nurendra Hidayati Khotimatul Khusna Lukito Mindi Cahyo Mamik Ponco Rahayu Marlina, Dian Masyitah Novia Mega Novita Niswah, Sukma Uswatun Nuraini Harmastuti Puspitasari, Ismi Rahmawati, Ismi Rini Setyowati Rita Septiana Shella Juana Putri Sri Rejeki Handayani Supriyadi Supriyadi Supriyadi Syamsul Arifin Taufik Turahman Thessarah Lia Turahman, Taufik Turahman, Taufik Wulandari, Destik