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All Journal Life Science Indonesian Journal of Life Sciences Jurnal Ilmiah Pengabdian Masyarakat Bidang Kesehatan Jurnal Sains Biomedis Journal of World Future Medicine, Health and Nursing
Rahajeng, Herera
Faculty Of Medicine, Universitas Pembangunan Nasional Veteran Jakarta, Indonesia.
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Perbedaan Kadar IgA dan IL6 Pada Penumpang “Biosmart and Safety Bus” pada Memakai Masker Herbal dan Masker Medis Rahajeng, Herera; Prasetyo, Awal; Susilaningsih, Neni; Sadhana, Udadi; Maharani, Nani; Asri, Hairul
Life Science Vol 10 No 1 (2021): April 2021
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/lifesci.v10i1.47177

Abstract

Viral infections that attack the respiratory tract are currently a major problem globally. The spread of viral infection can be one of the risks by passengers of the bus. The government's efforts being developed are the application of biosmart and safety buses designed to prevent the virus with stake holders. One of the health protocols is the use of masks. The purpose of this study was to see the differences in IgA and IL6 levels before and after the use of medical masks and herbal masks. Nasal wash samples were taken and analyzed by ELISA. The results obtained were the level of IgA for the control group before wearing medical masks was 23.46834 pg/ml and after wearing 29.74473 pg/ml. While the IL6 levels before were 1.10544 ng / ml and after -2.04119 ng/ml. The results of the IgA in the experimental group before using the herbal mask 24.00840 pg/ml and after using was 29.74473 pg/ml. Meanwhile, the level of IL6 before was 0.91682 ng/ml and after 0.500157 ng/ml. Based on the results, there was an increase in IgA levels after the use of medical masks and herbal masks while IL6 levels decreased after the use of medical and herbal masks. Keywords: Herbal mask; IgA; IL6, Masker herbal;IgA;IL6 Infeksi virus yang menyerang saluran pernapasan saat ini menjadi masalah utama secara global. Penyebaran agen infeksi virus dapat menjadi salah satu risiko yang dihadapi penumpang moda transportasi Bus. Upaya Pemerintah seperti yang saat ini dikembangkan adalah pengaplikasian biosmart and safety bus yang dirancang guna menghambat persebaran virus dengan stake holder yang tepat. Salah satu penerapan protokol kesehatan adalah penggunaan masker. Tujuan dari penelitian ini adalah melihat perbedaan kadar IgA dan IL6 sebelum dan sesudah pemakaian masker medis dan masker herbal pada penumpang biosmart and safety bus. Pengambilan sampel nasal wash dilakukan dan dianalisis dengan ELISA. Penelitian ini merupakan quasi experimental dengan prepost test randomized control design. Hasil yang didapat adalah kadar IgA untuk kelompok kontrol sebelum pemakaian masker medis 23,46834 pg/ml dan setelah memakai masker medis 29,74473 pg/ml. Sementara kadar IL6 sebelum adalah 1,10544 ng/ml dan setelah -2,04119 ng/ml. Hasil IgA kelompok eksperimen sebelum pemakaian masker herbal 24,00840 pg/ml dan setelah memakai masker herbal 29,74473 pg/ml. Sementara kadar IL6 sebelum adalah 0,91682 ng/ml dan setelah 0,500157 ng/ml. Berdasarkan hasil penelitian terdapat peningkatan kadar IgA setelah pemakaian masker medis dan masker herbal sementara kadar IL6 mengalami penurunan setelah pemakaian masker medis dan masker herbal. Keywords: Herbal mask; IgA; IL6, Masker herbal;IgA;IL6
Transformasi Biomedik Menuju Personalisasi dan Kesehatan Presisi pada Kanker Niken Rahmah Ghanny; Herera Rahajeng; Pararawendy Indarjo; Afifa Radhina; Muhammad Fadhil
Jurnal Sains Biomedis Vol. 1 No. 02 (2025): Jurnal Sains Biomedis
Publisher : Prodi Sains Biomedis Fakultas Ilmu Kesehatan Universitas Muhammadiyah Metro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24127/biomedis.v1i02.10545

Abstract

Biomedical transformation is redefining cancer research and clinical practice by integrating experimental and computational approaches, digital technologies, and patient-specific models to realize precision health. Wet lab experiments generate molecular, imaging, and clinical data, while computational biology and artificial intelligence (AI) interpret complex datasets to uncover predictive biomarkers, optimize therapy selection, and simulate tumor behavior. Digital transformation accelerates data integration through multi-omics, radiomics, and electronic health records, enabling the development of multimodal biomarkers and improved patient stratification. Furthermore, patient-specific models, such as patient-derived organoids (PDOs), xenografts, and digital twin systems preserve tumor heterogeneity and microenvironmental complexity, allowing individualized drug testing and treatment prediction. The convergence of these frameworks’ advances precision oncology from a population-based paradigm toward personalized, adaptive, and data-driven cancer care. This integrative approach strengthens translational research, enhances diagnostic accuracy, and promotes more effective, patient-centered therapeutic strategies.
Tinjauan Etis dan Privasi dalam Integrasi Kecerdasan Artifisial pada Sistem Kesehatan: Suatu Ulasan Kontemporer Herera Rahajeng; Niken Rahmah Ghanny; Afifa Radhina
Jurnal Sains Biomedis Vol. 1 No. 02 (2025): Jurnal Sains Biomedis
Publisher : Prodi Sains Biomedis Fakultas Ilmu Kesehatan Universitas Muhammadiyah Metro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24127/biomedis.v1i02.10621

Abstract

Integrasi keserdasan buatan (Artificial Intelegence/AI) dalam sistem kesehatan berkembang pesat dan menawarkan potensi signifikan dalam peningkatan mutu layanan, efisiensi proses klinis, dan personalisasi terapi. Namun, pemanfaatannya menimbulkan tantangan etis dan privasi yang tidak dapat diabaikan, terutama terkait perlindungan data pribadi, transparansi algoritma, akuntabilitas keputusan klinis, serta penghormatan terhadap otonomi pasien. Artikel tinjauan ini membahas isu-isu utama dalam etika dan privasi AI di layanan kesehatan, meliputi risiko bias dan ketidaksetaraan akses, kebutuhan informed consent yang bermakna, serta pentingnya tata kelola dan regulasi yang adaptif di stingkat global. Pendekatan multidisipiner dan kerangka kebijakan yang kuat diperlukan untuk menjamin bahwa penerapan AI berlangsung secara bertanggung jawab, berkeadilan, dan tetap menjaga kepercayaan pasien. Dengan keseimbangan antara inovasi dan perlindungan hak asasi individu, AI berpotensi menjadi komponen kunci dalam mewujudkan sistem kesehatan yang lebih efektif dan berkelanjutan.
Effectiveness of Mesenchymal Stem Cells and Their Derivatives in Modulating Oxidative Stress in Neurodegenerative Diseases: A Structured Narrative Review Niken Rahmah Ghanny; Putu Erma Pradnyani; Assyafiya Salwa; Herera Rahajeng; Afifa Radhina; Bunga Anggreini Sari; Ichwan Baihaki
Indonesian Journal of Life Sciences 2026: IJLS Vol 08 No.01
Publisher : Universitas Bio Scientia Internasional Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v8i01.297

Abstract

Background: Oxidative stress plays a critical role in the development and progression of neurodegenerative diseases such as Parkinson’s disease (PD), Alzheimer’s disease (AD), and amyotrophic lateral sclerosis (ALS). Mesenchymal stem cells (MSCs) and their derivatives have emerged as promising therapeutic strategies due to their antioxidant, anti-inflammatory, and neuroprotective properties. Objective: This review evaluated the effectiveness of MSC-based interventions in modulating oxidative stress in neurodegenerative disease models. Methods: A structured narrative review search was conducted following PRISMA 2020 guidelines using PubMed and Scopus databases for studies published between 2020 and 2025, with the last search in December 2025. Results: 33 studies met the inclusion criteria, primarily involving Parkinson’s and Alzheimer’s disease models. Overall, MSC-based therapies reduced oxidative stress markers, enhanced antioxidant defenses, activated the Nrf2/HO-1 pathway, improved mitochondrial function, and reduced neuroinflammation in experimental neurodegenerative disease models.
Beyond BMI in Community Health Promotion: An Integrated Anthropometric, Physiological, and Functional Screening Approach among Urban Women in East Jakarta, Indonesia Ichwan Baihaki; Taufiq Fredrik Pasiak; Afifa Radhina; Assyafiya Salwa; Bunga Anggreini Sari; Fransiskus Samuel Renaldi; Herera Rahajeng; Muhammad Fadhil; Niken Rahmah Ghanny; Ria Apriliani
Jurnal Ilmiah Pengabdian Masyarakat Bidang Kesehatan (Abdigermas) Vol. 4 No. 2 (2026): Jurnal Ilmiah Pengabdian Kepada Masyarakat Bidang Kesehatan (Abdigermas)
Publisher : CV Media Inti Teknologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58723/abdigermas.v4i2.750

Abstract

Background: Community-based preventive screening is important for reducing non-communicable disease risk among adult women, particularly those who influence household health practices. However, screening activities frequently emphasize Body Mass Index (BMI), although BMI alone may not adequately describe central adiposity, elevated blood pressure, and functional health indicators. This community service article aimed to describe the implementation of health education and integrated screening involving anthropometric, physiological, and functional measurements among female guardians at Yayasan Tarbiyatul Yatim, East Jakarta, Indonesia.Aims: This study aimed to (1) implement a community-based health education and screening program for adult female participants, (2) assess anthropometric, physiological, and functional health indicators including blood pressure, BMI, waist circumference, and hand grip strength, and (3) identify the prevalence of potential cardiometabolic and functional risk markers beyond BMI.Methods: This activity was implemented on January 8, 2026 using a preventive-promotive community service framework with descriptive program evaluation. Thirty-two adult female participants joined health education, screening, and individual consultation. The community service dataset included blood pressure, pulse, oxygen saturation, body temperature, body weight, height, BMI, waist circumference, hand grip strength, health history, lifestyle profile, and current complaints. Data were analyzed descriptively using frequency, percentage, mean, median, standard deviation, and range.Result: The participants had a mean age of 49.8 years. Mean systolic and diastolic blood pressure were 129.2 mmHg and 78.8 mmHg, respectively. Mean BMI was 24.9 kg/m²; 16/32 participants (50.0%) were categorized as normal, 9/32 (28.1%) overweight, 4/32 (12.5%) obese, and 3/32 (9.4%) underweight. Mean waist circumference was 97.7 cm, and 29/32 participants (90.6%) had waist circumference >80 cm. Mean hand grip strength was 16.5 kg, and 21/32 participants (65.6%) had values <18 kg.Conclusion: Integrated screening beyond BMI is feasible in community service settings and can help identify potential cardiometabolic and functional risk indicators that require counseling or referral. Future activities should include documented repeat measurements for abnormal findings, structured pretest-posttest educational evaluation, biochemical testing, and referral follow-up.
HISTOPATHOLOGICAL IMAGE OF THE NUMBER OF NEURONS IN THE BRAIN OF MICE (MUS MUSCULUS) INDUCED BY LEAD HEAVY METAL Herera Rahajeng; Eka Sri Haryati; Ichwan Baihaki; Niken Rahmah Ghanny; Afifa Radhina; Assyafiya Salwa; Fransiskus Samuel Renaldi
Journal of World Future Medicine, Health and Nursing Vol. 4 No. 2 (2026)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/health.v4i2.3677

Abstract

Lead is a known heavy metal from human history to date for various uses, abuses and toxicities. Lead poisoning has been recognized as one of the most serious environmental health issues worldwide, especially children living in developing countries. Lead can damage or affect the organs of the body, among others, the nervous system, kidneys, reproductive system, and heart, as well as disturbances in the brain so that intellectual and mental disorders in the brain. This study aims to see the effect of lead on the number of neurons in the hippocampus in mice experimental animals. The mice used amounted to 10 tails and divided into two for the control group and the treatment group. The control group, each of which was 5 tails, was then given unbleached drinking water while the treatment group was given drinking water mixed with acetate with concentration of 1000ppm for 17 days in adlibitum. The observations were taken from each of the 5 fields of view on each preparation with a magnification of 40x. The calculation of the number of neuron cells is then analyzed descriptive statistics and different test. The result showed that control group with mean ± SD were 127,6 ± 7,9, and for treatment group that was 80,0 ± 20,9. T independent test result showed p = 0,001 (p <0,05) which means that there was a significant difference between control and treatment group. The conclusion of this research is the existence of neuron cell damage in mice that get treatment. By showing the number of neurons less than the control mice. Suggestion to develop this research hence need to continue research to find neuro protector compound specially from lead work in brain.
Co-Authors Afifa Radhina Afifa Radhina Afifa Radhina Asri, Hairul Assyafiya Salwa Assyafiya Salwa Assyafiya Salwa Awal Prasetyo Bunga Anggreini Sari Bunga Anggreini Sari Eka Sri Haryati Erma Pradnyani, Putu Ichwan Baihaki Muhammad Fadhil Muhammad Fadhil Nani Maharani Neni Susilaningsih Niken Rahmah Ghanny Niken Rahmah Ghanny Niken Rahmah Ghanny Niken Rahmah Ghanny Pararawendy Indarjo Renaldi, Fransiskus Samuel Ria Apriliani Taufiq Fredrik Pasiak Udadi Sadhana, Udadi