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All Journal Life Science Indonesian Journal of Life Sciences Jurnal Sains Biomedis
Rahajeng, Herera
Faculty Of Medicine, Universitas Pembangunan Nasional Veteran Jakarta, Indonesia.
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Medicine & Pharmacology

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Perbedaan Kadar IgA dan IL6 Pada Penumpang “Biosmart and Safety Bus” pada Memakai Masker Herbal dan Masker Medis Rahajeng, Herera; Prasetyo, Awal; Susilaningsih, Neni; Sadhana, Udadi; Maharani, Nani; Asri, Hairul
Life Science Vol 10 No 1 (2021): April 2021
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/lifesci.v10i1.47177

Abstract

Viral infections that attack the respiratory tract are currently a major problem globally. The spread of viral infection can be one of the risks by passengers of the bus. The government's efforts being developed are the application of biosmart and safety buses designed to prevent the virus with stake holders. One of the health protocols is the use of masks. The purpose of this study was to see the differences in IgA and IL6 levels before and after the use of medical masks and herbal masks. Nasal wash samples were taken and analyzed by ELISA. The results obtained were the level of IgA for the control group before wearing medical masks was 23.46834 pg/ml and after wearing 29.74473 pg/ml. While the IL6 levels before were 1.10544 ng / ml and after -2.04119 ng/ml. The results of the IgA in the experimental group before using the herbal mask 24.00840 pg/ml and after using was 29.74473 pg/ml. Meanwhile, the level of IL6 before was 0.91682 ng/ml and after 0.500157 ng/ml. Based on the results, there was an increase in IgA levels after the use of medical masks and herbal masks while IL6 levels decreased after the use of medical and herbal masks. Keywords: Herbal mask; IgA; IL6, Masker herbal;IgA;IL6 Infeksi virus yang menyerang saluran pernapasan saat ini menjadi masalah utama secara global. Penyebaran agen infeksi virus dapat menjadi salah satu risiko yang dihadapi penumpang moda transportasi Bus. Upaya Pemerintah seperti yang saat ini dikembangkan adalah pengaplikasian biosmart and safety bus yang dirancang guna menghambat persebaran virus dengan stake holder yang tepat. Salah satu penerapan protokol kesehatan adalah penggunaan masker. Tujuan dari penelitian ini adalah melihat perbedaan kadar IgA dan IL6 sebelum dan sesudah pemakaian masker medis dan masker herbal pada penumpang biosmart and safety bus. Pengambilan sampel nasal wash dilakukan dan dianalisis dengan ELISA. Penelitian ini merupakan quasi experimental dengan prepost test randomized control design. Hasil yang didapat adalah kadar IgA untuk kelompok kontrol sebelum pemakaian masker medis 23,46834 pg/ml dan setelah memakai masker medis 29,74473 pg/ml. Sementara kadar IL6 sebelum adalah 1,10544 ng/ml dan setelah -2,04119 ng/ml. Hasil IgA kelompok eksperimen sebelum pemakaian masker herbal 24,00840 pg/ml dan setelah memakai masker herbal 29,74473 pg/ml. Sementara kadar IL6 sebelum adalah 0,91682 ng/ml dan setelah 0,500157 ng/ml. Berdasarkan hasil penelitian terdapat peningkatan kadar IgA setelah pemakaian masker medis dan masker herbal sementara kadar IL6 mengalami penurunan setelah pemakaian masker medis dan masker herbal. Keywords: Herbal mask; IgA; IL6, Masker herbal;IgA;IL6
Effectiveness of Mesenchymal Stem Cells and Their Derivatives in Modulating Oxidative Stress in Neurodegenerative Diseases: A Structured Narrative Review Ghanny, Niken Rahmah; Pradnyani, Putu Erma; Salwa, Assyafiya; Rahajeng, Herera; Radhina, Afifa; Sari, Bunga Anggreini; Baihaki, Ichwan
Indonesian Journal of Life Sciences 2026: IJLS Vol 08 No.01
Publisher : Universitas Bio Scientia Internasional Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v8i01.297

Abstract

Background: Oxidative stress plays a critical role in the development and progression of neurodegenerative diseases such as Parkinson’s disease (PD), Alzheimer’s disease (AD), and amyotrophic lateral sclerosis (ALS). Mesenchymal stem cells (MSCs) and their derivatives have emerged as promising therapeutic strategies due to their antioxidant, anti-inflammatory, and neuroprotective properties. Objective: This review evaluated the effectiveness of MSC-based interventions in modulating oxidative stress in neurodegenerative disease models. Methods: A structured narrative review search was conducted following PRISMA 2020 guidelines using PubMed and Scopus databases for studies published between 2020 and 2025, with the last search in December 2025. Results: 33 studies met the inclusion criteria, primarily involving Parkinson’s and Alzheimer’s disease models. Overall, MSC-based therapies reduced oxidative stress markers, enhanced antioxidant defenses, activated the Nrf2/HO-1 pathway, improved mitochondrial function, and reduced neuroinflammation in experimental neurodegenerative disease models.
Transformasi Biomedik Menuju Personalisasi dan Kesehatan Presisi pada Kanker Niken Rahmah Ghanny; Herera Rahajeng; Pararawendy Indarjo; Afifa Radhina; Muhammad Fadhil
Jurnal Sains Biomedis Vol. 1 No. 02 (2025): Jurnal Sains Biomedis
Publisher : Prodi Sains Biomedis Fakultas Ilmu Kesehatan Universitas Muhammadiyah Metro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24127/biomedis.v1i02.10545

Abstract

Biomedical transformation is redefining cancer research and clinical practice by integrating experimental and computational approaches, digital technologies, and patient-specific models to realize precision health. Wet lab experiments generate molecular, imaging, and clinical data, while computational biology and artificial intelligence (AI) interpret complex datasets to uncover predictive biomarkers, optimize therapy selection, and simulate tumor behavior. Digital transformation accelerates data integration through multi-omics, radiomics, and electronic health records, enabling the development of multimodal biomarkers and improved patient stratification. Furthermore, patient-specific models, such as patient-derived organoids (PDOs), xenografts, and digital twin systems preserve tumor heterogeneity and microenvironmental complexity, allowing individualized drug testing and treatment prediction. The convergence of these frameworks’ advances precision oncology from a population-based paradigm toward personalized, adaptive, and data-driven cancer care. This integrative approach strengthens translational research, enhances diagnostic accuracy, and promotes more effective, patient-centered therapeutic strategies.
Tinjauan Etis dan Privasi dalam Integrasi Kecerdasan Artifisial pada Sistem Kesehatan: Suatu Ulasan Kontemporer Herera Rahajeng; Niken Rahmah Ghanny; Afifa Radhina
Jurnal Sains Biomedis Vol. 1 No. 02 (2025): Jurnal Sains Biomedis
Publisher : Prodi Sains Biomedis Fakultas Ilmu Kesehatan Universitas Muhammadiyah Metro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24127/biomedis.v1i02.10621

Abstract

Integrasi keserdasan buatan (Artificial Intelegence/AI) dalam sistem kesehatan berkembang pesat dan menawarkan potensi signifikan dalam peningkatan mutu layanan, efisiensi proses klinis, dan personalisasi terapi. Namun, pemanfaatannya menimbulkan tantangan etis dan privasi yang tidak dapat diabaikan, terutama terkait perlindungan data pribadi, transparansi algoritma, akuntabilitas keputusan klinis, serta penghormatan terhadap otonomi pasien. Artikel tinjauan ini membahas isu-isu utama dalam etika dan privasi AI di layanan kesehatan, meliputi risiko bias dan ketidaksetaraan akses, kebutuhan informed consent yang bermakna, serta pentingnya tata kelola dan regulasi yang adaptif di stingkat global. Pendekatan multidisipiner dan kerangka kebijakan yang kuat diperlukan untuk menjamin bahwa penerapan AI berlangsung secara bertanggung jawab, berkeadilan, dan tetap menjaga kepercayaan pasien. Dengan keseimbangan antara inovasi dan perlindungan hak asasi individu, AI berpotensi menjadi komponen kunci dalam mewujudkan sistem kesehatan yang lebih efektif dan berkelanjutan.
Co-Authors Afifa Radhina Afifa Radhina Afifa Radhina Asri, Hairul Awal Prasetyo Bunga Anggreini Sari Erma Pradnyani, Putu Ghanny, Niken Rahmah Ichwan Baihaki Muhammad Fadhil Nani Maharani Neni Susilaningsih Niken Rahmah Ghanny Niken Rahmah Ghanny Pararawendy Indarjo Salwa, Assyafiya Udadi Sadhana, Udadi