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All Journal JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Science and Technology Indonesia PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JFIOnline Jurnal Layanan Masyarakat (Journal of Public Service) Borneo Journal Of Pharmascientech Berkala Ilmiah Kimia Farmasi JAMAS: Jurnal Abdi Masyarakat
Muhammad Agus Syamsur Rijal
Faculty Of Pharmacy, Universitas Airlangga
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Social Sciences Other

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Effect of CaCl2 Crosslinker Concentration On The Characteristics, Release and Stability of Ciprofloxacin HCl-Alginate-Carrageenan Microspheres Amiruddin; Muh. Agus Syamsur Rijal; Dewi Melani Hariyadi
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 10 No. 3 (2023): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v10i32023.312-323

Abstract

Background: Ciprofloxacin HCl is a broad-spectrum fluoroquinolone antibiotic that has the lowest MIC against Mycobacterium tuberculosis but has limitations in oral use, so inhalation microspheres are made. Objective: This study aimed to investigate the effect of CaCl2 crosslinker concentration on the characteristics, release and stability of ciprofloxacin-alginate-carrageenan microspheres. Methods: Microspheres were prepared by ionotropic gelation using aerosolization with calcium chloride 0.5M (F1), 1.0M (F2), 1.5M (F3), 2.0M (F4) as crosslinker and then dried using freeze dryer. Results: Ciprofloxacin-alginate-carrageenan microspheres formed of yellowish-white powder, smooth morphology and excellent flow properties with the particle size of less than 5µm, drug loading and entrapment efficiency were between    2.05% - 2.42% and 75.34% - 98.09%, yield was between 84.69% - 97.57%, moisture content of less than 10%. Ciprofloxacin-alginate-carrageenan microspheres with 1.5M crosslinker (F3) was the optimal formula. For 12 hours, ciprofloxacin released was 49.89% - 63.78% at pH 7.4, and the kinetics of drug release showed that of Korsmeyer-peppas with a mechanism based on fickian diffusion. The microspheres were discovered to be stable for up to 28 days of storage. Conclusion: The increased concentration of the CaCl2 crosslinker from 0.5M to 2.0M decreased the particle size and drug release but increased the yield, drug loading and entrapment efficiency.
Co-Authors Abdurahman Abdurrahman Amiruddin Andang Miatmoko Aulia Hanin Fakhira Aviatus Solikhah Bambang Tri Purwanto Cindi Dia Rakhmawati Denayu Pebrianti Dewi Isadiartuti Dewi Melani Hariyadi Dinda Monika Nusantara Ratri Dini Retnowati Dini Retnowati Dwi Mulyana, Septian Idha Kusumawati Isnaeni Juni Ekowati Kholis Amalia Nofianti Laila Nur Azizah Luqmanul Hakim Mahardian Rahmadi Marcellino Rudyanto Melanny Ika Sulistyowati Melanny Ika Sulistyowaty Mikhael Ardi Kristiawan Mochammad Yuwono Muhammad Hilal Salim Noorma Rosita Norhayati Nuzul Wahyuning Diyah Paramita, Diajeng Putri Prayoga, Adistiar Prof. Dr. Retno Sari, M.Sc., Apt. Rahman, Fakhrinnisa Wildani Retno Sari Rika Putri Septiawati Rima Hidayatul Qoiriyah Rizaldi, Gusti Rohana Ayu Pramesti Sairiyah, Siti Nasikatus Siti Nur Kholisah Suciati Suciati Sugiyartono, . Sugiyartono, . Tutiek Purwati Tutik Sri Wahyuni Yusuf, Helmy