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All Journal JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Science and Technology Indonesia PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JFIOnline Jurnal Layanan Masyarakat (Journal of Public Service) Borneo Journal Of Pharmascientech Berkala Ilmiah Kimia Farmasi JAMAS: Jurnal Abdi Masyarakat
Muhammad Agus Syamsur Rijal
Faculty Of Pharmacy, Universitas Airlangga
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Social Sciences Other

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Effect of CaCl2 Crosslinker Concentration On The Characteristics, Release and Stability of Ciprofloxacin HCl-Alginate-Carrageenan Microspheres Amiruddin; Muh. Agus Syamsur Rijal; Dewi Melani Hariyadi
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 10 No. 3 (2023): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v10i32023.312-323

Abstract

Background: Ciprofloxacin HCl is a broad-spectrum fluoroquinolone antibiotic that has the lowest MIC against Mycobacterium tuberculosis but has limitations in oral use, so inhalation microspheres are made. Objective: This study aimed to investigate the effect of CaCl2 crosslinker concentration on the characteristics, release and stability of ciprofloxacin-alginate-carrageenan microspheres. Methods: Microspheres were prepared by ionotropic gelation using aerosolization with calcium chloride 0.5M (F1), 1.0M (F2), 1.5M (F3), 2.0M (F4) as crosslinker and then dried using freeze dryer. Results: Ciprofloxacin-alginate-carrageenan microspheres formed of yellowish-white powder, smooth morphology and excellent flow properties with the particle size of less than 5µm, drug loading and entrapment efficiency were between    2.05% - 2.42% and 75.34% - 98.09%, yield was between 84.69% - 97.57%, moisture content of less than 10%. Ciprofloxacin-alginate-carrageenan microspheres with 1.5M crosslinker (F3) was the optimal formula. For 12 hours, ciprofloxacin released was 49.89% - 63.78% at pH 7.4, and the kinetics of drug release showed that of Korsmeyer-peppas with a mechanism based on fickian diffusion. The microspheres were discovered to be stable for up to 28 days of storage. Conclusion: The increased concentration of the CaCl2 crosslinker from 0.5M to 2.0M decreased the particle size and drug release but increased the yield, drug loading and entrapment efficiency.
Enhancing Chitosan-Carboxymethyl Chitosan Composite Film Properties by Silver Nanoparticles Grafting for Acne vulgaris Dwi Mulyana, Septian; Agus Syamsur Rijal, Muh.; Sari, Retno
Science and Technology Indonesia Vol. 11 No. 2 (2026): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2026.11.2.559-568

Abstract

Silver nanoparticles (AgNPs) have been widely used in developing antibacterial preparations. AgNPs are used in film preparation to enhance the film’s antibacterial properties. The combination of natural polymers is an effective strategy to enhance mechanical properties, prolong degradation time, preserve gas and vapor permeability, and maintain biocompatibility. This research aims to develop an AgNP-chitosan-carboxymethyl chitosan (CMChi) nanocomposite film that exhibits desirable physical properties and enhances antibacterial activity by incorporating AgNPs. Chitosan-CMChi composite films were prepared using the solvent casting method. Characterization and antibacterial tests using Propionibacterium acnes (P. acnes) were carried out for AgNO3 and AgNP-chitosan-CMChi nanocomposite films. The results showed that a 1 mM AgNO3 solution with 1% lime powder at pH 9 was the optimal formulation for AgNP formation, exhibiting an absorbance of 4.631 at 408.1 nm, a particle size of 68.4 nm, and antibacterial activity. To optimize the chitosan-CMChi composite film, a formula of 1.5% chitosan and 1.5% CMChi was selected, yielding a tensile strength value of 0.514 MPa. The AgNP solution was then added. In the AgNP-chitosan-CMChi nanocomposite film, it was observed that increasing the AgNP volume affected the mechanical strength of the film. The antibacterial activity of the AgNP-chitosan-CMChi nanocomposite film increased with the AgNP concentration. Combining AgNPs with the chitosan-CMChi polymer yields nanocomposite films with good physical properties and enhanced antibacterial activity against P. acnes compared with films without AgNPs.
Co-Authors Abdurahman Abdurrahman Amiruddin Andang Miatmoko Aulia Hanin Fakhira Aulia, Nanda Intan Aviatus Solikhah Bambang Tri Purwanto Cindi Dia Rakhmawati Denayu Pebrianti Dewi Isadiartuti Dewi Melani Hariyadi Dinda Monika Nusantara Ratri Dini Retnowati Dini Retnowati Dwi Mulyana, Septian Idha Kusumawati Isnaeni Juni Ekowati Kholis Amalia Nofianti Laila Nur Azizah Luqmanul Hakim Mahardian Rahmadi Marcellino Rudyanto Melanny Ika Sulistyowati Melanny Ika Sulistyowaty Mikhael Ardi Kristiawan Mochammad Yuwono Muhammad Hilal Salim Noorma Rosita Norhayati Nuzul Wahyuning Diyah Paramita, Diajeng Putri Prayoga, Adistiar Prof. Dr. Retno Sari, M.Sc., Apt. Rahman, Fakhrinnisa Wildani Retno Sari Rika Putri Septiawati Rima Hidayatul Qoiriyah Rizaldi, Gusti Rohana Ayu Pramesti Sairiyah, Siti Nasikatus Siti Nur Kholisah Suciati Suciati Sugiyartono, . Sugiyartono, . Tutiek Purwati Tutik Sri Wahyuni Yusuf, Helmy