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Journal : CERATA

Optimisasi Tween 80 dan Span 80 Sebagai Emulgator dalam Formula Krim Tabir Surya Kombinasi Ekstrak Etanol Daun Alpukat (Persea americana M.) dan Nanopartikel Seng Oksida Dengan Metode Simplex Lattice Design Erindyah Retno Wikantyasning; Nabilla Indianie
CERATA Jurnal Ilmu Farmasi Vol 12 No 1 (2021): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v12i1.198

Abstract

Avocado leaves contain flavonoid which act as antioxidant whereas nanoparticles of zinc oxide can protect the skin against a wide spectrum of UV. The purpose of this study was to determine the effect of variation of Tween 80 and span 80 as emulsifier and determine the optimum formula of sunscreen scream containing ethanol extract of avocado leaves and zinc oxide nanoparticles. Avocado leaves were extracted by maceration method using ethanol. Nano zinc oxide is obtained by the High Energy Ball Milling technique and characterized using Particle Size Analyzer. Determination of the optimal cream formula with variations in the concentration of Tween 80 and Span 80 is done by Simplex Lattice Design (SLD) method. The maceration resulted ethanolic extract of avocado leaves with a yield of 34.4%. The synthesised zinc oxide nanoparticles obtained showed 179.47±5.98 nm in diameter. The results showed that increasing concentrations of Tween 80 and decreasing concentration of Span 80 increased spreadability but decreased the viscosity and adhesiveness of creams. The SPF evaluation of creams showed a medium protection category (SPF>15). The optimum formula was obtained with the ratio of Tween 80 and Span 80 was 7,8 and 3,2%, respectively, with the desirability value of 0.863.
Co-Authors Abdellah, Yousra Nait El Haj Amalia Septianawati Amalia, Nastity Zhahwa Amanda Wahyu Kurniawan Ambar Yunita Ambar Yunita Nugraheni Andi Suhendi Arifah Sri Wahyuni Astuti, Devi Dwi Astuti, Kartika Fidi Audi Tahta Aurellia Brainandiva Ade Fitria Cahya Rahma Utami Cholisoh, Zakky Dedi Hanwar Devita Dwitama Setya Divayana, Destria Dwi Anggraini, Adinda Dzaki Fikri Firdaus Bakri Endang Setyaningsih Gayuh Ilham Rahmadi Gunawan Setyadi Hartanto, Riyan Eko Heppy Purbasari Hidayah Karuniawati Ika Ayu Mentari Ika Trisharyanti Dian Kusumowati Indah Hairunisa Indana Lazulfa Indrastuti, Annora Julianti, Tri Budi Karimah, Izqi Kartika Fidi Astuti Kayendeke, Joweria Khairani, Vita Fadlilah Khoirunnisa Khoirunnisa Kibedi, Cabral Bilal Larasati, Arindra Luluk Ria Rakhma Lusi Anggraini Morita Sari Muhammad Da'i Muhammad Ikhsan Al Af Ghani Muhtadi Muhtadi Muhtadi, M Nabilla Indianie Niken Dyaharesti Nor Laili Nurhakimah, Ulil Fikri Pertiwi, Hany Kartika Prasetiawan, Roseh Priyastiningrum, Anisa Rachma Putri, Nastity Zhahwa Amalia Ramadhani Dwi Sula Ramarohasina, Mika Notahiana Ramdani, Tasya Eka Ratsimandresy, Neciah Fahombiazana Refsya Azanti Putri Rima Munawaroh Roseh Prasetiawan Rosi Hayyu Anjani Salsabila Azzahra Sania Nayasari Khoirunnisa Sella Aprilia Setyo Nurwaini Shafira Widyanti Ssenku, Jamilu Edrisa Sula, Ramadhani Dwi Syamsul Arifin Teguh Imanto Tri Budi Julianti Ulayya, Hanidya Fidela Ulil Fikri Nurhakimah Wahyu Utami Walusansa, Abdul Yuka Aulia Rahma Yuniasti, Lainisah Purna Zahidah, Fairus