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All Journal ODONTO Dental Journal Dentino: Jurnal Kedokteran Gigi Padjadjaran Journal of Dentistry An-Nadaa: Jurnal Kesehatan Masyarakat Sinnun Maxillofacial Journal Odonto dental journal
Pramitha, Selviana Rizky
Fakultas Kedokteran Gigi Universitas Lambung Mangkurat
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Veterinary

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Journal : odonto dental journal

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Antibacterial, Antifungal And Subchronic Toxicity Test Of Ficus Deltoidea Jack Leaves Extract Apriasari, Maharani Laillyza; Adhiya, Geyanina Melda; Wasiaturrahmah, Yusrinie; Utami, Juliyatin Putri; Firdaus, I Wayan Arya Krishnawan; Pramitha, Selviana Rizky
Odonto : Dental Journal Vol 12, No 1 (2025): April 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.12.1.19-28

Abstract

Background: Ficus deltoidea Jack is a plant that is often used as herbs medicine because of secondary metabolites such as alkaloids, phenolics, flavonoids, and steroids. This study aims to determine the activity of antibacterial, antifungal and toxicity effect of Ficus deltoidea Jack leaves (FDLE) extract. Method: Pure experimental study with a posttest-only design with a control group design. The in vitro test by dilution methods using Staphylococcus aureus and Candida albicans.  The toxicity test used 16 male Rattus novergicus divided into four group consist a control group and three treatment group given FDLE doses with 1,250, 2,500, and 3,750 mg/kgBW. The treatment applied 2x1 ml FDLE every 24 hours orally for 28 days. Result: The MIC value and the MBC value of FDLE againts S. aureus were 8% and 10%, respectively. While, MIC and MBC value on C. albicans has similar value about 25%. The mean results of kidney toxicity test were still in the normal range. There was a significant difference in the results of the Kruskall Wallis test for urea (p<0.05), while there was no significant difference in the results of urea and creatinine level (p>0.05). Conclusion: There was antibacterial and antifungal efficacy of FDLE. Also, there was no toxic effect of giving FDLE at doses of 1,250, 2,500, and 3,750 mg/kgBW was showed on urea and creatinine normal level.
Pharmacotherapy And Behavioural-Modifying-Lifestyle For Oral Lesions Management In Multimorbid Patient Post-Pyelolithotomy: A Case Report Pramitha, Selviana Rizky; Izzati, Arissa; Apriasari, Maharani Laillyza; Carabelly, Amy Nindia; Puspitasari, Dewi
Odonto : Dental Journal Vol 13, No 1 (2026): April 2026
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.13.1.%p

Abstract

Background: Chronic kidney disease (CKD), a recognized complication of pyelolithotomy along with multimorbidity in the elderly population, presents a higher incidence of oral lesions. Further damage to the renal vasculature interchangeably affects oral-systemic conditions. We report oral lesions management in MCC patient post-pyelolithotomy for better outcomes.  Case: A 65-year-old male patient complained of painful ulceration on the atrophic tongue for two weeks with a fair oral hygiene score. The condition had been managed with various topical agents alternately with no improvement. There was a history of pyelolithotomy and emergency room admission. Laboratory examination presented diabetes mellitus, stage 3B kidney disease and anemia of chronic disease. A diagnosis of ulcerative-type uremic stomatitis with atrophic glossitis in multimorbid patient was obtained. Pharmacotherapy of oral lesion including aloe vera extract mouthwash and povidone-iodine mouthwash showed improvement on the following day. Behavioural-modifying lifestyle involved physical activity, healthy eating, and adherence to treatment (oral hygiene maintenance and regular dental appointment). Systemic conditions were managed by multidiscipline treatment with Internal Medicine. Conclusion: Pharmacotherapy and behavioral modifying lifestyle may support a better prognosis for oral manifestation in multimorbid patient post pyelolithotomy
Co-Authors Adhiya, Geyanina Melda Amy Nindia Carabelly Apriasari, Maharani Lallyza Ash-Shiddiq, Muhammad Hafizh Aulia Azizah Aulia, Shaula Nada Azizi, Fabillah Haikal Desiana Radithia, Desiana Dewi Puspitasari Dewi, Gremita Kusuma Diah Savitri Ernawati Dwipura, Irnamanda Fatma Yasmin Mahdani Firdaus, I Wayan Arya Krishnawan Gusti Muhammad Perdana Putera Hamdani, Riky Ishmah, Hana Nur Izzati, Arissa Kurniasari, Annisa Mahamad Apandi, Nurul Inaas Maharani Laillyza Apriasari Nafisah, Riznasyarielia Nikmatun Nurina Febriyanti Ayuningtyas Pasaribu, Togu Andrie Simon Pratiwi, Aulya Setyo Puspasari, Karlina Reiska Kumala Bakti Sari Fitri, Rahayu Wida Sutanti, Viranda Utami, Juliyatin Putri Yusrinie Wasiaturrahmah