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All Journal Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Pharmaceutical Science and Technology Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Pharmacon Forum Geografi IJoICT (International Journal on Information and Communication Technology) JOIN (Jurnal Online Informatika) Jurnal Teknologi dan Sistem Komputer Media Farmasi Journal of Dedicators Community JPSCR : Journal of Pharmaceutical Science and Clinical Research Forest and Society Jurnal Mandala Pharmacon Indonesia Abdimas UNWAHAS : Jurnal Pengabdian Masyarakat UNWAHAS Jurnal Ilmiah Cendekia Eksakta Jurnal Mandala Pengabdian Masyarakat Jurnal Pengabdian Masyarakat Abdimas Madani PROFICIO: Jurnal Pengabdian Masyarakat Jurnal DiMas (Jurnal Pengabdian Kepada Masyarakat) Media Farmasi Indonesia Jurnal Farmasi Sains dan Praktis Borneo Journal of Pharmacy
Ayu Shabrina
Universitas Wahid Hasyim
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Jurnal Mandala Pharmacon Indonesia

 1 
Physical Stability and Antihyperpigmentation Activity of Berenuk (Crescentia cujete Linn) Leaves Ethanol Extract in Cream with Variations of Cremophor RH40 as Surfactant Auliasari, Dewi Wulandari; Riyanti, Winanti Adi; Prihantini, Malinda; Shabrina, Ayu; Fithria, Risha Fillah
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 1 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i1.492

Abstract

Indonesia has high exposure to sunlight which can cause skin problems such as hyperpigmentation. Treatment of hyperpigmentation with hydroquinone can cause side effects. Therefore, it is necessary to develop antihyperpigmentation products from natural ingredients to minimize these side effects. Berenuk leaves (Crescentia cujete Linn) have antioxidant activity with an IC50 value of 80.21 µg/ml in ethanol extract. This antioxidant compound can be used to treat hyperpigmentation problems. In its use, Berenuk Leaf Ethanol Extract (BLEE) is formulated in a cream dosage form. Cremophor RH40 is a type of nonionic surfactant that can affect the physical stability of cream. This study aims to determine the effect of Cremophor RH40 on the physical stability of cream preparations and their antihyperpigmentation activity. Cream preparations were made with varying concentrations of Cremophor RH40 5% (F1), 10% (F2), 15% (F3). Physical stability evaluation was tested using the cycling test method. Data were analyzed statistically with paired samples t-test. Analysis of antihyperpigmentation test data in the form of the amount of melanin in all test groups was analyzed for differences using Kruskal Wallis and continued with the Mann-Whitney test. BLEE cream’s physical stability test result show that the most stable formula is formula 1 because it is stable up to the 5th cycle. in contrast, formula 2 only goes up to the 3rd cycle, and formula 3 in the first cycle has experienced 2-phase separation. BLEE cream (F1) has antihyperpigmentation activity because it has an average melanin intensity less than the negative and positive controls.
Co-Authors Adhi Gunawan Agnes Theresya Poerba AL Mamuda, Naila Annisa Rahayuning Pratiwi Arnida Lailatul Latifah Arsyada, Muhammad Farih Astri Risma Debi Auliasari, Dewi Wulandari Aza Zakiyatun Nida Aza Zakiyatun Nida Bambang Ari Wahyudi Daipadli Daipadli Dharmawan Dharmawan Dhimas Adhityasmara Diana Anisa Setyani Eka Sakti Wahyuningtyas Elya Zulfa Erika Indah Safitri Faza Putri_Maulina Hanik Firdausi, Zuhriya Muna Gunawan, Adhi Hafiz, Nur Heny Puspasari Heroweti, Junvidya Hidayati, Ishardina C. I Nyoman Sujana Ibrahim Arifin Ibrahim Arifin Ibrahim Arifin Icha Sabrina Milenia Khansa Ilma Nur Khafifa Inna Syafarina Intan Nuni Wahyuni Intan Pratiwi Irma Palupi Junvidya Heroweti Junvidya Herowety Kabur, Savio Ricardus Khoirul Anwar KHOIRUL ANWAR Kintoko Kintoko Kintoko, Kintoko Latifah, Arnida L Latifah, Arnida L. Lobma, Fadhil M Fatchur Rochman M Fatchur Rochman MARIA ULFAH Mimiek Muurukmihadi Misbahul Munir Muddiin, Muhammad Imaa Muhammad Ikhsan M_Rifki Pratama_Kharisma Akbar Nalaratih, Novinda Niswatus Sholihah Nuni Wahyuni, Intan Nurkhasanah Nurkhasanah Poerba, Agnes Theresya Pratama, Fandy Indra Pratiwi, Nevy Prihantini, Malinda Puspasari, Heny Puspita, Weni Rabiatul Adawiyah Ratna Hapsari Ratna Hapsari Tri Mustika Dewi Rima Nofitasari Ririn Lispita Wulandari Risha Fillah Fithria risha fillah fithria Riyanti, Winanti Adi Rizky Adityo Saputro Saniya Alfa Salsabila Sapto Yuliani Setyani, Diana Anisa Siti Setianingsih Sri Eka Rahmadany Sri Eka Rahmadany Sri Febri Haryati Sri Suwarni Sumantri Sumantri Surti Khayatul Fata Susiana Irmawati Urva Fresiva Uswatun Hasanah Vironica Rizky Fauziah Wahyu Setyo Wibowo Wahyuni, Intan N. Wahyuni, Intan Nuni Wijayatri, Ratna Yulias Ninik Windriati Zuhriya Muna Zuhriya Muna Firdausi