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All Journal Jurnal Pengabdian Kepada Masyarakat Sakai Sambayan Science and Technology Indonesia Jurnal Kartika Kimia Stannum : Jurnal Sains dan Terapan Kimia Jurnal Abdi Insani Mestaka: Jurnal Pengabdian Kepada Masyarakat JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai
Ambarwati, Yuli
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Experimental Synthesis and In Vivo Assessment of the Antidiabetic Activity of an Iron(III)-Glycine Complex Valencia, Pinkan; Ambarwati, Yuli; Nurhasanah, Nurhasanah; Widiarto, Sonny; Setiawan, Andi; Pandiangan, Kamisah Delilawati
Jurnal Kartika Kimia Vol 8 No 2 (2025): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v8i2.953

Abstract

Indonesia is one of the countries with a growing number of diabetes mellitus cases each year. This disease can cause damage to vital organs such as the liver, pancreas, kidneys, and heart. Type 1 diabetes is generally treated with insulin, while type 2 diabetes is commonly managed with oral medications. Recently, metal complexes have emerged as promising alternatives for antidiabetic therapy. Among these, iron(III) complexes are of interest, although research on Fe(III) complexes remains limited. This study aims to synthesize and evaluate the in vivo antidiabetic activity of an iron(III)-glycine complex. The synthesized complex appeared as an orange-brown solid with a yield of 95.02% and a sample mass of 0.267 g. UV-Vis spectrophotometric analysis showed absorption peaks at 210, 224, and 305 nm, indicating the presence of the Fe(III)-glycine complex. FTIR analysis revealed characteristic absorption bands corresponding to Fe–O at 523 cm⁻¹ and Fe–N at 823 cm⁻¹. In vivo tests were conducted on mice induced with alloxan. Body weight of the mice decreased after induction but stabilized after treatment during the third and fourth weeks. The highest reduction in blood glucose levels was observed at a dose of 200 μg/kg body weight, with a 68% decrease. These results suggest that the Fe(III)-glycine complex exhibits potential as an antidiabetic agent.
Co-Authors Aditya, Novi Ahmadi, Peni Andhulangi, Ganjar Andi Setiawan Annisa, Devi Nur Arai, Masayoshi Aspita Laila Ayumi, Eksa Berghuis, Nila Tanyela Ety Apriliana Hardiyanto, Candra Idris, Iswadi Ilim, Ilim Indri Windarti Janar Wulan, Anggraini John Hendri Juliasih, Ni Luh Gede Ratna Lutfiah, Rosyidatul Mulyono Mulyono Notiragayu, Notiragayu Nurfaradina, Zaskia Ayu Nurhasanah Nurhasanah Oktarina, Rasmi Zakiah Pandiangan, Kamisah Delilawati Purwadi, Ofik Taupik Qudus, Hardoko Insan Ratna, Maya Ganda Revita Sari Rinawati Rinawati Rodiani, Rodiani Septia Eva Lusina Septiani, Linda Setiawan, Fendi Siti Nurul Khotimah Sri Waluyo Susianti Susianti Sutopo Hadi SYAIFUL BAHRI Valencia, Pinkan WAWAN ABDULLAH SETIAWAN, WAWAN ABDULLAH Widiarto, Sonny Widiarto, Sony Wulandari, Ika Rizki Yula, Hesty Rodlotu Zipora Sembiring