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All Journal Mechatronics, Electrical Power, and Vehicular Technology Civis: Jurnal Ilmiah Ilmu Sosial dan Pendidikan Pharmasipha Jurnal Pembelajaran Pemberdayaan Masyarakat (JP2M) Jurnal Kewarganegaraan USRAH: Jurnal Hukum Keluarga Islam Journal of Halal Science and Research Borneo Journal of Pharmacy JEMABITEK
Ma'ruf, Muhammad
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Identification of Gene Variations Associated with Diabetic Neuropathy Using Bioinformatics Approach Sultan, Siti Fatimah; Novriyanti, Adisti Putri; Rohmah, Siti; Irham, Lalu Muhammad; Sulistyani, Nanik; Ma'ruf, Muhammad
Borneo Journal of Pharmacy Vol. 9 No. 1 (2026): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v9i1.7148

Abstract

Diabetic neuropathy is the most common complication of diabetes, experienced by almost 90% of diabetic patients. Pain is one of the most common symptoms of diabetic neuropathy, but the pathophysiologic mechanism of pain is not clearly known. The hypothesis of hyperglycemia toxicity to the development of pain complications has been widely accepted worldwide, but there are still other hypotheses proposed. The basic concept in the management of painful diabetic neuropathy is to exclude other causes of peripheral neuropathic pain, improve glycemic control for prophylactic therapy, and use drugs to reduce pain. Diabetic neuropathy variation data can be obtained from the Ensembl Genome Browser. Here, genes associated with 26 variants were selected according to Haploreg version 4.2. In addition, protein expression of missense gene variants was examined using the GTEx portal to determine two variants: rs55703767, which encodes the COL4A3 gene, and rs141560952, which encodes the DIS3L2 gene. According to data obtained from the Ensembl Genome Browser, the two most prevalent populations for SNP rs55703767, which is linked to the COL4A3 gene, are in Africa, while SNP rs141560952, which is linked to the DIS3L2 gene, is most prevalent in Africa, the Americas, East Asia, Europe, and South Asia.
Co-Authors Achmad Praptijanto Ade Kurniawan Ardilla, Mita Arif Budi Setianto Arifin Nur Bambang Wahono Budi Prawara Budianto, Hari Danang Prasetyaning Amukti Dimyani, Ahmad Eka Kumalasari Fuad, Nur Muhamad Hastangka Hastangka, Hastangka Hayoto, Vebriyanti Hidayat, Muhammad Novel Humolungo, Dwi Tiva Widyanti Sidik Ichwan Ridwan Rais Indriatmono, Dedy Lalu Muhammad Irham Lasanudin, Rindi Ibrahim Miya Dewi Suprihandari Moch. Saiful Bachri Mokhtar, Mokhtar Nanik Sulistyani Nina Salamah Nour Athiroh Abdoes Sjakoer Novriyanti, Adisti Putri Nugroho, Rudi Cahyo Nurul Jadid Mubarokati Pratama, Mulia Raharjo, Kusuma Adi Samanhudi, Ramadhani Deniartio Sapto Yuliani Siti Fatimah Sultan Siti Rohmah Soewono, Respatya Teguh Sri Wahyuni Suherman, Suherman Sukra, Kurnia Fajar Adhi Suryantoro, Muchammad Taufiq Wahidin, Agus Wardana, Muhammad Khristamto Aditya Yanuandri Putrasari Yuwono, Taufik