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All Journal Microbiology Indonesia Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Biotechnology Dentino: Jurnal Kedokteran Gigi Jurnal Surya Medika Anterior Jurnal Jurnal Farmasi Indonesia PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Borneo Journal of Medical Laboratory Technology Jurnal Farmagazine Jurnal Farmasi Sains dan Praktis Jurnal Pengabdian dan Pemberdayaan Masyarakat Indonesia Jurnal Farmasi SYIFA Borneo Journal of Pharmacy Journal of Pharmascience
Mohammad Rizki Fadhil Pratama
Universitas Muhammadiyah Palangkaraya
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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Introduction to Bibliometric Studies for Lecturers of the Faculty of Health Sciences, Universitas Muhammadiyah Palangkaraya Mohammad Rizki Fadhil Pratama; Muhamad Riza Syah Fahlevi
Jurnal Pengabdian dan Pemberdayaan Masyarakat Indonesia Vol. 3 No. 7 (2023)
Publisher : Peneliti Teknologi Teknik Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59247/jppmi.v3i7.134

Abstract

Bibliometric studies have become a new standard in finding gap research for further research. Mastering software such as VOSViewer can be beneficial in carrying out these bibliometric studies utilizing databases of international scientific publications. However, bibliometric research still needs to be discovered by some academics, especially those unfamiliar with it, such as lecturers at the Faculty of Health Sciences, Universitas Muhammadiyah Palangkaraya. Therefore, this service activity aims to introduce and train these lecturers regarding bibliometric studies using VOSviewer. The solution offered by the servant is to carry out introductory activities and training in operating VOSviewer in carrying out the bibliometric study. Apart from introducing the lecturers to the branch of science, which is currently in great demand worldwide, it also increases the enthusiasm for writing for the participants. Through the activities, the participants have carried out a bibliometric study in Pharmacy and Medical Laboratory Technology, which can then be published as a separate bibliometric study. As a follow-up to this activity, apart from being able to do it for lecturers in other faculties within the Universitas Muhammadiyah Palangkaraya, training is also planned to be carried out to publish scientific articles on the results of the bibliometric study.
Profil Penggunaan Obat Antihipertensi di RSUD Mas Amsyar Kasongan Kabupaten Katingan: A Profile of Antihypertensive Medicines in Mas Amsyar Hospital Kasongan Katingan Regency Syahrida Dian Ardhany; Wahyu Pandaran; Mohammad Rizki Fadhil Pratama
Borneo Journal of Pharmacy Vol. 1 No. 1 (2018): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v1i1.248

Abstract

Hypertension or high blood pressure is one of the lead causes of death. Hypertension can cause various complications with another disease, even the cause of heart disease, stroke, and kidney disorders. Hypertension is the second rank of the most diseases in Kabupaten Katingan. The purpose of this research is to know the profile of antihypertensive medicines in RSUD Mas Amsyar Kasongan. Method of this research was a descriptive method with saturation sampling used retrospective data on all prescription drugs in 2017. The results of this research based on the patient characteristic were found 43.3% men and 56.7% women, meanwhile 45.8% age < 45 years old and 54.2% for age > 45 years old. The antihypertensive drug items used are propranolol, telmisartan, amlodipine, lisinopril, furosemide, ramipril, valsartan, candesartan, irbesartan, and bisoprolol, meanwhile based on the classification of antihypertensive drugs. are angiotensin II receptor blockers (ARB), diuretics, angiotensin converting enzyme Inhibitors (ACEI), Calcium Channel Blockers (CCB) and alpha 2 adrenergic agonists. Based on the result, it can be concluded that hypertension patient in RSUD Mas Amsyar Kasongan is mostly female (56.7%) and age of hypertension patient is > 45 years old (54.2%). The most antihypertensive prescribed is monotherapy (72%) and the most item of the drug is amlodipine. (38%).
Profile of Thin-Layer Chromatography and UV-Vis Spectrophotometry of Akar Kuning Stem Extract (Arcangelisia flava) Mohammad Rizki Fadhil Pratama; Suratno Suratno; Evi Mulyani
Borneo Journal of Pharmacy Vol. 1 No. 2 (2018): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v1i2.367

Abstract

This study aims to obtain the profile of Thin-Layer Chromatography (TLC) and Ultraviolet-Visible (UV-Vis) spectrophotometry from the ethanol extract of akar kuning stems (Arcangelisia flava) from Central Kalimantan. The TLC method is used with the orientation phase of the combination of polar-non-polar solvents resulting from orientation, while ethanol is used as the solvent for UV-Vis spectrophotometers. TLC results showed the formation of three stains on a mixture of polar solvents chloroform : methanol : water while in a non-polar solvent combination n-hexane : ethyl acetate did not show any stains. Comparison of retention factor (Rf) values shows the best combination of polar solvents to separate stains at a ratio of 5 : 2 : 1, respectively. Separation in 2-dimensional TLC with polar solvents showed a similar pattern with 1-dimensional separation in the form of three stains. UV-Vis spectrophotometer results showed four main peaks with wavelength 227.2; 267.4; 345.2; and 425.3 nm, respectively. The profile of the peak formed is very similar to that shown by berberine, one of the primary metabolites of akar kuning. TLC and UV-Vis spectrophotometers profiles obtained are expected to support further research using akar kuning stems, especially those from Central Kalimantan.
In silico study of the essential oil compounds of ginger and thyme on Coronavirus-2 receptors Caroline Caroline; Martha Ervina; Muhammad Rizki Fadhil Pratama; Maria Anabella Jessica
Pharmaciana Vol 13, No 3 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v13i3.26964

Abstract

Coronavirus-2 (SARS-Cov-2) is a virus that attacks the respiratory system and causes the Covid-19 pandemic. After the pandemic, prevention and appropriate therapy research continue to be carried out to anticipate the emergence of more dangerous viruses. In line with the culture of consuming herbs that has arisen due to the effects of the pandemic, in this study, an insilico screening was carried out for essential oil compounds produced by ginger and thyme herbs which have been widely consumed by the public. The aim of the research was to find the essential oil content that has the most potential as an antiviral against coronavirus-2. The research method was carried out in silico, including ligand preparation, receptor and method validation, and analysis of ligand-receptor binding interactions using the AutoDoc 4.2.6 program. As a comparison, a study was conducted on remdesivir and favipiravir, which have been used as antivirals. The three components that have the most potential based on the calculation of the free energy value, were determined by the ADMET parameters using the Admet lab 2.0 program. The results showed that the three components in the essential oil exhibited better interactions when compared to remdesivir and favipiravir at the 3-Cl protease and spike glycoprotein receptors. The results of the insilico study and ADMET prediction test showed that of the three most potent compounds, lamda-farnesen was the most potent and safe to use
Improvement of Quality and Quantity of Technology-Based Learning in Pharmacy and Medical Laboratory Technology Chusna, Nurul; Novaryatiin, Susi; Purbayanti, Dwi; Mulyani, Evi; Ardina, Rinny; Rahmah, Windya Nazmatur; Pratama, Mohammad Rizki Fadhil
Borneo Journal of Medical Laboratory Technology Vol. 7 No. 2 (2025): Borneo Journal of Medical Laboratory Technology
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjmlt.v7i2.7166

Abstract

The enhancement of technology-based learning in the fields of pharmacy and medical laboratory technology is imperative to keep pace with advancements in healthcare and educational methodologies. This study investigates the strategies and impacts of integrating cutting-edge technologies into the curricula of these disciplines. Key areas of focus include the implementation of virtual simulations, online learning platforms, and interactive multimedia resources. The research highlights how these technologies improve the quality of education by providing students with realistic, hands-on experiences that enhance their practical skills and theoretical knowledge. Additionally, the study explores the scalability and accessibility of technology-based learning, which contributes to increased student engagement and enrollment. By leveraging data analytics and feedback mechanisms, educators can tailor learning experiences to meet individual student needs, thereby improving learning outcomes. The findings suggest that the thoughtful integration of technology not only enriches the educational experience but also prepares students more effectively for the evolving demands of the healthcare industry. This research underscores the necessity of continuous investment in educational technologies to sustain the quality and quantity of learning in pharmacy and medical laboratory technology programs.
Molecular Docking Study of Akar Kuning (Arcangelisia flava) Secondary Metabolites as Src Inhibitor Pratama, Mohammad Rizki Fadhil; Mulyani, Evi; Suratno, Suratno
Indonesian Journal of Cancer Chemoprevention Vol 10, No 3 (2019)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev10iss3pp122-130

Abstract

Proto-oncogene tyrosine-protein kinase Src is also known as simply Src is a tyrosine kinase protein which is one of the targets in various cancer therapies such as leukemia. Meanwhile, akar kuning (Arcangelisia flava) has gained significant attention as a medicinal plant that has a cytotoxic effect on various types of cancer cells. This study aims to determine the potential of secondary metabolites of akar kuning as Src inhibitors. Molecular docking was carried out using Autodock Vina 1.1.2 with 2HCK receptors, that quercetin and dasatinib were used as reference ligands. The docking results showed that the highest affinity was shown by berberine with a ΔG value of -9.0 kcal/mol, exceeded quercetin and dasatinib. However, the highest amino acid similarity to quercetin and dasatinib was produced by jatrorrhizine, with 93.33% and 73.91%, respectively. Interestingly, berberine is the ligand with the third-highest similarity after jatrorrhizine and palmatine, while jatrorrhizine has the second-highest affinity after berberine. The results concluded that the combination of berberine and jatrorrhizine is predicted to be optimally used as an Src inhibitor in cancer therapy.
Analisis Kelengkapan Administratif dan Farmasetik E-Resep Pasien Rawat Inap di RS X Kota Palangka Raya Puranti, Iswatun Desyla; Mulyani, Evi; Pratama, Mohammad Rizki Fadhil
Jurnal Farmasi SYIFA Vol 4 No 1 (2026): Jurnal Farmasi SYIFA
Publisher : CV. Wadah Publikasi Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63004/jfs.v4i1.1005

Abstract

Penggunaan e-resep merupakan inovasi digital di rumah sakit yang bertujuan untuk meminimalkan medication error dan meningkatkan standar mutu pelayanan kefarmasian. Penelitian ini bertujuan untuk memberikan gambaran profil kelengkapan e-resep pada pasien rawat inap di RS X Kota Palangka Raya periode Juli – Desember 2025. Jenis penelitian ini adalah deskriptif kuantitatif dengan pengambilan data secara retrospektif menggunakan 360 sampel e-resep yang diambil melalui teknik simple random sampling dengan rumus Slovin. Sistem digital rumah sakit menunjukkan performa sangat baik pada komponen invocatio dan subscriptio dengan tingkat kelengkapan mencapai 100%. Namun, efektivitas sistem masih terbatas pada komponen inscriptio (0%), prescriptio (22,78%), signatura (14,44%), dan pro (0%). Implementasi e-resep di RS X Kota Palangka Raya telah berhasil mengotomatisasi aspek legalitas waktu dan asal resep secara sempurna. Meskipun demikian, diperlukan perbaikan sistemik pada integrasi data klinis pasien (usia, berat badan, tinggi badan) serta pemutakhiran tampilan SIP dokter guna menjamin kelengkapan administratif dan keamanan pasien secara komprehensif.
Rambusa (Passiflora foetida L) vs. Free Radicals: In Vitro Study with DPPH Method Dewi Sari Mulia; Evi Mulyani; Muhammad Ikhwan Rizki; Mohammad Rizki Fadhil Pratama
Journal of Pharmascience Vol. 6 No. 2 (2019): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v6i2.7344

Abstract

ABSTRAK             Rambusa (Passiflora foetida L) adalah tumbuhan obat yang banyak terdapat di berbagai daerah di Indonesia, termasuk di Kalimantan Tengah. Beberapa bagian tumbuhan dari rambusa diketahui memiliki aktivitas antioksidan termasuk di bagian daunnya. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan dari daun rambusa yang berasal dari Kalimantan Tengah. Metode yang digunakan adalah metode 2,2-diphenyl-1-picrylhydrazyl (DPPH) yang diukur serapannya dengan Spektrofotometer UV Vis. Hasil yang diperoleh menunjukkan nilai IC50 dari ekstrak etanol daun rambusa senilai 93,269 μg/mL. Meskipun nilai IC50 yang diperoleh lebih rendah dibandingkan senyawa antioksidan standar seperti kuersetin, nilai IC50 dari ekstrak etanol daun rambusa asal Kalimantan Tengah masih lebih tinggi dibandingkan daun rambusa yang diperoleh dari daerah lain Kata Kunci—antioksidan, DPPH, Kalimantan Tengah, Passiflora foetida, rambusa  ABSTRACT Rambusa (Passiflora foetida L) is a medicinal plant that is widely found in various regions in Indonesia, including in Central Kalimantan. Some parts of the plant of rambusa are known to have antioxidant activities including in the leaves. This study aims to determine the antioxidant activity of rambusa leaves from Central Kalimantan. The method used was 2,2-diphenyl-1-picrylhydrazyl (DPPH) method which was measured by UV Vis spectrophotometer. The results obtained showed IC50 values of ethanol extract of rambusa leaves worth 93.269 μg/mL. Although the IC50 values obtained were lower than the standard antioxidant compounds such as quercetin, the IC50 value of the ethanol extract of the leaves of rambusa from Central Kalimantan was still higher than that of the rambusa leaves obtained from other regions or some other medicinal plant extracts. Keywords— antioxidants, DPPH, Central Kalimantan, Passiflora foetida, rambusa
Formulasi dan Evaluasi Gel Topikal Antibakteri Fraksi Aktif Akar Kuning (Arcangelisia flava Merr.) Evi Mulyani; Suratno Suratno; Mohammad Rizki Fadhil Pratama
Journal of Pharmascience Vol. 7 No. 1 (2020): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v7i1.8081

Abstract

ABSTRAK Akar kuning (Arcangelisia flava Merr.) merupakan salah satu tanaman yang tumbuh di Kalimantan Tengah dan secara turun temurun digunakan sebagai pilihan pengobatan beberapa penyakit kulit dan terbukti mempunyai aktivitas antibakteri. Pembuatan sediaan topikal antibakteri berbahan fraksi aktif A. flava sangat potensial dilakukan untuk mengoptimalkan penggunaan dalam pengobatan sekaligus meningkatkan nilai ekonomis dari A. flava. Tujuan penelitian ini untuk mendapatkan formula gel fraksi aktif A. flava sebagai antibakteri yang paling baik secara fisik.Formula gel dibuat dengan variasi jenis dan konsentrasi gelling agent.Gel fraksi aktif A. flava diuji secara fisika, kimia, dan biologi seperti organoleptis, homogenitas, daya sebar, pH, daya lekat, dan daya hambat terhadap Staphylococcus aureus. Hasil formulasi sediaan gel fraksi aktif A. flava dengan basis NaCMC memenuhi syarat sifat fisik dan zona hambatan 11,6 mm pada Formula 1 dan 13,4 mm pada Formula 2, sedangkan sediaan gel dengan basis Carbophol 943 pada Formula 1 dan 2 memenuhi syarat sifat fisik dan zona hambat 10,9 mm pada Formula 2.Formula gel yang memenuhi kriteria secara fisik adalah Formula 2 dengan Carbophol 1,5% sebagai gelling agent. Kata Kunci: Akar kuning, antibakteri, gel, Staphylococcus aureus  ABSTRACT Akar kuning (Arcangelisia flava Merr.) is a plant that grows in Central Kalimantan and has been used as a treatment option for several skin diseases and has been shown to have antibacterial activity. The making of topical antibacterial preparations made from the active fraction of A. flava is very potential to be done to optimize the use in treatment while increasing the economic value of A. flava. The purpose of this study was to obtain the active A. flava fraction gel formula as the best natural antibacterial. The gel formula was made with variations in the type and concentration of the gelling agent. Arcangelisia flava Merr. active fraction gel was tested physical, chemical, and biological, such as organoleptic, homogeneity, spreadability, pH, adhesion, and bacterial inhibitionagainst Staphylococcus aureus. The results of the formulation of the active gel of A. flava based on NaCMC base fulfills physical condition requirements and shows an inhibition zone of 11.6 mmin Formula 1 and 13.4 mm in Formula 2, while gel preparation based on Carbophol 943 Formula 1 and 2 fulfill the physical characteristic requirements and show the inhibition zone of 10.9 mm in Formula 2.Gel formula that meets the physical criteria is Formula 2, with 1.5% Carbophol as a gelling agent. Keywords: Akar kuning, antibacterial, gel, Staphylococcus aureus
Molecular Basis for the Enhanced CDK2 Inhibition by Artesunate: Superior Binding Affinity to the ATP-Catalytic Site Mohammad Rizki Fadhil Pratama; Evi Mulyani; Suratno Suratno; Punet Kumar; Daryono Hadi Tjahjono; Tutus Gusdinar Kartawinata
Journal of Pharmascience Vol. 13 No. 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.24555

Abstract

This study aimed to identify the most potent CDK2 inhibitor among seven artemisinin derivatives and, critically, to elucidate its binding mechanism and compare its affinity with that of the natural ligand, ATP. Molecular docking was performed using AutoDock 4.2.6 toward inactive and active forms of CDK2. Ligands were optimized using the Hartree-Fock method basis set 6-311G. Blind docking on the active form was used to determine the inhibition mechanism, employing the free energy of binding (ΔG) and dissociation constant (Ki) as affinity markers. Artesunate was the most potent derivative, exhibiting the highest affinity towards the active CDK2 form, with a ΔG of -11.7 kcal/mol and a Ki of 2.66 nM. Blind docking confirmed an ATP-competitive inhibition mechanism. Remarkably, Artesunate's Ki was significantly lower than that of ATP (8.73 nM). This enhanced affinity is attributed to specific interactions between the hemisuccinate side chain and the critical amino acid region, from 13-Gly to 16-Gly. Artesunate is suggested as a potent, ATP-competitive CDK2 inhibitor with an affinity exceeding that of ATP. These hypothesis-generating results suggest anticancer potential, yet require validation via MD or assays; limitations like scoring bias and protein flexibility necessitate cautious interpretation regarding the 13-Gly to 16-Gly target.
Co-Authors Ardina, Rinny Caroline Caroline Chusna, Nurul Daryono Hadi Tjahjono Daryono Hadi Tjahjono Dewi Melani Hariyadi Dewi Sari Mulia Dwi Purbayanti Eko Suhartono Endang Sri Suyati Evi Mulyani Evi Mulyani Evi Mulyani Guntur Satrio Pratomo Hadi Poerwono Handayani, Rosita Iin Nurbudiyani Imamatin Nufus Melania Juni Ekowati Maria Anabella Jessica Martha Ervina Melanny Ika Sulistyowaty Muhamad Ilham Royyan Nafi’ Muhamad Riza Syah Fahlevi Muhammad Ikhwan Rizki Praditapuspa, Ersanda Nurma Punet Kumar Puranti, Iswatun Desyla Putri Hamidah Khairunnisa Rossa Auli Tasha Siswandono, Siswandono Sonedi Sonedi Suratno Suratno Suratno Suratno Suratno Suratno Suratno Suratno Susi Novaryatiin Syahrida Dian Ardhany TUTUS GUSDINAR Tutus Gusdinar Kartawinata Utar, Zulkhurnain Wahyu Pandaran Windya Nazmatur Rahmah Zulkhurnain Utar