Article Per Year (5 Year)
p-Index From 2020 - 2025
1.431
P-Index
This Author published in this journals
All Journal Microbiology Indonesia Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Biotechnology Dentino: Jurnal Kedokteran Gigi Pharmascience Jurnal Surya Medika Anterior Jurnal Jurnal Farmasi Indonesia PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Borneo Journal of Medical Laboratory Technology Jurnal Farmagazine Jurnal Farmasi Sains dan Praktis Jurnal Pengabdian dan Pemberdayaan Masyarakat Indonesia Borneo Journal of Pharmacy
Mohammad Rizki Fadhil Pratama
Universitas Muhammadiyah Palangkaraya
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

Published : 18 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 18 Documents
Search

 1   2 
AKAR KUNING (Arcangelisia flava) SEBAGAI INHIBITOR EGFR : KAJIAN IN SILICO Mohammad Rizki Fadhil Pratama
Jurnal Farmagazine Vol 3, No 1 (2016): Jurnal Farmagazine
Publisher : STF Muhammadiyah Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47653/farm.v3i1.1

Abstract

Akar kuning (Arcangelisa flava) diketahui memiliki berbagai aktivitas farmakologi seperti antikanker. Beberapa metabolit sekunder akar kuning menunjukkan aktivitas antiproliferasi sel kanker. Overproliferasi pada sel kanker salah satunya disebabkan oleh kelainan pada EGFR, kelompok reseptor yang berperan pada saat inisiasi proliferasi sel. Inhibisi pada EGFR dapat menghambat proses proliferasi sel kanker. Penelitian ini bertujuan mengetahui metabolit sekunder dari akar kuning dengan potensi paling besar sebagai inhibitor berbagai EGFR. Metode yang digunakan adalah molecular docking beberapa metabolit sekunder akar kuning terhadap EGFR-1, EGFR-2, EGFR-3, dan EGFR-4. Hasil docking menunjukkan berberin memberikan energi bebas ikatan paling negatif dan konstanta inhibisi paling kecil pada seluruh EGFR, dengan afinitas paling tinggi ditunjukkan pada EGFR-2 dengan ΔG dan ki secara berturut-turut sebesar -9,34 kcal/mol dan 141,81 nM. Over-ekspresi aktivitas dari EGFR-2 sendiri seringkali terjadi pada kanker payudara, terutama kanker payudara HER2-positif. Hasil tersebut memberikan prediksi bahwa berberin memiliki aktivitas sebagai inhibitor EGFR terutama EGFR-2 dan berpotensi untuk dikembangkan pada terapi kanker payudara HER2-positif. Keyword : Akar Kuning, EGFR, Antikanker, Docking
IRRITATION TEST OF BAWANG DAYAK (Eleutherine bulbosa(Mill.) Urb.) EXTRACT CREAM WITH HUMAN PATCH TEST METHOD Syahrida Dian Ardhany; Susi Novaryatiin; Mohammad Rizki Fadhil Pratama; Zulkhurnain Utar
Jurnal Farmasi Sains dan Praktis Vol 7 No 1 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i1.4854

Abstract

Topical agents indicated for the treatment of acne have the potential to cause irritation or allergic contact dermatitis. This study investigates the irritancy potential of anti-acne cream of bawang dayak (Eleutherine bulbosa (Mill.) Urb.) previously tested for microbiological effectiveness with the lowest concentration of 5% and the highest concentration of 20%. The method used in this study is the human patch test. A total of 20 volunteers were recruited for the patch test study, testing the cream. The result showed that all volunteers did not experience irritation both in the 5% or 20% bawang dayak extract cream formulations. However, the interview results were found that some volunteers experienced a slight itching without any significant skin adverse reactions on the cream application. Therefore, based on these initial findings it can be safely concluded that the cream of bawang dayak does not cause significant skin adverse reaction and good enough for further development for anti-acne cream dosage form.
The Antifungal Activity of Artesunate toward Candida albicans: Two Opposite Activities MOHAMMAD RIZKI F ADHIL PRATAMA; DARYONO HADI TJAHJONO; TUTUS GUSDINAR
Microbiology Indonesia Vol. 13 No. 3 (2019): September 2019
Publisher : Indonesian Society for microbiology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1503.088 KB) | DOI: 10.5454/mi.13.3.5

Abstract

The artemisinin and its derivatives antifungal activity continue to be an interesting research object, with the potential shown to be developed as an antifungal compound. Artesunate, one of the artemisinin derivatives known to have antifungal activity against various pathogenic fungi, including Candida albicans. This study aims to determine the effect of artesunate on antifungal activity toward C. albicans in vitro at concentrations below 1 mg -1m L . The method used is yeast-plate count, with a parameter of observation were the number of C. albicans colonies viable after exposure with artesunate for five days. The concentration of artesunate used was divided into -1 -2 -3 -4 -1si x groups, which were 10; 1; 10 ; 10 ; 10 ; and 10 mg mL . Compared to control, a significant decrease in -1c olony counts was only shown at the highest concentration of 10 mg mL . Interestingly, at the lowest -4 -1c oncentration of 10 mgmL , it showed an increase in a number of colonies almost twice of the blank. These results suggest that while at higher concentration of artesunate may inhibit the growth of C. albicans, a lower concentration of artesunate may stimulate their growth.
Introduction to Bibliometric Studies for Lecturers of the Faculty of Health Sciences, Universitas Muhammadiyah Palangkaraya Mohammad Rizki Fadhil Pratama; Muhamad Riza Syah Fahlevi
Jurnal Pengabdian dan Pemberdayaan Masyarakat Indonesia Vol. 3 No. 7 (2023)
Publisher : Peneliti Teknologi Teknik Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59247/jppmi.v3i7.134

Abstract

Bibliometric studies have become a new standard in finding gap research for further research. Mastering software such as VOSViewer can be beneficial in carrying out these bibliometric studies utilizing databases of international scientific publications. However, bibliometric research still needs to be discovered by some academics, especially those unfamiliar with it, such as lecturers at the Faculty of Health Sciences, Universitas Muhammadiyah Palangkaraya. Therefore, this service activity aims to introduce and train these lecturers regarding bibliometric studies using VOSviewer. The solution offered by the servant is to carry out introductory activities and training in operating VOSviewer in carrying out the bibliometric study. Apart from introducing the lecturers to the branch of science, which is currently in great demand worldwide, it also increases the enthusiasm for writing for the participants. Through the activities, the participants have carried out a bibliometric study in Pharmacy and Medical Laboratory Technology, which can then be published as a separate bibliometric study. As a follow-up to this activity, apart from being able to do it for lecturers in other faculties within the Universitas Muhammadiyah Palangkaraya, training is also planned to be carried out to publish scientific articles on the results of the bibliometric study.
Profil Penggunaan Obat Antihipertensi di RSUD Mas Amsyar Kasongan Kabupaten Katingan: A Profile of Antihypertensive Medicines in Mas Amsyar Hospital Kasongan Katingan Regency Syahrida Dian Ardhany; Wahyu Pandaran; Mohammad Rizki Fadhil Pratama
Borneo Journal of Pharmacy Vol. 1 No. 1 (2018): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v1i1.248

Abstract

Hypertension or high blood pressure is one of the lead causes of death. Hypertension can cause various complications with another disease, even the cause of heart disease, stroke, and kidney disorders. Hypertension is the second rank of the most diseases in Kabupaten Katingan. The purpose of this research is to know the profile of antihypertensive medicines in RSUD Mas Amsyar Kasongan. Method of this research was a descriptive method with saturation sampling used retrospective data on all prescription drugs in 2017. The results of this research based on the patient characteristic were found 43.3% men and 56.7% women, meanwhile 45.8% age < 45 years old and 54.2% for age > 45 years old. The antihypertensive drug items used are propranolol, telmisartan, amlodipine, lisinopril, furosemide, ramipril, valsartan, candesartan, irbesartan, and bisoprolol, meanwhile based on the classification of antihypertensive drugs. are angiotensin II receptor blockers (ARB), diuretics, angiotensin converting enzyme Inhibitors (ACEI), Calcium Channel Blockers (CCB) and alpha 2 adrenergic agonists. Based on the result, it can be concluded that hypertension patient in RSUD Mas Amsyar Kasongan is mostly female (56.7%) and age of hypertension patient is > 45 years old (54.2%). The most antihypertensive prescribed is monotherapy (72%) and the most item of the drug is amlodipine. (38%).
Profile of Thin-Layer Chromatography and UV-Vis Spectrophotometry of Akar Kuning Stem Extract (Arcangelisia flava) Mohammad Rizki Fadhil Pratama; Suratno Suratno; Evi Mulyani
Borneo Journal of Pharmacy Vol. 1 No. 2 (2018): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v1i2.367

Abstract

This study aims to obtain the profile of Thin-Layer Chromatography (TLC) and Ultraviolet-Visible (UV-Vis) spectrophotometry from the ethanol extract of akar kuning stems (Arcangelisia flava) from Central Kalimantan. The TLC method is used with the orientation phase of the combination of polar-non-polar solvents resulting from orientation, while ethanol is used as the solvent for UV-Vis spectrophotometers. TLC results showed the formation of three stains on a mixture of polar solvents chloroform : methanol : water while in a non-polar solvent combination n-hexane : ethyl acetate did not show any stains. Comparison of retention factor (Rf) values shows the best combination of polar solvents to separate stains at a ratio of 5 : 2 : 1, respectively. Separation in 2-dimensional TLC with polar solvents showed a similar pattern with 1-dimensional separation in the form of three stains. UV-Vis spectrophotometer results showed four main peaks with wavelength 227.2; 267.4; 345.2; and 425.3 nm, respectively. The profile of the peak formed is very similar to that shown by berberine, one of the primary metabolites of akar kuning. TLC and UV-Vis spectrophotometers profiles obtained are expected to support further research using akar kuning stems, especially those from Central Kalimantan.
In silico study of the essential oil compounds of ginger and thyme on Coronavirus-2 receptors Caroline Caroline; Martha Ervina; Muhammad Rizki Fadhil Pratama; Maria Anabella Jessica
Pharmaciana Vol 13, No 3 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v13i3.26964

Abstract

Coronavirus-2 (SARS-Cov-2) is a virus that attacks the respiratory system and causes the Covid-19 pandemic. After the pandemic, prevention and appropriate therapy research continue to be carried out to anticipate the emergence of more dangerous viruses. In line with the culture of consuming herbs that has arisen due to the effects of the pandemic, in this study, an insilico screening was carried out for essential oil compounds produced by ginger and thyme herbs which have been widely consumed by the public. The aim of the research was to find the essential oil content that has the most potential as an antiviral against coronavirus-2. The research method was carried out in silico, including ligand preparation, receptor and method validation, and analysis of ligand-receptor binding interactions using the AutoDoc 4.2.6 program. As a comparison, a study was conducted on remdesivir and favipiravir, which have been used as antivirals. The three components that have the most potential based on the calculation of the free energy value, were determined by the ADMET parameters using the Admet lab 2.0 program. The results showed that the three components in the essential oil exhibited better interactions when compared to remdesivir and favipiravir at the 3-Cl protease and spike glycoprotein receptors. The results of the insilico study and ADMET prediction test showed that of the three most potent compounds, lamda-farnesen was the most potent and safe to use
Improvement of Quality and Quantity of Technology-Based Learning in Pharmacy and Medical Laboratory Technology Chusna, Nurul; Novaryatiin, Susi; Purbayanti, Dwi; Mulyani, Evi; Ardina, Rinny; Rahmah, Windya Nazmatur; Pratama, Mohammad Rizki Fadhil
Borneo Journal of Medical Laboratory Technology Vol. 7 No. 2 (2025): Borneo Journal of Medical Laboratory Technology
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjmlt.v7i2.7166

Abstract

The enhancement of technology-based learning in the fields of pharmacy and medical laboratory technology is imperative to keep pace with advancements in healthcare and educational methodologies. This study investigates the strategies and impacts of integrating cutting-edge technologies into the curricula of these disciplines. Key areas of focus include the implementation of virtual simulations, online learning platforms, and interactive multimedia resources. The research highlights how these technologies improve the quality of education by providing students with realistic, hands-on experiences that enhance their practical skills and theoretical knowledge. Additionally, the study explores the scalability and accessibility of technology-based learning, which contributes to increased student engagement and enrollment. By leveraging data analytics and feedback mechanisms, educators can tailor learning experiences to meet individual student needs, thereby improving learning outcomes. The findings suggest that the thoughtful integration of technology not only enriches the educational experience but also prepares students more effectively for the evolving demands of the healthcare industry. This research underscores the necessity of continuous investment in educational technologies to sustain the quality and quantity of learning in pharmacy and medical laboratory technology programs.
Co-Authors Ardina, Rinny Caroline Caroline Chusna, Nurul Daryono Hadi Tjahjono Dewi Melani Hariyadi Dewi Sari Mulia Dwi Purbayanti Eko Suhartono Endang Sri Suyati Evi Mulyani Evi Mulyani Guntur Satrio Pratomo Hadi Poerwono Handayani, Rosita Iin Nurbudiyani Imamatin Nufus Melania Juni Ekowati Maria Anabella Jessica Martha Ervina Melanny Ika Sulistyowaty Muhamad Ilham Royyan Nafi’ Muhamad Riza Syah Fahlevi Muhammad Ikhwan Rizki Praditapuspa, Ersanda Nurma Putri Hamidah Khairunnisa Rossa Auli Tasha Siswandono, Siswandono Sonedi Sonedi Suratno Suratno Suratno Suratno Susi Novaryatiin Syahrida Dian Ardhany TUTUS GUSDINAR Utar, Zulkhurnain Wahyu Pandaran Windya Nazmatur Rahmah Zulkhurnain Utar