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All Journal Biology, Medicine, & Natural Product Chemistry Jurnal Penelitian Sains Jurnal Wiyata : Penelitian Sains dan Kesehatan Jurnal Analis Kesehatan JPBIO (Jurnal Pendidikan Biologi) Jurnal Ilmiah Kesehatan Iqra Darmabakti : Junal Pengabdian dan Pemberdayaan Masyarakat LOSARI: Jurnal Pengabdian Kepada Masyarakat Jurnal Abdimas Sangkabira Archive: Jurnal Pengabdian Kepada Masyarakat Jurnal PADE: Pengabdian & Edukasi Folia Medica Indonesiana
Astuty, Eka
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SOSIALISASI PENCEGAHAN COVID-19 DI DESA WAIHERU KOTA AMBON Astuty, Eka
LOSARI: Jurnal Pengabdian Kepada Masyarakat Vol. 2 No. 1 (2020): Juni 2020
Publisher : LOSARI DIGITAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53860/losari.v2i1.22

Abstract

Covid-19 pertama dilaporkan di Indonesia pada tanggal 2 Maret 2020 sejumlah dua kasus. Data 31 Maret 2020 menunjukkan kasus yang terkonfirmasi berjumlah 1.528 kasus dan 136 kasus kematian. Tingkat mortalitas Covid-19 di Indonesia sebesar 8,9%, angka ini merupakan yang tertinggi di Asia Tenggara. Kota Ambon termasuk salah satu wilayah yang ditetapkan sebagai wilayah zona merah dengan jumlah kasus tertinggi dan menunjukkan trend peningkatan jumlah kasus positif Covid-19 di provinsi Maluku. Desa waiheru termasuk salah satu wilayah yang terpapar kasus positif Covid-19. Fokus dalam kegiatan ini adalah bahwa sebagian masyarakat di Desa Waiheru ini membutuhkan edukasi pencegahan penularan Covid-19 untuk menekan peningkatan jumlah kasus positif Covid-19. Penyuluhan dilakukan dengan membagikan leaflet juga booklet dari rumah ke rumah disertai penjelasan singkat dan memberikan bantuan bahan makanan (sembako). Kegiatan penyuluhan yang dilakukan ini mendapatkan respon yang sangat positif dari seluruh masyarakat Desa Waiheru dan masyarakat berkomitmen untuk melakukan segala langkah-langkah pencegahan atau antisipasi yang telah diinformasikan
Antifungal Activity of Kinar (Kleinhovia hospita L.) Leaf Ethanol Extract Against Malassezia furfur Wakano, Muhammad Zaid; Astuty, Eka; Manuputty, Amanda Gracia
Folia Medica Indonesiana Vol. 58, No. 4
Publisher : Folia Medica Indonesiana

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Abstract

Highlights : • Alternative medicine is needed for pityriasis versicolor because there are recurrence cases and resistance to antifungal agents. • Kinar leaf ethanol extract cannot inhibit the growth of Malassezia furfur. • Further studies are suggested on the type of solvent and appropriate concentration to attract more bioactive compounds. Abstract : Pityriasis versicolor is a superficial dermatomycosis that can decrease human self-confidence. This infection is caused by the fungus Malassezia furfur. Eighty percent of recurrence cases after treatment and resistance to antifungal agents were found. Therefore, alternative medicine is needed. Kinar (Kleinhovia hospita Linn.) is a tropical plant that have bioactive compounds, such as alkaloids, flavonoids, tannins, and saponins. The purpose of this study was to determine the effectiveness of kinar leaf extract against the growth of Malassezia furfur. This research was a laboratory experimental study using paper disc diffusion method. Kinar leaves (green and yellow leaves) were macerated using 96% ethanol and made into concentrations of 10%, 20%, 40%, 60%, 80%, and 100%. As much as 200 mg of ketoconazole was used as a positive control and distilled water as a negative control then tested on Malassezia furfur using Sabouraud dextrose agar (SDA). The parameter observed was the clear zone formed around the paper disc. The tests and observations showed that there was a clear zone formed around the paper disc. It means that the kinar leaf extract cannot inhibit the growth of Malassezia furfur.
ANTIFUNGAL ACTIVITY OF NUTMEG MACE (<i>Myristica Fragrans</i> Houtt) ETHANOL EXTRACT AGAINST <i>Candida</i> spp. Yandji, Muhammad Akbar; Astuty, Eka; Bandjar, Fitri Kadarsih
Folia Medica Indonesiana Vol. 61, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

Candida infections are increasingly common worldwide and represent one of the leading causes of death after cardiovascular disease. There are three types of candida that often infect humans, namely Candida albicans, Candida tropicalis and Candida parapsilosis. In the standard treatment used, immunity and side effects of treatment have been found. Therefore, other treatment options are needed, one of which is by using mace (Myristica fragrans Houtt) which is a native plant of Maluku and has secondary metabolite compounds that can be antifungal agents. This study aims to test the ability of ethanol extract of mace nutmeg (Myristica fragrans Houtt) with concentrations of 5%, 10%, 25%, 50%, 75%, and 100% on the growth of Candida albicans ATCC 10231, Candida tropicalis ATCC 750, and Candida parapsilosis ATCC 22019. This study was conducted using the disc diffusion method (Kirby-Bauer). The results showed that the strongest inhibition zone was shown at a concentration of 100% against Candida tropicalis with an average inhibition zone diameter of 7.93 mm. Meanwhile, the lowest inhibition zone was shown at a concentration of 5% against Candida parapsilosis with an average inhibition zone of 3.25 mm. This research can be concluded that ethanol extract of mace nutmeg at all concentrations is able to inhibit the growth of Candida albicans, Candida tropicalis and Candida. parapsilosis.
Antibacterial Potential of Endemic Medicinal Plants of the Maluku Islands, Indonesia, against Urinary Tract Infection Pathogens Astuty, Eka; Luhulima, Vinsa Delia; Ariwicaksono, Stefanus Cahyo
Folia Medica Indonesiana Vol. 60, No. 3
Publisher : Folia Medica Indonesiana

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Abstract

Highlights:1. Clove, cinnamon, and eucalyptus have found to be able to providing antibacterial agents for urinary tract infection (UTI).2. Ethanol extracts derived from clove leaves, cinnamon bark, and eucalyptus leaves can inhibit pathogenic bacteria responsible for UTI, indicating their potential as sources of bioactive compounds for UTI medication development. AbstractMedicinal plants possess antimicrobial properties that have been believed to be efficacious for treating various diseases. However, antimicrobial-based medicinal plants remain an untapped source of potential pharmaceuticals. This study aimed to evaluate the antibacterial properties of ethanolic extracts derived from several medicinal plants endemic to Maluku, Indonesia, specifically regarding their antibacterial activity against isolates of pathogenic bacteria found in the urine samples of urinary tract infection (UTI) patients. This was a true experimental research with a posttest-only control group design. The medicinal plant extraction was conducted using the maceration method. The pathogens were isolated using the dilution method. Following the pathogen isolation, the isolates were identified according to the colony morphology, Gram staining, and biochemical test results. The antibacterial activity was determined through the Kirby-Bauer disc diffusion test. The results indicated that five selected isolates (i.e., 0A1, 0A2, 0A3, 0A4, and 0A5) had a round shape with flat edges. Isolates 0A2 and 0A4 exhibited a solid white color, whereas isolates 0A1 and 0A3 displayed an off-white color, and isolate 0A5 showed a yellow color. Isolates 0A1, 0A2, and 0A4 were Gram-positive bacteria, while isolates 0A3 and 0A5 demonstrated Gram-negative characteristics. The biochemical testing revealed that the five selected isolates were identified as Staphylococcus warneri, Staphylococcus haemolyticus, Enterobacter aerogenes, Enterococcus faecium, and Escherichia coli. The ethanol extracts of clove (Syzygium aromaticum) leaves, cinnamon (Cinnamomum burmannii) bark, and eucalyptus (Melaleuca leucadendra) leaves demonstrated the ability to inhibit pathogenic bacteria responsible for UTI. Clove leaf ethanol extract exhibited the highest average clear zone compared to the other two ethanol extracts. This study concluded that medicinal plants from Maluku, Indonesia, the clove, cinnamon, and eucalyptus, have antibacterial potential that may be effective in treating UTI. Further investigation is necessary to fully comprehend the mechanisms of action, detection, and description of bioactive compounds, particularly against human pathogens.
ANALISIS CEMARAN BAKTERI PADA JAJANAN BAKSO IKAN DI SEKOLAH DASAR NEGERI KECAMATAN SIRIMAU KOTA AMBON Hermayani, Dian; Astuty, Eka; Hursepuny, Valentine
Jurnal Wiyata Penelitian Sains dan Kesehatan Vol 12 No 2 (2025)
Publisher : LP2M IIK (Lembaga Penelitian dan Pengabdian Masyarakat Institut Ilmu Kesehatan) Bhakti Wiy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56710/wiyata.v12i2.872

Abstract

Bakso menjadi salah satu jenis jajanan makanan yang dijajakan di lingkungan anak sekolah. Dalam indikator pemilihan makanan, anak-anak kurang memperhatikan tingkat keamanan dari jajanan sehingga dapat memicu terjadinya foodborne diseases. Penelitian ini dilakukan untuk mengetahui cemaran bakteri pada jajanan bakso ikan yang dijajakan di Sekolah Dasar Negeri Kecamatan Sirimau dengan parameter uji ALT. Penelitian ini dilakukan dengan menggunakan desain deskriptif kuantitatif pendekatan experiment laboratory. Pengambilan sampel dilakukan menggunakan teknik simple random sampling dengan jumlah sampel dari 2 penjual. Sampel jajanan bakso ikan dianalisis dengan menghitung jumlah angka lempeng total (ALT) dengan metode cawan tuang menggunakan media nutrient agar. Berdasarkan hasil penelitian didapatkan hasil uji ALT koloni tertinggi pada kode sampel SB 2,1 × 108 koloni/g sedangkan hasil ALT sampel dengan kode SA 2,8 × 107koloni/g. Sehingga dapat disimpulkan kedua sampel tersebut tidak memenuhi persyaratan mutu dan keamanan bakso ikan berdasarkan SNI 7266:2017 dengan parameter uji ALT batas maksimum bakteri yaitu 1,0 × 105 koloni/g.
Anticandidal Effects of Ethanolic Extract of Lada Katokkon (Capsicum annuum chinense) Against Emerging Fungal Pathogens Mangoting, Allen; Astuty, Eka; Manuputty, Amanda Gracia
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.1501-1507

Abstract

Candidiasis is an opportunistic mycotic infection with a high prevalence, caused by Candida species, especially Candida albicans, Candida tropicalis, and Candida parapsilosis. The increasing resistance of Candida spp. to conventional antifungals such as fluconazole poses a challenge in the management of candidiasis, thus the need for natural-based alternatives, such as Lada Katokkon. This condition encourages the need to explore alternative therapeutic agents based on natural ingredients. Lada Katokkon (Capsicum annuum chinense Jacq), a local chili variety cultivated in the Toraja region, is known to contain secondary metabolite compounds such as capsaicin, flavonoids, saponins, and alkaloids that have potential as antifungals. This study aims to evaluate the antifungal activity of ethanol extract of Lada Katokkon against the growth of C. albicans, C. tropicalis, and C. parapsilosis in vitro using disc diffusion method. The extract was tested at five concentrations: 1%, 3%, 5%, 7%, and 9%. There was a positive relationship between extract concentration and inhibition zone diameter. The highest activity was recorded at 9% concentration, particularly against C. parapsilosis (16.89 ± 4.74 mm), followed by C. albicans (9.03 ± 5.96 mm) and C. tropicalis (8.07 ± 0.81 mm). In contrast, 1% concentration produced the lowest zone of inhibition in all species tested. These results suggest that ethanol extract of Lada Katokkon has potential as an alternative natural antifungal agent in candidiasis therapy.
Co-Authors Abbas, Muthmainnah Alimudi, Saiful Bandjar, Fitri Kadarsih Bunyanis, Fitriana Dylan Tamalsir EKA RAHAYU Elpira Asmin Esmeraldine, Genevieva Hermayani, Dian Hursepuny, Valentine Intania Riska Putrie, Intania Riska Latuconsina, Vina Zakiah Luhulima, Vinsa Delia Mailoa, Joice Makatita, Miftah H Mangoting, Allen Manuputty, Amanda Gracia Melda Yunita Mus, Rosdiana Mutmainnah Abbas Ohiwal, Morgan Said, Ahmad Muntasar SILALAHI, PARNINGOTAN YOSI Stefanus Cahyo Ariwicaksono, Stefanus Cahyo Titin Agustina Umaternate, Fikram Wakano, Muhammad Zaid Warella, Juen Carla Yandji, Muhammad Akbar