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All Journal International Journal of Public Health Science (IJPHS) Medical Journal of Indonesia Health Notions Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Biomolecular and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Medica Arteriana (Med-Art) Majalah Biomorfologi (Biomorphology Journal) Cardiovascular and Cardiometabolic Journal (CCJ) CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Indian Journal of Forensic Medicine & Toxicology The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Journal of Global Pharma Technology Jurnal Penyakit Dalam Indonesia Indonesian Journal of Endocrinology Metabolism and Diabetes (InaJEMD) Folia Medica Indonesiana
Soelistijo, Soebagijo Adi
Departemen Ilmu Penyakit Dalam RSUD Dr. Soetomo – Fakultas Kedokteran Universitas Airlangga, Surabaya
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Diabetic foot score: a predictive model for leg amputation in patients with diabetic foot disease Vincent, Agustinus; Soelistijo, Soebagijo Adi; Ardiany, Deasy; Pranoto, Agung; Lusida, Michael Austin Pradipta; Pradhevi, Lukita; Saefudin, Rendra Prasetya
Medical Journal of Indonesia Vol. 33 No. 2 (2024): June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.247427

Abstract

BACKGROUND Patients with diabetes mellitus are at a higher risk for peripheral artery disease (PAD) and diabetic foot disease (DFD), which can ultimately result in leg amputation. This study aimed to develop a novel scoring system to predict the risk of leg amputation using widely available modalities, including demographic characteristics and various laboratory data. METHODS This study was conducted at Dr. Soetomo General Hospital and analyzed risk factors for leg amputation in 99 patients with DFD who underwent leg amputation compared with 80 control patients. This study presented a predictive model for leg amputation in patients with DFD, using odds ratio (OR) analysis and logistic regression approach with confidence intervals (CIs) set at 95%. The data analysis was conducted using SPSS software version 25.0. RESULTS PAD (OR 6.52, 95% CI = 2.19–19.37, p = 0.001), high low-density lipoprotein cholesterol (OR 5.97, 95% CI = 2.31–15.43, p<0.001), type of DFD (OR 4.58, 95% CI = 2.14–9.79, p<0.001), poor glycemic control (OR 4.48, 95% CI = 1.78–11.28, p = 0.001), and neutrophil-to-lymphocyte ratio level (OR 1.04, 95% CI = 1.00–1.07, p = 0.025) were the independent predictors for leg amputation. The predictive model, developed using multivariate analysis with an area under the curve of 89%, optimum threshold of 0.5 (score 6), sensitivity of 84.8%, and specificity of 78.8%, indicating a promising approach for predicting leg amputation outcomes. CONCLUSIONS The newly developed diabetic foot score may assist in making decisions regarding therapeutic options for patients with DFD.
Significant Role of Thyroid Stimulating Hormone in the Clinical Activity Score of Thyroid Eye Disease at a Tertiary Hospital in Surabaya, Indonesia Amatlulloh, Hasna Shahida; Lutfi, Delfitri; Soelistijo, Soebagijo Adi; Prastyani, Reni; Alhakiim, Muhammad Valeri
Folia Medica Indonesiana Vol. 60, No. 1
Publisher : Folia Medica Indonesiana

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Abstract

Highlights: 1. This study, conducted at a tertiary hospital, was the first to analyze the correlation between thyroid status and clinical activity score in thyroid eye disease. 2. This study offers valuable information regarding the crucial role of thyroid stimulating hormone (TSH) in determining the clinical activity score of thyroid eye disease. Abstract Thyroid eye disease is an autoimmune disorder characterized by inflammation of the orbital and periorbital tissues. This condition can lead to vision impairment, which is a notable manifestation of thyroid disease. The symptoms of thyroid disease reflected the level of inflammatory activity, whereas the clinical activity score was indicative of active and inactive phases. This retrospective analysis explored the intricate association between thyroid status and clinical activity score in thyroid eye disease patients, with the hope of providing a foundation for further research on the association between thyroid status and the occurrence of TED. This study utilized medical records from the years 2019 to 2022 from the Outpatient Department of Ophthalmic Oncology of Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. The variables examined in this study were thyroid status and the clinical activity score of thyroid eye disease. The statistical analysis was performed using Phi and Cramer's V as well as Spearman's correlation test (p<0.05). A total of 88 patients were diagnosed with thyroid eye disease during the study period. Thyroid eye disease primarily affected female patients (58%) and those who had a mean age of ≥41 years (58%). The Phi and Cramer's V analyses indicated no significant association (p > 0.05) between thyroid status and clinical activity score in thyroid eye disease patients. Intriguingly, the results exhibited the presence of euthyroidism as well as both overt and subclinical hypothyroidism and hyperthyroidism, regardless of the clinical activity score. Additionally, the Spearman test that incorporated the levels of thyroid hormones, i.e., triiodothyronine (T3), thyroxine (T4), thyroid stimulating hormone (TSH), and free thyroxine (FT4), showed a significant negative correlation (p<0.05) between TSH and clinical activity score. In conclusion, THS plays a crucial role in determining the clinical activity score of thyroid eye disease patients. This study underscores the imperative for further research to comprehensively elucidate the intricate correlation between TSH and clinical activity score.
Co-Authors Adhibagio, Aria Damarjiwo Agung Dwi Wahyu Widodo Agung Pranoto AGUNG PRANOTO Alhakiim, Muhammad Valeri Amatlulloh, Hasna Shahida Ardiany, Deasy Ari Sutjahjo, Ari Ariana, Audy Meutia Artaria Tjempakasari, Artaria Audy Meutia Ariana Bambang Purwanto Batari Retno Minanti Chabib Fachry Albab Chandra Adi Irawan Primasatya Dewi Ratna Sari Dwitama Adiwinoto, Robert Fajar Setiyawan Febri Kurniawati Febrianto, Dicky Hadisuwarno, Wiharjo Hafizha Firdaus Al-Fuady Haikal, Vikri Hakim, Arief Rakhman Hasna Shahida Amatlulloh Hendra Gunawan Hermina Novida, Hermina Jayawarsa, A.A. Ketut Jihan Jauza Fairuz Jongky Hendro Prajitno Jusak Nugraha Lefi, Achmad Lenny Octavia Lusida, Michael Austin Pradipta Lutfi Dewanda Nugroho Lutfi, Delfitri Muhammad Miftahussurur Muhammad Valeri Alhakiim Nadhya Allia Nurainy Trias Setyoputri Poernomo Boedi Setiawan Prabowo, Gwenny Ichsan Pradhevi, Lukita Prasmono, Agung Prastyani, Reni Primasatya, Chandra Adi Irawan Puspa Putri, Karina Widya Rejeki, Purwo Sri Robert Dwitama Adiwinoto Ronald Pratama Adiwinoto Saefudin, Rendra Prasetya Sasono, Wimbo Sony Wibisono Thamrin, Husin Titong Sugihartono Ummi Maimunah Vincent, Agustinus Wulansari, Ratih