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All Journal Syntax Literate: Jurnal Ilmiah Indonesia Poltekita : Jurnal Ilmu Kesehatan Jurnal Prima Medika Sains Jurnal Impresi Indonesia Buletin Kedokteran dan Kesehatan Prima
Edlin, Edlin
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Testing the Effect of Grape Seed Extract (Vitis Vinifera L) on the Healing Process of Cut Wounds in Wistar White Rats Rizali, Siska Saidi; Leslie, William; Chairul, Muhammad; Edlin, Edlin
Poltekita : Jurnal Ilmu Kesehatan Vol. 17 No. 4 (2024): February
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v17i4.3639

Abstract

Daily actions cause wounds. Normal and abnormal wounds generate inflammation. Grape (Vitis vinifera l) possesses antioxidant and wound-healing properties. The research aims to test grape seed extract’s ability to heal cuts in white Wistar rats. The study is conducted solely on white Wistar rats. The type of research used was lab-experimental quantitative research with SPSS data. The study sample consisted of white Wistar rats (Rattus norvegicus). In this trial, grape seed extract was given at 50, 100, 150, and 200 mg/kg BW. Animals were sliced at 2 cm length with a depth of ± 2 mm to the dermis layer and treated according to their group. Grape seed extract cream healed mice-cut wounds. On the 14th day, group P0 had 72.3% wound healing, group P1 84.3%, group P2 94%, group P3 93.9%, and group P4 100%. Thus, group P4 healed faster than P0, P1, P2, and P3. Grape seed extract cream accelerates skin regeneration and stimulates fibroblasts more than base cream, according to wound healing percentages. Grape seed extract at 200 mg/kgBW accelerated wound healing more than other treatments. The entire treatment group demonstrated considerable normalcy with a 0.200 > 0.05 score. Four homogenous test groups had a significance value of 0.200 > 0.05. The one-way ANOVA test yielded a significance value of 0.000 < 0.05. The research concluded that grape seed extract contains saponins, alkaloids, steroids, and flavonoids that may serve as anti-inflammatory agents and antioxidants to inhibit free radicals and speed wound healing in rats.
THE RELATIONSHIP OF THE NUMBER OF NEUTROFIL LYMPHOCYTE RATIO WITH THE PICTURE OF COLITIS Br Tarigan, Agita Angela; Xavier Ongko, Nicolas; Edlin, Edlin
Jurnal Impresi Indonesia Vol. 3 No. 2 (2024)
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jii.v2i12.4037

Abstract

Colitis is an acute or chronic inflammation of the colon. The gold standard for diagnosis and monitoring of disease activity in colitis patients is endoscopy combined with pathology biopsy. However, endoscopy has disadvantages related to invasiveness, cost, and feasibility of use for long-term follow-up. The neutrophil-lymphocyte ratio is a simple biomarker that can serve as a useful biomarker for diagnosing and predicting mucosal inflammation in colitis. This study aims to determine whether there is an influence between the number of neutrophil-lymphocyte ratios and the appearance of colitis. This research is a cross-sectional observational analytical research. In this study, 44 medical record data were used. A total of 44 colitis medical record data for the 2022-2023 period were collected. The largest age group is 61-70 years with 11 people (25%), based on the gender group the largest is male with 30 people (68.2%), and based on histopathology the largest is 25 (56.8%) patients. who suffers from chronic colitis. However, in the study, there was no relationship between the neutrophil-lymphocyte ratio and the appearance of colitis, P = 0.22 (P value> 0.05) and the Prevalence Ratio 95% CI 1,436 (0,832-2,476). Based on the results of this study, the majority of patients are male, based on the patient's age, the majority is between 61-70 years, and based on the histopathology picture, the majority is chronic colitis. However, in the study, there was no relationship between the neutrophil-lymphocyte ratio and the appearance of colitis, P = 0.22 (P value > 0.05), and the 95% Prevalence Ratio was 1,436 (0,832-2,476).
The Effect of Hordeum Vulgare on Spermatogenesis and Testical Histopathology in Diabetes Mellitus Rats Eka Putri Sihombing, Clarisa; Indra Mukti, Ade; Edlin, Edlin
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v9i12.55293

Abstract

Diabetes dapat memicu kerusakan pada sistem reproduksi pria dan merupakan salah satu faktor penyebab infertilitas pada pria. Tujuan dari penelitian ini adalah untuk menguji pengaruh Hordeum vulgare terhadap spermatogenesis pada tikus diabetes. Penelitian ini menggunakan desain penelitian True Experimental Pretest dan Posttest Control Group Design. Sampel tikus adalah tikus Wistar jantan (Rattus norvegicus), dengan berat sekitar 200 gram, dan berusia sekitar 2 bulan. Variabel independen dalam penelitian ini adalah Hordeum vulgare dan variabel dependennya adalah motilitas sperma dan ciri-ciri histopatologis testis tikus. Data akan diolah menggunakan uji Kruskal Wallis dengan SPSS. Hasil penelitian menunjukkan bahwa tidak ada perbedaan yang signifikan dalam spermatogenesis tikus antar kelompok. Pengaruh Hordeum vulgare pada skor rata-rata Johnsen dan gambaran histopatologis testis tikus diabetes menunjukkan bahwa kelompok tikus diabetes yang diberi makan Hordeum vulgare memiliki banyak spermatozoa tetapi epitel germinal tidak teratur yang ditandai dengan exfol.
Co-Authors Adek Amansyah Br Tarigan, Agita Angela Bu'ulolo, Christian Siuwandy Budi, Andre Chairul, Muhammad DENI SETIAWAN Eka Putri Sihombing, Clarisa Fibrini, Dewi Girsang, Ermi Harahap, Halimah Indra Mukti, Ade Lazuardi, Maulana Umar Leslie, William Lina, Juliana Lumbantobing, Christina JRE. Matondang, Lasma Ani Giot Marito Mukti, Ade Indra Napitu, Sabar Hamonangan Victoranius Nazara, Novita Mirna Sari Olidya, Desyoma Rapael Ginting Razoki, Razoki Rizali, Siska Saidi Siagian, Masryna Suyono, Tan Tarigan, Susiani Wirawan, Nur Surya Xavier Ongko, Nicolas Yulizal, Ok