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All Journal Syntax Literate: Jurnal Ilmiah Indonesia Poltekita : Jurnal Ilmu Kesehatan Jurnal Prima Medika Sains Buletin Kedokteran dan Kesehatan Prima
Edlin, Edlin
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Humanities Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Testing the Effect of Grape Seed Extract (Vitis Vinifera L) on the Healing Process of Cut Wounds in Wistar White Rats Rizali, Siska Saidi; Leslie, William; Chairul, Muhammad; Edlin, Edlin
Poltekita : Jurnal Ilmu Kesehatan Vol. 17 No. 4 (2024): February
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v17i4.3639

Abstract

Daily actions cause wounds. Normal and abnormal wounds generate inflammation. Grape (Vitis vinifera l) possesses antioxidant and wound-healing properties. The research aims to test grape seed extract’s ability to heal cuts in white Wistar rats. The study is conducted solely on white Wistar rats. The type of research used was lab-experimental quantitative research with SPSS data. The study sample consisted of white Wistar rats (Rattus norvegicus). In this trial, grape seed extract was given at 50, 100, 150, and 200 mg/kg BW. Animals were sliced at 2 cm length with a depth of ± 2 mm to the dermis layer and treated according to their group. Grape seed extract cream healed mice-cut wounds. On the 14th day, group P0 had 72.3% wound healing, group P1 84.3%, group P2 94%, group P3 93.9%, and group P4 100%. Thus, group P4 healed faster than P0, P1, P2, and P3. Grape seed extract cream accelerates skin regeneration and stimulates fibroblasts more than base cream, according to wound healing percentages. Grape seed extract at 200 mg/kgBW accelerated wound healing more than other treatments. The entire treatment group demonstrated considerable normalcy with a 0.200 > 0.05 score. Four homogenous test groups had a significance value of 0.200 > 0.05. The one-way ANOVA test yielded a significance value of 0.000 < 0.05. The research concluded that grape seed extract contains saponins, alkaloids, steroids, and flavonoids that may serve as anti-inflammatory agents and antioxidants to inhibit free radicals and speed wound healing in rats.
The Effect of Hordeum Vulgare on Spermatogenesis and Testical Histopathology in Diabetes Mellitus Rats Eka Putri Sihombing, Clarisa; Indra Mukti, Ade; Edlin, Edlin
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v9i12.55293

Abstract

Diabetes dapat memicu kerusakan pada sistem reproduksi pria dan merupakan salah satu faktor penyebab infertilitas pada pria. Tujuan dari penelitian ini adalah untuk menguji pengaruh Hordeum vulgare terhadap spermatogenesis pada tikus diabetes. Penelitian ini menggunakan desain penelitian True Experimental Pretest dan Posttest Control Group Design. Sampel tikus adalah tikus Wistar jantan (Rattus norvegicus), dengan berat sekitar 200 gram, dan berusia sekitar 2 bulan. Variabel independen dalam penelitian ini adalah Hordeum vulgare dan variabel dependennya adalah motilitas sperma dan ciri-ciri histopatologis testis tikus. Data akan diolah menggunakan uji Kruskal Wallis dengan SPSS. Hasil penelitian menunjukkan bahwa tidak ada perbedaan yang signifikan dalam spermatogenesis tikus antar kelompok. Pengaruh Hordeum vulgare pada skor rata-rata Johnsen dan gambaran histopatologis testis tikus diabetes menunjukkan bahwa kelompok tikus diabetes yang diberi makan Hordeum vulgare memiliki banyak spermatozoa tetapi epitel germinal tidak teratur yang ditandai dengan exfol.
Co-Authors Adek Amansyah Bu'ulolo, Christian Siuwandy Budi, Andre Chairul, Muhammad DENI SETIAWAN Eka Putri Sihombing, Clarisa Fibrini, Dewi Girsang, Ermi Harahap, Halimah Lazuardi, Maulana Umar Leslie, William Lina, Juliana Lumbantobing, Christina JRE. Matondang, Lasma Ani Giot Marito Mukti, Ade Indra Napitu, Sabar Hamonangan Victoranius Nazara, Novita Mirna Sari Olidya, Desyoma Rapael Ginting Razoki, Razoki Rizali, Siska Saidi Siagian, Masryna Suyono, Tan Tarigan, Susiani Wirawan, Nur Surya Yulizal, Ok