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All Journal E-Jurnal Medika Udayana Berkala Ilmu Kesehatan Kulit dan Kelamin Jurnal Antropologi: Isu-Isu Sosial budaya ISM (Intisari Sains Medis) : Jurnal Kedokteran Jurnal Biomedika dan Kesehatan Bioscientia Medicina : Journal of Biomedicine and Translational Research Review of Primary Care Practice and Education (Kajian Praktik dan Pendidikan Layanan Primer) Bali Dermatology and Venereology Journal Indonesian Journal of Global Health research JOURNAL LA MEDIHEALTICO Bioscientia Medicina : Journal of Biomedicine and Translational Research Gema Kesehatan Bali Dermatology Venereology and Aesthetic Journal
Ni Luh Putu Ratih Vibriyanti Karna
Departemen Dermatologi Dan Venereologi, Fakultas Kedokteran, Universitas Udayana, Rumah Sakit Umum Pusat Sanglah, Denpasar, Bali, Indonesia
Arts Humanities Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Journal : JOURNAL LA MEDIHEALTICO

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Serum Interleukin-6 Levels are Positively Correlated with the Severity of Acne Vulgaris Triatmakusuma, Yogi; Praharsini, I Gusti Ayu Agung; Darmaputra, I Gusti Nyoman; Winaya, Ketut Kwartantaya; Karna, Ni Luh Putu Ratih Vibriyanti; Puspawati, Ni Made Dwi
Journal La Medihealtico Vol. 5 No. 1 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i1.1056

Abstract

Acne vulgaris is a chronic inflammatory disease that affects the pilosebaceous unit. This disease occurs on the skin of the face, body, back, and other areas of the body, and can leave scars on the skin which can be temporary or permanent. Recent data shows that the inflammatory process is the initial process in the pathogenesis of acne, several pro-inflammatory cytokines, one of which is interleukin 6 (IL-6), which plays a role in acne vulgaris. Analytical observational study with a cross-sectional approach. The research was carried out from February - November 2023 at the Skin and Venereology Polyclinic, RSUP Prof. Dr. I.G.N.G. Ngoerah Denpasar and the Clinical Pathology Laboratory of Prof IGNG Ngoerah Hospital. The sample consisted of 47 samples of patients with acne and 20 samples without acne aged 8 - 45 years who were selected through consecutive sampling according to inclusion and exclusion criteria. A sample of 3 milliliters of venous blood is taken which will then be checked for IL-6 with an ELISA kit. Data analysis with SPSS version 24 and p value <0.05 is significant. The mean IL-6 serum levels in the acne group was 110.2 ± 88.3 pg/ml while in the non-acne group it was 26.7 ± 23.7 pg/ml. There was a significant difference in the category of IL-6 levels in the acne and non-acne groups (95% CI 55.1 - 155.3, p<0.001). The correlation analysis of IL-6 levels with the severity of acne was strongly positive (r=0.951, p<0.001).
Co-Authors A.A.G.P. Wiraguna Anak Agung Gde Putra Wiraguna Anak Agung Indah Jayanthi Andrew Wicaksono Aurelia Stephanie Aurelia Stephanie Bharata, Putu Evindya Vipascitadewi Nandanaya Darmaputra, I Gusti Nyoman Desak Nyoman Trisepti Utami Dewa Ayu Agung Dwita Arthaningsih Dewa Ayu Agung Dwita Arthaningsih Dewi Gotama Dewi Gotama Duarsa, Putu Laksmi Anggari Putri Elice Wijaya Elice Wijaya Elvina Veronica Elvina Veronica Gotama, Dewi Hartawan, I Gusti Ngurah Bagus Rai Mulya Herman Saputra Herman Saputra I Gusti Ayu Agung Dwi Karmila I Gusti Ayu Agung Elis Indira I Gusti Ayu Agung Praharsini I Gusti Ayu Agung Praharsisni I Gusti Ayu Sattwika Pramita I Gusti Ngurah Bagus Rai Mulya Hartawan I Gusti Ngurah Bagus Rai Mulya Hartawan Ida Ayu Ide Nanda Divyani Ida Ayu Uttari Priyadarshini Ida Ayu Uttari Priyadarshini Juliari, Gusti Ayu Made Karina Chandra Ketut Kwartantaya Winaya Ketut Wida Komalasari Komang Saputra Yadnya Luh Made Mas Rusyati Luh Putu Sustiana Kartika Sari Made Hermina Laksmi Made Hermina Laksmi Made Martina Windari Made Wardhana Mario Korwa Nandya Dwizella Nevristia Pratama Ni Made Ari Purwaningrum Ni Made Dwi Puspawati Ni Putu Ayu Riska Yunita Sari Ni Putu Tamara Bidari Sweta Ni Putu Tamara Bidari Sweta Nyoman Suryawati Prima Saraswati Sanjiwani Sudarsa Prima Sudarsa Primasari, Putu Yunita Priyadarshini, Ida Ayu Uttari Putu Gde Hari Wangsa Putu Gde Hariwangsa Roslina Horo Sadeli, Marrietta Sugiarti Sissy Sissy Sissy Sissy, Sissy Somia Sri Subramaniam Sudarsa, Prima Sweta, Ni Putu Tamara Bidari Triatmakusuma, Yogi Veronica, Elvina Winaya, Ketut Kwartantaya