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Karmilah
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Pemberdayaan Kader Posyandu Tentang Swamedikasi dengan Edukasi GEMA CERMAT Menggunakan Metode CBIA (Cara Belajar Insan Aktif) di Puskesmas Lepo-Lepo Kendari Musdalipah Musdalipah; Eny Nurhikma; Reymon Reymon; Randa Wulaisfan; Esti Badia; Nirwati Rusli; Karmilah Karmilah; Selfyana Austin Tee; Muhammad Syaiful Saehu; Anisa Arfan
Jurnal Abdi dan Dedikasi kepada Masyarakat Indonesia Vol 1 No 1 (2023): NADIKAMI: Januari 2023
Publisher : POLITEKNIK BINA HUSADA KENDARI

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Abstract

Swamedikasi merupakan salah satu pengobatan alternatif untuk mengatasi gejala penyakit tanpa resep dokter dan pertolongan dari tenaga kesehatan. Pada pelaksanaannya swamedikasi dapat menjadi sumber terjadinya kesalahan pengobatan (medication error) karena keterbatasan pengetahuan masyarakat akan obat dan penggunaannya. Salah satu metode alternatif dalam melakukan swamedikasi melalui edukasi Gerakan Masyarakat Cerdas Menggunakan Obat (GEMA CERMAT). Dalam upaya memaksimalkan GEMA CERMAT, kader kesehatan berperan untuk memberikan informasi kepada masyarakat terkait penggunaan obat. Kegiatan ini dilakukan untuk mengetahui tingkat pengetahuan kader posyandu tentang swamedikasi dengan edukasi GEMA CERMAT menggunakan metode CBIA (cara belajar insan aktif) di wilayah kerja puskesmas Lepo-lepo, Kendari. Kader posyandu yang aktif yang diseleksi menggunakan metode Purposive Sampling sebanyak 30 orang. Alat yang digunakan berupa angket (kuesioner) dan paket obat sebagai alat peraga. Hasil kegiatan memperlihatkan bahwa pengetahuan kader posyandu pada saat pretest di Puskesmas Lepo-lepo sebesar 12,27 (61,3 %) dengan kategori cukup dan pada saat post test sebesar 17,03 (85,2 %) dengan kategori baik. Hasil analisis statistik menggunakan Paired samples test diperoleh nilai p = 0,000 < 0,05 bahwa ada perbedaan yang bermakna antara hasil pretest dengan posttest dalam edukasi GEMA CERMAT pada kader posyandu.
Swamedikasi “Dagusibu” Obat Bebas, Multivitamin Dan Jamu Pada Masyarakat Di Kecamatan Nambo Kota Kendari Karmilah Karmilah; Selfyana Austin Tee; Muhammad Azdar Setiawan; Esti Badia; Syaiful Saehu; Nur Saadah Daud; Yulianti Fauziah; Hasnawati Hasnawati; Inggit Suryaningsih; Musdalipah Musdalipah
Jurnal Abdi dan Dedikasi kepada Masyarakat Indonesia Vol 1 No 2 (2023): NADIKAMI: Juli 2023
Publisher : POLITEKNIK BINA HUSADA KENDARI

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Abstract

Di era new normal peningkatan imunitas tubuh sangat diperlukan untuk menunjang kesehatan yang optimal. Pemulihan Kesehatan Selama pandemi COVID-19 memerlukan situasi adaptasi kebiasaan baru untuk menjaga sistem imun tubuh. Upaya yang dapat dilakukan melalui penerapan protokol kesehatan, konsumsi makanan dan minuman yang sehat, multivitamin dan herbal (jamu). Swamedikasi merupakan upaya awal yang dilakukan diri sendiri untuk pencegahan dan pengobatan gejala penyakit ringan menggunakan obat-obatan golongan obat bebas, bebas terbatas dan multivitamin. Tujuan kegiatan edukasi ini ialah untuk meningkatkan pengetahuan dan pemahaman masyarakat tentang DAGUSIBU (dapatkan, gunakan, simpan dan buang) obat dan jamu pada masyarakat di Kel. Tondonggeu, Kec. Nambo, Kota Kendari. Metode edukasi dilaksanakan dengan metode ceramah dan diskusi interaktif disertai alat peraga obat dan jamu. Kegiatan edukasi terlaksana dengan baik dengan antusias masyarakat memberikan pertanyaan dan aktif membangun komunikasi yang efektif dua arah mengenai cara mendapatkan, menggunakan, menyimpan dan membuang obat dengan benar. Kegiatan edukasi dirangkaikan dengan pembagian multivitamin, obat bebas, handsanitizer dan jamu (herbal).
Formulation of Snail Slime (Achatina Fulica) Anti-Acne Emulgel using Tween 80-Span 80 as Emulsifying and HPMC as Gelling Agent Nur Saadah Daud; Achnis Jum Akbar; Eny Nurhikma; Karmilah Karmilah
Borneo Journal of Pharmacy Vol. 1 No. 2 (2018): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v1i2.369

Abstract

Acne is the condition of abnormal skin which is indicated by inflammation caused by the bacterial infection of Propionibacterium acnes. The natural one which can be used for the medical treatment of acne is the snail mucus (Achatina fulica). The achasin protein of it has antibacterial activity. That snail mucus was made to the emulgel form. This research has used an experimental method and the emulgel formulation used the various concentration of emulsifying agents and the gelling agent. They were Tween 80 1.76%, 2.44%, 3.12%, Span 80 2.24%, 4.06%, 5.88% and HPMC 3.5%, 4.5%, 5.5%. Other additives were propylene glycol, Methylparaben, Propylparaben, paraffin liquid, menthol, and aquadest. Those formulations were tested in physical evaluation during 4 weeks of storage in room temperature, irritation test, hedonic test, and cycling test. The organoleptic test showed that the emulgel were the milk-white color with a distinctive smell. All emulgel were homogenous, non-irritant, with emulsion type oil in water (o/w). This emulgel also met the normal skin of pH value and spread ability’s range. The emulgel viscosity shift was < 10%, with the viscosity value inversely proportional to spreadability. Formula C with 3.12% of Tween 80, 5.88% of Span 80 and 5.5% of HPMC was claimed as the most stable formula both in room temperature and after cycling test. It was also the most preferred by the panelist.
Total Phenolic and Flavonoid Content, Antioxidant, and Toxicity Test with BSLT of Meistera chinensis Fruit Fraction from Southeast Sulawesi Musdalipah Musdalipah; Selfyana Austin Tee; Karmilah Karmilah; Sahidin Sahidin; Adryan Fristiohady; Agung Wibawa Mahatva Yodha
Borneo Journal of Pharmacy Vol. 4 No. 1 (2021): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v4i1.1686

Abstract

Zingiberaceae have a large number of species and still need research to reveal their chemical content. Meistera chinensis is one of the new generations of the Zingiberaceae family, a local and widespread plant in Konawe Regency, Southeast Sulawesi. Empirically, M. chinensis is used as a flavor enhancer in food, aches, and increases body immunity. There are no reports of chemical content or its biological activity. In this study, the fruit of M. chinensis was tested for phytochemicals, antioxidants using the ABTS test, total phenolic, total flavonoid content, and toxicity test with a lethal test for brine shrimp (BSLT). Meistera chinensis was extracted with ethanol and fractionated by ethyl acetate solvent using vacuum liquid chromatography. Phytochemical screening was carried out qualitatively by using the calorimetric method. The fraction toxicity was monitored by BSLT. These fractions for the ABTS method obtained fractions 1-8 (F1-F8) and ascorbic acid were used as controls. The results showed radical scavenging activities fraction of M. chinensis fruit was a very strong activity with IC50 of 42.7±3.53 mg/L (F8). The total phenolic and flavonoid contents were 30.72±1.07 mgGAE/g and 8.02±0.48 mgQE/g, respectively. The phytochemical evaluation contains terpenoids, saponins, phenolics, steroids, alkaloids, and flavonoids. The BSLT toxicity test was found to be very toxic, with an IC50 of 5.2±0.72 mg/L. These findings indicate that the fruit of M. chinensis acts as an antioxidant and toxicity agent.
Formulasi Emulgel Antiinflamasi Ekstrak Kulit Batang Jambu Mete (Anacardium occidentale L.) DAUD, NUR SAADAH; Angraeni, Ni Kadek Ayu; ., Karmilah; Fauziah, Yulianti
E-Jurnal Medika Udayana Vol 12 No 7 (2023): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2023.V12.i07.P17

Abstract

Inflamasi merupakan suatu respons protektif normal terhadap luka jaringan yang disebabkan oleh trauma fisik, zat kimia yang merusak atau zat-zat mikrobiologik. Salah satu tanaman yang dapat digunakan sebagai antiinflamasi yang berasal dari alam adalah jambu mete (Anacardium occidentale L.). Kulit batang jambu mete mengandung senyawa fenolik menghambat inflamasi dengan mekanisme penangkapan radikal bebas dan menghambat enzim siklooksigenase. Ekstrak kulit batang jambu mete dapat diformulasi menjadi sediaan emulgel untuk memudahkan pemanfaatannya sebagai antiinflamasi topikal. Carbomer 980 0,5% digunakan sebagai gelling agent dengan beberapa varian konsentrasi ekstrak yaitu 2,5 % (Formula A), 5 % (Formula B) dan 7,5 % (Formula C). Bahan tambahan lain terdiri atas parafin cair, span 80, tween 80, propilenglikol, nipagin, nipasol, trietanolamin dan akuades. Evaluasi fisik sediaan dilakukan setiap 3 hari sekali sebanyak 4 kali pengujian. Hasil evaluasi fisik menunjukkan ketiga formula menghasilkan sediaan berbentuk massa emulgel yang berwarna coklat muda, bau khas, homogen, rata-rata pH 5,0 dan daya sebar berkisar antara 5,15 - 5,56 cm. Sedangkan hasil uji stabilitas, formula A dengan konsentrasi ekstrak 2,5 % adalah yang paling stabil setelah dilakukan uji sentrifugasi dan cycling test.
Aktivitas Antibakteri Rimpang Meistera chinensis terhadap Bakteri Staphylococcus aureus ATCC 25023 dan Eschericia coli ATCC 35218 Secara Difusi Agar Karmilah; Reymon; Daud, Nur Saadah; Badia, Esti; Yodha, Agung Wibawa Mahatva; Setiawan, Muh. Azdar; Tee, Selfyana Austin; Musdalipah
Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati Vol 8, No 1 (2023): February 2023
Publisher : Universitas Atma Jaya Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24002/biota.v8i1.5651

Abstract

Meistera chinensis merupakan generasi baru famili Zingiberaceae yang tumbuh di Sulawesi Tenggara. Ekstrak buah mengandung metabolit sekunder seperti flavonoid, terpenoid, alkaloid, steroid, dan tanin yang memiliki efektivitas sebagai antioksidan dan antibakteri. Namun, belum ada laporan tentang antibakteri pada bagian rimpang. Penelitian ini bertujuan untuk mengetahui kandungan metabolit sekunder dan aktivitas antibakteri ekstrak etanol rimpang M. chinensis. Serbuk kering rimpang M. chinensis diekstraksi dengan maserasi menggunakan pelarut etanol 96%. Ekstrak dipekatkan menggunakan rotary vacuum evaporator. Metode analisis aktivitas antibakteri menggunakan difusi agar dengan konsentrasi ekstrak 10%, 20%, 30%, dan kontrol positif (Ciprofloxacin 30µg) terhadap Staphylococcus aureus ACTT 25023 dan Escherichia coli ACTT 35218 selama 24 jam. Hasil penelitian menunjukkan bahwa ekstrak etanol rimpang M. chinensis mengandung flavonoid, saponin, alkaloid, steroid, dan fenol, Ekstrak terbukti menghambat pertumbuhan E. coli dengan diameter zona hambat rata-rata secara berturut-turut pada konsentrasi 10%, 20%, dan 30% sebesar 6,08±1,79; 8,16±0,11 dan  10,57±1,34 mm. Pada S. aureus, zona hambat masing-masing konsentrasi 10%, 20%, dan  30% sebesar 5,02±0,79; 6,01±0,69; 8,03±0,76. Analisis One Way ANOVA menunjukkan perbedaan aktivitas antibakteri yang signifikan antar konsentrasi ekstrak pada E. coli dan S. aureus. Dapat disimpulkan rimpang M. chinensis memiliki aktivitas sebagai antibakteri. 
POTENSI ANTIINFLAMASI EKSTRAK BATANG WUNDU WATU (Alpinia monopleura) TANAMAN ENDEMIK ASAL SULAWESI TENGGARA SECARA IN VITRO Musdalipah; Austin Tee, Selfyana; Wibawa Mahatva Yodha, Agung; Reymon; Azdar Setiawan, Muh.; Karmilah; Oktaviani, Santi
Jurnal Insan Farmasi Indonesia 2023: JIFI: Webinar & call for paper
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v6i3.1642

Abstract

The wundu watu plant (Alpinia monopleura), is one of the endemic plants typical of Southeast Sulawesi which is commonly found in South Konawe Regency. The results of previous research on the essential oil content of the leaves and fruit of wundu watu are α-caryophyllene, β-pinene, limonene, α-pinene, β-caryophyllene and caryophyllene oxide. The essential oils of the leaves and fruit show antibacterial, antioxidant and anti-inflammatory properties. Pharmacological studies of this plant are not widely known, especially its efficacy as an anti-inflammatory. The purpose of this study was to determine the anti-inflammatory potential of extracts and fractions of wundu watu stem against inhibition of protein denaturation in Vitro. Wundu watu stem extract was extracted by maceration method using methanol solvent and ethyl acetate fraction. Anti-inflammatory testing using the protein denaturation inhibitor method using bovine and albumin and measured on a UV-Vis Spectrophotometer at a wavelength of 660 nm. The results showed that the extract and ethyl acetate fraction of wundu watu stem had anti-inflammatory activity with IC50 values of 10.59 mg/L and 2.02 mg/L. Based on the test results, it can be concluded that the stem extract of wundu watu has anti-inflammatory potential against protein denaturation with a very strong category.
Antioxidant and Anti-inflammatory Activities of Diarylheptanoid from Etlingera calophrys Fruit Karmilah, Karmilah; Yodha, Agung Wibawa Mahatva; Hamsidi, Rini; Daud, Nur Saadah; Malaka, Muhammad Hajrul; Musdalipah, Musdalipah; Sahidin, Sahidin
Molekul Vol 19 No 3 (2024)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2024.19.3.12413

Abstract

Diarylheptanoids compounds from the genus Etlingera have attracted widespread attention due to their various structural diversity and potential pharmacological effects. This is certainly an important part to continue to study, especially from Sulawesi endemic species, one of which is Etlingera calophrys. The fruit of E. calophrys is widely utilized in the Sulawesi community. The lack of information on the content of chemical compounds and their pharmacological activities, so the study is very important. Diarylheptanoid compounds were obtained by chromatography technique, molecular structure interpretation by spectroscopy technique while pharmacological activity was tested against radical scavenging as antioxidant and inhibition of protein denaturation as anti-inflammatory. Two diarylheptanoid compounds were successfully isolated from E. calophrys fruit namely 1-(3'-methoxy-4'- hydroxyphenyl)-7-phenyl- 3-heptanone and 1-(3'-methoxy-4'- hydroxyphenyl)-7-(4"-hydroxyphenyl)- 3-heptanone. Antioxidant properties showed very strong ability with IC50 values of 32.21 ± 0.42 and 21.64 ± 0.63 µg/mL, respectively, while anti-inflammatory properties were strongly shown by the compound with IC50 values of 25.71 ± 0.54 and 15.28 ± 0.66 µg/mL, respectively. The presence of diarylheptanoid content that has good pharmacological activity can support the used of E. calophrys as a nutraceutical source. Keywords: Anti-inflammatory, antioxidant, diarylheptanoid, Etlingera calophrys, fruit
FORMULASI DAN UJI EFEKTIVITAS MASKER PEEL OFF PATI JAGUNG (Zea mays sacchrata) SEBAGAI PERAWATAN KULIT WAJAH Karmilah Karmilah; Nirwati Rusli
Jurnal Ilmiah Manuntung Vol 4 No 1 (2018): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v4i1.140

Abstract

Corn is one ingredient that has been used empirically as a facial skin care. Peel-off facial mask has the advantage over the other types, it can lifted or removed as an elastic membrane easily. The purpose of this research was to formulate a peel-off facial mask of corn starch that qualifed for the evaluation of the preparation and its effectiveness test as skin care. This research is experimental research, that is making 3 formula with variation of corn starch concentration as active substance that is 5%, 10%, and 15% which aim to know optimal concentration as peel-off mask facial skin care. Based on the results of evaluation of formula A preparations with 5% active ingredient that meets the dosage evaluation, the formula that meets the evaluation of the dosage is then tested effectiveness as facial skin care. Effectiveness test using 3 respondents that is acne skin, blackhead skin, and oily skin. Test result conducted for 4 days with a view before and after use, peel-off corn starch mask capable of providing facial skin care effect is characterized by changes in skin becomes brighter, less acne and blackheads. Keywords : Peel-off facial mask, corn starch, facial skin care
EFEK SAMPING OBAT ANTI TUBERKULOSIS (OAT) DAN PENANGANANNYA PADA PASIEN TUBERKULOSIS (TB) DI PUSKESMAS PERUMNAS KOTA KENDARI Musdalipah Musdalipah; Eny Nurhikma; Karmilah Karmilah; Muh. Fakhrurazi
Jurnal Ilmiah Manuntung Vol 4 No 1 (2018): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v4i1.144

Abstract

Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis, which mostly (80%) attacks the lungs. Tuberculosis is one of the diseases that attacks people with the relatively high percentage and can effect in death. This study aims to determine how the use of anti-tuberculosis drugs in TB patients cause bad side effects and how the treatment of the side effect.The method of this research is descriptive with cross sectional study design. The sampling techniques are Retrospective and Prospective research. The data tabulation taken by distributed questionnaires and interviews to the TB patients and health worker. The data was collected at the Perumnas public health center of Kendari, which was 21 patients who were undergoing treatment stage and also had fulfilled the inclusion criteria that have been determined. The results showed that 21 tuberculosis patients at the Perumnas public health center of Kendari experienced the side-effects such as nausea and vomiting, hematuria, loss of appetite, fever, joint, itch, and skin redness. The most common side effects were queasy and hematuria with the same percentage of 71,5%. The treatment of side effects done by giving the drugs information and providing the drug therapy in agree with the complaints. Keywords : Tuberculosis, Side-effects, Anti-Tuberculosis
Co-Authors Achnis Jum Akbar Ado, Moldefya Wahid Agung Wibawa Mahatva Yodha Agustini Angraeni, Ni Kadek Ayu Angriani Fusvita Anisa Arfan ARFAN ARFAN Audina, Fina Badia, Esti Daud, Nur Saadah Dhea, Alisha Dian Pratiwi, Arini Eny Nur Hikma Eny Nurhikma Evi Apriani Arifin Evi Nur Indah Sari Fadhliyah Malik Fakhrurazi, Muh. Fauziah, Yulianti Firdayanti, Firdayanti Fristiohady, Adryan Hasnawati Hasnawati Indriyani Pratiwi Hapsari Inggit Suryaningsih Irma Malaka, Muhammad Hajrul Muh. Fakhrurazi MUHAMMAD HAJRUL MALAKA Muhammad Ilyas Muhammad Ilyas Y Muhammad Syaiful Saehu Musdalipah Niken Satuti Nur Handayani Nirwati Rusli Nuralifah Nuralifah, Nuralifah Nurhikma Nurhikma Reymon, Reymon Rifcha Selviana Puput RINI HAMSIDI Rini Hamsidi Rusli, Nirwati Sahidin Sahidin Santi Oktaviani, Santi Selfyana Austin Tee Setiawan, Muhammad Azdar Sri Aprilianti Idris Sri Susanti Suripto Suripto Susanti Susanti Wenty, Darmayanita Wulaisfan, Randa Wulandari Pryangan Yusuf, Muh. Ilyas Zeptiano, Zeptiano