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All Journal E-Jurnal Medika Udayana Berkala Ilmu Kesehatan Kulit dan Kelamin Jurnal Biomedika dan Kesehatan JOURNAL LA MEDIHEALTICO MAHESA : Malahayati Health Student Journal Media Dermato-Venereologica Indonesiana Bali Dermatology Venereology and Aesthetic Journal
Winaya, Ketut Kwartantaya
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Journal : Bali Dermatology Venereology and Aesthetic Journal

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Cyclooxygenase-2 as potential intervention target of leprosy reactions: a systematic review Rusyati, Luh Made Mas; Sari, Luh Gede Melia Puspita; Winaya, Ketut Kwartantaya
Bali Dermatology Venereology and Aesthetic Journal BDVAJ - Volume 6, Issue 2 (December 2023)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/wf9qxd44

Abstract

Background: Leprosy reaction is an acute inflammatory of leprosy complication that potentially cause disability. Prompt and appropriate treatment is needed to prevent this permanent neurological complication. As inflammation of this reaction is mediated by cyclooxygenase-2 (COX-2), therefore targeting this substance may potential to prevent disability. This systematic review aimed to define COX-2 as a potential target of intervention in leprosy reaction. Method: Medline, Cochrane library, PubMed, and Google scholar databases were searched for articles published at any time. Observational study and clinical trial, comparative, prospective, retrospective, and descriptive study were extracted, analyzed, and discussed. Results: We found 6 studies that met the inclusion and exclusion criteria, with 104 participants with leprosy reactions and 143 comparators included in this review. In leprosy reactions, COX-2 expression was found in the vessels and nerves of the dermis and subcutis. Macrophages are cell mostly abundantly expressing COX-2. The COX-2 expression was found higher in the leprosy reaction compare to the non-leprosy reaction. Genetically, genes PTGS2 and TNFAIP6 encode COX-2 production also tend to increase especially in type 1 reaction. Conclusions: Preclinically and genetically, COX-2 is a potential target for intervention of leprosy reaction.
Effectiveness and tolerability of bakuchiol (Psolarea corylifolia) as a dermal anti-aging modality: A systematic review on skin wellness and harmony Limanda, Claudia Felicia; Els, Vanessa; Hernowo, Elliana Freya; Winaya, Ketut Kwartantaya
Bali Dermatology Venereology and Aesthetic Journal BDVAJ - Volume 8, Issue 1 (2025)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/balidervenaesthj.v8i1.116

Abstract

Skin aging is a natural phenomenon caused by a decline in collagen production that leads to skin thinning, dry and pale skin, wrinkles, and sagging. Skin aging may not contribute to the mortality rate. However, people tend to connect their symbol of inner self to external appearance. Therefore, psychosocial effects such as social anxiety, low self-esteem, and low satisfaction in life will affect their personal and social life. Anti-aging procedures focus on the prevention of damage, replacement of tissues, and skin rejuvenation. Bakuchiol (Psolarea corylifolia) is a novel anti-aging product with antioxidant, anti-inflammatory, and anti-aging properties that is deemed effective and tolerable in skin rejuvenation. This comprehensive review aims to further examine the effectiveness and tolerability of bakuchiol based on previous studies in order to provide new insights into delaying skin aging. A comprehensive literature search was conducted to assess the effectiveness and tolerability of bakuchiol as a dermal anti-aging modality from search engines, PubMed, Google Scholar, CORE, Science Direct, and Cochrane using search terms (“Bakuchiol” OR “Psolarea corylifolia”) AND (“Dermal Aging” OR “Skin Aging”). Bakuchiol proved to have anti-inflammatory and antioxidant properties to maintain youthfulness and skin appearance. Regarding tolerability, bakuchiol has fewer side effects compared to other commonly used modalities. Therefore, bakuchiol (Psolarea corylifolia) is an effective and tolerable modality in the treatment of aging skin.
Co-Authors Darmaputra, I Gusti Nyoman Edward Wijaya, Edward Els, Vanessa Hernowo, Elliana Freya I Gusti Ayu Agung Dwi Karmila I Gusti Ayu Agung Praharsini I Gusti Nyoman Darmaputra Indira, I Gusti Ayu Agung Elis Kewatiting, Agnes Susanti Laksmi, Hermina Laksmi, I Gusti Ayu Agung Mini Limanda, Claudia Felicia Luh Made Mas Rusyati Ni Luh Putu Ratih Vibriyanti Karna Ni Made Dwi Puspawati Nyoman Suryawati Primasari, Putu Yunita Richard Richard Sadeli, Marrietta Sugiarti Sari, Luh Gede Melia Puspita Stella, Aurelia Stephanie, Aurelia Sutiawan, Indry Salonika Triatmakusuma, Yogi Utami, Desak Nyoman Trisepti Wardhana, I Made