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SOSIALISASI DAN EDUKASI PENGETAHUAN KONSUMSI MAKANAN SERTA OBAT-OBATAN SEBAGAI FAKTOR ASAM URAT PADA PASIEN DI PUSKESMAS RANCAH KABUPATEN CIAMIS Yuliana, Anna; Shaleha, Resha Resmawati; Amin, Saeful; Rahmiyani, Ira; Pebiansyah, Anisa; Zain, Dichy Nuryadin; Hidayat, Taufik; Alifiar, Ilham
Abdimas Galuh Vol 5, No 2 (2023): September 2023
Publisher : Universitas Galuh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25157/ag.v5i2.10431

Salah satu gangguan kesehatan yang diderita oleh masyarakat yaitu peningkatan kadar asam urat. Asam urat merupakan bagian normal dari darah dan urin. Asam urat dihasilkan dari pemecahan dan sisa-sisa pembuangan dari bahan makanan tertentu yang mengandung nukleutida purin atau berasal dari nukleutida purin yang diproduksi oleh tubuh. Jika pola makan tidak tepat, maka kadar asam urat yang berlebihan dalam darah akan terjadi penumpukan kristal asam urat, sehingga akan terjadi nyeri hebat yang timbul secara mendadak. Pengabdian masyarakat ini bertujuan untuk mengetahui apakah pola makan, obat-obatan, dan tingkat pengetahuan berpengaruh terhadap kadar asam urat. Kurangnya pemahaman dan pengetahuan terkait penyakit asam urat dan penyebabnya ini mendorong dosen dan mahasiswa Universitas Bakti Tunas Husada untuk melakukan pengabdian masyarakat di Puskesmas Rancah Kabupaten Ciamis. Metode yang digunakan yaitu sosialisasi dengan melakukan penyebaran poster, pemberian kuesioner dan edukasi. Peserta yang mengikuti sebanyak 87 pasien yang sedang melakukan rawat jalan di Puskesmas Rancah Kabupaten Ciamis dengan diberikan kuesioner secara pre-test dan post-test sebanyak 5 pertanyaan terkait penyakit asam urat.

Kelor (Moringa oleifera) Bioactive Compounds as Potential Anti-Breast Cancer Agents: In Silico Studies Amin, Saeful; Sheryl, Vanessa Angelica; Aprillia, Ade Yeni; Pebiansyah, Anisa
Borneo Journal of Pharmacy Vol. 8 No. 4 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i4.7435

Breast cancer is the most common type of cancer in women. Kelor (Moringa oleifera) leaves are a plant with medicinal properties for treatment. This study aimed to determine the activity and identify the metabolite compounds of M. oleifera leaves that are more effective and stable at the estrogen receptor (ER), potentially serving as an anticancer agent for breast cancer. The methods employed are computational studies, including molecular docking, PKCSM tests, and molecular dynamics simulations. The results of a computational molecular docking study of 23 M. oleifera leaf compounds identified the three best compounds from the docking results of the best ER genistein compounds on the 1QKM receptor, as well as genistein and luteolin compounds on the 1X7J receptor, all with low free energy values. From the pkCSM test of 23 compounds, three compounds were selected that showed good absorbance and distribution, and the toxicity prediction indicated that one compound did not exhibit hepatotoxicity. Molecular dynamics results for the Luteolin 1X7J compound, simulated for 100 ns, showed lower and more stable RMSD and RMSF values compared to those of compounds on the ER.

Bioactive Pigments of Monascus purpureus: Identification and Characterization Shaleha, Resha Resmawati; Yuliana, Anna; Rahmiyani, Ira; Pebiansyah, Anisa; Indriyanti, Indriyanti
Journal of Food and Pharmaceutical Sciences Vol 13, No 4 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.22574

Monascus purpureus is a filamentous fungus that has long been recognized as one of the main producers of natural pigments. These pigments, including yellow (ankaflavin, monascin), orange (rubropunctatin, monascorubrin), and red (rubropunctamine, monascorubramine), are widely used as natural coloring agents. Compared to synthetic dyes, Monascus pigments are considered safer and possess additional biological activities, making them attractive for applications in the food, pharmaceutical, and cosmetic industries. Therefore, accurate identification of the pigments in Monascus purpureus is essential to ensure their safety, functionality, and potential industrial applications. The aim of this research is to determine the results of pigment identification Monascus purpureus using UV-Vis Spectrophotometry, Fourier Transform Infra-Red (FTIR), Thin Layer Chromatography (TLC), Preparative Thin Layer Chromatography (Preparative TLC), and Liquid Chromatography- Mass Spectrometry (LC-MS). The method used is method laboratory experiments. Samples are tested using several instruments. The extraction results show that the % yield value meets the requirements, namely >10%, then the fractionation results show that the water fraction gets more thick extract, the TLC results for the water fraction show a spot height of 4.7 cm with a value of Rf 0.78, the results of Preparative TLC on the water fraction show the presence of a single fluorescent band at wavelengths of 254 nm and 366 nm. The UV-Vis spectrophotometry results were identified at a wavelength of 477 nm with an absorbance of 0.364, then the FTIR results on Preparative TLC scrapings from the water fraction showed the presence of functional groups from the orange pigment structure and the LC-MS results showed that the sample was a compound. Monascorubrin (C23H28O5) with a molecular weight of 384.99 g/mol and compound rubropunctatin (C21H22O5) with a molecular weight of 354.74 g/mol. These results provide information that the sample is an orange pigment from Monascus purpureus with two compounds monascorubrin and rubropunctatin.

Bioactive Pigments of Monascus purpureus: Identification and Characterization Shaleha, Resha Resmawati; Yuliana, Anna; Rahmiyani, Ira; Pebiansyah, Anisa; Indriyanti, Indriyanti
Journal of Food and Pharmaceutical Sciences Vol 13, No 4 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.22574

Monascus purpureus is a filamentous fungus that has long been recognized as one of the main producers of natural pigments. These pigments, including yellow (ankaflavin, monascin), orange (rubropunctatin, monascorubrin), and red (rubropunctamine, monascorubramine), are widely used as natural coloring agents. Compared to synthetic dyes, Monascus pigments are considered safer and possess additional biological activities, making them attractive for applications in the food, pharmaceutical, and cosmetic industries. Therefore, accurate identification of the pigments in Monascus purpureus is essential to ensure their safety, functionality, and potential industrial applications. The aim of this research is to determine the results of pigment identification Monascus purpureus using UV-Vis Spectrophotometry, Fourier Transform Infra-Red (FTIR), Thin Layer Chromatography (TLC), Preparative Thin Layer Chromatography (Preparative TLC), and Liquid Chromatography- Mass Spectrometry (LC-MS). The method used is method laboratory experiments. Samples are tested using several instruments. The extraction results show that the % yield value meets the requirements, namely >10%, then the fractionation results show that the water fraction gets more thick extract, the TLC results for the water fraction show a spot height of 4.7 cm with a value of Rf 0.78, the results of Preparative TLC on the water fraction show the presence of a single fluorescent band at wavelengths of 254 nm and 366 nm. The UV-Vis spectrophotometry results were identified at a wavelength of 477 nm with an absorbance of 0.364, then the FTIR results on Preparative TLC scrapings from the water fraction showed the presence of functional groups from the orange pigment structure and the LC-MS results showed that the sample was a compound. Monascorubrin (C23H28O5) with a molecular weight of 384.99 g/mol and compound rubropunctatin (C21H22O5) with a molecular weight of 354.74 g/mol. These results provide information that the sample is an orange pigment from Monascus purpureus with two compounds monascorubrin and rubropunctatin.

PENYULUHAN PENCEGAHAN DBD DI PC PERSISTRI KOTA TASIKMALAYA Zain, Dichy Nuryadin; Pebiansyah, Anisa; Yuliana, Anna; Amin, Saeful; Rahmiyani, Ira; Alifiar, Ilham; Hidayat, Taufik; Shaleha, Resha Resmawati
JMM (Jurnal Masyarakat Mandiri) Vol 8, No 3 (2024): Juni
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jmm.v8i3.23025

Abstrak: Demam Berdarah Dengue (DBD) merupakan salah satu masalah kesehatan di Indonesia yang disebabkan oleh virus dengue dan ditandai dengan tingginya jumlah nyamuk Aedes aegypti, sehingga mempengaruhi lingkungan dan kemampuan masyarakat dalam mengendalikan penularan DBD di suatu wilayah. Tujuan penyuluhan ini adalah peningkatan pengetahuan dan kesadaran masyarakat dalam mencegah penularan DBD. Proses penyuluhan mencakup persiapan, instruksi edukasi DBD, pengenalan aplikasi android RESIX, pemasangan paket tempat sampah, penyerahan alat kebersihan, diskusi dan evaluasi kegiatan melalui kuisioner pretest dan postest yang terdiri dari lima soal pada 110 ibu-ibu di PC Persistri Kota Tasikmalaya. Hasil evaluasi menunjukkan pengetahuan tentang DBD meningkat secara signifikan, dengan peningkatan skor sebesar 24.43%.Abstract: Blood dengue fever is a health problem in Indonesia that is part of a type of infectious disease caused by the dengue virus and is transmitted through aegypti mosquito bite characterized by high heat.Environmental factors as well as the role of society in the efforts to prevent the occurrence of DBD disease are closely related to the occurrence of DBD in a region.The purpose of this dissemination is to increase public knowledge and awareness in preventing the transmission of DBD.Preparation methods include preparation, DBD education, Introduction to Android Resix, Installation of garbage packages, submission of hygiene equipment as well as discussion and evaluation of activities through a pretest and postest query of up to 5 questions on 110 persistry PC mothers.The evaluation results showed a significant increase in knowledge of DBD with an increase in score by 24.43%.

Aktivitas Antidiare Ekstrak Etanol Kulit Pisang Tongka Langit (Musa Troglodytarum L) Menggunakan Model Protektif Pebiansyah, Anisa; Rahayu, Intan Puji Sri; Zain, Dichy Nuryadin
Jurnal Kesehatan Bakti Tunas Husada: Jurnal Ilmu-ilmu Keperawatan, Analis Kesehatan dan Farmasi Vol 26 No 1 (2026)
Publisher : LPPM Universitas Bakti Tunas Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36465/jkbth.v26i1.1897

Diare masih menjadi masalah kesehatan masyarakat utama di Indonesia, khususnya pada anak usia di bawah lima tahun, dan tergolong penyakit endemik yang berpotensi menimbulkan kejadian luar biasa. Oleh karena itu, eksplorasi bahan alam sebagai agen antidiare terus dikembangkan. Kulit pisang Tongka Langit (Musa troglodytarum L.) diketahui mengandung senyawa bioaktif, antara lain flavonoid dan steroid, yang berpotensi memiliki aktivitas antidiare. Penelitian ini bertujuan untuk mengevaluasi aktivitas antidiare ekstrak etanol kulit Musa troglodytarum menggunakan metode proteksi pada tikus putih jantan galur Wistar. Hewan uji dibagi menjadi enam kelompok, yaitu kontrol normal yang diberi air suling, kontrol negatif yang diberi suspensi Na-CMC 0,5%, kontrol positif yang diberi loperamide HCl, serta tiga kelompok perlakuan yang masing-masing diberi ekstrak dengan dosis 100 mg/200 gBB, 150mg/200gBB, dan 200mg/200gBB. Diare diinduksi menggunakan oleum ricini, dan aktivitas antidiare dievaluasi berdasarkan frekuensi diare, lama diare, serta konsistensi feses. Data dianalisis menggunakan uji ANOVA satu arah dengan tingkat signifikansi P<0,05, dilanjutkan dengan uji lanjut Least Significant Difference (LSD). Hasil penelitian menunjukkan bahwa dosis tertinggi (200 mg/200 g berat badan) memberikan aktivitas antidiare yang sebanding dengan loperamide. Nilai signifikansi metode proteksi sebesar 1,000 (P>0,05) menunjukkan tidak terdapat perbedaan bermakna antara dosis tertinggi ekstrak dan kontrol positif. Dengan demikian, ekstrak etanol kulit Musa troglodytarum berpotensi dikembangkan sebagai agen antidiare berbasis bahan alam.

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