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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Jurnal Mandala Pharmacon Indonesia Jurnal Pengabdian kepada Masyarakat Nusantara Jurnal Mandala Pengabdian Masyarakat Jurnal Pharmacia Mandala Waluya Nursing Genius Journal Karya Kesehatan Journal of Community Engagement
Saranani, Selpirahmawati
Unknown Affiliation
Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Journal : Indonesian Journal of Pharmaceutical Science and Technology

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Immunomodulatory Activity of Purple Button Herb (Borreria laevis Lamk.) on Macrophage Phagocytosis Prasetyo, Mulyadi; Yuliastri, Wa Ode; Pusmarani, Jasria; Saranani, Selpirahmawati; Handayani, Putri
Indonesian Journal of Pharmaceutical Science and Technology 2024: Suppl. 6, no. 3 (The 3rd Mandala Waluya International Conference on Pharmaceutical Science and
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v6i3.53924

Abstract

Immunomodulators operate through various mechanisms, one of which involves enhancing phagocytic activity. The purple button herb (Borreria laevis Lamk.) is recognized for containing secondary metabolites that may function as immunomodulators; however, its influence on phagocytosis has not been previously assessed. Consequently, a study explored the immunomodulatory effects of distinct fractions of the purple button herb on macrophage phagocytosis in male mice. Over seven days, the mice were orally administered ethanolic extract, ethyl acetate, and n-hexane fractions of the purple button herb. On the eighth day, the subjects were infected with Staphylococcus aureus. After euthanization, intraperitoneal fluid was collected to analyze macrophage phagocytosis activity. The study's results suggested that the ethanolic extract, ethyl acetate, and n-hexane fractions of the purple button herb tended to enhance macrophage activity, with the n-hexane fraction achieving the highest phagocytosis rate of 84.7%. The corresponding p-value > 0.05 in the LSD test indicated no statistically significant difference when compared to the positive control. In conclusion, the n-hexane fraction of the purple button herb demonstrates potential as an immunostimulant by augmenting macrophage activity.
Cellulose Nata de Sago-Hyaluronic Acid Microneedle for Pneumococcal Conjugate Vaccine Saranani, Selpirahmawati; Laugi, Putri S.; K., Intan N.A.; Lakapu, Sonia M.; Syian, Alfiyani; Jayanti, Seftika
Indonesian Journal of Pharmaceutical Science and Technology 2024: Suppl. 6, no. 3 (The 3rd Mandala Waluya International Conference on Pharmaceutical Science and
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v6i3.54045

Abstract

The use of syringe-administered vaccines has significantly increased immunization coverage among children. Still, pneumonia remains the leading cause of death in children under five worldwide, accounting for over 70% of fatalities in this age group. To address challenges such as needle phobia, transdermal drug delivery systems offer a promising, minimally invasive alternative for both local and systemic medication administration. This study focuses on developing and evaluating a nata de sago-hyaluronic acid cellulose microneedle formulation for the transdermal delivery of pneumonia vaccines in children. The study consisted of preparing nata de sago, cellulose suspension, microneedle fabrication, and subsequent characterization and effectiveness testing. Results showed that the microneedle reached swelling equilibrium with a swelling degree of 1. Diffusion tests revealed a drug release rate of 1.173% within 90 minutes, successfully penetrating the stratum corneum. Scanning Electron Microscopy (SEM) analysis confirmed an average microneedle length of 763.6 μm and a width of 191.7 μm for Pin 12, demonstrating its suitability for transdermal application. These findings highlight the nata de sago-hyaluronic acid microneedle as a well-designed and effective platform for pneumococcal vaccine delivery, offering a novel solution to improve pediatric immunization and address key challenges in child healthcare.
Co-Authors Adha, Muhammad Aidil Agastia, Gayuh Ali, Nur Fitriana Muhammad Andriani, Rina Anisa Purnamasari Ari Nofitasari Baco, Juliana Bai Athur Ridwan Burhan, Hesti Trisnianti Citra Dewi Fauziah, Rismayanti Firdayani Malik, Mayurni Fitrah, Nur Fitriah, Wa Ode Ida Fitriani, Rezky Dwi Fratiwi, Nuning Fristiohady, Adryan Hasanuddin, Silviana Himaniarwati Jabbal Apriawal Jayanti, Seftika K., Intan N.A. Kamalia, La Ode Lakapu, Sonia M. Laugi, Putri S. Liaumin Azim, La Ode Lolok, Nikeherpianti Muhammad Isrul Pebrianti Prasetyo, Mulyadi Purnama, Titi Purnamasari, Anisa Pusmarani, Jasria Putri Handayani Rauf, Aulia Azizah Rudi Kusuma, Nyoman Saparina, Titi Selin, Arta Sesilia, Sesilia Sjahrul, Enjelin Nur Fathika Syian, Alfiyani Yuliastri, Wa Ode