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PAKAN, PRISCA DEVIANI
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Uji Efektivitas Ekstrak Daun Sirih (Piper betel l.) dalam Hand Sanitizer terhadap Aktivitas Bakteri Staphylococcus aureus Go, Dinsella; Pakan, Prisca Deviani; Setianingrum, Elisabeth Levina Sari; Damanik, Efrisca M. Br.
Cendana Medical Journal Vol 10 No 2 (2022): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cmj.v10i2.8636

Abstract

The importance of self-hygiene needs to be taken seriously by everyone. Small habits such as washing hands can save and protect people from infectious diseases, mainly COVID-19. The usage of hand sanitizers can be another alternative in keeping one’s hands clean from germs and bacteria. This study will be utilizing piper leaf extract (Piper betel l.) as the main ingredient in hand sanitizer formulation.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL 70% RIMPANG KENCUR (Kaempferia galanga Linn) TERHADAP Streptococcus pyogenes SECARA In Vitro Ratu Edo, Megaputri Yoriska; Pakan, Prisca Deviani; Rini, Desi Indria
Cendana Medical Journal Vol 10 No 2 (2022): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cmj.v10i2.9059

Abstract

Streptococcus pyogenes is a gram-positive bacterium that causes extensive infection, particularly in the respiratory tract and skin, also the 90% cause of pharyngitis cases encountered in the primary health care unit. Pharyngitis infections by S. pyogenes are treated with Penicillin G or other beta-lactam derivates, if left untreated or delayed may occur sekuele immunity, Acute Rheumatic Fever (ARF) that causes permanent damage to the heart valves or Rheumatic Heart Disease (RHD). Morbidity due to heart failure in RHD patient. In recent years there have been reports of resistance to antibiotic treatment in S. pyogenes infections cases. In East Nusa Tenggara, Kencur rhizomes (Kaempferia galanga Linn) is used for generations to cure complaints such as cough, flu, asthma, flatulence and abdominal pain. In accordance with previous research that proved Kencur rhizomes extract is an analgesic, anti-inflammatory, anti-helmintic, mosquito repellent, mosquito larvae growth inhibitor, vasodilator, anti-cancer, anti oxidant, sedative, anti-UVB and anti bacteria. The purpose of this research was to know the antibacterial activity of ethanol extract of kencur rhizome on S. pyogenes in vitro, effectiveness of Kencur rhizome extract as antibacterial and minimal concentration of Kencur rhizome extract which can inhibit the growth of S. pyogenes. The method of this research is True Experimental Research with Posttest Only Control Group Design as design. The sample of this study, used extract ethanol of Kencur rhizome which tested using the well diffusion method to observe the antibacterial activity prepare in eight concentrations (1 (100%), 2 (50%), 25%, 12.5%, 6.25%, 3.12%, 1, 56% and 0.78%), one positive control group (amoxicillin) and one negative control group (sterile aquadest) with three times replications. The results showed that the extract of ethanol Kencur rhizome has antibacterial activity but not effective as anti bacteria on the growth of S. pyogenes bacteria and the concentration 0.78% was determined as minimum inhibitory concentration.
Uji Perbandingan Efektivitas Antibakteri Sabun Cuci Tangan Komersial Berbahan Sirih Hijau, Jeruk Nipis Dan Lidah Buaya Terhadap Bakteri Staphylococcus Aureus Seran, Dania Ekasanti M.; Pakan, Prisca Deviani; Wungouw, Herman Pieter L; Lidia, Kartini
Cendana Medical Journal Vol 10 No 2 (2022): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cmj.v10i2.9172

Abstract

ABSTRACTBackground : Currently, there are many antibacterial soap products circulating in the community. To inhibit or kill bacteria, some soaps add an active substance that acts as an antimicrobial. However, repeated use of synthetic soap can cause skin irritation, dry skin, rashes and bacterial resistance. Some soap products add herbal ingredients to reduce side effects, including soap made from green betel, lime and aloe vera.Objective : This study was conducted with the aim of knowing the differences in antibacterial inhibitory ability of hand soap products made from green betel, lime and aloe vera on the market against the growth of staphylococcus aureus bacteria. Methods : The type of research used is a Quasi Eksperimental disc diffusion method with a research design of the Posttest – only Nonequivalent control group design. The treatment group in this study consisted of a positive control (triclosan), a negative control (Sterile distilled water) and commercial handwashing soap made from green betel, lime and aloe vera with 5 repetitions for each group against the staphylococcus aureus bacteria. Data analysis used One Way Anova statistical test with 95% confidence level.Result : Based on the measurement result, the largest inhibition zones were soap made from lime which was 26.4 mm, aloe vera 22.0 mm and green betel 18.8 mm which indicated that each experimental preparation had antibacterial potential and soap made from lime had a more effective inhibitory power in inhibiting the growth of staphylococcus aureus. Analysis of One Way Anova and Dunnet T3 tests obtained p result smaller than a = 0.05, whuch means that there is a significant difference in the mean diameter of the inhibition zone between the treatment groups. Conclusion : There is a significant difference in the antibacterial effectiveness of hand washing soap made from green betel, lime and aloe vera against staphylococcus aureus bacteria.Keywords : Hand soap, Antibacterial, Inhibition, Staphylococcus aureus
Uji Perbandingan Efektivitas Antibakteri Pasta Gigi Komersial Berbahan Daun Sirih, Siwak Kombinasi atau Lidah Buaya Terhadap Staphylococcus Aureus Edon, Cindy Marie Agnes Lorenza Aurelia; Pakan, Prisca Deviani; Lada, Christina Olly
Cendana Medical Journal Vol 11 No 1 (2023): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cmj.v11i1.10496

Abstract

Abstract Background: Dental health problem if not treated will cause coronary heart disesase and stroke. Toothpaste products are widely marketed to be antibacterial substances, by adding herbal active ingredient including betel leaf, siwak combination, or aloe vera. Research Objectives: To compare the antibacterial efficacy of commercial toothpaste with betel leaf, siwak combination, or aloe vera active components against Staphylococcus aureus. Research Methods: This study used a quasi-experimental design method with posttest–only nonequivalent control group design. The treatment group consisted of a commercial toothpaste containing the active ingredients betel leaf, siwak combination or aloe vera as well as positive control of non-herbal toothpaste, and negative control of sterile distilled water as a comparison with five repetitions for each treatment group of Staphylococcus aureus bacteria. The data was analyzed using the One Way ANOVA statistical test, which had a 95% confidence level. Positive inhibitory zone is characterized by a clear zone with a diameter of 5-20 mm. Results: The One Way ANOVA analysis test showed p-value = 0.000 where there were significant differences between the treatment groups. Betel leaf toothpaste (9.44 mm) in medium category, siwak combination (13.28 mm) with strong category or aloe vera (18.24 mm) with strong category. Conclusion: Toothpaste with active ingredients of betel leaf, siwak combination, or aloe vera have different antibacterial properties Keywords: Toothpaste, Inhibitory, Antibacterial
Hubungan Tingkat Pengetahuan dengan Self Efficacy Vaksinasi COVID-19 di Puskesmas Tarus Kabupaten Kupang Sumbayak, Anastasia Emma Reinaita; Koamesah, Sangguana Marthen Jacobus; Pakan, Prisca Deviani; Sagita, Sidarta
Cendana Medical Journal Vol 11 No 1 (2023): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cmj.v11i1.10590

Abstract

Background : The 2019 Corona Virus Disease pandemic is still a concern until today. The virus that causes COVID-19 can keep mutating and producing new variants over time. The government has attempted various health protocols including a national vaccination program, with the aim of forming herd immunity. Vaccination has 2 stages of primary vaccination and additional or booster dose of vaccination. Based on data from the Ministry of Health as of 19 January 2022, Kupang Regency has the lowest vaccination rate in East Nusa Tenggara. This can be caused by a lack of self efficacy or belief in receiving the COVID-19 vaccine. Several survey results show that people’s refusal and doubts about receiving vaccinations are due to concerns about the safety and effectiveness as well as the side effect of COVID-19 vaccine, which can be caused by lack of knowledge about the COVID-19 vaccination. Objective : This study aims to determine whether there is a relationship between the level of knowledge and self efficacy of COVID-19 vaccination at the Tarus Health Center, Kupang Regency. Method : This study used an analytical observational research design with a cross sectional design. Samples were choosen using a non-probability sampling technique with a type of consecutive sampling with a total sample of 103 people. The data were collected using a questionnaire on Knowledge of COVID-19 Vaccination and Self Efficacy of COVID-19 Vaccination to the visitors of Tarus Health Center, Kupang Regency. The data analysis used is the Rank Spearmen Correlation test. Result : From the test results using the Rank Spearman Correlation test, there was no significant correlation between the level of knowledge with the self efficacy of COVID-19 vaccination at the Tarus Health Center, Kupang Regency with the sig(2-tailed) > 0.005. Conclusion : There is no significant correlation between the level of knowledge with the self efficacy of COVID-19 vaccination at the Tarus Health Center, Kupang Regency.
Hubungan Frekuensi Makan Terhadap Gejala Gastritis pada Mahasiswa Prodi Pendidikan Dokter Universitas Nusa Cendana Zefania, Zefania; Pakan, Prisca Deviani; Manafe, Derri Tallo
Cendana Medical Journal Vol 11 No 2 (2023): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cmj.v11i2.13900

Abstract

Background: Gastritis is an inflammatory process caused by irritating and infectious factors in the mucosa and submucosa of the stomach. Common gastritis symptoms include feeling completely quickly, belching, abdominal discomfort, bloating, nausea and vomiting. A good frequency of eating is if the frequency of eating every day is 3 main meals 2 times a snack and is said to be less if the frequency of eating every day is 2 main meals or less. Research Objectives: It knows the relationship between eating frequency and gastritis symptoms in Nusa Cendana University Medical Education Study Program students. Methods: This research is quantitative with an analytic observational method with a cross-sectional design. The sample selection technique in this study used the Stratified Random Sampling technique with a total sample of 95 people. The data analysis used is the Chi-Square test. Result: From the Chi-Square test results, there is a relationship between eating frequency and gastritis symptoms in students of the Nusa Cendana University Medical Education Study Program with p = 0.000. Conclusion: Eating frequency affects symptoms of gastritis in students of the Medical Education Study Program at Nusa Cendana University.
Uji Potensi Ekstrak Daun Kelor (Moringa oleifera) Sebagai Bahan Aktif Hand Sanitizer Alami Thaal, Mario Bernardo; Pakan, Prisca Deviani; Woda, Rahel Rara
Cendana Medical Journal Vol 11 No 2 (2023): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cmj.v11i2.13917

Abstract

Abstract Background: Antiseptic hand sanitizers can prevent the transmission of infectious diseases. Antiseptic hand sanitizer consists of alcohol and synthetic chemicals which are relatively expensive. It is necessary to look for antiseptics from natural ingredients as active ingredients in hand sanitizers which are relatively cheaper, safe, effective and easily available to all levels of society. One of the plants cultivated as a medicinal plant is the Moringa oleifera. Objective: This research was conducted to determine the potential of Moringa oleifera leaf extract as an active ingredient in natural hand sanitizers. Methods : The type of research used is true experimental design with posttest only control group design. The treatment group in the study consisted of positive control for alcohol-based hand sanitizer, negative control for sterile aquadest, and a group of moringa oleifera leaf extract concentrations of 100%, 75%, 50%, 25%, 10%, 5%, 1% with 3 repetitions for each group against Staphylococcus aureus and Escherichia coli test bacteria. Data analysis used the One Way Anova statistical test with a confidence degree of 95%. Results : Based on the results of testing the antibacterial potential of Moringa oleifera leaf extract against the growth of Staphylococcus aureus and Escherichia coli showed that the extracts had antibacterial potential. One Way Anova test analysis showed that the value of p = 0.000 was smaller than α = 0.05 which means that there is a significant difference in the mean diameter of the inhibition zone between the treatment groups. Conclusions : Moringa oleifera leaf extracts have the potential as an active ingredient in natural hand sanitizers.
Effect of turmeric extract on glutathione levels in diclofenac-induced oxidative stress in rats Jumba, Cynthia Benedikta; Amat, Anita Lidesna Shinta; Pakan, Prisca Deviani; Rini, Desi Indria
Acta Biochimica Indonesiana Vol. 8 No. 2 (2025): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.222

Abstract

Background: Glutathione (GSH), the primary endogenous antioxidant, protects cells against oxidative stress. Diclofenac sodium, a commonly prescribed nonsteroidal anti-inflammatory drug (NSAID), depletes GSH through hepatic metabolic byproducts, causing oxidative damage. Objective: To evaluate the protective effect of turmeric extract (Curcuma longa L.) on glutathione levels in rats subjected to diclofenac-induced oxidative stress. Methods: Twenty-eight male Wistar rats were randomly divided into four groups (n=7): normal control, negative control (diclofenac sodium 10 mg/kg body weight [BW]), and two treatment groups receiving turmeric extract (100 mg/kg BW or 200 mg/kg BW) following diclofenac induction. Diclofenac was administered for 7 days; turmeric extract was given orally for 14 days. Cardiac blood glutathione levels were measured spectrophotometrically. Results: Turmeric extract significantly increased glutathione levels in diclofenac-induced rats compared to negative controls (p<0.05). The 200 mg/kg BW dose produced superior protection, elevating GSH levels significantly above all groups (p<0.001), demonstrating a dose-dependent antioxidant effect. Conclusion: Turmeric extract demonstrates significant dose-dependent antioxidant activity against diclofenac-induced oxidative stress, with the 200 mg/kg BW dose achieving superior GSH elevation (p < 0.001), suggesting potential as a protective agent against NSAID-induced oxidative damage.
Co-Authors Amat, Anita Lidesna Shinta Artawan, I Made Christina Olly Lada Damanik, Efrisca M. Br. Deri Riskiyanti Tallo Manafe Dhenge, Neumensia Febrianti Djahi, Sri Nur Nur Saidah E D, Maria Agnes Edon, Cindy Marie Agnes Lorenza Aurelia Flugentius, Bartolomeus Umbu Foni, Maria Laranita Meak Go, Dinsella Go, Stephannie Felicia Hutasoit, Regina M Ina Tuto, Yolanda Yasinta Jumba, Cynthia Benedikta Kartikahadi, Anselma Dyah Koamesah, Sangguana Marthen Jacobus Konay, Soeharty Megawaty Kresnawati Wahyu Setiono Lidia, Kartini Maromon, Yeyen Nurina, Rr. Listyawati Pandie, Sinyo Demitrio Kurniawan Qurrota’ayun, Aisyah Rahmaningtyas, Dewinda Rambu Kareri, Dyah Gita Rante, Su Djie To Ratu Edo, Megaputri Yoriska Ratu, Kristian Riantoby, Raphaeline Murtiastari Rini, Desi Indria Riwu, Magdarita Sagita, Sidarta Septyowati, Mega Ayu Sequera, Maria Trisya Goncalves Seran, Dania Ekasanti M. Setianingrum, Elisabeth Levina Sari Setiawan, I Made Buddy Suki, Alce Apri Feranita Sumbayak, Anastasia Emma Reinaita Supardi, Fretrien Jiliamarch Tandang, Fransiskus Tarigan, Gloria Josephin Thaal, Mario Bernardo Woda, Rahel Rara Wungouw, Herman Pieter L Zefania, Zefania