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All Journal JURNAL MEDIA KESEHATAN Jurnal Kedokteran Raflesia J.Pelastek Jurnal PADAMU NEGERI (Pengabdian pada Masyarakat Bidang Eksakta) ANJANI Journal (Medical Science & Healthcare Studies) Jurnal Pharmacopoeia
Oktoviani, Oktoviani
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AKTIVITAS ANTIBAKTERI EKSTRAK DAUN NANGKA KUNING (VINCETOXICUM VILLOSUM (BLUME) KUNTZE) TERHADAP BAKTERI ENTEROCOCCUS FAECALIS DAN PSEUDOMONAS AERUGINOSA Oktoviani, Oktoviani; Pertiwi, R; Notriawan, D.; Putri, B. A. N.; Karlina, Y. D.
JURNAL MEDIA KESEHATAN Vol 14 No 1 (2021): Jurnal Media Kesehatan Poltekkes Kemenkes Bengkulu Volume 14 No 1 Juni 2021
Publisher : Politeknik Kesehatan Kemenkes Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33088/jmk.v14i1.631

Abstract

Nangka kuning leaves (Vincetoxicum villosum Blume) are widely used by the community as a traditional medicine but research on nangka kuning leaves is still very limited so that it has great potential for the development of herbal medicine. This study used two bacteria representing gram-positive and gram-negative groups. From the gram-positive group, one of the most common bacteria that can cause disease is the Enterococcus faecalis. Then from the gram-negative group used Pseudomonas aeruginosa which is the most common cause of opportunistic infections in hospitalized patients. To test the antibacterial activity of the ethanol extract, bacteria were divided into 8 groups, namely the positive control group with chloramphenicol, the negative control group with 10% Dimethyl Sulfoxide (DMSO) solvent, and 6 treatment groups using 12.5% ​​ethanol extract; 15%; 17.5%; 20%; 22.5%; 25%. Bacterial culture was carried out using media and incubated for 24 hours at 37oC. Enterococcus faecalis bacteria used Trypticase Soy Both (TSB) media and Pseudomonas Aeruginosa bacteria used Trypticase Soy Agar (TSA) media. The optimal inhibition for Enterococcus faecalis bacteria is in the ethanol extract of Vincetoxicum Villosum Blume with a concentration of 25% and for Pseudomonas aeruginosa is the ethanol extract of Vincetoxicum Villosum Blume with a concentration of 15%.
EFEK ANTIDIABETES DAUN JAMBU BIJI PADA HEWAN COBA: TINJAUAN KEPUSTAKAAN SISTEMATIS oktoviani, oktoviani; sania aulia fasa; ahmad azmi
JURNAL KEDOKTERAN RAFLESIA Vol 9 No 2 (2023)
Publisher : UNIVERSITAS BENGKULU

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/juke.v9i2.33175

Abstract

Background: Indonesia ranks fifth in the world with diabetes and diabetes cases are expected to increase continuously. The treatment of diabetes is taking medication and modifying life style. Herbal medicine is used as an additional or substitute drug for diabetes because of its efficacy and has few side effects. Guava leaf is one of the traditional plants that are widely used by the community. Guava leaves have been used as a treatment for diabetes and hypertension in South Africa. Secondary metabolites found in guava leaves such as flavonoids, phenolics and terpenoids were found to have antidiabetic activity. Previous studies have been conducted, but there was no systematic literature review that discussed the efficacy of the antidiabetic effect administration of guava leaves on experimental animals comprehensively. Methods: This systematic literature review was conducted on three databases, namely Pubmed, Cochrane and Elsevier. Duplicate and irrelevant studies are eliminated, abstracts are screened and followed by reading the entire articles to select journals that fit the inclusion criteria. Critical appraisal uses Joana Brigs Institute tool. Results: There were three articles met the criterias. The result of the three studies showed that administration of guava leaf extract is reported able to reduce blood glucose level and improve sensitivity insulin. Conclusion: Administration of guava leaf extract significantly reduce blood glucose level and improve insulin sensitivity on animal laboratory.
Pelatihan pembuatan hand sanitizer sebagai antiseptik berstandar WHO Oktoviani, Oktoviani; Rizqoh, Debie; Handayani, Dian; Rachmawati, Indah Dwi; Kumala, Wulan Okta
Jurnal PADAMU NEGERI (Pengabdian pada Masyarakat Bidang Eksakta) Vol 2, No 2 (2021)
Publisher : Perkumpulan Dosen Muda (PDM) Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (394.844 KB) | DOI: 10.37638/padamunegeri.v2i2.437

Abstract

The incessant socialization of the government regarding health protocols to a new life order has resulted in most Indonesians becoming introspective in maintaining cleanliness. However, some of the community also experienced panic, so that they acted unnaturally by buying up more goods than they needed, including hand sanitizers. This is one of the reason the price of hand sanitizers has increased. That’s why people need to know how to make hand sanitizers so that they are no longer worry about the scarcity of hand sanitizers and can make their own hand sanitizers. The purpose of this activity is to meet the needs of residents for hand sanitizer as an antiseptic with WHO standards. The method used in training in making hand sanitizers in a direct demonstration. Demonstrations are also supported by a PowerPoint and video that is displayed repeatedly with the help of an LCD projector. This was done to repeat the key points of the demonstration sp that a good level of understanding was achieved by the citizens. Then the Citizen representativeswere asked to repeat the demonstration so that the activities of seeingm listening and practicing the knowledge  of making hand sanitizers were completed. Then at the end of the event, an evaluation was carried out using the discussion or question and answer method. The results of the training in making hand sanitizers have helped meet the needs of residents for hand sanitizers, helped residents to be more independent in meeting their needs for hand sanitizers, and increased knowledge and skills of residents regarding making hand sanitizers as WHO standard antiseptics
”Kampanya DaGuSiBu (Dapatkan, Gunakan, Simpan dan Buang) Kehati-hatian Menyikapi Peredaran Informasi dan Obat Secara Online” Versita, Riana; Rachmawati, Suci; Oktoviani, Oktoviani
Jurnal PADAMU NEGERI (Pengabdian pada Masyarakat Bidang Eksakta) Vol 2, No 2 (2021)
Publisher : Perkumpulan Dosen Muda (PDM) Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (898.517 KB) | DOI: 10.37638/padamunegeri.v2i2.442

Abstract

DaGuSiBu merupakan salah satu upaya dalam peningkatan kesadaran masyarakat tentang cara penggunaan obat  yang baik dan benar. Kegiatan Pengabdian Pada Masyarakat (PPM) ini bertujuan untuk meningkatkan pengetahuan masyarakat Bengkulu tentang cara mendapatkan, menggunakan, menyimpan dan membuang obat dengan benar. Hasil kegiatan diukur dengan menggunakan kuisioner berisi 10 butir pertanyaan dengan tipe multiple choice question. Analisa kuisioner dilakukan secara deskriptif dimana responden yang memperoleh skor ≥70 memiliki pemahaman yang baik dan responen yang memiliki skor ≤70 belum memiliki pemahaman yang baik tentang DaGuSiBu. Evaluasi pelaksanaan menunjukkan dari 49 peserta kegiatan PPM 71,42% memiliki pemahaman yang baik dan 28,58% belum memiliki pemahaman yang baik tentang cara mendapatkan, menggunakan, menyimpan dan membuang obat dengan benar. Hasil evaluasi menunjukkan bahwa terdapat 70% masyarakat telah memenuhi indikator keberhasilan pelaksanaan kegiatan PPM.
Skrining Fitokimia Metabolid Sekunder Ektrak Etil Asetat Kulit Buah Durian (durio zibethinus murr) Diambil Dari Kabupaten Bengkulu Tengah Versita, Riana; Ekuansah, Muhammad; Oktoviani, Oktoviani
ANJANI Journal (Medical Science & Healthcare Studies) Vol 3, No 2 (2023)
Publisher : Perkumpulan Dosen Muda Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37638/anjani.v3i2.696

Abstract

Pendahuluan: Durian (Durio zibenthinus Murr) merupakan salah satu sumber daya genetik (SDG) tanaman lokal Provinsi Bengkulu yang memiliki nilai ekonomis yang cukup tinggi. Tanaman durian adalah tumbuhan tropis Asia Tenggara yang hanya dimanfaatkan buah dan batang pohonya saja sedangkan kulit buah durian hanya sebagai limbah” Metode: Penelitian ini menggunakan pemeriksaan di laboratorium yang bertujuan untuk mengetahui metabolit sekunder yang terdapat pada kulit buah Durian (Durio zibenthinus Murr) dalam proses skrining fitokimia menggunakan pelarut etil asetat “Hasil dan Pembahasan: Hasil ekstrak etil asetat kulit buah Durian (Durio zibenthinus Murr) mengandung senyawa alkaloid ditandai dengan berubahnya warna pada sampel setelah ditetesi dengan reagen dragendroff, mayer dan wagner. Selain itu ekstrak etil asetat kulit Durian (Durio zibenthinus Murr)  juga mengandung senyawa triterpenoid, flavonoid dan tanin yang dapat dimanfaatkan didalam pengobatan herbal seperti antikanker.” Namun tidak mengandung senyawa steroid, saponin karena pada saat penelitian tidak terjadi perubahan warna seperti warna cincin biru kehijauan untuk steroid melainkan berwarna hijau kebiruan yang dapat diketahui bahwasanya mengandung senyawa steroid. “Kesimpulan: dari penelitian ini adalah komponen yang terkandung dalam kulit Durian (Durio zibenthinus Murr)  diekstrak dengan pelarut etil asetat yaitu alkaloid, flavonoid, triterpenoid dan tanin. ABSTRACTIntroduction: Durian (Durio zibenthinus Murr) is one of the genetic resources (SDGs) of the local plant of Bengkulu Province which has quite high economic value. The durian plant is a tropical plant in Southeast Asia. Methods: This study used laboratory tests to determine the secondary metabolites present in the rind of Durian (Durio zibenthinus Murr) during the phytochemical screening process using ethyl acetate solvent. Result and Discussion: Alkaloid compounds are characterized by changes in color in the sample after being dripped with Dragendroff, Mayer and Wagner reagents. In addition, the ethyl acetate extract of Durian peel (Durio zibenthinus Murr) also contains triterpenoid compounds, flavonoids and tannins which can be used in herbal medicine. However, it does not contain steroid compounds, saponins because at the time of the study there was no color change such as the color of the greenish-blue ring for steroids but rather a bluish-green color which can be seen to contain steroid compounds. Conclusion: from this study, the components contained in Durian peel (Durio zibenthinus Murr) were extracted with ethyl acetate solvent, namely alkaloids, flavonoids, triterpenoids and tannins.
SKRINING FITOKIMIA INFUSA DAUN SUNGKAI (Peronema canescens Jack.) DENGAN METODE REAKSI WARNA Rahmawati, Suci; Marliza, Marliza; Sari, Rose Intan Perma; Wirahmi, Nori; Oktoviani, Oktoviani; Sipriyadi, Sipriyadi
Jurnal Pharmacopoeia Vol 2 No 2 (2023): September 2023
Publisher : Poltekkes Kemenkes Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33088/jp.v2i2.482

Abstract

Sungkai (Peronema canescens Jack) was used traditionally as a medicine to help relieve fever, malaria and flu. In general, people was used sungkai leaves in the form as infusion. This study was aimed to screening of secondary metabolite of Sungkai leaf infusion using the color reaction method. The sample in this study was sungkai leaf that obtained from Bengkulu city. The infusion was obtained by boiling 10 gram of sungkai leaf simplicia with 100 ml of distilled water for 15 minutes at 90 0C until a concentration of 10% (w/v) was obtained. Secondary metabolite screening was carried out using the color reaction method to identify alkaloids, flavonoids, saponins, tannins and steroids. Phytochemical screening using specific reagents with the test was repeated three times. The results were showed that sungkai leaves infusion was positive in alkaloid test as evidenced by the presence of white precipitate with Mayer reagent, brown precipitate with Wagner reagent, and orange precipitate with Dragendorff reagent. Positive results were also shown in flavonoid, saponin and tannin tests. While, negative result was seen in steroid test using Liebermann Burchard reagent. In this study it can be concluded that sungkai leaf infusion positively contains alkaloids, flavonoids, saponins and tannins.
OPTIMASI EKSTRAKSI DAUN NANGKA KUNING (Vincetoxicum villosum (Blume) Kuntze) DARI BERBAGAI PELARUT DAN METODE Oktoviani, Oktoviani; Taurina, Hilda; Triana, Dessy; Rahmawati, Suci; Sari, Yulita Gumala; Melati, Putjha; Sari, Delia Komala
JURNAL PENGELOLAAN LABORATORIUM SAINS DAN TEKNOLOGI Vol 2 No 1: Juni 2022
Publisher : Universitas Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/labsaintek.v2i1.22754

Abstract

Extraction of a plant in traditional medicine is a very crucial stage for the success of the treatment. For example, nangka kuning (Vincetoxicum villosum (Blume) Kuntze) which has been scientifically researched, its leaves are extracted with ethanol solvent using the maceration method. Meanwhile, by local people,nangka kuning leaves are processed by boiling using water. This attracted the attention of researchers to re-analyze the content of secondary metabolites in nangka kuning leaf extract made with different solvents and methods. Researchers carried out the extraction using water with heating (infusion), ethanol without heating (maceration) and chloroform without heating (maceration). The results obtained from the three types of extracts contained secondary metabolites of alkaloids in the three extracts. While steroids are only found in extracts with a water solvent. Then the tannins are found in the extract with water and ethanol as solvents. Negative results from the three extracts were shown for secondary metabolites of flavonoids and saponins. So it can be concluded that nangka kuning leaf extract which has the most optimal secondary metabolite is the extract using water as a solvent by heating.
Co-Authors ahmad azmi Debie Rizqoh Delia Komala Sari, Delia Komala Dessy Triana Dian Handayani Ekuansah, Muhammad Karlina, Y. D. Kumala, Wulan Okta Marliza Marliza Melati, Putjha Notriawan, D. Pertiwi, R Putri, B. A. N. Rachmawati, Indah Dwi Rachmawati, Suci sania aulia fasa Sari, Rose Intan Perma Sari, Yulita Gumala Sipriyadi Suci Rahmawati Taurina, Hilda Versita, Riana Wirahmi, Nori