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Fioni, Fioni
Universitas Prima Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Dentistry Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Physics Public Health Social Sciences Transportation Veterinary

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Journal : Jurnal EduHealth

 1 
Tests of Burn Wound Healing with Nanogel Preparations from Ethanol Extract of Andaliman Fruit Janice, Janice; Erwina Putri, Riri; Fioni, Fioni
Jurnal EduHealth Vol. 14 No. 04 (2023): Jurnal eduHealt, 2023, December
Publisher : Sean Institute

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Abstract

Andaliman (Zanthoxylum acanthopodium DC) is a plant known for its diverse bioactive compounds, including antimicrobial and anti-inflammatory properties. Nano-gel formulations were prepared using appropriate techniques, and their physicochemical properties, including particle size, pH, viscosity, and centrifugation stability, were evaluated. Additionally, organoleptic tests were conducted to assess the sensory characteristics of the nano-gels. Furthermore, an irritation test was performed to ensure the formulation's safety when applied to the skin. The percentage of wound closure was evaluated at various time points, including days 2, 4, 6, 8, 10, 12, and 14, comparing it to a commercially available wound healing product, Bioplacenton. Initial findings showed that the nano gel formulations exhibited favorable physicochemical properties, including appropriate particle size within the nano-scale range. The pH values were within an acceptable range, and the formulations demonstrated suitable viscosity and stability during centrifugation. Organoleptic tests indicated good sensory characteristics, and the irritation test showed the formulation's safety without significant skin irritation. The percentage of wound closure increased over time for all three concentrations (F1: 5%, F2: 10%, F3: 20%). In conclusion, nano gel formulations containing various concentrations of Andaliman extract exhibited good physicochemical properties, favorable sensory characteristics, and safe application on the skin. Moreover, they demonstrated promising wound healing effects, potentially comparable to commercial wound healing agents.
An Investigation on The Impact of Orally Administered Celery and Orange Juices on The Production of Collagen in Rats Exposed to Ultraviolet-B Light Arhani, Adli; Fioni, Fioni; Pratama , Irza Haicha
Jurnal EduHealth Vol. 14 No. 04 (2023): Jurnal eduHealt, 2023, December
Publisher : Sean Institute

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At the correct dosage, ultraviolet (UV) radiation has many positive health effects and is essential for the body. The flip side is that exposure to excessive amounts of ultraviolet light (UV) can be harmful. Repetitive exposure to UVB light causes reactive oxygen species (ROS) to be produced, reducing the production of antioxidant enzymes, increasing oxidative protein modification, and causing glycation and lipid peroxidation products to accumulate. Because of this, it's essential to take precautions to guard the skin from free radical damage and slow the aging process by employing antioxidants in various forms. In this study, rats were exposed to UVB light and then given either celery juice (Apium graveolens) or orange juice (Citrus) orally to see if it would increase the quantity of collagen in the rats. True experimentation, or study in a controlled laboratory setting, is the method of choice. Each of the three groups consisted of eight white rats, for a total of twenty-four rats. Due to their high concentrations of antioxidant components, the phytochemicals found in celery and orange juices were determined to have therapeutic potential in the study's conclusions. With a collagen density value of 3+ and a density of collagen fibers in the skin ranging from 50 to 90% per field of view, the group given orange juice had a more substantial impact on the collagen growth of rat skin tissue after exposure to UVB light compared to the group given celery juice.
Oral Red Pomegranate (Punica granatum) Extract Administration to Elevate Blood Glutathione Peroxidase Levels in Female Wistar Rats (Rattus Norvegicus) Following Maximum Physical Activity Liena, Liena; Rahma Sari; Fioni, Fioni
Jurnal EduHealth Vol. 14 No. 04 (2023): Jurnal eduHealt, 2023, December
Publisher : Sean Institute

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There is a significant danger to human health from oxidative stress. This disorder does not have any apparent symptoms. However, it is linked to the start and progression of many diseases. There are also no established medical procedures for detecting oxidative stress. Finding out how oral administration of red pomegranate (Punica granatum) extract increases blood glutathione peroxidase levels in female rats (Rattus norvegicus) strains is the goal of this experimental quantitative study, which employs a pre-test-post-test control group design. Maximum physical activity was induced in Wistar rats. Twenty-four animals were used in the experiments, with six in each group. Three, four, and five milliliters of red pomegranate extract were used in this experiment. With an antioxidant value of 8.33 ppm, pomegranate extract (Punica granatum) was determined to have a very robust action, according to the research. In terms of composition, the 5-milliliter dose of red pomegranate (Punica granatum) extract outperforms the others when compared to average levels of glutathione peroxidase. Researchers discovered that supplementing with red pomegranate extract (Punica granatum) considerably raised glutathione peroxidase levels, suggesting that this fruit may aid in the body's antioxidant defenses against free radicals generated by strenuous exercise.
Co-Authors Arhani, Adli ARILYN, ERIKA JIMENA Aulia, Hilda Rafni Binarwan Halim Chen Wei Dewi Riastawaty Edy Fachrial Erwina Putri, Riri Fibrini, Dewi Florenly Florenly Florenly Florenly Florenly Florenly Girsang, Ermi Janice Janice Ji Junfeng Jiang Fan Johannes Bastira Ginting Khainir Akbar, Khainir Li Sha Li Wei Liana Liana Liena Liena Liena, Liena Lister, I Nyoman Ehrich Lubis, Asyrun Alkhairi Lumbantobing, Christina JRE Meutia, Rena Nardi, Leo Nasution, Ali Napiah Nasution, Chairul Radjab Pratama , Irza Haicha Rahimi, Armon Rahma Sari Razoki, Razoki Reh Malem br Karo Rizal Rizal Simatupang, Veronica Triwindari Sinurat, Jhon Patar Siregar, Lidya Siregar, Lusyana Tarigan, Antje Irmella WAHYU WIDOWATI Wienaldi, Wienaldi