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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Kebijakan Kesehatan Indonesia MPI (Media Pharmaceutica Indonesiana) Universa Medicina Jurnal Kedokteran Anatomica (Anatomica Medical Journal) Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Journal of Islamic Medicine Alami Journal (Alauddin Islamic Medical) Journal Jurnal Manajemen Informasi dan Administrasi Kesehatan Jurnal Medika Malahayati Care : Jurnal Ilmiah Ilmu Kesehatan Jurnal Kesmas dan Gizi (JKG) Viva Medika: Jurnal Kesehatan, Kebidanan dan Keperawatan Health and Medical Journal Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia UMI Medical Journal Jurnal PORKES Nommensen Journal of Medicine AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Keluwih: Jurnal Kesehatan dan Kedokteran Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran JK Unila (Jurnal Kedokteran Universitas Lampung) International Islamic Medical Journal The Avicenna Medical Journal GALENICAL : Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh Indonesian Journal of Cancer Ahmad Dahlan Medical Journal Jurnal Kedokteran Ibnu Nafis Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara Prominentia Medical Journal Healthcaring: Jurnal Ilmiah Kesehatan Medical and Health Journal Biomedika Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran Berkala Ilmiah Kedokteran dan Kesehatan Masyarakat Jurnal Widya Medika
Laksono, Sidhi
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Case Report : Diagnosis and Management of Peripartum Cardiomyopathy Laksono, Sidhi; Puteri Nandifa, Veronica Nadya
Jurnal Medis Islam Internasional Vol 5 No 1 (2023): December
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v5i1.5202

Abstract

Introduction: Peripartum cardiomyopathy (PPCM) is generally viewed as diagnosis of exclusion in women presenting with heart failure and systolic dysfunction of unclear identifiable etiology. Etiology of PPCM is not fully understood and multifactorial. The purpose of this case is to review the diagnosis and management PPCM based on our experience in managing 31 years old woman with PPCM. Case: A 31 year old woman presented with dyspnea persisting for two days, exacerbated over the last 24 hours. She gave birth to her third child seven months ago. Patient had been experiencing dyspnea since 4 months earlier but seek no medical help. Upon physical examination, hemodynamic was stable, wet rales was noted in two thirds of the lung fields. Echocardiography revealed dilated left ventricle with eccentric hypertrophy and reduced ejection fraction (18%). Treatment was initiated with furosemide IV to resolve dyspnea, then Ramipril, bisoprolol, forxiga and spironolactone was given as heart failure therapy. Discussion: PPCM should be suspected in any peripartum women presenting with symptoms and signs of heart failure. Careful history taking and diagnostic testing especially echocardiography is important to help physicians determine the diagnosis. Conclusion: Treatment with medication adjusted for pregnancy and lactation may prevent adverse outcome, improve clinical symptoms and improve the overall cardiac functions. Long term follow up is important for patients with PPCM, since the optimal duration of medications after recovery is still unknown.  
Vasospastic Angina and its Contemporary Review of Pathophysiology, Diagnosis and Management Laksono, Sidhi; Suhandoko, Lidya Pertiwi
Jurnal Medis Islam Internasional Vol 5 No 2 (2024)
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v5i2.5760

Abstract

Introduction: Nearly half of patients who present with angina have non-obstructed coronary arteries. Patients with chest pain in the absence of obstructive coronary artery disease (CAD) remain a challenge. These patients undergoing invasive coronary angiography do not have epicardial coronary disease obstructive enough to explain these symptoms. This condition is potentially serious and can sometimes trigger severe arrhythmia resulting in ventricular fibrillation and sudden death. However, the pathophysiological mechanisms underlying this phenomenon are incompletely understood, which has resulted in limited therapeutic options for patients afflicted with this condition. This review article provides a comprehensive summary of the underlying pathophysiological mechanisms of VSA and the current therapeutic options. We also appraise the current diagnostic approach in patients with suspected VSA. Result: Coronary microvascular tone and subsequently, its blood flow is regulated through various vasodilating and vasoconstricting mechanisms. Coronary endothelial dysfunction and vascular smooth muscle hyperreactivity are proposed mechanism causing coronary artery spams. This may cause transient ST-Elevations, malignant arrhythmias and significant heart blocks. Various non-invasive and invasive exams may identify and differentiate these variant anginas. Conclusions: VSA can be diagnosed accurately and safely in the catheter laboratory. The mainstay of management is pharmacological treatment.
INFARK MIOKARD VENTRIKEL KANAN Arga Putra Mangitung, Muhammad; Laksono, Sidhi
Bahasa Indonesia Vol 5 No 1 (2024): Prominentia Medical Journal
Publisher : Universitas Ciputra Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37715/pmj.v5i1.4590

Abstract

Right ventricular myocardial infarction (RVMI) is a serious complication of myocardial infarction, in particular inferior infarction. This condition is characterized by impaired blood flow to the right ventricle resulting in ventriculary dysfunction and hemodynamic disorders. Diagnosis of RVMI requires clinical examination, electrocardiography, and echocardiography. The primary management of RVMI is revascularization as soon as possible to restore blood flow and improve ventricular function. The prognosis of RVMI depends on the location and extent of the infarction, with the blockage of the right marginal artery of the proximal artery having a worse prognosis.
COVID-19 Has Gone, But Not Its Cardiac Sequela: A Case Report Mohammad, Masmahathir; Laksono, Sidhi
AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Averrous, Volume 10 No.2 November 2024
Publisher : Fakultas Kedokteran Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/averrous.v10i2.19163

Abstract

Nearly 3 years have passed since the WHO declared COVID-19 as a pandemic. The pandemic left some problems, including cardiac, even after it has gone. Myocarditis is a common cardiac complication among COVID-19 infections. We present an interesting case of a 23-year-old male admitted with chronic heart failure after COVID-19 infections. A 23-Years Old Male patient came to our emergency department (ER) with Heart Failure (HF) symptoms and signs. He had history of flu like symptom, with positive COVID marker 3 weeks prior to admission. Patient was a sailor with history of healthy lifestyle, no cardiovascular risk factor and normal medical checkup result. Cardiomegaly with LVH configuration appeared in chest x-ray. The ECG 12-lead showed sinus bradycardia with PVC multifocal and episode of Torsade de Pointes auto convert. Echocardiography revealed reduced of Ejection Fraction (EF). Patient also had history of recurrent hospital admission with ADHF within 6 months. Cardiac MRI was done to distinguish the etiology of heart failure which support the diagnosis of non-ischemia cardiomyopathy caused by chronic myocarditis. From those data, we conclude that the etiology of heart failure in this patient was due to chronic myocarditis related Covid-19 infection. Myocarditis in post COVID-19 condition is an uncommon but still possible condition that needs to be considered. This case report emphasizes the etiology of HF must be sought in all cases, because its recognition can direct the therapy and influence the prognosis of these patients.
MIKRO-FISTULA MULTIPEL ARTERI KORONER KONGENITAL KE VENTRIKEL KIRI: SUATU LAPORAN KASUS: MULTIPLE CONGENITAL MICRO-FISTULES OF LEFT VENTRICULAR CORONARY ARTERY: A CASE REPORT Laksono, Sidhi
Jurnal Kedokteran Ibnu Nafis Vol. 13 No. 1 (2024): Juni 2024
Publisher : Fakultas Kedokteran Universitas Islam Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/jkin.v13i1.638

Abstract

Mikro-fistula multipel ventrikel kiri arteri koroner kongenital adalah beberapa fistula kaliber kecil yang dapat menyebabkan kekeruhan rongga ventrikel kiri dan kejadian ini relatif jarang terjadi. Kami laporkan kasus perempuan 85 tahun datang dengan keluhan nyeri dada khas infark dan sesak nafas. Faktor risiko berupa hipertensi, menopause dan diabetes mellitus tipe 2. Tidak didapatkan kelainan dalam pemeriksaan fisik, EKG didapatkan atrial fibrilasi, serta Troponin T sensitif dengan hasil tinggi. Didiagnosis dengan infark miokard non-ST elevasi risiko tinggi dan gagal jantung akut. Diberikan manajemen sindroma koroner akut dan angiografi koroner. Hasil angiografi didapatkan mikro-fistula multipel ventrikel kiri arteri koroner kongenital. Terapi sindroma koroner akut dihentikan dan obat antihipertensi dan antidiabetic tetap dilanjutkan. Fenomena pencurian arteri koroner dianggap sebagai dasar patofisiologi utama CAF dan berkaitan erat dengan gejala dan komplikasi fistula koroner.
PENGGUNAAN KEMBALI (REUSE) ALAT SEKALI PAKAI DI LABORATORIUM KATETERISASI JANTUNG: SUATU PANDUAN PRAKTIS: REUSE OF SINGLE-USE DEVICES IN THE CARDIAC CATHETERIZATION LABORATORY: A PRACTICAL GUIDE Laksono, Sidhi
Jurnal Kedokteran Ibnu Nafis Vol. 13 No. 2 (2024): Desember 2024
Publisher : Fakultas Kedokteran Universitas Islam Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/jkin.v13i2.674

Abstract

Penyakit kardiovaskuler semakin meningkat seiring waktu dan menjadi beban layanan kesehatan dunia terutama biaya belanja alat sekali pakai (Single Use Device, SUD). SUD adalah perangkat medis yang direkomendasikan untuk digunakan satu kali (yaitu hanya pada satu pasien untuk satu prosedur). Penggunaan kembali SUD di laboratorium kateterisasi jantung diperlukan dalam hal penghematan dan efisiensi biaya. SUD pada laboratorium kateterisasi jantung dapat berupa alat habis pakai kateter angiografi dan intervensi koroner, elektrofisiologi dan alat pacu jantung. Penggunaan kembali SUD membutuhkan sterilisasi yang baik untuk mencegah infeksi dan morfologi bentuk serta integritas dari SUD tersebut. Beberapa protokol sterilisasi dapat digunakan untuk mensterilisasi SUD ini jika akan digunakan kembali. Selain itu, perlu diperhatikan mengenai etik dan hukum dalam penggunaan kembali SUD ini.
PERAWATAN PALIATIF KARDIOVASKULAR: PENDEKATAN PENYAKIT JANTUNG TERMINAL Setianto, Budhi; Laksono, Sidhi
Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara Vol. 23 No. 2 (2024): Juli 2024
Publisher : Faculty of Medicine Universitas Islam Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/ibnusina.v23i2.659

Abstract

Penyakit kardiovaskular merupakan penyakit dengan morbiditas dan mortalitas tertinggi di dunia. Mortalitas dan morbiditas tersebut mempengaruhi kualitas hidup pasien hariannya dan menjelang kematiannya. Diperlukan perawatan holistik yang berguna untuk meningkatan kualitas hidup pasien dengan penyakit serius atau terminal kardiovaskular dan komplikasinya. Perawatan tersebut adalah perawatan paliatif, dimana perawatan ini multidisiplin dengan dukungan psikososial dan spiritual. Perawatan paliatif ini dibagi menjadi dua yaitu, primer dan sekunder. Perawatan paliatif primer dilakukan oleh ahli jantung, sedangkan perawatan sekunder dilakukan oleh ahli paliatif dengan tim lain. Perawatan ini dapat diterapkan pada pasien dengan penyakit jantung iskemik, penyakit katup jantung berat, gangguan irama, penyakit arteri perifer dan penyakit jantung kongenital dewasa. Penggunaan pereda nyeri dapat digunakan pada penyakit jantung iskemik, juga pengaturan ICD pada aritmia. Pada pasien dengan masalah katup, penyakit arteri perifer, maupun penyakit jantung kongenital, tindakan invasif maupun prosedur operasi perlu didiskusikan bersama dengan preferensi dari pasien. Diharapkan para ahli jantung dapat menggunakan layanan perawatan paliatif kardiovaskular untuk pasien tahap terminal kardiovaskular di kemudian hari.
Role of Omega-3 Acids in Cardiovascular Health: A Literature Review Laksono, Sidhi; Hosanna, Cliffian
JURNAL KESMAS DAN GIZI (JKG) Vol. 7 No. 1 (2024): Jurnal Kesmas dan Gizi (JKG)
Publisher : Fakultas Kesehatan Masyarakat Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jkg.v7i1.2239

Abstract

Introduction: Cardiovascular disease (CVD) is the leading cause of death in the world, with 27% of deaths in 2020 attributable to CVD. American Heart Association recommends adopting Mediterranean diet and eating 2-3 servings of fish to increase cardiovascular health and decrease morbidity and mortality caused by CVDs. This effect is thought to be attributed to Omega-3 content in those diets. But, conclusive evidence about the role of Omega-3 in cardiovascular disease hasn’t been reached. This paper aims to discuss further on to the topic of effects of Omega-3 on cardiovascular health. Method: Searching PubMed using keywords “Omega-3 Fatty Acids” AND “Cardiovascular”, and filtering relevant journals. Results: A literature review will be made from 6 choosen RCTs that fulfill all the criteria. Discussion: Bhatt et al concludes that supplementation of icosapent ethyl decreases CVD mortality, non-fatal MI, non-fatal stroke and unstable angina by 25%. But other RCTs fail to demonstrate said effects. Studies by Bowman et al, Kalstad et al, Manson et al, Nicholls et al, and Roncaglioni et al. concludes that supplementation of omega-3 fatty acid does not produce a significant change in CVD. These different findings across different studies may be caused by different doses of Omega-3 given, different baseline characteristics of patients and medications that masks the effects of Omega-3. Conclusion: Further studies are needed to determine the effects of omega-3 in CVD, but consumption of omega-3 appears to be safe and shows a slight reduction in CVD events based on a recent meta-analysis by Bernasconi et al.
Layanan Paliatif Pasien Gagal Jantung: Suatu Narasi Singkat Laksono, Sidhi; Hosanna, Cliffian
UMI Medical Journal Vol 9 No 2 (2024): UMI Medical Journal
Publisher : Fakultas Kedokteran Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/umj.v9i2.311

Abstract

Latar belakang: Gagal jantung merupakan penyakit dengan prevalensi cukup tinggi dengan angka mortalitas yang juga tinggi. Di samping itu, meskipun pengobatan dilakukan secara optimal, masih terdapat kemungkinan terjadinya perburukan. Isi: Dalam kasus gagal jantung lanjut, di mana fungsi atau struktur jantung telah mengalami kerusakan signifikan, penerapan terapi maksimal sesuai pedoman tidak lagi mampu mengatasi gejala. Populasi pasien gagal jantung lanjutan memiliki angka harapan hidup pasien yang lebih pendek. Gejala sesak dan nyeri juga akan mengganggu kualitas hidup pasien. Pasien dengan gagal jantung perlu dirujuk ke layanan paliatif sedini mungkin, terutama ketika prognosis pasien diketahui buruk dan harapan hidupnya rendah. Tinjauan literatur ini bertujuan untuk memberikan gambaran kajian ilmiah tentang layanan paliatif bagi pasien gagal jantung yang bertujuan untuk meringankan keluhan dan meningkatkan kualitas hidup pada pasien dan keluarga. Metodologi tinjauan literatur dengan melalui pencarian basis data medis pada jurnal kedokteran, pedoman, dan artikel medis. Kesimpulan: Peran layanan paliatif pada pasien dengan gagal jantung lanjutan telah direkomendasikan berbagai perkumpulan kardiologi di berbagai macam negara karena dapat membantu pasien mendapat pelayanan paling optimal sesuai dengan keinginan pasien.
Mekanisme Penghambat Sodium-Glukosa Transport Protein-2 (SGLT2-i) pada Penyakit Kardiovaskular: Sebuah Tinjauan Besmaya, Benazier Marcella; Laksono, Sidhi
MPI (Media Pharmaceutica Indonesiana) Vol. 5 No. 1 (2023): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v5i1.5266

Abstract

Proteksi kardiovaskular penting sebagai salah satu target tatalaksana pasien diabetes mellitus (DM) tipe 2. Penghambat sodium-glukosa kotransporter 2 (SGLT2-i), obat antidiabetik relatif baru yang bekerja dengan cara memblokade transporter SGLT-2 di tubulus proksimal ginjal, diketahui memiliki fungsi proteksi kardiovaskular yang baik. Uji klinis CANVAS, EMPA-REG, DECLARE-TIMI 58, VERTIS-CV masing-masing menggunakan kanagliflozin, empagliflozin, dapagliflozin, dan ertugliflozin menunjukkan superioritas atau setara dengan plasebo. Penulisan studi literatur ini menggunakan telaah jurnal-jurnal penelitian menggunakan PubMed, SAGE, dan Google Scholar. Tujuan tinjauan ini adalah untuk merangkum konsep terkini mekanisme protektif SGLT2-i pada kejadian kardiovaskular dan penggunaannya pada pasien jantung dengan atau tanpa diabetes mellitus. SGLT2-i ditemukan menurunkan risiko hospitalisasi akibat gagal jantung (30%) dan penyakit ginjal (45%) pada pasien DM tipe 2. SGLT2-i juga lebih terjangkau dan menurunkan biaya perawatan rumah sakit. Karena masih relatif baru, penelitian-penelitian yang ada masih berfokus pada luaran klinis, mortalitas dan keamanan obat ini. Mekanisme kerja efek proteksi kardiovaskular obat ini kebanyakan masih berdasarkan uji preklinis. SGLT2-i memiliki banyak efek farmakologis yang terbukti bermanfaat dalam mencegah penyakit kardiovaskular terutama gagal jantung. Uji klinis menunjukkan manfaat kardioprotektif SGLT2-i bukan berasal dari efek antiglikemiknya, namun melalui mekanisme kompleks yang berhubungan dengan volume dan diuresis, penurunan beban jantung, metabolisme jantung, serta proteksi vaskular. Cardiovascular protection is one of the treatment targets for type 2 DM patients. Sodium- glucose cotransporter 2 inhibitor (SGLT2-i), a relatively new antidiabetic drug that works by blocking the SGLT-2 transporter in the proximal renal tubule, is not expected to have a cardiovascular protectivefunction. CANVAS, EMPA-REG, DECLARE-TIMI 58, VERTIS-CV clinical evaluation using kanagliflozin, empagliflozin, dapagliflozin, and ertugliflozin showed the superiority or equal to the placebo. This literature study uses a review of research journals using PubMed, SAGE, and Google Scholar. This review aims to summarize the current concept of the protective mechanism of SGLT2-i in cardiovascular events and its use in cardiac patients with or without diabetes mellitus. SGLT2-i was found to reduce the risk of hospitalization due to heart failure (30%) and kidney disease (45%) in type 2 DM patients. SGLT2-i is also more affordable and lowers hospitalization costs. Because it is still relatively new, the existingstudies still focus on clinical outcomes, mortality, and safety of this drug. The mechanism of action for cardiovascular protection is mostly based on preclinical trials. SGLT2-i has many pharmacological effects that have proven beneficial in preventing cardiovascular disease, especially heart failure. Clinical trials have shown that the cardioprotective benefits of SGLT2-i are not derived from its anti-glycemic effect, but through complex mechanisms related to volume and diuresis, decreased cardiac load, cardiac metabolism, and vascular protection.
Co-Authors Afiyani, Nadia Angkasa, Irwan Surya Arga Putra Mangitung, Muhammad BESMAYA, BENAZIER MARCELLA Budhi Setianto Candra, Wincent Hertanto, Yoseph Jeffry Hosana, Cliffian Hosanna, Cliffian Hosea, Grace Trifena Jusuf, Axel Kusharsamita, Hillary Lasanudin, Hengkie Frankie Manuputty, Ferel Mohammad, Masmahathir Nokik Stujanna, Endin Nugraha, Dhiki Nurbaeti, Putri Nurusshofa, Zahra Oktaverina, Danisa Pertiwi Suhandoko, Lidya Prawara, Ananta Siddhi Puteri Nandifa, Veronica Nadya PUTRA, RAMI PRATAMA Putri Nurbaeti Sakura, Ayumi Syifa Sartika, Divina Rana Siregar, Reynaldo Halomoan Suhandoko, Lidya Pertiwi Surya Angkasa, Irwan Surya, Steven Philip Syahirah, A Tenri Syukran Widyani, Wella Zheng, Tonni Zheng, Tonny