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All Journal Amerta Nutrition World Nutrition Journal Journal of Indonesian Specialized Nutrition
Wasito, Erika
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Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Immunity as key factors that influence cognitive development on children Oktarina, Molly Dumakuri; Sekartini, Rini; Wasito, Erika; Kartjito, Melissa Stephanie
World Nutrition Journal Vol. 6 No. S2 (2023): Special Issue : expert perspectives on the interconnections between immunity,
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V06.S2.0003

Abstract

Immune cells in the central nervous system (CNS) of the fetus are essential for normal neurodevelopment. Innate immunity-related molecules, including cytokines, toll-like receptors and complement family, are known to be expressed in the brain. Microglia, macrophage-like immune cells that reside in the brain and spinal cord, constitute 80% of all immune cells in the brain, making them the most abundant immune cell type. Acquired immunity-related molecules, such as major histocompatibility complex and antibody receptor, are also known to be expressed in the brain. In addition to this, research has demonstrated that they play important functions in the development of the brain. Neurodevelopmental diseases, including schizophrenia, autism spectrum disorders, autism-like obsessive-compulsive behaviours and social impairment, are characterized by a disruption of a wide variety of processes in the developing brain that depend on the normal function of microglia. Enteric infections and malnutrition in the first two years of life are linked to later cognitive impairment. Multiple studies have shown that bacterial and viral illnesses have direct or indirect impacts on cognitive performance in children. The immune system is in constant communication with the central nervous system and participates in the control of behaviour and a range of other essential neurological activities throughout the lifespan.
The narrative review of recent studies in understanding the relationship between gut (microbiota)-brain axis, nutrition and cognitive function Pasiak, Taufiq Fredrik; Wiguna, Tjhin; Sekartini, Rini; Surapsari, Juwalita; Sundjaya, Tonny; Wasito, Erika; Basrowi, Ray Wagiu; Kartjito, Melissa Stephanie
World Nutrition Journal Vol. 6 No. S2 (2023): Special Issue : expert perspectives on the interconnections between immunity,
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V06.S2.0004

Abstract

The concept of the gut (microbiota)-brain axis, which influences the development and function of the gastrointestinal, immune, neuroendocrine, and metabolic systems, is gaining popularity. Recent animal studies have demonstrated that the gut (microbiota)-brain axis also plays a role in establishing cognitive function. It is known that a disruption in the environment's microbiota balance can increase disease susceptibility in children. Historically, it has been hypothesized that neurodevelopmental disorders are the results of a disruption in children’s health. However, it is becoming clear that the gut microbiota and the central nervous system communicate in both directions, which could explain how microbiota affects cognitive function. Dietary factors also play important role in the central nervous system via the gut (microbiota)-brain axis, demonstrating the importance of nutrition in optimizing cognitive function. This narrative review of recently published studies and current knowledge aims to elucidate the relationship between the gut (microbiota)-brain axis and cognitive function, as well as the variables that may influence it.
Co-Authors Azzahra, Adelia Basrowi, Ray Wagiu Dilantika, Charisma Fathiya, Dina Nurul Ibrahim, Ratih Kartjito, Melissa Stephanie Kinesya, Edwin Murti, Laksmi Oktarina, Molly Dumakuri Pasiak, Taufiq Fredrik Pelangi, Bunga Ramayulis, Rita Rini Sekartini Shella, Shella Sitorus, Nova Sundjaya, Tonny Surapsari, Juwalita Tjhin Wiguna