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All Journal Jurnal Ilmu Kesehatan Masyarakat Global Medical and Health Communication Public Health of Indonesia Jurnal Ilmiah Kedokteran Wijaya Kusuma Jurnal Kesehatan Komunitas The Indonesian Journal of Infectious Diseases Media Keperawatan Indonesia Medica Hospitalia Jurnal Peduli Masyarakat Indonesian Journal of Global Health research Narra J Indonesian Journal of Cancer
Murtiani, Farida
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Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Other

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Comparison of c-MYC Expression between Patients with Germinal Center and Non-Germinal Center B-cell-like Diffuse Large B Cell Lymphoma Hanum, Sitti Fatimah; Hardjolukito, Endang Sri Roostini; Kusmardi, Kusmardi; Murtiani, Farida; Widiantari, Aninda Dinar; Setiawaty, Vivi
Indonesian Journal of Cancer Vol 19, No 2 (2025): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i2.1277

Abstract

Background: c-MYC expression has been used as a prognostic marker to predict prognosis and determine therapeutic strategies in both Diffuse Large B Cell Lymphoma (DLBCL) subtypes. No study on c-MYC expression associated with DLBCL has ever been conducted in Indonesia. Our study aimed to evaluate differences in c-MYC expression in both DLBCL subtypes and assess the immunophenotype profile.Method: We selected 40 DLBCL cases and divided them into Germinal Center B-cell (GCB) and non-GCB subtypes using Hans Criteria. We evaluated c-MYC expression, and a cut-off value of 60.4% was determined using Receiver Operating Characteristic (ROC) curve analysis.Results: We found that c-MYC expression was significantly higher in GCB subtypes compared to non-GCB subtypes (n = 17 (42.5%) vs n = 20 (7.5%), p 0.000 and mostly had an immunophenotype of CD10+/BCL6+/MUM1+.Conclusion: Higher c-MYC expression is found more frequently in GCB subtypes. These findings suggest that c-MYC may play a subtype-specific role in DLBCL pathogenesis, potentially influencing therapeutic decisions for Indonesian patients. Future studies should validate these results in larger, multi-center cohorts and explore the mechanistic link between c-MYC and the GCB subtype and its clinical implications for targeted therapies.
Biomarkers for predicting COVID-19 mortality: A study at Sulianti Saroso Infectious Disease Hospital, Indonesia Maemun, Siti; Widiantari, Aninda D.; Murtiani, Farida; Herlina, Herlina; Tanjungsari, Dian W.; Wijiarti, Kunti; Pratiwi, Tiara Z.; Matondang, Faisal; Rusli, Adria; Rivaldiansyah, Rivaldiansyah; Tampubolon, Maria L.; Mariana, Nina; Setiawaty, Vivi; Purnama, Tri B.
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.1936

Abstract

The high transmissibility and mortality rates of the COVID-19 pandemic pose significant challenges. Patients can deteriorate rapidly, making it crucial to identify laboratory biomarkers for high-risk individuals. The aim of this study was to evaluate the predictive value of various laboratory parameters, including C-reactive protein (CRP), D-dimer, ferritin, neutrophil-to-lymphocyte ratio (NLR), prothrombin time (PT), and procalcitonin (PCT), in predicting COVID-19 mortality. A retrospective cohort study was conducted at Sulianti Saroso Infectious Disease Hospital, where COVID-19 patients were categorized into survivors and non-survivors. The Mann-Whitney test was used to assess group differences, while receiver operating characteristic (ROC) curve analysis was performed to evaluate the predictive performance of each biomarker, with Youden's index (J) determining optimal cut-off values. Kaplan-Meier analysis was used to compare median survival times, and Cox regression assessed hazard rates and the relationship between biomarkers and mortality. A total of 1,598 patients were analyzed, the majority of whom were admitted with oxygen saturation levels >95% and classified as having mild to moderate disease severity. Among them, 216 patients died, resulting in a mortality rate of 13.52%. Significant variations in mortality rates were observed along the survival functions for NLR, ferritin, D-dimer, CRP, and PCT (p<0.001). The survival curves for these biomarkers demonstrated distinct trends across tertiles over time. Among hematological markers, NLR was significantly associated with mortality (p<0.001), with a 1.5–2.2% increased risk per unit increase. Biochemical markers (complete blood count) proved to be more effective than hematological parameters (NLR, ferritin, PT, D-dimer, CRP, PCT) when evaluating individual prognostic performance. Bivariate analysis of CRP, D-dimer, ferritin, NLR, PT, and PCT between survivors and non-survivors showed significant differences. Notably, NLR and PCT were highly relevant for predicting disease prognosis and mortality, with sensitivity and specificity values exceeding 80%.
Predicting Unfavorable Treatment Outcomes in Multi-Drug Resistance Tuberculosis Patients: A Retrospective Study in Jakarta, Indonesia Hadayna, Saila; Adisasmita, Asri C.; Murtiani, Farida
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.6664

Abstract

Treatment of multidrug-resistant tuberculosis (MDR-TB) with a short-term regimen offers promise in terms of higher effectiveness and reduced therapy duration. However, treatment failure remains a major challenge in its implementation. This study aimed to identify predictive factors associated with unfavorable treatment outcome (UTO) among MDR-TB patients receiving the short-term regimen in DKI Jakarta Province from 2020 to 2022. Methods: A retrospective cohort study, using data from the National TB Information System (SITB). We retrieved all MDR-TB patients who started short-term treatment regimens at referral hospitals in DKI Jakarta Province in the period January 2020 to December 2022, totaling 166 patients. Each patient was followed for up to 11 months from the initiation of treatment, with final treatment outcomes collected through November 2023. Survival analysis using Cox proportional hazards regression was employed to assess the association between patient characteristics and time to UTO. Results: A total of 43.4% of patients is UTO. The cumulative probability of remaining free from UTO was 38% after day 400. Multivariate regression analysis showed that HIV-positive status (aHR = 2.98; 95% CI: 1.77–4.99) and comorbid diabetes mellitus (aHR = 1.92; 95% CI: 1.19–3.11) were significantly associated with an increased risk of UTO. Conclusion: UTO among MDR-TB patients on the short-term regimen remains high. HIV status and diabetes comorbidity are critical factors influencing treatment outcomes and should be prioritized in clinical management strategies for MDR-TB.
The Combination Diagnostic Test for Tuberculosis Screening in HIV Patients in Referral Hospitals in Indonesia Murtiani, Farida; Rosamarlina, Rosamarlina; Purnama, Asep; Farhanah, Nur; Utama, Made Susila; Agustin, Heidy; Sarif, Armaji Kamaludi; Widiantari, Aninda Dinar; Hasugian, Armedy Ronny
Public Health of Indonesia Vol. 11 No. 3 (2025): July - September
Publisher : YCAB Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36685/phi.v11i3.1094

Abstract

Background: Screening tests are needed to help screen suspected Tuberculosis (TB) pulmonary with HIV positive. With the limitation of specificity of the screening test and the need for combination with laboratory tools to increase that, a combination with standard examination is still needed, especially for limited healthcare facilities. Objective: This study aimed to determine Pulmonary TB screening tests with Human Immunodeficiency Syndrome (HIV) positive. Method: This observational study with a cross-sectional design was conducted in four government hospitals. Study subjects were inpatients and outpatients who met study inclusion criteria (> 14 years of age, HIV positive based on HIV test results, had clinical symptoms of episodic history of fever, and volunteered to take part in the study). Total subjects were 193 people, with episodic history of fever from <24 hours to 120 hours. Result: This study assessed a subject's clinical manifestation, physical examination and X-ray test. The “Night Sweat”, Infiltrates in the Upper Lobe”, “Enlargement of Lymph Nodes and “Left Rhonchi” and their combination have a sensitivity of>85%. Still, only the complete combination has a specificity of> 70%. The combination of “Night Sweat + Enlargement of Lymph Nodes + Left Rhonchi + Infiltrates in the Upper Lobe” and then “Enlargement of Lymph Nodes + Left Rhonchi + Infiltrates in the Upper Lobe” can be an alternative for screening Pulmonary TB-HIV positive with history of fever. Conclusion: Pulmonary TB screening in HIV patients with a history of fever can be used by completely combining clinical manifestation, physical examination, and X-ray. the variables "Night Sweat, Enlarged Lymph Nodes, left rhonchi breath sounds and pulmonary upper lobe infiltrates" in a gradual manner. Keywords: Diagnostic Combination Test; HIV-Tb Coinfection; Tuberculosis Screening; Clinical Manifestations in TB-HIV; Pulmonary TB in HIV Patients
Co-Authors Achmad Shidiq, Achmad Adria Rusli, Adria Afrina, Yeni Agustin Agustin Agustin, Heidy Aliza, Nur Amin, Desrinawati Muhammad Apriliani, Isnawati Armedy Ronny Hasugian Aryanto, Dara Tyas Putri Asep Purnama, Asep Asri C. Adisasmita Ciuputri, Pauline Darmawan, Flora Honey Dinar Widiantari, Aninda Djajaningrat, Husjain Endang Sri Roostini Hardjolukito Fajrunni’mah, Rizana Fitri Nurhayati Fitri, Desi Yulia Fitrianur Laili, Fitrianur Hadayna, Saila Hanum, Sitti Fatimah Harimat Hendarwan Hendrawati, Nunung Herlina Herlina Indawati, Eli Jahiroh, Jahiroh Kunti Wijiarti, Kunti Kusmardi Kusmardi Maemun, Siti Maryani Maryani Matondang, Faisal Mieska Despitasari Mochammad Hatta Muhammad Atoillah Isfandiari Nina Mariana, Nina Norma Norma Nugroho, Anita Puspitasari Dyah Nur Farhanah, Nur Nuraidah Nuraidah, Nuraidah Nurhayati Nurhayati PERTIWI, INTAN Pratiwi, Tiara Z. Purnama, Tri B. Rahmawani, Atika Rivaldiansyah, Rivaldiansyah rosamarlina, rosamarlina Sarif, Armaji Kamaludi Setianingsih, Tri Yuli Sudarto Ronoatmodjo Suliati Suliati Syafendra, Mega Oktariena Tampubolon, Maria L. Tanjungsari, Dian W. Tanjungsari, Dian Wahyu Titi Sundari Utama, Made Susila Vivi Setiawaty Wasilah Wasilah Widiantari, Aninda D. Widiantari, Aninda Dinar Wirasmi, Sundari Yoenoes, Dedet Hidayati Yulianto, Aris