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All Journal Jurnal Kesehatan Masyarakat (IKESMA) Global Medical and Health Communication JURNAL PENDIDIKAN KEPERAWATAN INDONESIA Public Health of Indonesia Jurnal Ilmiah Kedokteran Wijaya Kusuma Jurnal Kesehatan Komunitas The Indonesian Journal of Infectious Diseases Media Keperawatan Indonesia Medica Hospitalia Jurnal Ilmiah Keperawatan Imelda JURNAL PENELITIAN PERAWAT PROFESIONAL Jurnal Peduli Masyarakat Indonesian Journal of Global Health research Narra J Indonesian Journal of Cancer
Murtiani, Farida
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Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Veterinary Other

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Comparison of c-MYC Expression between Patients with Germinal Center and Non-Germinal Center B-cell-like Diffuse Large B Cell Lymphoma Hanum, Sitti Fatimah; Hardjolukito, Endang Sri Roostini; Kusmardi, Kusmardi; Murtiani, Farida; Widiantari, Aninda Dinar; Setiawaty, Vivi
Indonesian Journal of Cancer Vol 19, No 2 (2025): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i2.1277

Abstract

Background: c-MYC expression has been used as a prognostic marker to predict prognosis and determine therapeutic strategies in both Diffuse Large B Cell Lymphoma (DLBCL) subtypes. No study on c-MYC expression associated with DLBCL has ever been conducted in Indonesia. Our study aimed to evaluate differences in c-MYC expression in both DLBCL subtypes and assess the immunophenotype profile.Method: We selected 40 DLBCL cases and divided them into Germinal Center B-cell (GCB) and non-GCB subtypes using Hans Criteria. We evaluated c-MYC expression, and a cut-off value of 60.4% was determined using Receiver Operating Characteristic (ROC) curve analysis.Results: We found that c-MYC expression was significantly higher in GCB subtypes compared to non-GCB subtypes (n = 17 (42.5%) vs n = 20 (7.5%), p 0.000 and mostly had an immunophenotype of CD10+/BCL6+/MUM1+.Conclusion: Higher c-MYC expression is found more frequently in GCB subtypes. These findings suggest that c-MYC may play a subtype-specific role in DLBCL pathogenesis, potentially influencing therapeutic decisions for Indonesian patients. Future studies should validate these results in larger, multi-center cohorts and explore the mechanistic link between c-MYC and the GCB subtype and its clinical implications for targeted therapies.
Biomarkers for predicting COVID-19 mortality: A study at Sulianti Saroso Infectious Disease Hospital, Indonesia Maemun, Siti; Widiantari, Aninda D.; Murtiani, Farida; Herlina, Herlina; Tanjungsari, Dian W.; Wijiarti, Kunti; Pratiwi, Tiara Z.; Matondang, Faisal; Rusli, Adria; Rivaldiansyah, Rivaldiansyah; Tampubolon, Maria L.; Mariana, Nina; Setiawaty, Vivi; Purnama, Tri B.
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.1936

Abstract

The high transmissibility and mortality rates of the COVID-19 pandemic pose significant challenges. Patients can deteriorate rapidly, making it crucial to identify laboratory biomarkers for high-risk individuals. The aim of this study was to evaluate the predictive value of various laboratory parameters, including C-reactive protein (CRP), D-dimer, ferritin, neutrophil-to-lymphocyte ratio (NLR), prothrombin time (PT), and procalcitonin (PCT), in predicting COVID-19 mortality. A retrospective cohort study was conducted at Sulianti Saroso Infectious Disease Hospital, where COVID-19 patients were categorized into survivors and non-survivors. The Mann-Whitney test was used to assess group differences, while receiver operating characteristic (ROC) curve analysis was performed to evaluate the predictive performance of each biomarker, with Youden's index (J) determining optimal cut-off values. Kaplan-Meier analysis was used to compare median survival times, and Cox regression assessed hazard rates and the relationship between biomarkers and mortality. A total of 1,598 patients were analyzed, the majority of whom were admitted with oxygen saturation levels >95% and classified as having mild to moderate disease severity. Among them, 216 patients died, resulting in a mortality rate of 13.52%. Significant variations in mortality rates were observed along the survival functions for NLR, ferritin, D-dimer, CRP, and PCT (p<0.001). The survival curves for these biomarkers demonstrated distinct trends across tertiles over time. Among hematological markers, NLR was significantly associated with mortality (p<0.001), with a 1.5–2.2% increased risk per unit increase. Biochemical markers (complete blood count) proved to be more effective than hematological parameters (NLR, ferritin, PT, D-dimer, CRP, PCT) when evaluating individual prognostic performance. Bivariate analysis of CRP, D-dimer, ferritin, NLR, PT, and PCT between survivors and non-survivors showed significant differences. Notably, NLR and PCT were highly relevant for predicting disease prognosis and mortality, with sensitivity and specificity values exceeding 80%.
The Combination Diagnostic Test for Tuberculosis Screening in HIV Patients in Referral Hospitals in Indonesia Murtiani, Farida; Rosamarlina, Rosamarlina; Purnama, Asep; Farhanah, Nur; Utama, Made Susila; Agustin, Heidy; Sarif, Armaji Kamaludi; Widiantari, Aninda Dinar; Hasugian, Armedy Ronny
Public Health of Indonesia Vol. 11 No. 3 (2025): July - September
Publisher : YCAB Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36685/phi.v11i3.1094

Abstract

Background: Screening tests are needed to help screen suspected Tuberculosis (TB) pulmonary with HIV positive. With the limitation of specificity of the screening test and the need for combination with laboratory tools to increase that, a combination with standard examination is still needed, especially for limited healthcare facilities. Objective: This study aimed to determine Pulmonary TB screening tests with Human Immunodeficiency Syndrome (HIV) positive. Method: This observational study with a cross-sectional design was conducted in four government hospitals. Study subjects were inpatients and outpatients who met study inclusion criteria (> 14 years of age, HIV positive based on HIV test results, had clinical symptoms of episodic history of fever, and volunteered to take part in the study). Total subjects were 193 people, with episodic history of fever from <24 hours to 120 hours. Result: This study assessed a subject's clinical manifestation, physical examination and X-ray test. The “Night Sweat”, Infiltrates in the Upper Lobe”, “Enlargement of Lymph Nodes and “Left Rhonchi” and their combination have a sensitivity of>85%. Still, only the complete combination has a specificity of> 70%. The combination of “Night Sweat + Enlargement of Lymph Nodes + Left Rhonchi + Infiltrates in the Upper Lobe” and then “Enlargement of Lymph Nodes + Left Rhonchi + Infiltrates in the Upper Lobe” can be an alternative for screening Pulmonary TB-HIV positive with history of fever. Conclusion: Pulmonary TB screening in HIV patients with a history of fever can be used by completely combining clinical manifestation, physical examination, and X-ray. the variables "Night Sweat, Enlarged Lymph Nodes, left rhonchi breath sounds and pulmonary upper lobe infiltrates" in a gradual manner. Keywords: Diagnostic Combination Test; HIV-Tb Coinfection; Tuberculosis Screening; Clinical Manifestations in TB-HIV; Pulmonary TB in HIV Patients
Effectiveness of in-Tray Early Waring System Training on Knowledge and Practice of Nurses Nuraidah, Nuraidah; Widiantari, Aninda Dinar; Maemun, Siti; Hutabarat, Veronika; Khamid, Abdul; Wahyuning, Indah; Sumaryati, Sumaryati; Ambarwati, Desi; Murtiani, Farida
Indonesian Journal of Global Health Research Vol 6 No 5 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6i5.3367

Abstract

Death marks the conclusion of the disease trajectory. Prevention of fatality in patients facing acute and chronic diseases requires the competence of reliable health workers, with nurses playing a crucial role in delivering proficient care. Aiming for early detection of patients' clinical deterioration, nurses use an early warning system. Objective: to determine the effectiveness of EWS training in-tray method on knowledge and practice of EWS. We conducted a quasi-experimental study using one group pretest-posttest without a control group. The sample of this study was 70 executive nurses with consecutive sampling techniques. The research was held at the Inpatient Installation of Sulianti Saroso Infectious Disease Hospital (SSIDH) in June 2023. Observation sheets were utilized to assess Early Warning System (EWS) practices, and we employed valid and reliable questionnaires to gather information on respondents' knowledge. We performed univariate analysis using frequency distribution and bivariate analysis using the Wilcoxon test. Most respondents were in the late adult category (52.9%), female (80.0%), graduate Diploma III in nursing education (54.3%), and the most working period of 5 years (78.6%). The knowledge of participants increased significantly from 7.00 (2.00-13.00) (pretest) to 11.50 (5.00-20.00) (posttest) (p-value = 0.000). There was an increase in nurses' EWS knowledge and practice (p-value <0.05). Efforts to improve nurse competence in caring for patients with critical conditions are necessary. This can be achieved through coaching and regular training with the priority target of implementing nurses in the intensive care room.
Implementasi Teknik Clapping pada Anak Prasekolah dengan Pneumonia: Studi Kasus Darmawan, Dadang; Andriyani, Septian; Rahmi, Upik; Putri, Suci Tuty; Fitriana, Lisna Anisa; Malisa, Novi; Setiawan, Guling; Apriany, Dyna; Norma, Norma; Murtiani, Farida
Jurnal Penelitian Perawat Profesional Vol 6 No 6 (2024): Desember 2024, Jurnal Penelitian Perawat Profesional
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/jppp.v6i6.4657

Abstract

Pneumonia masih menjadi penyebab kematian yang signifikan, terutama pada anak usia prasekolah. Kondisi ini terjadi karena adanya penumpukan patogen di dalam alveoli yang menyebabkan terbentuknya eksudat inflamasi. Penelitian ini bertujuan untuk mengevaluasi intervensi clapping pada ana kusa prasekolah dengan pneumonia. Penelitian ini dirancang sebagai studi kasus dengan menggunakan pendekatan deskriptif kualitatif. Pengumpulan data dilakukan dengan wawancara, pemeriksaan fisik, observasi, dan analisis dokumentasi penelitian. Penelitian kami menghasilkan temuan yang signifikan yang menunjukkan efektivitas teknik clapping dalam membersihkan saluran napas, mengurangi akumulasi dahak, meningkatkan difusi gas, dan meringankan beban pernapasan. Teknik clapping sebagai salah satu komponen dari fisioterapi dada, memiliki potensi untuk diterapkan dalam intervensi penanganan pneumonia pada anak-anak.
PENGARUH TINDAKAN SUCTION PADA PERUBAHAN SATURASI OKSIGEN PADA PASIEN PNEUMONIA Yogasara, Yoseph; Rakhmawati, Arifah; Murtiani, Farida; Widiantari, Aninda Dinar
Jurnal Ilmiah Keperawatan IMELDA Vol. 9 No. 2 (2023): Jurnal Ilmiah Keperawatan IMELDA
Publisher : Program Studi S1/DIII-Keperawatan Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jikeperawatan.v9i2.1241

Abstract

ICU patients who use mechanical ventilators need intensive monitoring including blood gas analysis which contains oxygen saturation (SpO2). Suctioning is performed to clear airway, reduce sputum retention and prevent lung infection in advance. We studied effect of suctioning on oxygen saturation in pneumonia patients who used mechanical ventilator. This research was a quasi-experimental research with one group pretest-posttest design. We investigated 30 intensive care unit patients. Intervention was suctioning in semifowler position. Oxygen saturation was measured with pulse oximetry. Results showed that average oxygen saturation before intervention was 94,87% while after intervention was 96,93%. We performed Wilcoxon test and obtained p-value = 0.001. It concluded that suction affects oxygen saturation in pneumonia patients on ventilators in the ICU RSPI Sulianti Saroso with an average increase of 2.067%.
Pengaruh Infeksi Oportunistik, Kepatuhan ARV dan Dukungan Keluarga Terhadap Kualitas Hidup ODHA Saputra, Mohamad Hendra; Mochartini, Tri; Pertiwi, Intan; Rusli, Adria; Murtiani, Farida
The Indonesian Journal of Infectious Diseases Vol. 9 No. 1 (2023): The Indonesian Journal of Infectious Disease
Publisher : Rumah Sakit Penyakit Infeksi Prof Dr. Sulianti Saroso

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32667/ijid.v9i1.173

Abstract

Latar Belakang : Penderita HIV/AIDS dalam kehidupan sehari-hari dituntut untuk mampu menghadapi masalah yang kompleks, baik fisik, psikis, maupun spiritual. Beratnya permasalahan ODHA akan mempengaruhi aspek psikologis, sosial dan spiritual yang berdampak pada kualitas hidup yang buruk. Tujuan : mengetahui pengaruh infeksi oportunistik, kepatuhan pengobatan dan dukungan keluarga terhadap kualitas hidup ODHA di Pokja HIV RSPI Prof Dr. Sulianti Saroso. Metode : rancangan penelitian deskriptif korelasional dengan metode analitik melalui pendekatan cross sectional. Total sampel 98 sampel pasien HIV/AIDS di Pokja HIV RSPI Prof. Dr. Sulianti Saroso. Hasil : Sebagian besar pasien berusia dewasa akhir (36-45 tahun) (49%), jenis kelamin laki-laki (71,4%), dengan menyatakan pernah mengalami infeksi oportunistik (IO) (66,3%),patuh pada pengobatan (91,8%), mendapat dukungan keluarga (86,7%) dan kualitas hidup baik (85,7%). Terdapat hubungan infeksi oportunistik dengan kualitas hidup d(p value 0,030 < 0,05). Ada hubungan antara  kepatuhan pengobatan ARV dengan kualitas hidup ODHA (p value 0,001 < 0,05). Ada Hubungan keluarga dengan kualitas hidup ODHA ( p value 0,019 < 0,05). Kesimpulan : Kualitas hidup ODHA dipengaruhi oleh infeksi oportunistik, kepatuhan pengobatan ARV dan dukungan dari keluarga.
Case Series: Confirmed Diphtheria at Sulianti Saroso Infection Center Hospital in The Post-pandemic Period Nugroho, Anita Puspitasari Dyah; Herlina, Herlina; Hendrawati, Nunung; Aliza, Nur; Hartono, Teguh Sarry; Widiantari, Aninda Dinar; Murtiani, Farida
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol. 14 No. 1 (2025): MARET 2025
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v14i1.4121

Abstract

Background: Diphtheria vaccine coverage decreased during the Covid-19 pandemic. Diphtheria is caused by Corynebacterium diphtheria, which infects the upper respiratory system and produces toxins circulating in the body. The disease was fatal, with a mortality rate higher in children. This study described a case series of confirmed hospitalised diphtheria patients at Sulianti Saroso Infectious Disease Hospital (SSIDH) eighteen months post-pandemic. Objective: to describe epidemiological characteristics, laboratory examinations and outcomes of hospitalised diphtheria patients at SSIDH from January 1st, 2022, to June 31st,2023. Case Presentation: We reported ten confirmed diphtheria cases based on RT-PCR and clinical and epidemiological diagnosis. Of the ten cases, nine were children (<18 years old), six were male patients, and five lived in Jakarta. Based on Albert staining, 9 of 10 samples were found to be bacilli, positive-gram bacteria with metachromatic granular. Result: According to the RT-PCR examination, eight cases were confirmed positive for toxigenic diphtheria, five were a mitis subtype, one was a gravis subtype, and the other four were undetected. Based on clinical examination, eight cases were classified as severe diphtheria, five cases included myocarditis, and three patients passed away. Pediatric cases dominated diphtheria cases. RT-PCR examinations are more accurate and specific to finding toxigenic subtypes in the Jakarta Metropolitan Area. Conclusion: The detection of diphtheria cases in adult’s highlights concerns about adult immunity and awareness of vaccination. Vaccination campaigns and booster shots are essential, alongside continuous surveillance and accurate testing to prevent a resurgence of the disease.
The Efficacy of Warm and Cold Compresses in Reducing Body Temperature among Hyperthermic Sepsis Patients Lukito, Kurniawan Raharjo; Sahrudi, Sahrudi; Widiantari, Aninda Dinar; Murtiani, Farida
Jurnal Pendidikan Keperawatan Indonesia Vol 10, No 1 (2024): Volume 10, Nomor 1, Juni 2024
Publisher : Universitas Pendidikan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17509/jpki.v10i1.67349

Abstract

Introduction: Clinical manifestations in sepsis patients include high fever (hyperthermia). Interventions to reduce fever can be done through non-pharmacological therapy, including cold and warm compresses. Objective: This study was determine the effectiveness of warm and cold compresses on temperature changes in hyperthermic patients in the ICU. Methods: This study was a quantitative study with a quasi-experimental pre-post design with a control group. The study was conducted at Sulianti Saroso Infectious Disease Hospital (SSIDH). The sample consisted of sixty (60) patients diagnosed with sepsis in the ICU, with thirty (30) patients receiving warm compress intervention and thirty (30) patients receiving cold compress intervention. The intervention involved a compressing procedure according to the hospital's SOP. Results: In the warm compress intervention group, the average body temperature before intervention was 38.740C; after intervention, it was 36.760C. In the cold compress intervention group, the body temperature before intervention was 38.590C; after intervention, it was 36.750C. There was a difference in body temperature before and after intervention for both warm and cold compresses (p-value=0.0001) but the changes in the two interventions were not statistically different (p-value=0.437). Conclusion: Both compresses are effective in reducing the body temperature of sepsis patients experiencing hyperthermia. The results of this study can be used as input for nursing interventions in ICU patients with hyperthermia problems with non-pharmacological interventions through warm compresses and cold compresses.
Co-Authors Abdul Khamid, Abdul Achmad Shidiq, Achmad Adria Rusli, Adria Afrina, Yeni Agustin Agustin Agustin, Heidy Aliza, Nur Ambarwati, Desi Amin, Desrinawati Muhammad Apriliani, Isnawati Armedy Ronny Hasugian Aryanto, Dara Tyas Putri Asep Purnama, Asep Ciuputri, Pauline Dadang Darmawan Darmawan, Flora Honey Dinar Widiantari, Aninda Djajaningrat, Husjain Dyna Apriany Endang Sri Roostini Hardjolukito Fitri Nurhayati Fitri, Desi Yulia Fitrianur Laili, Fitrianur Hanum, Sitti Fatimah Harimat Hendarwan Hendrawati, Nunung Herlina Herlina Hutabarat, Veronika Indawati, Eli Jahiroh, Jahiroh Kunti Wijiarti, Kunti Kusmardi , Lisna Anisa Fitriana, Lisna Anisa Lukito, Kurniawan Raharjo Maemun, Siti Maryani Maryani Matondang, Faisal Mieska Despitasari Mochammad Hatta Mochartini, Tri Muhammad Atoillah Isfandiari Nina Mariana, Nina Norma Norma Novi Malisa, Novi Nugroho, Anita Puspitasari Dyah Nur Farhanah, Nur Nuraidah Nuraidah, Nuraidah Nurhayati Nurhayati PERTIWI, INTAN Pratiwi, Tiara Z. Purnama, Tri B. Rahmawani, Atika Rakhmawati, Arifah Rivaldiansyah, Rivaldiansyah Rizana Fajrunni’mah rosamarlina, rosamarlina Sahrudi, Sahrudi Saputra, Mohamad Hendra Sarif, Armaji Kamaludi Septian Andriyani, Septian Setianingsih, Tri Yuli Setiawan, Guling Suci Tuty Putri, Suci Tuty Sudarto Ronoatmodjo Suliati Suliati Sumaryati Sumaryati Syafendra, Mega Oktariena Tampubolon, Maria L. Tanjungsari, Dian W. Tanjungsari, Dian Wahyu Teguh Sarry Hartono, Teguh Sarry Titi Sundari Upik Rahmi, Upik Utama, Made Susila Vivi Setiawaty Wahyuning, Indah Wasilah Wasilah Widiantari, Aninda D. Widiantari, Aninda Dinar Wirasmi, Sundari Yoenoes, Dedet Hidayati Yogasara, Yoseph Yulianto, Aris