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All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Jurnal Fitofarmaka Indonesia JFL : Jurnal Farmasi Lampung Jurnal Ilmu Kefarmasian Indonesia SULUH: Jurnal Abdimas Science Midwifery Pharmaceutical And Biomedical Sciences Journal (PBSJ) Indonesian Journal of Multidisciplinary Science Journal of Natural Product for Degenerative Diseases Indonesian Journal of Jamu Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Djamil, Ratna
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Penambatan Molekul Senyawa Swietemacrophyllanin dari Kulit Batang Mahoni (Swietenia macrophylla King,) sebagai Inhibitor Enzim Alfa Glukosidase Khaerunnisa, Arini; Djamil, Ratna; Sulastri, Lilik; Rudiana, Tarso; Simanjuntak, Partomuan
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 5 No. 2 (2023)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i2.32926

Abstract

Mahogany (Swietenia macrophylla King.) is one of the plants used as an antidiabetic agent. 96% ethanol extract of S. macrophylla stem bark can inhibit the α-glucosidase enzyme. Methanol and aqueous extracts of S. macrophylla stem bark can reduce rat blood glucose levels induced by streptozotocin. Molecular docking is one of the most widely used structural-based drug design strategies due to its wide application in the analysis of binding energy and molecular interactions between drug compounds and receptors. This study aims to identify the compounds in the stem bark of S. macrophylla and analyze the molecular anchoring of the compounds produced by the aid. The research was carried out by means of the water fraction of the stem bark of S. macrophylla and was purified by column chromatography. Fraction 2 was identified by LCMS-MS. Molecular docking using AutoDock 4.2.6. The results of Fraction 2 showed the presence of catechins, evodionol, swietemacrophyllanin, swietenitin K and β-sitosterol. The results of an in-silico study showed that swietemacrophyllanin provided a better affinity than acarbose with a binding energy value of -8.57 kcal/mol and an inhibition constant of 0.52 µM. Forms hydrogen bonds with catalytic residues (Glu277 and Asp352) from the active site of the α-glucosidase enzyme. Swietemacrophyllanin has potential as an antidiabetic agent
Phytochemical profile, antioxidant activity, and sun protection potential of selected Annonaceae species Djamil, Ratna; Iskandar, Maria Clarissa; Pratami, Diah Kartika
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1671

Abstract

Excessive sun exposure can damage the skin, highlighting the need for effective natural sunscreens. This study aimed to evaluate the phytochemical profile, antioxidant activity, total phenolic content (TPC), total flavonoid content (TFC), and sun protection factor (SPF) of five Annonaceae species. Methanolic leaf extracts of Annona muricata (soursop), Annona squamosa (sugar apple), Cananga odorata (cananga), Annona reticulata (nona), and Monoon longifolium (glodokan tiang) were analyzed. Phytochemical screening was performed to identify secondary metabolites. Antioxidant activity was determined using the DPPH radical scavenging assay, while TPC and TFC were measured spectrophotometrically. SPF values were calculated using the Mansur method. Phytochemical screening confirmed the presence of flavonoids, saponins, tannins, steroids, and phenolics in all extracts, with cananga leaves additionally containing alkaloids, coumarins, and essential oils. The DPPH assay showed antioxidant activity with IC₅₀ values ranging from 12.89–228.98 ppm, classified from very strong to weak. TPC and TFC values ranged from 12.33–31.75 mg GAE/g extract and 8.83–28.19 mg QE/g extract, respectively. SPF values ranged from 19.32–35.03, indicating all extracts fall under the ultra-protection category, with soursop leaf extract exhibiting the highest SPF. This study highlights the potential of Annonaceae leaf extracts, particularly A. muricata, as promising natural antioxidant and photoprotective agents due to their high polyphenolic and flavonoid content.
Co-Authors Anindita, Kintan Apriandini, Lisya Arini Khaerunnisa Chaidir Chaidir Diah Kartika Pratami Djoko, Wahyuni endah, endah Faizatun, Faizatun Iskandar, Maria Clarissa Lamsari, Lamsari Lilik Sulastri Muhammad Hanafi Narrij Lotulung, Puspa Dewi Nina Artanti Noor, Siti Umrah Novi Yantih Nuralih Nuralih, Nuralih Partomuan Simanjuntak Pratiwi, Inda Qodriah, Rahmatul Swandiny, Greesty Finotory Syamsudin Syamsudin Tarso Rudiana, Tarso Taurhesia, Shelly Vidia Riyantika, Lola Witono Basuki, Witono Yesi Desmiaty, Yesi Yolandari, Febby Ola Zaidan, Sarah