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All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Global Medical and Health Communication Biology, Medicine, & Natural Product Chemistry Jurnal Surya Medika Jurnal Biomedika dan Kesehatan Jurnal Hutan Tropika Journal of Experimental and Clinical Pharmacy (JECP) Kontribusi: Jurnal Penelitian dan Pengabdian Kepada Masyarakat Jurnal Pengabdian Masyarakat Bangsa International Journal of Health, Engineering and Technology
Nawan, Nawan
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In Silico Exploration of Bioactive Compounds from Dracaena cochinchinensis as Potential Inhibitors of Streptococcus pyogenes Inosine-5'-Monophosphate Dehydrogenase (IMPDH) Handayani, Septi; Nawan, Nawan; Toemon, Agnes
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.1265-1271

Abstract

The emergence of multidrug-resistant Streptococcus pyogenes presents a significant global health threat, demanding the urgent discovery of novel antibacterial agents. This study utilized a comprehensive in silico framework to investigate 17 compounds from the traditional medicinal plant Dracaena cochinchinensis as potential inhibitors of Inosine-5'-monophosphate dehydrogenase (IMPDH), a validated antimicrobial drug target. The workflow included predictive modeling of physicochemical properties, pharmacokinetics (ADME), toxicity profiles, and molecular docking simulations to elucidate binding affinities and interaction patterns within the enzyme's active site. Physicochemical analysis revealed that 11 of the 17 compounds exhibited drug-like properties. Molecular docking identified several ligands with high binding affinities, notably Isopimaric acid (-8.2 kcal/mol) and Cochinchinenene D (-8.1 kcal/mol), whose stability was mediated by interactions with key catalytic residues. ADMET predictions indicated that most compounds possess favorable pharmacokinetic profiles. Crucially, Isopimaric acid demonstrated a superior safety profile, with a high LD50 (5000 mg/kg), no predicted mutagenicity, and no risk of drug-induced liver injury (DILI). This computational investigation successfully identified Isopimaric acid as a standout candidate, and its combination of strong target affinity and a favorable ADMET profile positions it as a promising scaffold for the development of novel antibacterial agents against S. pyogenes. These findings provide a strong impetus for experimental validation.
In Vitro Antibacterial Activity of Ethanolic Extract of Pasak Bumi (Eurycoma longifolia) root against Streptococcus Pyogenes Naulita Turnip, Oktaviani; Urdha, Adyatma; Teresa, Astrid; Nawan, Nawan; Arleny, Ina
Media Farmasi: Jurnal Ilmu Farmasi Vol. 23 No. 1 (2026): March 2026
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v23i1.31803

Abstract

Infectious diseases remain a major public health concern in Indonesia, particularly upper respiratory tract infections such as pharyngitis caused by Streptococcus pyogenes. The increasing incidence of antibiotic resistance highlights the need for alternative antimicrobial agents from natural sources. Eurycoma longifolia (pasak bumi) is a medicinal plant known to contain bioactive compounds with potential antibacterial properties. This study aimed to evaluate the in vitro antibacterial activity of Eurycoma longifolia root extract against Streptococcus pyogenes. This study used a true experimental design with a post-test only control group. Antibacterial activity was tested using the disc diffusion method on Mueller Hinton Agar (MHA). Seven groups were tested: five extract concentrations (5%, 10%, 15%, 25%, and 50%), a positive control (erythromycin), and a negative control (aquades). Data were analysed using one-way ANOVA (p < 0.05). The extraction yielded 2.67% extract. The results showed inhibition zone diameters of 0 mm (negative control) and 22.35 mm (positive control). The extract exhibited inhibition zones of 2.0 mm, 3.25 mm, 3.5 mm, 3.75 mm, and 5.42 mm at concentrations of 5%, 10%, 15%, 25%, and 50%, respectively. Statistical analysis indicated significant differences among treatment groups. In conclusion, Eurycoma longifolia root extract demonstrated concentration-dependent antibacterial activity against Streptococcus pyogenes, with effects classified as weak to moderate. These findings suggest its potential as a natural antibacterial agent, although further studies are needed to optimize its efficacy.
Co-Authors Abbas, Aziz Syamsuddin Alexandra, Francisca Diana Anjarrisna, Rifa Arleny, Ina Astuti, Yuni Wiji Fasya, Muhamad Ikmal Furtuna, Dewi Klarita Hanasia, Hanasia Handayani, Septi Ina Arleny Izzi, Muhamad Syafiul Lautt, Bambang S. Liswara Neneng Ludang, Yetrie Miftahul Jannah Miko, Seth Nafisah, Laela Natalia Sri Martani Naulita Turnip, Oktaviani Nisa Kartika Komara Nurhalimah Nurhalimah Oktaviannur, Zoelva Permatasari, Silvani Purwono, Wahyu Adi Rahman, Reza Arifin Rian Ka Praja Rusmanto, Joni Sanchia Cleosha Viorina Septi Handayani Simatupang, Tumpal Susanda, Meita Riyan Teresa, Astrid Toemon, Agnes Toemon, Agnes Immanuela Turnip, Oktaviani Naulita Urdha, Adyatma Usop, Aswin Wulandari, Intan Wahyu