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All Journal Indonesian Journal of Pharmaceutical Science and Technology Indonesian Journal of Biotechnology Universa Medicina Sumatera Medical Journal Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Cermin Dunia Kedokteran Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Indonesian Journal of Cancer The Indonesian Journal of General Medicine Cermin Dunia Kedokteran
Muhar, Adi Muradi
Department Of Surgical, Medical Faculty, Universitas Sumatera Utara (USU), Medan 20155, Indonesia
Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Veterinary

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Diffuse Large B-Cell Lymphoma (DLBCL) of the Mesocolon in A Young Man with Intussusception: A Case Report Laksmi, Lidya Imelda; Muhar, Adi Muradi; Hasibuan, Winda Syahfitri
Indonesian Journal of Cancer Vol 20, No 1 (2026): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v20i1.1449

Abstract

Introduction: Diffuse Large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma (NHL), accounting for 25% to 30% of NHL cases. Diffuse large B-cell lymphoma (DLBCL) commonly happens in the seventh decade and often arises in the lymph nodes but can also present as an extra nodal disease. Nodal DLBCL involves the lymph nodes and does not involve the organ under the lymph nodes. In this case, we want to report a case of 25 men diagnosed with intussusception caused by nodal mesocolon enlargement, and histomorphology examinations revealed that the nodal enlargement is DLBCL. Here we reported a case of 25 years old man diagnosed with invagination caused by nodal mesocolon enlargement and, histomorphology examinations revealed the nodal enlargement is DLBCL.Case Presentation: We reported a case of 25 years old man complaints nausea, vomiting, abdominal pain, and was diagnosed with intussusception. Macroscopic examination showed nodal enlargement without colon mucosal involvement. Microscopic examination showed a relatively uniform and monotonous distribution of lymphoid cells with large cell sizes, enlarged nuclei with a round to oval shape, vesicular chromatin, amphophilic cytoplasm and some foci of tumour cells arranged in loose stroma. Macrophage and atypical mitoses were found. Immunohistochemical examination results were as follows: CD 117 (-), DOG 1 (-), CK (-), CD 45 (+), Myogenin (-), MyoD1 (-), CD20 (-), CD3 (-), Ki67 50%, CD 20 (+), CD3 (-), CD 10 (-), BCL6 (-), MUM1 (+).Conclusion: Diffuse large B-cell lymphoma (DLBCL) can occur in gastrointestinal as extra nodal lymphoma. The mesocolon contains many lymph nodes, but gastrointestinal lymphoma usually involves the gastrointestinal tissue. This case reports a case of 25 years old man who presents with intussusception caused by DLBCL in nodal mesocolon without colon involvement.
Co-Authors Adeodatus Yuda Handaya Adianto Nugroho Agung Ary Wibowo, Agung Ary Agung Putra Agung Putra Aziizah Gita Azizah Retno Kustiyah Dedy Hermansyah Edwin Saleh Siregar, Edwin Saleh Eko Setiawan Faizal Mukharim Fransiscus Arifin Haitamy, Mohammad Nurrizki Hasibuan, Winda Syahfitri Ibrahim, Sugeng Iffan Alif Indah Situmorang Irwan Irwan Laksmi, Lidya Imelda Lalisang, Arnetta Naomi Louise Lesmana, Tommy Maria Mayasari Mazni, Yarman Mohammad, Fawzan Muhammad Aflah Muhammad Aflah Mulyawan, I Made Niam, Muhammad Shobachun Nur Dina Amalina Nurul Hidayah Parluhutan Siagian Prabowo, Erik Putra, Jeffri Reno Rudiman Rivai, Muhammad Iqbal Setyadi, Kunsemedi Setyo Trisnadi Siagian, Novi Andriani Sinaga, Bintang Yinke Magdalena Suprapto, Bambang Taskworo, Dodik Tendean, Michael Titiek Sumarawati Toar J.M. Lalisang Utami, Wulan Dyah Warsinggih, Warsinggih Zulkhairi Zulkhairi