This study aims to determine the effect of the Problem Based Learning (PBL) model on students' problem-solving abilities in the topic of the human respiratory system at SMA Negeri 1 Bahorok. The research employed a quantitative approach using a quasi-experimental design with a pretest-posttest control group design. The sample consisted of 60 11th-grade science students divided into two groups: an experimental class (using PBL) and a control class (using conventional learning). The instrument used was an essay test consisting of 10 questions. The results showed a significant difference between the posttest scores of the experimental and control classes. The average posttest score of the experimental class was 95.00, while the control class scored 63.33. The Independent Samples t-Test indicated a significance value of 0.000 (< 0.05), confirming that the PBL model significantly influenced the improvement of students' problem-solving abilities. Therefore, the PBL model is effective in enhancing students' problem-solving skills, particularly in biology lessons on the respiratory system.